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The map label for this gene is nuoF2 [H]

Identifier: 78223287

GI number: 78223287

Start: 2339231

End: 2341138

Strand: Reverse

Name: nuoF2 [H]

Synonym: Gmet_2080

Alternate gene names: 78223287

Gene position: 2341138-2339231 (Counterclockwise)

Preceding gene: 78223288

Following gene: 78223286

Centisome position: 58.57

GC content: 61.84

Gene sequence:

>1908_bases
ATGACAAGGTTAAGCTCCCCTGAAAAATTGGAATGTGCCAGGAAGGACATCGTCTCCCGCATTGACCCGACCAAGCCGTG
CATCTCGGTATGCGCCGGTGCCGGCTGCCTCGCCTCCGGGGCAGCCGAGGTCATCGCGGCCTTCAAGACGGAGCTTGAAT
TCCATGGCCTGACGACTGAAGTGAACACCAAGGGAACCGGCTGTCCCGGCTTTTGCGAACGCGGGCCCATCGTGATGATC
TACCCCGAGGGGATCTGCTATCTCAAGGTGAAGCCCGAGGACGTACCCGAGATCGTCTCCCACACCATCAAGGAGAAAAA
GGTGGTGGACCGCCTCCTCTACGAGGATCCGGCCACGGGAACAAGGGCGCTGCGGGAGTCGGATATTCCCTTCTACAAGA
ACCAGCAGCGCAACATCCTCAGCGAGAACCTCCGGCTCGATTCCAAGAGCATGGACGACTATCTCGCCATCGGCGGCTAC
TCGGCCCTCTCCAAGGTTCTCTTCCAGATGACCCCGGAAGACGTGATGGGGGAGATCAAGAAGTCGAACCTGCGGGGGAG
GGGAGGGGGCGGATTCCCCGCCTGGCGCAAGTGGGAAGAGTCCCGCAATGCCCCGGACCCGATCAAGTACGTGATCGTCA
ACGCCGACGAGGGTGACCCCGGCGCCTTCATGGACCGGGCGCTCATCGAGGGGAATCCCCACTCGATCCTCGAAGGCCTG
ATCATCGGCGCCTATGCGGTCGGTGCCCATGAGGGGTTCATCTACGTCCGCCAGGAATATCCCCTGGCCGTCGAGAACAT
CAACCTCGCTATCCGGCAGGCCAGTGAGCGCGGGTTCGTCGGCAAGGATATCCTCGGGTCGGGTTTTGATTTCACCGTCA
AGGTCCACATGGGTGCCGGCGCCTTTGTCTGCGGCGAATCCTCGGCACTCATGACGGCTCTGGAGGGGCGAGCCGGCGAG
CCGCGGCCCAAGTACATTCATACCGCTGTCAAGGGGGTCTGGGACCACCCGAGCGTCCTGAACAACGTAGAGACCTGGGC
AAACGTTACCCAGATCATCACCAAGGGGGCGGACTGGTTCACCTCGTACGGCACCGCGGGGAGCACGGGGACCAAGATCT
TCTCCCTGGTGGGGAAGATCACCAATACCGGCCTCGTGGAAGTGCCGATGGGCGTTACCCTGAGGGACATCATCACGAAA
GTGGGGGGAGGCATACCGGGAGGCAAAAAGTTCAAGGCCGTTCAGACCGGCGGCCCCTCCGGCGGCTGCATCCCCGAGGC
GATGCTGGACCTGCCAGTGGATTTCGACGAATTGACCAAGGCAGGCTCCATGATGGGTTCCGGCGGCATGATCGTCATGG
ACGAAGACACCTGCATGGTGGACATCGCCCGGTACTTCATCGACTTCCTCAAGGACGAATCGTGCGGCAAGTGCACCCCG
TGCCGGGAGGGTATCCGCCAGATGCTGGCGGTCCTCACCAGGATCACCGTCGGCAAGGGGAAAGAGGGGGACATCGAGCT
TCTGGAGGAGTTGGCCGAGTCCACGGGAGCGGCCCTCTGCGCCCTGGGCAAGAGTGCTCCCAACCCGGTCCTCAGCACCA
TCCGCTACTTCCGTGATGAGTACGAGGCCCACATCAGGGAGAAGAAATGCCCGGCCCTCTCATGCAAGGAGATGATCGCC
TTCCATATCGATCCGGAGAAGTGCAAGGCCTGCGGCAGCTGCTTCAGGCAGTGCCCCGCCGAGGCGATCCAGGGCGGCAA
GAAGCTGATTCACATCATCGACCAGGAAAAGTGCACGAAGTGCGGAACCTGCCTGGACGTCTGCCCGTCACGCTTCGGCG
CGGTGCGGAAGATTTCCGGCGAACCGGTTCCGGCCCCTGTCCCTGAAGACAAACGAGCTATTGCCTGA

Upstream 100 bases:

>100_bases
CGCCCTCGGGCCGGTTATGGAAGTGGACGGCAAACACCATGGCAACATTGCCCCGTCCCAGATTGCATCCGTGCTGAATA
ACTGCGAGTAAGGGTGATTT

Downstream 100 bases:

>100_bases
GAGAGAAAACCATGAGCGAAATCAACTTGCAGATTGACGGGAAAGAGGTTGTCGCCACCGAAGGGATGACCATTCTGGAC
GCGGCGAAGTCCGTGGGGAT

Product: respiratory-chain NADH dehydrogenase domain-containing protein

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 635; Mature: 634

Protein sequence:

>635_residues
MTRLSSPEKLECARKDIVSRIDPTKPCISVCAGAGCLASGAAEVIAAFKTELEFHGLTTEVNTKGTGCPGFCERGPIVMI
YPEGICYLKVKPEDVPEIVSHTIKEKKVVDRLLYEDPATGTRALRESDIPFYKNQQRNILSENLRLDSKSMDDYLAIGGY
SALSKVLFQMTPEDVMGEIKKSNLRGRGGGGFPAWRKWEESRNAPDPIKYVIVNADEGDPGAFMDRALIEGNPHSILEGL
IIGAYAVGAHEGFIYVRQEYPLAVENINLAIRQASERGFVGKDILGSGFDFTVKVHMGAGAFVCGESSALMTALEGRAGE
PRPKYIHTAVKGVWDHPSVLNNVETWANVTQIITKGADWFTSYGTAGSTGTKIFSLVGKITNTGLVEVPMGVTLRDIITK
VGGGIPGGKKFKAVQTGGPSGGCIPEAMLDLPVDFDELTKAGSMMGSGGMIVMDEDTCMVDIARYFIDFLKDESCGKCTP
CREGIRQMLAVLTRITVGKGKEGDIELLEELAESTGAALCALGKSAPNPVLSTIRYFRDEYEAHIREKKCPALSCKEMIA
FHIDPEKCKACGSCFRQCPAEAIQGGKKLIHIIDQEKCTKCGTCLDVCPSRFGAVRKISGEPVPAPVPEDKRAIA

Sequences:

>Translated_635_residues
MTRLSSPEKLECARKDIVSRIDPTKPCISVCAGAGCLASGAAEVIAAFKTELEFHGLTTEVNTKGTGCPGFCERGPIVMI
YPEGICYLKVKPEDVPEIVSHTIKEKKVVDRLLYEDPATGTRALRESDIPFYKNQQRNILSENLRLDSKSMDDYLAIGGY
SALSKVLFQMTPEDVMGEIKKSNLRGRGGGGFPAWRKWEESRNAPDPIKYVIVNADEGDPGAFMDRALIEGNPHSILEGL
IIGAYAVGAHEGFIYVRQEYPLAVENINLAIRQASERGFVGKDILGSGFDFTVKVHMGAGAFVCGESSALMTALEGRAGE
PRPKYIHTAVKGVWDHPSVLNNVETWANVTQIITKGADWFTSYGTAGSTGTKIFSLVGKITNTGLVEVPMGVTLRDIITK
VGGGIPGGKKFKAVQTGGPSGGCIPEAMLDLPVDFDELTKAGSMMGSGGMIVMDEDTCMVDIARYFIDFLKDESCGKCTP
CREGIRQMLAVLTRITVGKGKEGDIELLEELAESTGAALCALGKSAPNPVLSTIRYFRDEYEAHIREKKCPALSCKEMIA
FHIDPEKCKACGSCFRQCPAEAIQGGKKLIHIIDQEKCTKCGTCLDVCPSRFGAVRKISGEPVPAPVPEDKRAIA
>Mature_634_residues
TRLSSPEKLECARKDIVSRIDPTKPCISVCAGAGCLASGAAEVIAAFKTELEFHGLTTEVNTKGTGCPGFCERGPIVMIY
PEGICYLKVKPEDVPEIVSHTIKEKKVVDRLLYEDPATGTRALRESDIPFYKNQQRNILSENLRLDSKSMDDYLAIGGYS
ALSKVLFQMTPEDVMGEIKKSNLRGRGGGGFPAWRKWEESRNAPDPIKYVIVNADEGDPGAFMDRALIEGNPHSILEGLI
IGAYAVGAHEGFIYVRQEYPLAVENINLAIRQASERGFVGKDILGSGFDFTVKVHMGAGAFVCGESSALMTALEGRAGEP
RPKYIHTAVKGVWDHPSVLNNVETWANVTQIITKGADWFTSYGTAGSTGTKIFSLVGKITNTGLVEVPMGVTLRDIITKV
GGGIPGGKKFKAVQTGGPSGGCIPEAMLDLPVDFDELTKAGSMMGSGGMIVMDEDTCMVDIARYFIDFLKDESCGKCTPC
REGIRQMLAVLTRITVGKGKEGDIELLEELAESTGAALCALGKSAPNPVLSTIRYFRDEYEAHIREKKCPALSCKEMIAF
HIDPEKCKACGSCFRQCPAEAIQGGKKLIHIIDQEKCTKCGTCLDVCPSRFGAVRKISGEPVPAPVPEDKRAIA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=430, Percent_Identity=38.8372093023256, Blast_Score=292, Evalue=8e-79,
Organism=Homo sapiens, GI260656005, Length=418, Percent_Identity=39.4736842105263, Blast_Score=291, Evalue=2e-78,
Organism=Escherichia coli, GI1788620, Length=417, Percent_Identity=40.5275779376499, Blast_Score=333, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI17531727, Length=447, Percent_Identity=37.1364653243848, Blast_Score=282, Evalue=4e-76,
Organism=Drosophila melanogaster, GI19920794, Length=376, Percent_Identity=40.6914893617021, Blast_Score=282, Evalue=5e-76,
Organism=Drosophila melanogaster, GI45550452, Length=378, Percent_Identity=40.2116402116402, Blast_Score=281, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24653819, Length=385, Percent_Identity=32.987012987013, Blast_Score=218, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24653817, Length=361, Percent_Identity=31.3019390581717, Blast_Score=192, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 68600; Mature: 68469

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00645 COMPLEX1_51K_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLSSPEKLECARKDIVSRIDPTKPCISVCAGAGCLASGAAEVIAAFKTELEFHGLTTE
CCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEE
VNTKGTGCPGFCERGPIVMIYPEGICYLKVKPEDVPEIVSHTIKEKKVVDRLLYEDPATG
ECCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
TRALRESDIPFYKNQQRNILSENLRLDSKSMDDYLAIGGYSALSKVLFQMTPEDVMGEIK
HHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHEECCHHHHHHHHHHCCCHHHHHHHH
KSNLRGRGGGGFPAWRKWEESRNAPDPIKYVIVNADEGDPGAFMDRALIEGNPHSILEGL
HHCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHH
IIGAYAVGAHEGFIYVRQEYPLAVENINLAIRQASERGFVGKDILGSGFDFTVKVHMGAG
HHHHHHCCCCCCEEEEEECCCEEEECCCEEEEECCCCCCCCHHHHCCCCCEEEEEEECCC
AFVCGESSALMTALEGRAGEPRPKYIHTAVKGVWDHPSVLNNVETWANVTQIITKGADWF
EEEECCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
TSYGTAGSTGTKIFSLVGKITNTGLVEVPMGVTLRDIITKVGGGIPGGKKFKAVQTGGPS
HHCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCCCC
GGCIPEAMLDLPVDFDELTKAGSMMGSGGMIVMDEDTCMVDIARYFIDFLKDESCGKCTP
CCCCHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCH
CREGIRQMLAVLTRITVGKGKEGDIELLEELAESTGAALCALGKSAPNPVLSTIRYFRDE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHH
YEAHIREKKCPALSCKEMIAFHIDPEKCKACGSCFRQCPAEAIQGGKKLIHIIDQEKCTK
HHHHHHHHCCCCCCHHHHHEECCCHHHHHHHHHHHHHCCHHHHCCCHHEEHHHCHHHHHH
CGTCLDVCPSRFGAVRKISGEPVPAPVPEDKRAIA
HCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRLSSPEKLECARKDIVSRIDPTKPCISVCAGAGCLASGAAEVIAAFKTELEFHGLTTE
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEE
VNTKGTGCPGFCERGPIVMIYPEGICYLKVKPEDVPEIVSHTIKEKKVVDRLLYEDPATG
ECCCCCCCCCCCCCCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCH
TRALRESDIPFYKNQQRNILSENLRLDSKSMDDYLAIGGYSALSKVLFQMTPEDVMGEIK
HHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCHHEECCHHHHHHHHHHCCCHHHHHHHH
KSNLRGRGGGGFPAWRKWEESRNAPDPIKYVIVNADEGDPGAFMDRALIEGNPHSILEGL
HHCCCCCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHCCCHHHHHHHH
IIGAYAVGAHEGFIYVRQEYPLAVENINLAIRQASERGFVGKDILGSGFDFTVKVHMGAG
HHHHHHCCCCCCEEEEEECCCEEEECCCEEEEECCCCCCCCHHHHCCCCCEEEEEEECCC
AFVCGESSALMTALEGRAGEPRPKYIHTAVKGVWDHPSVLNNVETWANVTQIITKGADWF
EEEECCCHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHH
TSYGTAGSTGTKIFSLVGKITNTGLVEVPMGVTLRDIITKVGGGIPGGKKFKAVQTGGPS
HHCCCCCCCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHCCCCCCCCEEEEEECCCCC
GGCIPEAMLDLPVDFDELTKAGSMMGSGGMIVMDEDTCMVDIARYFIDFLKDESCGKCTP
CCCCHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCH
CREGIRQMLAVLTRITVGKGKEGDIELLEELAESTGAALCALGKSAPNPVLSTIRYFRDE
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHH
YEAHIREKKCPALSCKEMIAFHIDPEKCKACGSCFRQCPAEAIQGGKKLIHIIDQEKCTK
HHHHHHHHCCCCCCHHHHHEECCCHHHHHHHHHHHHHCCHHHHCCCHHEEHHHCHHHHHH
CGTCLDVCPSRFGAVRKISGEPVPAPVPEDKRAIA
HCCHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]