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The map label for this gene is hbd [H]

Identifier: 78223408

GI number: 78223408

Start: 2493076

End: 2493948

Strand: Reverse

Name: hbd [H]

Synonym: Gmet_2203

Alternate gene names: 78223408

Gene position: 2493948-2493076 (Counterclockwise)

Preceding gene: 78223409

Following gene: 78223407

Centisome position: 62.39

GC content: 56.13

Gene sequence:

>873_bases
ATGGGTGACATAAAAAAGGTGGCAATACTGGGTGCAGGGATGATGGGAAGCGATATCGCTCTTAGCTGTGCCCTGGCGGG
GTATGACGTGCTCCTGAAAGAAGTGAGTCTTGATCTTGCCGCAGCTGGCGTGGAACGGATCAGGGGGAGTCTGGCAAAGT
GGTCGGAGAAGGGGCGCCTTGCGGTTGACGCTGAGCAGCAGAAAAGTGCCGTAGCCAGGATAACCCCCGTTGACAATTTC
AGCGGATTCGGCGATGTGGATCTCGTCATCGAGGCAATCTTCGAGGATCTCGACGTGAAATCCCAGAATTTCAGGCAATT
GGAAGAGGTGTGCAAGCCTTCGTGCATCATCGCCTCCAATACCTCTTCCCTCCCCATCACGAAACTCGGGGCGTGTTTCA
GTTCCGCCGAAAGGAAGTCGCGCTTCGTGGGGATGCACTTCTTCTCGCCAGCCGCCATCATGAAGCTGGTCGAGGTCGTC
AATGGCGAGGATACCTCGGCGGAAACGGTGGAGACCGCGTGTGCGTTTTGTACCAGTATCGGCAAAGAGCCGATAAAGGT
GAACGACTGTGCCGGTTTCGTCGTCAACAGGATCCTGGGCGCCATCAACGATGAGGCGATCCGGCTCCTTGAAGAGAATG
TGGCCTCGGCGGCAGACATCGACAAGGCCTGCCAACTAGGTCTTGGTCATCCGGTCGGGCCCTTTGCCTTGATGGACCAG
ATCAGCAATGAACTGAACCTGAAGATCGCCCGCATTTTCCACGGGATTTACGGTGACAGGTTCCTGCCGCGGCCAGCCCT
GGTCCGGAAGGTGGACGCTGGTCATTTTGGGCGCAAGACGGGTAAGGGATGGTTTGATTACAGCAAAAAATAG

Upstream 100 bases:

>100_bases
GATGTGGAGTGACTACGATCCTGTGGCACAGGGTTCGACCCCGTAAGTAAATTTGTGATTTCGTCATGCAAAATCATGTT
TGTGCAAAGGAGATCGTACG

Downstream 100 bases:

>100_bases
GGCATGCGGATCGCCGGCAGGCGTTCCCAATGTCTCTATCAGATGAACTCTTTCTGGGGGGCGGGTCATGCACCCGCCTT
TCTTATTGCCTGGCTCTTTG

Product: 3-hydroxyacyl-CoA dehydrogenase-like

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MGDIKKVAILGAGMMGSDIALSCALAGYDVLLKEVSLDLAAAGVERIRGSLAKWSEKGRLAVDAEQQKSAVARITPVDNF
SGFGDVDLVIEAIFEDLDVKSQNFRQLEEVCKPSCIIASNTSSLPITKLGACFSSAERKSRFVGMHFFSPAAIMKLVEVV
NGEDTSAETVETACAFCTSIGKEPIKVNDCAGFVVNRILGAINDEAIRLLEENVASAADIDKACQLGLGHPVGPFALMDQ
ISNELNLKIARIFHGIYGDRFLPRPALVRKVDAGHFGRKTGKGWFDYSKK

Sequences:

