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The map label for this gene is zwf [H]

Identifier: 78223816

GI number: 78223816

Start: 2963482

End: 2965020

Strand: Reverse

Name: zwf [H]

Synonym: Gmet_2619

Alternate gene names: 78223816

Gene position: 2965020-2963482 (Counterclockwise)

Preceding gene: 78223817

Following gene: 78223815

Centisome position: 74.17

GC content: 64.39

Gene sequence:

>1539_bases
ATGGATACAACGATGAATTCTCGGATGGAACCGACCGTGATGGTGGTCTTCGGCGCCGCAGGTGATCTCACGTGGCGCAA
GCTTGTGCCGGCCCTCTACAACCTCTACCTTGACGGTCGTCTCCCCGAGCGGTTCGCCATCGTCGGGGTCGCCCGGCAAG
AGATGGATGATGCGGGATTCCGCCGAAAACTCAGGGAGGGGGTGGACCTCCACTCACGGCGCAGCGTGACGGACGAGTCA
ACGTGGAGTGGCTTCGCCGACCGGCTGTCGTACCTTGCCGGGGACTTCACCACGGCGGAAACCGGGGCACTCCTCAGCCG
GAGACTCGAAGGGCTGGACCGGGAGTGGAACGGCCGTGCGGTTCGGGTCTTCTACTTCGCCATTCCTCCCGGTCTTATGG
AAGCGGCGGCCCGCCAGTTGGAGAGCCTCGGCGTTTGCAGGGACTGCTCCCGGGACCGGCTCGTGGTTGAGAAACCCTTT
GGCCGCGACCTCGCTTCGGCCCGGCAGTTGAACGGGCTTCTCACCTCCCTGTTCGCCGAGACGCAGATCTATCGGATCGA
CCACTACCTGGGCAAGGAGACGGTGCAGAACATCCTCGCTTTCCGTTTCGCCAACTCTCTGTTCGAGCCGGTCTGGAACC
GGCGCTACATCGACCACGTGCAGATCACCGTCGCCGAAGCGGTGGGGGTGGGGAAGAGGGGAGGCTACTACGATACATCC
GGCGCCTTGCGTGACATGGTGCAGAATCACCTCCTCCAGATCCTCTGCCTGATTGCCATGGAGCCGCCGGTGTCGTTTTC
CGCCGACGAAGTGCGCAACAAGAAGGTGGATGTCTTGCGGGCCATTCGTCCCATTCGCCCCGAAGAAGTCCACCGGGTGG
CGGTCCGCGGCCAGTACGGCAGGGGGATGGTGGCCTGCGAGGGAGTGACGGGATACCGGGAAGAGCAGGGGGTGCCACCT
GACTCCGTCACCGAGACCTTTGCCGCCCTCAAGCTGTGGATCGACAATTGGCGCTGGCAAGGGGTGCCGTTCTATCTTCG
CACCGGTAAACGCCTGCGCGCCAAGGTCTCCGAGGTGGCCATCCTCTTCCGCCCGGCTCCGCACCAGCTCTTCCCCTCCG
CGGCCGTGGAGAGCTGGCAGCCGAACCGGCTCGTCCTTCGCATCCAGCCCGAGGAGGGGATTGCCTCCCGCATCCAGGTC
AAACAGCCGGGAACGCGCCTGCTGCTGGGAGCGGTGGACATGGGATTCCGTTACCATGACGCCTTCCACGCCGCCTCTCC
GGAAGCCTACGAGACTCTGCTCCTGGACGTCATCTGCGGCGACGCTACCCTCTTCATGCGGGCCGACCAGGTGGAGAGCG
CCTGGGGAGTCATTTCACCGATCCTCGATACCTGGGAATCGGTGCCGCCGGCCGATTTCCCCAACTACCAGGCCGGCGGC
TGGGGGCCGGAAACTGCTGATCTCCTCATCGCCAAGGAGGGGCACAGCTGGGTCCAACCCGACCTTCCGACGGAAGAGGG
AGAGACGGAGGCTCCATGA

Upstream 100 bases:

>100_bases
GACGACTTTGCCAATCGGCTTCTCTCTGCGATGCGCTACGAATTCGGGGGGCACCGGGAAAAGTCCTGACAGTCTGAGCA
TGCCCAAGGGGTAGATGGCG

Downstream 100 bases:

>100_bases
TCAGGGTCTACCTCGACCGGGAAGCCTTGAGCATGGCTGCCGCCGAACTCTTTGCAACCGCGGCGCACTCTGCCATGCGG
GACACGGGGAGGTTTGCCGT

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MDTTMNSRMEPTVMVVFGAAGDLTWRKLVPALYNLYLDGRLPERFAIVGVARQEMDDAGFRRKLREGVDLHSRRSVTDES
TWSGFADRLSYLAGDFTTAETGALLSRRLEGLDREWNGRAVRVFYFAIPPGLMEAAARQLESLGVCRDCSRDRLVVEKPF
GRDLASARQLNGLLTSLFAETQIYRIDHYLGKETVQNILAFRFANSLFEPVWNRRYIDHVQITVAEAVGVGKRGGYYDTS
GALRDMVQNHLLQILCLIAMEPPVSFSADEVRNKKVDVLRAIRPIRPEEVHRVAVRGQYGRGMVACEGVTGYREEQGVPP
DSVTETFAALKLWIDNWRWQGVPFYLRTGKRLRAKVSEVAILFRPAPHQLFPSAAVESWQPNRLVLRIQPEEGIASRIQV
KQPGTRLLLGAVDMGFRYHDAFHAASPEAYETLLLDVICGDATLFMRADQVESAWGVISPILDTWESVPPADFPNYQAGG
WGPETADLLIAKEGHSWVQPDLPTEEGETEAP

Sequences:

>Translated_512_residues
MDTTMNSRMEPTVMVVFGAAGDLTWRKLVPALYNLYLDGRLPERFAIVGVARQEMDDAGFRRKLREGVDLHSRRSVTDES
TWSGFADRLSYLAGDFTTAETGALLSRRLEGLDREWNGRAVRVFYFAIPPGLMEAAARQLESLGVCRDCSRDRLVVEKPF
GRDLASARQLNGLLTSLFAETQIYRIDHYLGKETVQNILAFRFANSLFEPVWNRRYIDHVQITVAEAVGVGKRGGYYDTS
GALRDMVQNHLLQILCLIAMEPPVSFSADEVRNKKVDVLRAIRPIRPEEVHRVAVRGQYGRGMVACEGVTGYREEQGVPP
DSVTETFAALKLWIDNWRWQGVPFYLRTGKRLRAKVSEVAILFRPAPHQLFPSAAVESWQPNRLVLRIQPEEGIASRIQV
KQPGTRLLLGAVDMGFRYHDAFHAASPEAYETLLLDVICGDATLFMRADQVESAWGVISPILDTWESVPPADFPNYQAGG
WGPETADLLIAKEGHSWVQPDLPTEEGETEAP
>Mature_512_residues
MDTTMNSRMEPTVMVVFGAAGDLTWRKLVPALYNLYLDGRLPERFAIVGVARQEMDDAGFRRKLREGVDLHSRRSVTDES
TWSGFADRLSYLAGDFTTAETGALLSRRLEGLDREWNGRAVRVFYFAIPPGLMEAAARQLESLGVCRDCSRDRLVVEKPF
GRDLASARQLNGLLTSLFAETQIYRIDHYLGKETVQNILAFRFANSLFEPVWNRRYIDHVQITVAEAVGVGKRGGYYDTS
GALRDMVQNHLLQILCLIAMEPPVSFSADEVRNKKVDVLRAIRPIRPEEVHRVAVRGQYGRGMVACEGVTGYREEQGVPP
DSVTETFAALKLWIDNWRWQGVPFYLRTGKRLRAKVSEVAILFRPAPHQLFPSAAVESWQPNRLVLRIQPEEGIASRIQV
KQPGTRLLLGAVDMGFRYHDAFHAASPEAYETLLLDVICGDATLFMRADQVESAWGVISPILDTWESVPPADFPNYQAGG
WGPETADLLIAKEGHSWVQPDLPTEEGETEAP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=496, Percent_Identity=38.1048387096774, Blast_Score=337, Evalue=2e-92,
Organism=Homo sapiens, GI109389365, Length=496, Percent_Identity=38.1048387096774, Blast_Score=336, Evalue=2e-92,
Organism=Homo sapiens, GI52145310, Length=498, Percent_Identity=31.3253012048193, Blast_Score=180, Evalue=3e-45,
Organism=Escherichia coli, GI1788158, Length=490, Percent_Identity=42.8571428571429, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17538218, Length=504, Percent_Identity=37.1031746031746, Blast_Score=347, Evalue=7e-96,
Organism=Saccharomyces cerevisiae, GI6324088, Length=495, Percent_Identity=36.5656565656566, Blast_Score=308, Evalue=2e-84,
Organism=Drosophila melanogaster, GI24643350, Length=483, Percent_Identity=37.2670807453416, Blast_Score=311, Evalue=7e-85,
Organism=Drosophila melanogaster, GI24643352, Length=483, Percent_Identity=37.2670807453416, Blast_Score=311, Evalue=1e-84,
Organism=Drosophila melanogaster, GI221513548, Length=484, Percent_Identity=32.8512396694215, Blast_Score=248, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 57480; Mature: 57480

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTTMNSRMEPTVMVVFGAAGDLTWRKLVPALYNLYLDGRLPERFAIVGVARQEMDDAGF
CCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHH
RRKLREGVDLHSRRSVTDESTWSGFADRLSYLAGDFTTAETGALLSRRLEGLDREWNGRA
HHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCE
VRVFYFAIPPGLMEAAARQLESLGVCRDCSRDRLVVEKPFGRDLASARQLNGLLTSLFAE
EEEEEEECCHHHHHHHHHHHHHCCHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
TQIYRIDHYLGKETVQNILAFRFANSLFEPVWNRRYIDHVQITVAEAVGVGKRGGYYDTS
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEHHHHCCCCCCCCCCCH
GALRDMVQNHLLQILCLIAMEPPVSFSADEVRNKKVDVLRAIRPIRPEEVHRVAVRGQYG
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHEEHCCCCCC
RGMVACEGVTGYREEQGVPPDSVTETFAALKLWIDNWRWQGVPFYLRTGKRLRAKVSEVA
CCEEEECCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCEECCCCEEECCCHHHHHHHHHEE
ILFRPAPHQLFPSAAVESWQPNRLVLRIQPEEGIASRIQVKQPGTRLLLGAVDMGFRYHD
EEEECCCHHHCCHHHHCCCCCCEEEEEECCCCCCHHCEEECCCCCEEEEEHHHCCCCHHH
AFHAASPEAYETLLLDVICGDATLFMRADQVESAWGVISPILDTWESVPPADFPNYQAGG
HHHCCCCHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
WGPETADLLIAKEGHSWVQPDLPTEEGETEAP
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDTTMNSRMEPTVMVVFGAAGDLTWRKLVPALYNLYLDGRLPERFAIVGVARQEMDDAGF
CCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCHHEEEHHHHHHHHHHHH
RRKLREGVDLHSRRSVTDESTWSGFADRLSYLAGDFTTAETGALLSRRLEGLDREWNGRA
HHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCE
VRVFYFAIPPGLMEAAARQLESLGVCRDCSRDRLVVEKPFGRDLASARQLNGLLTSLFAE
EEEEEEECCHHHHHHHHHHHHHCCHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHH
TQIYRIDHYLGKETVQNILAFRFANSLFEPVWNRRYIDHVQITVAEAVGVGKRGGYYDTS
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEHHHHCCCCCCCCCCCH
GALRDMVQNHLLQILCLIAMEPPVSFSADEVRNKKVDVLRAIRPIRPEEVHRVAVRGQYG
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHEEHCCCCCC
RGMVACEGVTGYREEQGVPPDSVTETFAALKLWIDNWRWQGVPFYLRTGKRLRAKVSEVA
CCEEEECCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCEECCCCEEECCCHHHHHHHHHEE
ILFRPAPHQLFPSAAVESWQPNRLVLRIQPEEGIASRIQVKQPGTRLLLGAVDMGFRYHD
EEEECCCHHHCCHHHHCCCCCCEEEEEECCCCCCHHCEEECCCCCEEEEEHHHCCCCHHH
AFHAASPEAYETLLLDVICGDATLFMRADQVESAWGVISPILDTWESVPPADFPNYQAGG
HHHCCCCHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
WGPETADLLIAKEGHSWVQPDLPTEEGETEAP
CCCCCCEEEEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]