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The map label for this gene is sdhA

Identifier: 78223599

GI number: 78223599

Start: 2706806

End: 2708719

Strand: Reverse

Name: sdhA

Synonym: Gmet_2396

Alternate gene names: 78223599

Gene position: 2708719-2706806 (Counterclockwise)

Preceding gene: 78223600

Following gene: 78223598

Centisome position: 67.76

GC content: 59.61

Gene sequence:

>1914_bases
GTGATACTCGACGGAAAATGTCCGACTGGACCAATTGAGAAAACATGGGACAAGCACCGCTTCGACATGAAGCTGGTTAA
CCCCTCCAACAAGCGTAAGTACAAGATCCTTGTCGTTGGGACCGGCCTTGCCGGCGGCGCCGCTGCCGCGTCCCTCGGTG
AACTCGGCTACAATGTCGAGGCTTTCTGCTACCAGGATAGCCCCCGCCGCGCCCACTCCATCGCTGCCCAAGGGGGGATC
AACGCCGCCAAGAACTACCCGAACGACGGTGACAGCATCTACCGTCTCTTCTACGACACCATCAAGGGGGGCGACTTCCG
TGCCCGCGAGGCCGACGTCTGGCGTCTGGCCCAGGTTTCCAACAACATCATCGACCAGTGCGTGGCCCAAGGTGTTCCCT
TTGCCCGTGACTACGCCGGCTATCTGGACAACCGCTCCTTCGGCGGCGCCCAGGTTTCCCGTACGTTCTACGCCCGGGGG
CAAACGGGGCAGCAGCTCCTGCTCGGCGCCTACTCGGCCCTTGCCCGCCAGATCAAGGCAGGGACCGTCAAGATGTTCCC
CCGCACCGAGATGCTTGACCTGATCGTTGTTGACGGTGAGGCCAAGGGGATCACAGTCCGTGACCTGGTTACCGGCGAGA
TTCGTAGCCACGTGGGTGACGCGGTTGTGCTCTGCACCGGCGGCTACGTGAACGTCTTCTACCTCTCCACCAACGCCATG
GGGTGCAGCGTTACCGCCGCCTGGAAGGCCCACCGGAAAGGCGCCTTCTTTGCCAACCCCTGCTACACACAGATTCACCC
GACCTGTATTCCGCAGCATGGTGACAAGCAGTCCAAGCTGACTCTCATGTCAGAGTCGCTCCGTAACGACGGCCGTTGCT
GGGCTCCCAAGAAGAAGGGCGACAAGCGCGCGCCGGGGGAGATTCCCGAGGAAGAGCGTGACTATTACCTCGAGCGGAAG
TACCCGAGCTTCGGTAACCTGGCTCCCCGTGACATCGCCTCCCGCGCCGCTAAGGAGCAGTGCGACGACGATCGTGGCGT
TGGACCGGGTGGTCGCGGTGTTTATCTTGACTTCGCCGCTTCCATCAAGCGCCTCGGTGAAGACACGATCCGCGAGCGGT
ACGGCAACCTCTTCGAGATGTACGAGAAGATCACCGACGAGAATGGCTACAAGGTGCCGATGCGTATCTACCCGGCACCC
CACTATTCAATGGGTGGTCTCTGGGTTGACTACAACTGCGAGAGCAACGTTCCCGGTCTCTTCGTTCTGGGCGAGGCAAA
CTTCTCGGTTCACGGGGCGAACCGTCTTGGCGCCAGCGCCCTCATGCAGGGTCTTGCCGACGGTTACTTCGTCATTCCCT
ACACCATCGCCAACTATCTGGCCAAGACGGCTCCGGGCAAGGTCAAGGCCGATAACCCCGAGTGCAAGAAGTCGGTTGAC
GATGTAAATAACAACTTGAAGAAGCTCATGTCGATCAACGGGAAGAAGACTGTCAGCGAATTCCACCGCGAGCTGGGCAG
GATCATGTGGGAGAACGTCGGCATGGCCCGCAGCGAGCAGAGCTGCAAGGAAGCCCTCAAGAAGATCCCCGCACTTCGTG
AAGAATTCTGGAAGAACGTCAAGGTCAGCGGTTCTGGCGCCCAGTTCAACCAGGACCTGGAGAACGCCGGTCGCGTAGCT
GACTTCCTTGAATTCGGGGAGCTTCTGACCCGCGACGCCCTCTACCGTAACGAGTCCTGTGGTGGTCACTTCCGGGTCGA
GCACCAGATGCCTGACGGCGAAGCAAAGCGCGACGACGAAAACTTCTGCCACGCTGCTGCATGGGAGTTCAAAGGGGCTA
ATGCAGAGCCTGAACTCCACATCGAACCTCTGAAGTTTGAAAACGTCCATCTGGCGATAAGGAGCTACAAATAA