>Translated_290_residues
MGDIKKVAILGAGMMGSDIALSCALAGYDVLLKEVSLDLAAAGVERIRGSLAKWSEKGRLAVDAEQQKSAVARITPVDNF
SGFGDVDLVIEAIFEDLDVKSQNFRQLEEVCKPSCIIASNTSSLPITKLGACFSSAERKSRFVGMHFFSPAAIMKLVEVV
NGEDTSAETVETACAFCTSIGKEPIKVNDCAGFVVNRILGAINDEAIRLLEENVASAADIDKACQLGLGHPVGPFALMDQ
ISNELNLKIARIFHGIYGDRFLPRPALVRKVDAGHFGRKTGKGWFDYSKK
>Mature_289_residues
GDIKKVAILGAGMMGSDIALSCALAGYDVLLKEVSLDLAAAGVERIRGSLAKWSEKGRLAVDAEQQKSAVARITPVDNFS
GFGDVDLVIEAIFEDLDVKSQNFRQLEEVCKPSCIIASNTSSLPITKLGACFSSAERKSRFVGMHFFSPAAIMKLVEVVN
GEDTSAETVETACAFCTSIGKEPIKVNDCAGFVVNRILGAINDEAIRLLEENVASAADIDKACQLGLGHPVGPFALMDQI
SNELNLKIARIFHGIYGDRFLPRPALVRKVDAGHFGRKTGKGWFDYSKK

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=290, Percent_Identity=38.2758620689655, Blast_Score=188, Evalue=6e-48,
Organism=Homo sapiens, GI296179427, Length=307, Percent_Identity=36.1563517915309, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI20127408, Length=289, Percent_Identity=34.6020761245675, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI261878539, Length=298, Percent_Identity=32.8859060402685, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI68989263, Length=298, Percent_Identity=32.8859060402685, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI115430219, Length=239, Percent_Identity=30.1255230125523, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1787661, Length=289, Percent_Identity=38.4083044982699, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1788682, Length=233, Percent_Identity=38.1974248927039, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790281, Length=287, Percent_Identity=33.7979094076655, Blast_Score=144, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17553560, Length=295, Percent_Identity=37.2881355932203, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17549919, Length=294, Percent_Identity=38.0952380952381, Blast_Score=176, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17563036, Length=292, Percent_Identity=36.6438356164384, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI25144276, Length=288, Percent_Identity=37.5, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17508951, Length=288, Percent_Identity=37.5, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17508953, Length=288, Percent_Identity=37.5, Blast_Score=170, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17558304, Length=288, Percent_Identity=36.4583333333333, Blast_Score=161, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71985923, Length=285, Percent_Identity=31.2280701754386, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI71985930, Length=290, Percent_Identity=29.6551724137931, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI115533614, Length=208, Percent_Identity=27.8846153846154, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI193203623, Length=208, Percent_Identity=27.8846153846154, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24583077, Length=286, Percent_Identity=36.7132867132867, Blast_Score=170, Evalue=9e-43,
Organism=Drosophila melanogaster, GI24583079, Length=286, Percent_Identity=36.7132867132867, Blast_Score=170, Evalue=9e-43,
Organism=Drosophila melanogaster, GI19921000, Length=286, Percent_Identity=36.7132867132867, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI45549573, Length=236, Percent_Identity=30.5084745762712, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI20129993, Length=229, Percent_Identity=27.0742358078603, Blast_Score=88, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 31188; Mature: 31057

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDIKKVAILGAGMMGSDIALSCALAGYDVLLKEVSLDLAAAGVERIRGSLAKWSEKGRL
CCCHHEEHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
AVDAEQQKSAVARITPVDNFSGFGDVDLVIEAIFEDLDVKSQNFRQLEEVCKPSCIIASN
EECCHHHHCHHEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECC
TSSLPITKLGACFSSAERKSRFVGMHFFSPAAIMKLVEVVNGEDTSAETVETACAFCTSI
CCCCCHHHHHHHHHHHHHHHHEEEHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GKEPIKVNDCAGFVVNRILGAINDEAIRLLEENVASAADIDKACQLGLGHPVGPFALMDQ
CCCCCEECHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ISNELNLKIARIFHGIYGDRFLPRPALVRKVDAGHFGRKTGKGWFDYSKK
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GDIKKVAILGAGMMGSDIALSCALAGYDVLLKEVSLDLAAAGVERIRGSLAKWSEKGRL
CCHHEEHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
AVDAEQQKSAVARITPVDNFSGFGDVDLVIEAIFEDLDVKSQNFRQLEEVCKPSCIIASN
EECCHHHHCHHEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEECC
TSSLPITKLGACFSSAERKSRFVGMHFFSPAAIMKLVEVVNGEDTSAETVETACAFCTSI
CCCCCHHHHHHHHHHHHHHHHEEEHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
GKEPIKVNDCAGFVVNRILGAINDEAIRLLEENVASAADIDKACQLGLGHPVGPFALMDQ
CCCCCEECHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ISNELNLKIARIFHGIYGDRFLPRPALVRKVDAGHFGRKTGKGWFDYSKK
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA