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The map label for this gene is yqeC [H]

Identifier: 78223817

GI number: 78223817

Start: 2965052

End: 2966062

Strand: Reverse

Name: yqeC [H]

Synonym: Gmet_2620

Alternate gene names: 78223817

Gene position: 2966062-2965052 (Counterclockwise)

Preceding gene: 78223818

Following gene: 78223816

Centisome position: 74.2

GC content: 63.2

Gene sequence:

>1011_bases
ATGCAAATTGGCATGATTGGCCTTGGACGGATGGGTGCGGATATGGTGCGGCGCCTGCGGAAGGGGGGACATGAGTGCGT
CGTGTATGATCTGAATGTCAACGCGGTCCAGGCGCTGGAGCGCGAAGGGATCGCGGGAGCGCGATCAATCGAGGAATTCT
GCGCCAAGCTCGTCAAGCCGCGGGTGGTATGGCTGATGGTGCCGGCCGCCGTGGTGGATTCGATGCTCCAGCGCATGACC
CCCCTGCTGGCGGCCAACGATATCGTAATCGATGGCGGCAACTCCCATTACCAGGACGACATCCGACGTGCGGACCAGAT
GCGGGCACAGGGAATCACCTACGTGGATGTCGGGACAAGCGGCGGCATCTTCGGGTTGGAGCGGGGCTATTGCCTGATGA
TCGGCGGCGAGAAACAGGCGGTGGAGCGGCTCGACCCGGTTTTCAGAACGCTGGCCCCCGGCATCGGCGCGGCACCACGC
ACTCCCGGCCGCGAGAAACGGGAAGGGACCGCCGAACTGGGCTATCTCCACTGCGGACCGAGCGGCGCCGGGCACTTCGT
CAAAATGGTTCATAACGGGATCGAATACGGTCTGATGGCAGCCTATGCGGAAGGGTTGAACATCCTCCACCATGCCAATG
CCGGCAAAGAGGGACAGGGTGCCGATGCGGAGACGGCGCCGCTCCGTAACCCCGACTTCTATCGCTATGACCTTGATCTC
GCCGATATCACCGAAGTCTGGCGGCGCGGAAGCGTGATTTCCTCCTGGCTCCTCGATCTCAGCGCGACGGCACTGCTCGA
CAGCCCCGATTTGCAGGAGTTCCAGGGGCGGGTGTCGGACTCGGGGGAAGGGCGCTGGACCGTCGCTGCCGCCATTGACG
AGGGGGTCCCGGCCCATGTACTCAGCTCCGCACTCTACGAGCGCTTCAGTTCCCGTGGCGAGGACGACTTTGCCAATCGG
CTTCTCTCTGCGATGCGCTACGAATTCGGGGGGCACCGGGAAAAGTCCTGA

Upstream 100 bases:

>100_bases
GCTGGTCAGGGCCTTCCTCGCCGCCACCTTCAGCGGGGCCGAGCGCCACCGTCGCCGCCTGGCCAAGGTGGCGGCCCTGG
AACAGTGCGGGAGGTGACCG

Downstream 100 bases:

>100_bases
CAGTCTGAGCATGCCCAAGGGGTAGATGGCGATGGATACAACGATGAATTCTCGGATGGAACCGACCGTGATGGTGGTCT
TCGGCGCCGCAGGTGATCTC

Product: 6-phosphogluconate dehydrogenase-like protein

Products: D-ribulose 5-phosphate; CO2; NADPH

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MQIGMIGLGRMGADMVRRLRKGGHECVVYDLNVNAVQALEREGIAGARSIEEFCAKLVKPRVVWLMVPAAVVDSMLQRMT
PLLAANDIVIDGGNSHYQDDIRRADQMRAQGITYVDVGTSGGIFGLERGYCLMIGGEKQAVERLDPVFRTLAPGIGAAPR
TPGREKREGTAELGYLHCGPSGAGHFVKMVHNGIEYGLMAAYAEGLNILHHANAGKEGQGADAETAPLRNPDFYRYDLDL
ADITEVWRRGSVISSWLLDLSATALLDSPDLQEFQGRVSDSGEGRWTVAAAIDEGVPAHVLSSALYERFSSRGEDDFANR
LLSAMRYEFGGHREKS

Sequences:

>Translated_336_residues
MQIGMIGLGRMGADMVRRLRKGGHECVVYDLNVNAVQALEREGIAGARSIEEFCAKLVKPRVVWLMVPAAVVDSMLQRMT
PLLAANDIVIDGGNSHYQDDIRRADQMRAQGITYVDVGTSGGIFGLERGYCLMIGGEKQAVERLDPVFRTLAPGIGAAPR
TPGREKREGTAELGYLHCGPSGAGHFVKMVHNGIEYGLMAAYAEGLNILHHANAGKEGQGADAETAPLRNPDFYRYDLDL
ADITEVWRRGSVISSWLLDLSATALLDSPDLQEFQGRVSDSGEGRWTVAAAIDEGVPAHVLSSALYERFSSRGEDDFANR
LLSAMRYEFGGHREKS
>Mature_336_residues
MQIGMIGLGRMGADMVRRLRKGGHECVVYDLNVNAVQALEREGIAGARSIEEFCAKLVKPRVVWLMVPAAVVDSMLQRMT
PLLAANDIVIDGGNSHYQDDIRRADQMRAQGITYVDVGTSGGIFGLERGYCLMIGGEKQAVERLDPVFRTLAPGIGAAPR
TPGREKREGTAELGYLHCGPSGAGHFVKMVHNGIEYGLMAAYAEGLNILHHANAGKEGQGADAETAPLRNPDFYRYDLDL
ADITEVWRRGSVISSWLLDLSATALLDSPDLQEFQGRVSDSGEGRWTVAAAIDEGVPAHVLSSALYERFSSRGEDDFANR
LLSAMRYEFGGHREKS

Specific function: May act as NAD-dependent 6-P-gluconate dehydrogenase [H]

COG id: COG1023

COG function: function code G; Predicted 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=346, Percent_Identity=31.5028901734104, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1788341, Length=347, Percent_Identity=28.2420749279539, Blast_Score=137, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17542558, Length=325, Percent_Identity=32.6153846153846, Blast_Score=152, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6321695, Length=334, Percent_Identity=32.3353293413174, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321977, Length=317, Percent_Identity=33.1230283911672, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24639279, Length=325, Percent_Identity=31.3846153846154, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR004849
- InterPro:   IPR006114
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: 1.1.1.44

Molecular weight: Translated: 36595; Mature: 36595

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIGMIGLGRMGADMVRRLRKGGHECVVYDLNVNAVQALEREGIAGARSIEEFCAKLVKP
CCCCCEECCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCC
RVVWLMVPAAVVDSMLQRMTPLLAANDIVIDGGNSHYQDDIRRADQMRAQGITYVDVGTS
CEEEEEECHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCC
GGIFGLERGYCLMIGGEKQAVERLDPVFRTLAPGIGAAPRTPGREKREGTAELGYLHCGP
CCEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECC
SGAGHFVKMVHNGIEYGLMAAYAEGLNILHHANAGKEGQGADAETAPLRNPDFYRYDLDL
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCH
ADITEVWRRGSVISSWLLDLSATALLDSPDLQEFQGRVSDSGEGRWTVAAAIDEGVPAHV
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCHHHH
LSSALYERFSSRGEDDFANRLLSAMRYEFGGHREKS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MQIGMIGLGRMGADMVRRLRKGGHECVVYDLNVNAVQALEREGIAGARSIEEFCAKLVKP
CCCCCEECCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHHCC
RVVWLMVPAAVVDSMLQRMTPLLAANDIVIDGGNSHYQDDIRRADQMRAQGITYVDVGTS
CEEEEEECHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCC
GGIFGLERGYCLMIGGEKQAVERLDPVFRTLAPGIGAAPRTPGREKREGTAELGYLHCGP
CCEEEECCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECC
SGAGHFVKMVHNGIEYGLMAAYAEGLNILHHANAGKEGQGADAETAPLRNPDFYRYDLDL
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEECCH
ADITEVWRRGSVISSWLLDLSATALLDSPDLQEFQGRVSDSGEGRWTVAAAIDEGVPAHV
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCEEEEEECCCCCHHHH
LSSALYERFSSRGEDDFANRLLSAMRYEFGGHREKS
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.05 {6-phosphogluconate}} 0.01 {6-phosphogluconate}} [C]

Substrates: 6-phospho-D-gluconate; NADP+

Specific reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]