Upstream 100 bases:

>100_bases
CTCCACGATTGGTAAGGTCGCTGCGGTTGTGTTTCTCCTCGGCTATGCGTCCATTCCTTTTGTCATCGTTACCGGCATTC
TGAAAGGTTAGGGGGTTCAA

Downstream 100 bases:

>100_bases
TGAGCCACGATAATACCATGAATCTTACTCTCCATGTTTGGCGCCAGAATGGCCCAAAAGATCCGGGAAAGTTCGAGGTC
TACGAGGCCAAGAATGTCAG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 637; Mature: 637

Protein sequence:

>637_residues
MILDGKCPTGPIEKTWDKHRFDMKLVNPSNKRKYKILVVGTGLAGGAAAASLGELGYNVEAFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYSALARQIKAGTVKMFPRTEMLDLIVVDGEAKGITVRDLVTGEIRSHVGDAVVLCTGGYVNVFYLSTNAM
GCSVTAAWKAHRKGAFFANPCYTQIHPTCIPQHGDKQSKLTLMSESLRNDGRCWAPKKKGDKRAPGEIPEEERDYYLERK
YPSFGNLAPRDIASRAAKEQCDDDRGVGPGGRGVYLDFAASIKRLGEDTIRERYGNLFEMYEKITDENGYKVPMRIYPAP
HYSMGGLWVDYNCESNVPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIANYLAKTAPGKVKADNPECKKSVD
DVNNNLKKLMSINGKKTVSEFHRELGRIMWENVGMARSEQSCKEALKKIPALREEFWKNVKVSGSGAQFNQDLENAGRVA
DFLEFGELLTRDALYRNESCGGHFRVEHQMPDGEAKRDDENFCHAAAWEFKGANAEPELHIEPLKFENVHLAIRSYK

Sequences:

>Translated_637_residues
MILDGKCPTGPIEKTWDKHRFDMKLVNPSNKRKYKILVVGTGLAGGAAAASLGELGYNVEAFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYSALARQIKAGTVKMFPRTEMLDLIVVDGEAKGITVRDLVTGEIRSHVGDAVVLCTGGYVNVFYLSTNAM
GCSVTAAWKAHRKGAFFANPCYTQIHPTCIPQHGDKQSKLTLMSESLRNDGRCWAPKKKGDKRAPGEIPEEERDYYLERK
YPSFGNLAPRDIASRAAKEQCDDDRGVGPGGRGVYLDFAASIKRLGEDTIRERYGNLFEMYEKITDENGYKVPMRIYPAP
HYSMGGLWVDYNCESNVPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIANYLAKTAPGKVKADNPECKKSVD
DVNNNLKKLMSINGKKTVSEFHRELGRIMWENVGMARSEQSCKEALKKIPALREEFWKNVKVSGSGAQFNQDLENAGRVA
DFLEFGELLTRDALYRNESCGGHFRVEHQMPDGEAKRDDENFCHAAAWEFKGANAEPELHIEPLKFENVHLAIRSYK
>Mature_637_residues
MILDGKCPTGPIEKTWDKHRFDMKLVNPSNKRKYKILVVGTGLAGGAAAASLGELGYNVEAFCYQDSPRRAHSIAAQGGI
NAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVSNNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARG
QTGQQLLLGAYSALARQIKAGTVKMFPRTEMLDLIVVDGEAKGITVRDLVTGEIRSHVGDAVVLCTGGYVNVFYLSTNAM
GCSVTAAWKAHRKGAFFANPCYTQIHPTCIPQHGDKQSKLTLMSESLRNDGRCWAPKKKGDKRAPGEIPEEERDYYLERK
YPSFGNLAPRDIASRAAKEQCDDDRGVGPGGRGVYLDFAASIKRLGEDTIRERYGNLFEMYEKITDENGYKVPMRIYPAP
HYSMGGLWVDYNCESNVPGLFVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIANYLAKTAPGKVKADNPECKKSVD
DVNNNLKKLMSINGKKTVSEFHRELGRIMWENVGMARSEQSCKEALKKIPALREEFWKNVKVSGSGAQFNQDLENAGRVA
DFLEFGELLTRDALYRNESCGGHFRVEHQMPDGEAKRDDENFCHAAAWEFKGANAEPELHIEPLKFENVHLAIRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=558, Percent_Identity=26.5232974910394, Blast_Score=152, Evalue=9e-37,
Organism=Escherichia coli, GI1790597, Length=577, Percent_Identity=27.7296360485269, Blast_Score=200, Evalue=3e-52,
Organism=Escherichia coli, GI1786942, Length=579, Percent_Identity=26.2521588946459, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1788928, Length=595, Percent_Identity=24.3697478991597, Blast_Score=132, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17505833, Length=543, Percent_Identity=28.3609576427256, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17550100, Length=538, Percent_Identity=27.8810408921933, Blast_Score=161, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6322701, Length=598, Percent_Identity=28.5953177257525, Blast_Score=193, Evalue=8e-50,
Organism=Saccharomyces cerevisiae, GI6322416, Length=620, Percent_Identity=27.9032258064516, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI17137288, Length=547, Percent_Identity=27.4223034734918, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24655642, Length=547, Percent_Identity=27.4223034734918, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24655647, Length=547, Percent_Identity=27.4223034734918, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24663005, Length=572, Percent_Identity=26.3986013986014, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70703; Mature: 70703

Theoretical pI: Translated: 8.18; Mature: 8.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILDGKCPTGPIEKTWDKHRFDMKLVNPSNKRKYKILVVGTGLAGGAAAASLGELGYNVE
CEECCCCCCCCCHHCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEE
AFCYQDSPRRAHSIAAQGGINAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVS
EEEECCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
NNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARGQTGQQLLLGAYSALARQIKA
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHC
GTVKMFPRTEMLDLIVVDGEAKGITVRDLVTGEIRSHVGDAVVLCTGGYVNVFYLSTNAM
CEEEECCCCCEEEEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEEECCEEEEEEEECCCC
GCSVTAAWKAHRKGAFFANPCYTQIHPTCIPQHGDKQSKLTLMSESLRNDGRCWAPKKKG
CCEEEHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCC
DKRAPGEIPEEERDYYLERKYPSFGNLAPRDIASRAAKEQCDDDRGVGPGGRGVYLDFAA
CCCCCCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHH
SIKRLGEDTIRERYGNLFEMYEKITDENGYKVPMRIYPAPHYSMGGLWVDYNCESNVPGL
HHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCE
FVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIANYLAKTAPGKVKADNPECKKSVD
EEEECCCEEEECCHHCCHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCEECCCCHHHHHHH
DVNNNLKKLMSINGKKTVSEFHRELGRIMWENVGMARSEQSCKEALKKIPALREEFWKNV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCE
KVSGSGAQFNQDLENAGRVADFLEFGELLTRDALYRNESCGGHFRVEHQMPDGEAKRDDE
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
NFCHAAAWEFKGANAEPELHIEPLKFENVHLAIRSYK
HHHHHHHEEECCCCCCCCEEEECEEECCEEEEEEECC
>Mature Secondary Structure
MILDGKCPTGPIEKTWDKHRFDMKLVNPSNKRKYKILVVGTGLAGGAAAASLGELGYNVE
CEECCCCCCCCCHHCCCCCCCEEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCEE
AFCYQDSPRRAHSIAAQGGINAAKNYPNDGDSIYRLFYDTIKGGDFRAREADVWRLAQVS
EEEECCCCHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
NNIIDQCVAQGVPFARDYAGYLDNRSFGGAQVSRTFYARGQTGQQLLLGAYSALARQIKA
HHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHC
GTVKMFPRTEMLDLIVVDGEAKGITVRDLVTGEIRSHVGDAVVLCTGGYVNVFYLSTNAM
CEEEECCCCCEEEEEEECCCCCCEEEHHHHHHHHHHCCCCEEEEEECCEEEEEEEECCCC
GCSVTAAWKAHRKGAFFANPCYTQIHPTCIPQHGDKQSKLTLMSESLRNDGRCWAPKKKG
CCEEEHHHHHHCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCC
DKRAPGEIPEEERDYYLERKYPSFGNLAPRDIASRAAKEQCDDDRGVGPGGRGVYLDFAA
CCCCCCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHH
SIKRLGEDTIRERYGNLFEMYEKITDENGYKVPMRIYPAPHYSMGGLWVDYNCESNVPGL
HHHHHCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCEEEEECCCCCCCCE
FVLGEANFSVHGANRLGASALMQGLADGYFVIPYTIANYLAKTAPGKVKADNPECKKSVD
EEEECCCEEEECCHHCCHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCEECCCCHHHHHHH
DVNNNLKKLMSINGKKTVSEFHRELGRIMWENVGMARSEQSCKEALKKIPALREEFWKNV
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCE
KVSGSGAQFNQDLENAGRVADFLEFGELLTRDALYRNESCGGHFRVEHQMPDGEAKRDDE
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCC
NFCHAAAWEFKGANAEPELHIEPLKFENVHLAIRSYK
HHHHHHHEEECCCCCCCCEEEECEEECCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]