Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 78223869

GI number: 78223869

Start: 3020942

End: 3022153

Strand: Reverse

Name: coaBC [H]

Synonym: Gmet_2673

Alternate gene names: 78223869

Gene position: 3022153-3020942 (Counterclockwise)

Preceding gene: 78223870

Following gene: 78223867

Centisome position: 75.6

GC content: 65.1

Gene sequence:

>1212_bases
ATGCTCAACGGCAAGCAGATCGTCCTCGGCGTCACCGGCGGCATAGCCGTCTACAAGGCGGTGGAGCTCGTGCGGCTCCT
GACCAAGGCGGGGGCCGACGTCCACGTCATCATGACCCGCTCGGCCACGGAATTCGTGGGGCCCCTCACCTTTCAGACCC
TCACCGCGAATCCGGTCCACACGGAGATTTTCAACCTGATCGCCGAGCGGGAGATCGGCCACATTGCCCTGGCCGACCGG
GCCGATCTCTTCATCATTGCCCCGGCCACGGCCAACGTCATCGGCAAGATCGCGGGCGGCATCGCCGATGACATGCTCAC
CACCACCGTCATGGCCACCAGGGCGTCGGTCCTCATTGCCCCGGCCATGAATGTGAACATGTGCACCAATCCCATCTACC
GTGAAAACGAGGAGAAGCTCCGCCGCCACGGCTATCGCTTCGTGGCTCCGGTCAAGGGGATGCTCGCCTGCGGTTGGGAG
GGGGAGGGGAAGCTCCAGGACCCGGCCATTATCATGGAGGAGGCGGTCTGCGCCCTCACGCGGCAGGACCTGGTTGGTGA
GCGGGTTCTCGTGACCGCTGGCCCGACCCTGGAGGAGATCGACCCGGTCCGCTTCATCAGCAACCACTCGTCGGGAAAGA
TGGGATACTCCATTGCCCGGGCCGCCCGGCGCCGCGGGGCCGAGGTGGTTCTCGTGGCCGGACCCACCTGCCTCGACGAC
CCCTGGGGGATCGAGACGGTCCATGTCTGCTCCGCCGCCGAGATGCGCGACGCGGTCATGGAGCGGGTCGCGGCGAGCAC
CGTCATCGTCAAGGCGGCGGCCGTGGCCGACTACTGCCCAAAGAGTCGGGCTGCGGGGAAGATCAAGAAGTCAGCCGATG
CCATGGTGCTGGAGCTGGAGAAAAACCCCGACATCCTGGCGGAAGTGGGGCGGGTGAAGGGGGATCGGGTTCTGGTGGGA
TTTGCCGCCGAAACCAGCGATTTGGTGGAGAATGCCCGGAAGAAGCTGACCGGCAAGAACCTGGACCTGGTGGTGGCCAA
CGACATCGGCCAGCCAGGGGCCGGTTTCAACGTGGATACCAACATCGCCAAGCTCCTCCACCGGGATGGGCGTGTCGAGG
AACTCCCCCTCATGGGGAAGGATGAGATGGCGACGATTATCCTCGACCGGGCGGCCGGGCTGCGGAAGCAGGGAATGAGA
GGAGAAGAGTAG

Upstream 100 bases:

>100_bases
CTCCCCGACGAGACCCAGGTCTTCCCGGGACACGGCGAGGCGAGCTCCATCGGGCGGGAGAAGCTGTACAATCCGTACCT
GAACGGGTAGGAGACCATCC

Downstream 100 bases:

>100_bases
GGGGTTCGGGAGTCAGGAGTCAGAATGCAGAAGTCGGAATGAAATTCGCGCAACAGCATTCTGAACTTGTGTTCGAGTGG
ACTTTCTCCTGAATTCTGAC

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MLNGKQIVLGVTGGIAVYKAVELVRLLTKAGADVHVIMTRSATEFVGPLTFQTLTANPVHTEIFNLIAEREIGHIALADR
ADLFIIAPATANVIGKIAGGIADDMLTTTVMATRASVLIAPAMNVNMCTNPIYRENEEKLRRHGYRFVAPVKGMLACGWE
GEGKLQDPAIIMEEAVCALTRQDLVGERVLVTAGPTLEEIDPVRFISNHSSGKMGYSIARAARRRGAEVVLVAGPTCLDD
PWGIETVHVCSAAEMRDAVMERVAASTVIVKAAAVADYCPKSRAAGKIKKSADAMVLELEKNPDILAEVGRVKGDRVLVG
FAAETSDLVENARKKLTGKNLDLVVANDIGQPGAGFNVDTNIAKLLHRDGRVEELPLMGKDEMATIILDRAAGLRKQGMR
GEE

Sequences:

>Translated_403_residues
MLNGKQIVLGVTGGIAVYKAVELVRLLTKAGADVHVIMTRSATEFVGPLTFQTLTANPVHTEIFNLIAEREIGHIALADR
ADLFIIAPATANVIGKIAGGIADDMLTTTVMATRASVLIAPAMNVNMCTNPIYRENEEKLRRHGYRFVAPVKGMLACGWE
GEGKLQDPAIIMEEAVCALTRQDLVGERVLVTAGPTLEEIDPVRFISNHSSGKMGYSIARAARRRGAEVVLVAGPTCLDD
PWGIETVHVCSAAEMRDAVMERVAASTVIVKAAAVADYCPKSRAAGKIKKSADAMVLELEKNPDILAEVGRVKGDRVLVG
FAAETSDLVENARKKLTGKNLDLVVANDIGQPGAGFNVDTNIAKLLHRDGRVEELPLMGKDEMATIILDRAAGLRKQGMR
GEE
>Mature_403_residues
MLNGKQIVLGVTGGIAVYKAVELVRLLTKAGADVHVIMTRSATEFVGPLTFQTLTANPVHTEIFNLIAEREIGHIALADR
ADLFIIAPATANVIGKIAGGIADDMLTTTVMATRASVLIAPAMNVNMCTNPIYRENEEKLRRHGYRFVAPVKGMLACGWE
GEGKLQDPAIIMEEAVCALTRQDLVGERVLVTAGPTLEEIDPVRFISNHSSGKMGYSIARAARRRGAEVVLVAGPTCLDD
PWGIETVHVCSAAEMRDAVMERVAASTVIVKAAAVADYCPKSRAAGKIKKSADAMVLELEKNPDILAEVGRVKGDRVLVG
FAAETSDLVENARKKLTGKNLDLVVANDIGQPGAGFNVDTNIAKLLHRDGRVEELPLMGKDEMATIILDRAAGLRKQGMR
GEE

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=173, Percent_Identity=34.6820809248555, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI87082301, Length=393, Percent_Identity=46.0559796437659, Blast_Score=297, Evalue=1e-81,
Organism=Caenorhabditis elegans, GI17560194, Length=175, Percent_Identity=32, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322762, Length=192, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24657262, Length=186, Percent_Identity=30.1075268817204, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43183; Mature: 43183

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNGKQIVLGVTGGIAVYKAVELVRLLTKAGADVHVIMTRSATEFVGPLTFQTLTANPVH
CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCEEEEEECCCHH
TEIFNLIAEREIGHIALADRADLFIIAPATANVIGKIAGGIADDMLTTTVMATRASVLIA
HHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHCEEEEE
PAMNVNMCTNPIYRENEEKLRRHGYRFVAPVKGMLACGWEGEGKLQDPAIIMEEAVCALT
CCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
RQDLVGERVLVTAGPTLEEIDPVRFISNHSSGKMGYSIARAARRRGAEVVLVAGPTCLDD
HHHHCCCEEEEECCCCHHHCCCHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCC
PWGIETVHVCSAAEMRDAVMERVAASTVIVKAAAVADYCPKSRAAGKIKKSADAMVLELE
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEC
KNPDILAEVGRVKGDRVLVGFAAETSDLVENARKKLTGKNLDLVVANDIGQPGAGFNVDT
CCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCH
NIAKLLHRDGRVEELPLMGKDEMATIILDRAAGLRKQGMRGEE
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCC
>Mature Secondary Structure
MLNGKQIVLGVTGGIAVYKAVELVRLLTKAGADVHVIMTRSATEFVGPLTFQTLTANPVH
CCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHCCCEEEEEECCCHH
TEIFNLIAEREIGHIALADRADLFIIAPATANVIGKIAGGIADDMLTTTVMATRASVLIA
HHHHHHHHHCCCCEEEEECCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHCEEEEE
PAMNVNMCTNPIYRENEEKLRRHGYRFVAPVKGMLACGWEGEGKLQDPAIIMEEAVCALT
CCCCCCCCCCCCCCCCHHHHHHCCCEEEECCCCEEEECCCCCCCCCCCHHHHHHHHHHHH
RQDLVGERVLVTAGPTLEEIDPVRFISNHSSGKMGYSIARAARRRGAEVVLVAGPTCLDD
HHHHCCCEEEEECCCCHHHCCCHHHCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCC
PWGIETVHVCSAAEMRDAVMERVAASTVIVKAAAVADYCPKSRAAGKIKKSADAMVLELE
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCEEEEEEC
KNPDILAEVGRVKGDRVLVGFAAETSDLVENARKKLTGKNLDLVVANDIGQPGAGFNVDT
CCCHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCH
NIAKLLHRDGRVEELPLMGKDEMATIILDRAAGLRKQGMRGEE
HHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]