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The map label for this gene is pgl [H]

Identifier: 78223815

GI number: 78223815

Start: 2962760

End: 2963485

Strand: Reverse

Name: pgl [H]

Synonym: Gmet_2618

Alternate gene names: 78223815

Gene position: 2963485-2962760 (Counterclockwise)

Preceding gene: 78223816

Following gene: 78223812

Centisome position: 74.13

GC content: 63.64

Gene sequence:

>726_bases
ATGATCAGGGTCTACCTCGACCGGGAAGCCTTGAGCATGGCTGCCGCCGAACTCTTTGCAACCGCGGCGCACTCTGCCAT
GCGGGACACGGGGAGGTTTGCCGTTGCCCTTGCCGGAGGAGACACACCACGCCGTACCTACGAAATTCTTGCCCATGAGC
CATTCCGGAAGCGGGTGCCATGGGAGAAAACCCATGTTTTTTGGGGTGACGAACGCTGCGTGCCTGCCGCTGATCCCCGC
AACAATGCCCGAATGGCGAGTCGGGCGCTCCTCGACCATGTCCTGGTCCCGGATGGGCAGGTCCATCCCATGGTCTGCGG
CCGGGCCCCGCAAGATGCCGCAAAGGAGTATGAAGCGCTCCTCCGCAGCTGGTTTCCCGGCGAGTTGCCTCGCTTCGACC
TGATCCTGCTGGGGCTGGGGGAGAACGGGCACACCGCTTCCCTCTTTCCGGAAACACCTGTCCTGGATGAACGGCGGCGC
TGGGTGGCGGATGTCTCCCCGGCCAATGACGGGATGCACCGACTCACCCTGACGGTTCCCGTCATCAACCAGGCATCCCG
GGTTGTTTTCCTGGTGTCGGGAGCCAACAAGGCGCCGATCCTGCGGGAGGTGCTGGAAGGCTCCCCGGACCCGCATCGCA
TTCCTGCCTGTCTGATCAGGCCGGCAGGTCAGTTGGTATGGCTGGTGGACCGTGATGCTGCCCGCCTGCTTCGAAATGCC
ACGTGA

Upstream 100 bases:

>100_bases
GCGGCTGGGGGCCGGAAACTGCTGATCTCCTCATCGCCAAGGAGGGGCACAGCTGGGTCCAACCCGACCTTCCGACGGAA
GAGGGAGAGACGGAGGCTCC

Downstream 100 bases:

>100_bases
CAGGGGCGTTTTACCGGAACACGATCCGGAAATCCTCCCGCTCCTCCGTCAGGTCCTTGAGAAGGGCAACGACCCGTTCG
TAGTCCTTTCCCATCGAGCG

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MIRVYLDREALSMAAAELFATAAHSAMRDTGRFAVALAGGDTPRRTYEILAHEPFRKRVPWEKTHVFWGDERCVPAADPR
NNARMASRALLDHVLVPDGQVHPMVCGRAPQDAAKEYEALLRSWFPGELPRFDLILLGLGENGHTASLFPETPVLDERRR
WVADVSPANDGMHRLTLTVPVINQASRVVFLVSGANKAPILREVLEGSPDPHRIPACLIRPAGQLVWLVDRDAARLLRNA
T

Sequences:

>Translated_241_residues
MIRVYLDREALSMAAAELFATAAHSAMRDTGRFAVALAGGDTPRRTYEILAHEPFRKRVPWEKTHVFWGDERCVPAADPR
NNARMASRALLDHVLVPDGQVHPMVCGRAPQDAAKEYEALLRSWFPGELPRFDLILLGLGENGHTASLFPETPVLDERRR
WVADVSPANDGMHRLTLTVPVINQASRVVFLVSGANKAPILREVLEGSPDPHRIPACLIRPAGQLVWLVDRDAARLLRNA
T
>Mature_241_residues
MIRVYLDREALSMAAAELFATAAHSAMRDTGRFAVALAGGDTPRRTYEILAHEPFRKRVPWEKTHVFWGDERCVPAADPR
NNARMASRALLDHVLVPDGQVHPMVCGRAPQDAAKEYEALLRSWFPGELPRFDLILLGLGENGHTASLFPETPVLDERRR
WVADVSPANDGMHRLTLTVPVINQASRVVFLVSGANKAPILREVLEGSPDPHRIPACLIRPAGQLVWLVDRDAARLLRNA
T

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=241, Percent_Identity=38.1742738589212, Blast_Score=133, Evalue=1e-31,
Organism=Homo sapiens, GI6912586, Length=242, Percent_Identity=34.297520661157, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI115533058, Length=219, Percent_Identity=29.2237442922374, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115533060, Length=219, Percent_Identity=29.2237442922374, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324362, Length=218, Percent_Identity=34.8623853211009, Blast_Score=111, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6319918, Length=220, Percent_Identity=37.2727272727273, Blast_Score=106, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321957, Length=257, Percent_Identity=30.7392996108949, Blast_Score=99, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6321687, Length=226, Percent_Identity=29.2035398230088, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24641119, Length=234, Percent_Identity=32.4786324786325, Blast_Score=89, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26772; Mature: 26772

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVYLDREALSMAAAELFATAAHSAMRDTGRFAVALAGGDTPRRTYEILAHEPFRKRVP
CEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCHHHCCC
WEKTHVFWGDERCVPAADPRNNARMASRALLDHVLVPDGQVHPMVCGRAPQDAAKEYEAL
CCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHH
LRSWFPGELPRFDLILLGLGENGHTASLFPETPVLDERRRWVADVSPANDGMHRLTLTVP
HHHCCCCCCCCEEEEEEEECCCCCEEEECCCCCCHHHHHHHEECCCCCCCCCEEEEEEEE
VINQASRVVFLVSGANKAPILREVLEGSPDPHRIPACLIRPAGQLVWLVDRDAARLLRNA
CCCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECHHHHHHHCC
T
C
>Mature Secondary Structure
MIRVYLDREALSMAAAELFATAAHSAMRDTGRFAVALAGGDTPRRTYEILAHEPFRKRVP
CEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCHHHCCC
WEKTHVFWGDERCVPAADPRNNARMASRALLDHVLVPDGQVHPMVCGRAPQDAAKEYEAL
CCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHH
LRSWFPGELPRFDLILLGLGENGHTASLFPETPVLDERRRWVADVSPANDGMHRLTLTVP
HHHCCCCCCCCEEEEEEEECCCCCEEEECCCCCCHHHHHHHEECCCCCCCCCEEEEEEEE
VINQASRVVFLVSGANKAPILREVLEGSPDPHRIPACLIRPAGQLVWLVDRDAARLLRNA
CCCCCCEEEEEEECCCCCHHHHHHHCCCCCCCCCCEEEECCCCCEEEEEECHHHHHHHCC
T
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231; 9298645 [H]