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The map label for this gene is cheA [H]

Identifier: 78223906

GI number: 78223906

Start: 3059482

End: 3061815

Strand: Direct

Name: cheA [H]

Synonym: Gmet_2710

Alternate gene names: 78223906

Gene position: 3059482-3061815 (Clockwise)

Preceding gene: 78223905

Following gene: 78223907

Centisome position: 76.54

GC content: 65.0

Gene sequence:

>2334_bases
TTGTATTCACCCGTGCGCCGACGCGCTTCAGCGCACAGGCACTGGTCGCCCCTACATGGAACACCCATGGATAAAGACTT
TCTGAAAAAACTTCTGGCAACCTTCGCGGTCGAATCCAGGGAGCGCCTCGACGCCATCTCCACCACACTCGTGGAACTGG
AGCAGAGCAGTTCCCCCGCGAGGGAGCTGGAGCTGATCGAGGCGCTCTTCAGGGAAACCCACAGCCTGAAAGGTGCTGCC
CGCTCCGTCAATGCGGCGTCCATCGAGGCGGTGAGCCATGCCTTGGAGAACCTCTTCTCGGCCATGAAACGCCGGGAGGT
GGAGCCGGTGCCGGAACTGTTCGATCTCCTCCACACGGCGGTCGACACGATAGGGGGACTACTCCCGTCCCTTGAAACCG
GCCCCTCCACCACGGAAAAGGAGCGTCTCAAGGAGGTGGTGTTCCGCCTGCACCAGGCCCAGCGGGGCACCCTTCCCCCC
CGTCCTCCGGCACCCGCTCCCCCCCCGGAACAGGAGGAACCCTCCCAGGCCGGGAAAGCGACAGCACCGCAGACCGTGAG
AATAGCCACCGAGAAACTCGACACCCTTCTCCACCAGACCGAAGGGATGCTGACGGCGAAGCTGGCCGCGGCCCAAAGGG
CGAAGGAGTTGCGTGGTGAACTCCAGGCGCTGGCCCTCTGGGAAAAGGAGTGGAAAAAGCTGCTGCCTTCATTGCGGCGC
CTGCGCAGGGAGCTGAAAAGCGGGGCGAACAGCGGGACCGCTTCGGAGGGAAGCGATGCGCCCACCAGGAAACTCCTCGA
ATTCCTCGACTGGAATCAGGTGGTGGTCAAGATGACACGGTATCGGCTGAGCCGCCTGACCAGAGGGGCGGAGCACGACC
TCATGCACCTGGGGGACATGGTGGAGAGCCTCCTGGGAGATGTGCGGGAGGCGCTGATGCTCCCCTTCTCGTCACTGCTG
TCGCTCCTCCCGAAGCTCGTCCGCGACCTCTCCCGGGACCGGGGCAAGGAGGTGGAGCTGGTCGTGGAGGGGGAGGCCAT
CGAGATCGACCGGCGGGTCCTGGAGGAGATGAAGGACCCCTTCGTGCACCTGGTACGGAACTGCATCGACCACGGCATCG
AACGCCCCGCGGAGCGGGAGCGGCAGGGGAAGCCCCCCCGCGGGAGGATCGCCATCACCGTCGCCCTCTCTGATAACAAG
AGGGTCGAGATCGTCATTGCCGACGACGGGGCCGGCATCAACGTCATCCGCCTTCAGGAAGCGGCCGTGAAGCTGGGCCT
TGTCTCCCTGGAAGGGGCGGAACAGGATGAGGGACAGGATCCCCTCTCCCTCATCTTCGCCTCGGGACTGTCAACGAGCC
CTGTCATCGACGACATCTCGGGGAGGGGGCTCGGCCTCGCCATCGTGCGGGATAAAGTGGAGCGGCTCGGCGGAACCATC
GCCGTCGAAAGCGAGGCGGGACTCGGGACCACCTTCCGCATCACCCTCCCCCTGACCCTCTCCACCTTCAGGGGGGTGCT
GGTCCGGGCGGGCGGCCACCTCTTCGTGCTGCCGACCACCGACGTGGAGCGCGTGGCCCGGAAAGGGAGAACGGCCATCG
CCACCGTTGAAAACCGGGAAACCATCGAACTGGACGGCCGAACTCTCTCCTTTGCCAGATTGAGCGACGTCCTGGAGCTT
CCGCGCACGGAAAGGGGCGATGGAGACGGGGAGCACCTCTCCTTCTTCGTCCTCCCCACCGAGCACGGGGGAATCGCCTT
CGGGGTGGACGAGGTCGTGGGGGAGCAGGAGGTGACGGTCAAGGGGCTCGGGCCTCAACTGCGCCGCGTGCGCAACATTG
CCGGCGCCACGGTTCTGGGGAGCGGCAAGGTGGCGCCGATCCTGAACAGCAGCGACCTGGTAAAGTCGGCGGTCAGGGTC
GCCGGGGCAGGCACCGTCACCGGCTACGCACCTCCTGCGGAGGAAGCGGCTCCGCGCTCGATCTTGGTCGTAGAGGATTC
GATCACCGCCCGGACGCTCCTGAAGAACATCCTGGAAGCGGCAGGCTACCGGGTAAAAACCGCCGTGGACGGTGTCGACG
CCCTGACGCTGCTCGGCACCGAGGATTTCGACCTGGTGGTCTCCGACGTGGACATGCCGCGCATGAACGGCTTCGAGTTG
ACCGGAAGGATCCGTGAATCACGGCAGCTGGCCGAGCTGCCGGTGGTGCTGGTAACTTCCCTCGACTCCCGCGAGGACCG
GGAACGGGGGGTCGATGCCGGGGCAAACGCCTATATCGTGAAGAGCAGTTTCGACCAGAGCAATCTGCTGGATGCCATAC
GGAGGCTGATTTGA

Upstream 100 bases:

>100_bases
ACGAAACAGGCCGAGTCCTCCGCCCAGAATCTCCATGAGTTGGGACAGAAGCTGAAGCGGCTGGTGGAGCAACTCAAACT
GTAACGGGCAAGGGGCAATC

Downstream 100 bases:

>100_bases
GCTGTGGAGTAAGAGGCTGAGATGGTGAAGGTTCTCATTGTGGACGACTCGGCGAGCGTGCGGCTGTTCCTTCAGGGGCT
GCTCGCCGCCGACCCGGGGA

Product: CheA signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 777; Mature: 777

Protein sequence:

>777_residues
MYSPVRRRASAHRHWSPLHGTPMDKDFLKKLLATFAVESRERLDAISTTLVELEQSSSPARELELIEALFRETHSLKGAA
RSVNAASIEAVSHALENLFSAMKRREVEPVPELFDLLHTAVDTIGGLLPSLETGPSTTEKERLKEVVFRLHQAQRGTLPP
RPPAPAPPPEQEEPSQAGKATAPQTVRIATEKLDTLLHQTEGMLTAKLAAAQRAKELRGELQALALWEKEWKKLLPSLRR
LRRELKSGANSGTASEGSDAPTRKLLEFLDWNQVVVKMTRYRLSRLTRGAEHDLMHLGDMVESLLGDVREALMLPFSSLL
SLLPKLVRDLSRDRGKEVELVVEGEAIEIDRRVLEEMKDPFVHLVRNCIDHGIERPAERERQGKPPRGRIAITVALSDNK
RVEIVIADDGAGINVIRLQEAAVKLGLVSLEGAEQDEGQDPLSLIFASGLSTSPVIDDISGRGLGLAIVRDKVERLGGTI
AVESEAGLGTTFRITLPLTLSTFRGVLVRAGGHLFVLPTTDVERVARKGRTAIATVENRETIELDGRTLSFARLSDVLEL
PRTERGDGDGEHLSFFVLPTEHGGIAFGVDEVVGEQEVTVKGLGPQLRRVRNIAGATVLGSGKVAPILNSSDLVKSAVRV
AGAGTVTGYAPPAEEAAPRSILVVEDSITARTLLKNILEAAGYRVKTAVDGVDALTLLGTEDFDLVVSDVDMPRMNGFEL
TGRIRESRQLAELPVVLVTSLDSREDRERGVDAGANAYIVKSSFDQSNLLDAIRRLI

Sequences:

>Translated_777_residues
MYSPVRRRASAHRHWSPLHGTPMDKDFLKKLLATFAVESRERLDAISTTLVELEQSSSPARELELIEALFRETHSLKGAA
RSVNAASIEAVSHALENLFSAMKRREVEPVPELFDLLHTAVDTIGGLLPSLETGPSTTEKERLKEVVFRLHQAQRGTLPP
RPPAPAPPPEQEEPSQAGKATAPQTVRIATEKLDTLLHQTEGMLTAKLAAAQRAKELRGELQALALWEKEWKKLLPSLRR
LRRELKSGANSGTASEGSDAPTRKLLEFLDWNQVVVKMTRYRLSRLTRGAEHDLMHLGDMVESLLGDVREALMLPFSSLL
SLLPKLVRDLSRDRGKEVELVVEGEAIEIDRRVLEEMKDPFVHLVRNCIDHGIERPAERERQGKPPRGRIAITVALSDNK
RVEIVIADDGAGINVIRLQEAAVKLGLVSLEGAEQDEGQDPLSLIFASGLSTSPVIDDISGRGLGLAIVRDKVERLGGTI
AVESEAGLGTTFRITLPLTLSTFRGVLVRAGGHLFVLPTTDVERVARKGRTAIATVENRETIELDGRTLSFARLSDVLEL
PRTERGDGDGEHLSFFVLPTEHGGIAFGVDEVVGEQEVTVKGLGPQLRRVRNIAGATVLGSGKVAPILNSSDLVKSAVRV
AGAGTVTGYAPPAEEAAPRSILVVEDSITARTLLKNILEAAGYRVKTAVDGVDALTLLGTEDFDLVVSDVDMPRMNGFEL
TGRIRESRQLAELPVVLVTSLDSREDRERGVDAGANAYIVKSSFDQSNLLDAIRRLI
>Mature_777_residues
MYSPVRRRASAHRHWSPLHGTPMDKDFLKKLLATFAVESRERLDAISTTLVELEQSSSPARELELIEALFRETHSLKGAA
RSVNAASIEAVSHALENLFSAMKRREVEPVPELFDLLHTAVDTIGGLLPSLETGPSTTEKERLKEVVFRLHQAQRGTLPP
RPPAPAPPPEQEEPSQAGKATAPQTVRIATEKLDTLLHQTEGMLTAKLAAAQRAKELRGELQALALWEKEWKKLLPSLRR
LRRELKSGANSGTASEGSDAPTRKLLEFLDWNQVVVKMTRYRLSRLTRGAEHDLMHLGDMVESLLGDVREALMLPFSSLL
SLLPKLVRDLSRDRGKEVELVVEGEAIEIDRRVLEEMKDPFVHLVRNCIDHGIERPAERERQGKPPRGRIAITVALSDNK
RVEIVIADDGAGINVIRLQEAAVKLGLVSLEGAEQDEGQDPLSLIFASGLSTSPVIDDISGRGLGLAIVRDKVERLGGTI
AVESEAGLGTTFRITLPLTLSTFRGVLVRAGGHLFVLPTTDVERVARKGRTAIATVENRETIELDGRTLSFARLSDVLEL
PRTERGDGDGEHLSFFVLPTEHGGIAFGVDEVVGEQEVTVKGLGPQLRRVRNIAGATVLGSGKVAPILNSSDLVKSAVRV
AGAGTVTGYAPPAEEAAPRSILVVEDSITARTLLKNILEAAGYRVKTAVDGVDALTLLGTEDFDLVVSDVDMPRMNGFEL
TGRIRESRQLAELPVVLVTSLDSREDRERGVDAGANAYIVKSSFDQSNLLDAIRRLI

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Membrane (Potential). Note=It is not known whether CheA is actually membrane bound although CheA has two regions at the C-terminal end with the potential to be transmembrane regions [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=657, Percent_Identity=27.3972602739726, Blast_Score=206, Evalue=6e-54,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=45.0980392156863, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI1788713, Length=102, Percent_Identity=42.156862745098, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI87082012, Length=114, Percent_Identity=36.8421052631579, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1788191, Length=101, Percent_Identity=40.5940594059406, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI1790863, Length=101, Percent_Identity=38.6138613861386, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1787487, Length=111, Percent_Identity=34.2342342342342, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI1786784, Length=117, Percent_Identity=32.4786324786325, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR010808 [H]

Pfam domain/function: PF01584 CheW; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt; PF07194 P2 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 84809; Mature: 84809

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSPVRRRASAHRHWSPLHGTPMDKDFLKKLLATFAVESRERLDAISTTLVELEQSSSPA
CCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
RELELIEALFRETHSLKGAARSVNAASIEAVSHALENLFSAMKRREVEPVPELFDLLHTA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VDTIGGLLPSLETGPSTTEKERLKEVVFRLHQAQRGTLPPRPPAPAPPPEQEEPSQAGKA
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCC
TAPQTVRIATEKLDTLLHQTEGMLTAKLAAAQRAKELRGELQALALWEKEWKKLLPSLRR
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRRELKSGANSGTASEGSDAPTRKLLEFLDWNQVVVKMTRYRLSRLTRGAEHDLMHLGDM
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VESLLGDVREALMLPFSSLLSLLPKLVRDLSRDRGKEVELVVEGEAIEIDRRVLEEMKDP
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHH
FVHLVRNCIDHGIERPAERERQGKPPRGRIAITVALSDNKRVEIVIADDGAGINVIRLQE
HHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEEECCCCEEEEEEECCCCCEEEEEEHH
AAVKLGLVSLEGAEQDEGQDPLSLIFASGLSTSPVIDDISGRGLGLAIVRDKVERLGGTI
HHHHHEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEE
AVESEAGLGTTFRITLPLTLSTFRGVLVRAGGHLFVLPTTDVERVARKGRTAIATVENRE
EEECCCCCCEEEEEEEEEEHHHHHHHHEECCCCEEEEECCCHHHHHHCCCEEEEEECCCC
TIELDGRTLSFARLSDVLELPRTERGDGDGEHLSFFVLPTEHGGIAFGVDEVVGEQEVTV
EEEECCCEEHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCEEECHHHHHCCCCEEE
KGLGPQLRRVRNIAGATVLGSGKVAPILNSSDLVKSAVRVAGAGTVTGYAPPAEEAAPRS
ECCCHHHHHHHHHHCCEEECCCCCCEECCCHHHHHHHHHHCCCCCCCCCCCCCHHCCCCE
ILVVEDSITARTLLKNILEAAGYRVKTAVDGVDALTLLGTEDFDLVVSDVDMPRMNGFEL
EEEEECCHHHHHHHHHHHHHCCCEEEEHHCCCCEEEEECCCCCEEEEECCCCCCCCCEEH
TGRIRESRQLAELPVVLVTSLDSREDRERGVDAGANAYIVKSSFDQSNLLDAIRRLI
HHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHC
>Mature Secondary Structure
MYSPVRRRASAHRHWSPLHGTPMDKDFLKKLLATFAVESRERLDAISTTLVELEQSSSPA
CCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
RELELIEALFRETHSLKGAARSVNAASIEAVSHALENLFSAMKRREVEPVPELFDLLHTA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VDTIGGLLPSLETGPSTTEKERLKEVVFRLHQAQRGTLPPRPPAPAPPPEQEEPSQAGKA
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHCCCC
TAPQTVRIATEKLDTLLHQTEGMLTAKLAAAQRAKELRGELQALALWEKEWKKLLPSLRR
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRRELKSGANSGTASEGSDAPTRKLLEFLDWNQVVVKMTRYRLSRLTRGAEHDLMHLGDM
HHHHHHCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
VESLLGDVREALMLPFSSLLSLLPKLVRDLSRDRGKEVELVVEGEAIEIDRRVLEEMKDP
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHH
FVHLVRNCIDHGIERPAERERQGKPPRGRIAITVALSDNKRVEIVIADDGAGINVIRLQE
HHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEEECCCCEEEEEEECCCCCEEEEEEHH
AAVKLGLVSLEGAEQDEGQDPLSLIFASGLSTSPVIDDISGRGLGLAIVRDKVERLGGTI
HHHHHEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEE
AVESEAGLGTTFRITLPLTLSTFRGVLVRAGGHLFVLPTTDVERVARKGRTAIATVENRE
EEECCCCCCEEEEEEEEEEHHHHHHHHEECCCCEEEEECCCHHHHHHCCCEEEEEECCCC
TIELDGRTLSFARLSDVLELPRTERGDGDGEHLSFFVLPTEHGGIAFGVDEVVGEQEVTV
EEEECCCEEHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCCCEEECHHHHHCCCCEEE
KGLGPQLRRVRNIAGATVLGSGKVAPILNSSDLVKSAVRVAGAGTVTGYAPPAEEAAPRS
ECCCHHHHHHHHHHCCEEECCCCCCEECCCHHHHHHHHHHCCCCCCCCCCCCCHHCCCCE
ILVVEDSITARTLLKNILEAAGYRVKTAVDGVDALTLLGTEDFDLVVSDVDMPRMNGFEL
EEEEECCHHHHHHHHHHHHHCCCEEEEHHCCCCEEEEECCCCCEEEEECCCCCCCCCEEH
TGRIRESRQLAELPVVLVTSLDSREDRERGVDAGANAYIVKSSFDQSNLLDAIRRLI
HHHHHHHHHHHHCCEEEEECCCCHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1938941; 9384377 [H]