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The map label for this gene is echA8 [H]

Identifier: 78223409

GI number: 78223409

Start: 2494081

End: 2494872

Strand: Reverse

Name: echA8 [H]

Synonym: Gmet_2204

Alternate gene names: 78223409

Gene position: 2494872-2494081 (Counterclockwise)

Preceding gene: 78223410

Following gene: 78223408

Centisome position: 62.41

GC content: 51.01

Gene sequence:

>792_bases
ATGAAGTATACCGTTTTCAAGGTTGAAAGGAAGAAAAACTACGGCATCATTACCTTCAACCGTCCGGACAAGTTCAATGC
CGCCAATGCCCAGATTTTCAAGGAACTGGCTGCTGCAGTGCGGGAACTTGACGCGGACAAGAAGGTAGGCTGCATCGTCC
TGACGGGCCAGACCTTCAAGCATCCGAAAAAAGGGACCGATTATCCGGTGTTTTCCGCAGGGGCCGATGTGGAGCAGTTT
GCAACTGTTGGCAAGGTTGAAGCTGGTTTTGATTTCATCAAGCTCTGTTTTGAGCCATTCAAGGCCATTGAACTTGCTGA
AACGCCGATCATTGCAGCCGTGAATGGTGCGGCATTCGGTTTTGGCTTCGAAATTTCCGGTTGCTGCGATATGGTCTTTG
CCGCCAAGAGCGCCAAGTTTGCCCTCAAGGAAATAAATCATGGCGCCATTCCTGCCTGGTGTATTACCCGCGGTCTGGAA
AAGTACGGTAAGAATGTGGCCGCCTACCTCTGTTTCTCGGCAAAAGAACTGGATGCCGATGAAGCGCAGCGTCTCGGTAT
TGTGGTGGATGTCTATGAAGACAACGAACTCCTTCCCCGATGCGAAGAGCTTGCCGAGCGTATCGCTGAAAAAAGCCATG
TTGCCAAGACCTTTATCAAGACACTGCTGAACCGGAAAGCAGTTGAAGGATATCAGGAGGCAGAACGATTCATGCCGACG
GTCTTTGCCACGCAGTACATGCAGGGTGCCTTTGCACGGTTCCTTGGTGGCGAGACGAAGAACGTCAAATAG

Upstream 100 bases:

>100_bases
CTTCAAGAGGAATGGGATTCAGTGTAGCGGGGAACCAGGCCCCCTCGAAGGGGGAATATTGATACGATTATGGCTGTTAG
CCGAAAGGAGATGACTAACA

Downstream 100 bases:

>100_bases
TTGCCTGATATGGCGAGTAATCGCCCGATGGGGATGTGGAGTGACTACGATCCTGTGGCACAGGGTTCGACCCCGTAAGT
AAATTTGTGATTTCGTCATG

Product: enoyl-CoA hydratase/isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKYTVFKVERKKNYGIITFNRPDKFNAANAQIFKELAAAVRELDADKKVGCIVLTGQTFKHPKKGTDYPVFSAGADVEQF
ATVGKVEAGFDFIKLCFEPFKAIELAETPIIAAVNGAAFGFGFEISGCCDMVFAAKSAKFALKEINHGAIPAWCITRGLE
KYGKNVAAYLCFSAKELDADEAQRLGIVVDVYEDNELLPRCEELAERIAEKSHVAKTFIKTLLNRKAVEGYQEAERFMPT
VFATQYMQGAFARFLGGETKNVK

Sequences:

>Translated_263_residues
MKYTVFKVERKKNYGIITFNRPDKFNAANAQIFKELAAAVRELDADKKVGCIVLTGQTFKHPKKGTDYPVFSAGADVEQF
ATVGKVEAGFDFIKLCFEPFKAIELAETPIIAAVNGAAFGFGFEISGCCDMVFAAKSAKFALKEINHGAIPAWCITRGLE
KYGKNVAAYLCFSAKELDADEAQRLGIVVDVYEDNELLPRCEELAERIAEKSHVAKTFIKTLLNRKAVEGYQEAERFMPT
VFATQYMQGAFARFLGGETKNVK
>Mature_263_residues
MKYTVFKVERKKNYGIITFNRPDKFNAANAQIFKELAAAVRELDADKKVGCIVLTGQTFKHPKKGTDYPVFSAGADVEQF
ATVGKVEAGFDFIKLCFEPFKAIELAETPIIAAVNGAAFGFGFEISGCCDMVFAAKSAKFALKEINHGAIPAWCITRGLE
KYGKNVAAYLCFSAKELDADEAQRLGIVVDVYEDNELLPRCEELAERIAEKSHVAKTFIKTLLNRKAVEGYQEAERFMPT
VFATQYMQGAFARFLGGETKNVK

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=263, Percent_Identity=28.8973384030418, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI70995211, Length=224, Percent_Identity=28.125, Blast_Score=75, Evalue=7e-14,
Organism=Homo sapiens, GI4502327, Length=190, Percent_Identity=33.1578947368421, Blast_Score=71, Evalue=8e-13,
Organism=Escherichia coli, GI1787659, Length=264, Percent_Identity=29.9242424242424, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI221142681, Length=231, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI87082183, Length=225, Percent_Identity=26.2222222222222, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787660, Length=237, Percent_Identity=26.1603375527426, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17554946, Length=244, Percent_Identity=33.1967213114754, Blast_Score=120, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI25145438, Length=256, Percent_Identity=30.46875, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17536985, Length=255, Percent_Identity=27.4509803921569, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17534483, Length=267, Percent_Identity=26.9662921348315, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17540714, Length=210, Percent_Identity=28.0952380952381, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17540306, Length=261, Percent_Identity=24.904214559387, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129971, Length=237, Percent_Identity=32.0675105485232, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653477, Length=237, Percent_Identity=32.0675105485232, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19920382, Length=213, Percent_Identity=28.169014084507, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24653139, Length=202, Percent_Identity=28.2178217821782, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24654903, Length=260, Percent_Identity=24.6153846153846, Blast_Score=68, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 29135; Mature: 29135

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTVFKVERKKNYGIITFNRPDKFNAANAQIFKELAAAVRELDADKKVGCIVLTGQTFK
CCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCC
HPKKGTDYPVFSAGADVEQFATVGKVEAGFDFIKLCFEPFKAIELAETPIIAAVNGAAFG
CCCCCCCCCCEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEE
FGFEISGCCDMVFAAKSAKFALKEINHGAIPAWCITRGLEKYGKNVAAYLCFSAKELDAD
CCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHCCHH
EAQRLGIVVDVYEDNELLPRCEELAERIAEKSHVAKTFIKTLLNRKAVEGYQEAERFMPT
HHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFATQYMQGAFARFLGGETKNVK
HHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKYTVFKVERKKNYGIITFNRPDKFNAANAQIFKELAAAVRELDADKKVGCIVLTGQTFK
CCEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCC
HPKKGTDYPVFSAGADVEQFATVGKVEAGFDFIKLCFEPFKAIELAETPIIAAVNGAAFG
CCCCCCCCCCEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEE
FGFEISGCCDMVFAAKSAKFALKEINHGAIPAWCITRGLEKYGKNVAAYLCFSAKELDAD
CCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEHHHHHHHHCCHH
EAQRLGIVVDVYEDNELLPRCEELAERIAEKSHVAKTFIKTLLNRKAVEGYQEAERFMPT
HHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFATQYMQGAFARFLGGETKNVK
HHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11234002 [H]