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The map label for this gene is ndk

Identifier: 78223882

GI number: 78223882

Start: 3033502

End: 3033915

Strand: Reverse

Name: ndk

Synonym: Gmet_2686

Alternate gene names: 78223882

Gene position: 3033915-3033502 (Counterclockwise)

Preceding gene: 78223883

Following gene: 78223881

Centisome position: 75.9

GC content: 53.62

Gene sequence:

>414_bases
ATGGAAAGAACATTCGCTATTATCAAGCCTGATGCGGTTGAGAGGAATATTGTCGGCAAGGTTCTCGAGAAGATCGAGGC
CGCTGGCTTCAGGATTGTGGGCATGAAGAAGATTCAGCTCTCCAAGAAGGAAGCCGAGGGCTTCTATTATGTTCACAGTG
AGCGTCCCTTCTTTGGCGATCTCTGCTCCTTCATGTCGCGCAGCCCAGTGGTTGTGCTTGCTCTTGAGCGTGAGAACGCC
ATTGCCAAGTGGCGTGAAGTTATGGGCGCCACCAATCCGGCCAACGCCGATGCCGGCACGATTCGCAAGGAATTCGGTCT
CAGCATCGAGGAGAACACGGTTCACGGTTCCGATTCACCCGAGTCGGCTGCCTTCGAGATCCCTTACTTTTTCAGCCAGC
TTGAACTCCTCTAG

Upstream 100 bases:

>100_bases
AGGCCTTTTTCTATTTGAGCTTCCGAACCGGATTGACACAGGACCAGTTACGTGGTATCTAGTGAGGTCATTTTATCTCG
TATATATACTGGAGGCCACG

Downstream 100 bases:

>100_bases
GTCATCCCAAGATTGCGAGGAAAAAGCCCTTCCCTTGAAGGGCTTTTTTATATTCAATAAACCATGATGAACGGCAAAAT
TGATATTAAGAACCTGACCC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 137; Mature: 137

Protein sequence:

>137_residues
MERTFAIIKPDAVERNIVGKVLEKIEAAGFRIVGMKKIQLSKKEAEGFYYVHSERPFFGDLCSFMSRSPVVVLALERENA
IAKWREVMGATNPANADAGTIRKEFGLSIEENTVHGSDSPESAAFEIPYFFSQLELL

Sequences:

>Translated_137_residues
MERTFAIIKPDAVERNIVGKVLEKIEAAGFRIVGMKKIQLSKKEAEGFYYVHSERPFFGDLCSFMSRSPVVVLALERENA
IAKWREVMGATNPANADAGTIRKEFGLSIEENTVHGSDSPESAAFEIPYFFSQLELL
>Mature_137_residues
MERTFAIIKPDAVERNIVGKVLEKIEAAGFRIVGMKKIQLSKKEAEGFYYVHSERPFFGDLCSFMSRSPVVVLALERENA
IAKWREVMGATNPANADAGTIRKEFGLSIEENTVHGSDSPESAAFEIPYFFSQLELL

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=42.6470588235294, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI4557797, Length=136, Percent_Identity=42.6470588235294, Blast_Score=117, Evalue=3e-27,
Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=41.9117647058824, Blast_Score=117, Evalue=4e-27,
Organism=Homo sapiens, GI66392203, Length=137, Percent_Identity=40.8759124087591, Blast_Score=115, Evalue=8e-27,
Organism=Homo sapiens, GI66392227, Length=137, Percent_Identity=40.8759124087591, Blast_Score=115, Evalue=9e-27,
Organism=Homo sapiens, GI66392205, Length=137, Percent_Identity=40.8759124087591, Blast_Score=115, Evalue=9e-27,
Organism=Homo sapiens, GI4505409, Length=137, Percent_Identity=40.8759124087591, Blast_Score=115, Evalue=9e-27,
Organism=Homo sapiens, GI66392192, Length=137, Percent_Identity=40.8759124087591, Blast_Score=115, Evalue=9e-27,
Organism=Homo sapiens, GI4826862, Length=136, Percent_Identity=38.9705882352941, Blast_Score=103, Evalue=6e-23,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=40.6015037593985, Blast_Score=102, Evalue=8e-23,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=40.6015037593985, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=38.5185185185185, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI4505413, Length=137, Percent_Identity=32.8467153284672, Blast_Score=78, Evalue=2e-15,
Organism=Homo sapiens, GI148839372, Length=120, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=8e-15,
Organism=Homo sapiens, GI30023828, Length=139, Percent_Identity=32.3741007194245, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1788866, Length=136, Percent_Identity=52.9411764705882, Blast_Score=155, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=39.2592592592593, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6322783, Length=136, Percent_Identity=38.2352941176471, Blast_Score=113, Evalue=1e-26,
Organism=Drosophila melanogaster, GI45549037, Length=136, Percent_Identity=43.3823529411765, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18860097, Length=138, Percent_Identity=34.0579710144928, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_GEOMG (Q39S70)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_385629.1
- ProteinModelPortal:   Q39S70
- SMR:   Q39S70
- STRING:   Q39S70
- GeneID:   3740109
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_2686
- NMPDR:   fig|269799.3.peg.3200
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q39S70
- ProtClustDB:   PRK00668
- BioCyc:   GMET269799:GMET_2686-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15332; Mature: 15332

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTFAIIKPDAVERNIVGKVLEKIEAAGFRIVGMKKIQLSKKEAEGFYYVHSERPFFGD
CCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCEEEEECCCCCHHH
LCSFMSRSPVVVLALERENAIAKWREVMGATNPANADAGTIRKEFGLSIEENTVHGSDSP
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEECCEECCCCCC
ESAAFEIPYFFSQLELL
CCCEEECCHHHHHHHCC
>Mature Secondary Structure
MERTFAIIKPDAVERNIVGKVLEKIEAAGFRIVGMKKIQLSKKEAEGFYYVHSERPFFGD
CCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCEEEEECCCCCHHH
LCSFMSRSPVVVLALERENAIAKWREVMGATNPANADAGTIRKEFGLSIEENTVHGSDSP
HHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHHHCCCEECCEECCCCCC
ESAAFEIPYFFSQLELL
CCCEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA