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The map label for this gene is atoB [H]

Identifier: 78223281

GI number: 78223281

Start: 2333226

End: 2334401

Strand: Reverse

Name: atoB [H]

Synonym: Gmet_2074

Alternate gene names: 78223281

Gene position: 2334401-2333226 (Counterclockwise)

Preceding gene: 78223282

Following gene: 78223279

Centisome position: 58.4

GC content: 63.01

Gene sequence:

>1176_bases
ATGAGTGACGTTTATGTAATCGAATCGCTGCGCACTCCCCTCGGCTCCTTCGGGGGGGAGTTGTCCGACGTGGAGGCGCC
GCGCCTGGCCGCCACCGTCATCCGGGAACTGCTCCAGCGTTCCGGCCTTCCTGCCGAGGGCGTCGACGAGGTGATTGTCG
GTCAGGTTCTCGCGGGCGGGACGGGACAGGCCCCGGCCCGGCAGGCCATGCGCTACGCCGAACTCCCCGACAGCATTCCC
GCCATGACCATCAACAAGGTCTGCGGCAGCGGCCTCAAGGCGCTCATGCTCGGCGCCGATGCCATCCGCCTCGGTGATGT
CGGCGTGGTGATCGCCGGCGGCATGGAGAACATGTCCCTGGCCCCCTATGTACTGAGCAAGGGGCGTAACGGCTATCGTC
TGGGTAACGGCGAGCTGATCGACCTCCTGGTAAATGACGGCCTCCTGGATCCCTACAGCGGCAATCACATGGGGGTAATC
GCCGAGGCCACCACGGAAAAGCACGGCATCTCCCGGGCAGACCAGGATGCCTTTGCCTTCCGCTCCTACCAGAAAGCGCA
GACAGCGGTTAAGGAAGGGATATTCCGGGATGAGATCGTCCCGGTGGTCAAAAAGGGGCGCAAGGGGGACGTGACCGTCA
GCGACGACGAAGAGCCATTCAAGGTGGACTTCACCAAACTCATGGGGTTGAAGAGCGCCTTCAAGAAGGAAGGGACCATC
ACCGCCGGCAACGCCTCAACCATCAATGATGGTGCGGCCCTGACCCTTCTGGCCAGTGGAGAGGCGGTGAAAAAATACGG
TCTCAAGCCCAGGGCCCGACTGGTCGCCTATGCCTCCAACAGCTTGCATCCCGACCAATTCACCGAGGCGCCGGTGGGAG
CCATCGAAAAGGCCTGCGCCAAGGCCGGTCTGAAGCTCGAAGACATTGATCTGTTCGAGATCAACGAGGCCTTTGCCGCC
GTGACCATGCTTGCCATCAAGCAACTGGGGCTCGATCCGGAAAAGGTCAACGTCAACGGCGGGGCAGTGGCCATTGGCCA
TCCCCTGGGGGCAAGCGGCGGACGTCTTGCCGCTACCCTGGTTCGGGAACTGCACCGGCGCCAGGCCCGCTTCGGGCTCG
CAACCCTCTGCATTGGGGGTGGTGAAGCAGTGGCGGCAATCTTCGAGCGGGTCTGA

Upstream 100 bases:

>100_bases
GGAGGCCGTCTATACCTACGAGGGTACCCACGACATGCATCTCCTGATCATCGGCGAAAAAGTCACCGGCATTTCGGCCT
TCCGGTAAGGAGCGACAGAT

Downstream 100 bases:

>100_bases
AAACCATTTGAAACACAGAGCAACCGTGTTCTCAGTCAACAAATTAGTGCAGAAGTGGAGTGAATTTCGAGTGATCCCAC
TTCTGGTTGTTTTTCACCAT

Product: thiolase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MSDVYVIESLRTPLGSFGGELSDVEAPRLAATVIRELLQRSGLPAEGVDEVIVGQVLAGGTGQAPARQAMRYAELPDSIP
AMTINKVCGSGLKALMLGADAIRLGDVGVVIAGGMENMSLAPYVLSKGRNGYRLGNGELIDLLVNDGLLDPYSGNHMGVI
AEATTEKHGISRADQDAFAFRSYQKAQTAVKEGIFRDEIVPVVKKGRKGDVTVSDDEEPFKVDFTKLMGLKSAFKKEGTI
TAGNASTINDGAALTLLASGEAVKKYGLKPRARLVAYASNSLHPDQFTEAPVGAIEKACAKAGLKLEDIDLFEINEAFAA
VTMLAIKQLGLDPEKVNVNGGAVAIGHPLGASGGRLAATLVRELHRRQARFGLATLCIGGGEAVAAIFERV

Sequences:

>Translated_391_residues
MSDVYVIESLRTPLGSFGGELSDVEAPRLAATVIRELLQRSGLPAEGVDEVIVGQVLAGGTGQAPARQAMRYAELPDSIP
AMTINKVCGSGLKALMLGADAIRLGDVGVVIAGGMENMSLAPYVLSKGRNGYRLGNGELIDLLVNDGLLDPYSGNHMGVI
AEATTEKHGISRADQDAFAFRSYQKAQTAVKEGIFRDEIVPVVKKGRKGDVTVSDDEEPFKVDFTKLMGLKSAFKKEGTI
TAGNASTINDGAALTLLASGEAVKKYGLKPRARLVAYASNSLHPDQFTEAPVGAIEKACAKAGLKLEDIDLFEINEAFAA
VTMLAIKQLGLDPEKVNVNGGAVAIGHPLGASGGRLAATLVRELHRRQARFGLATLCIGGGEAVAAIFERV
>Mature_390_residues
SDVYVIESLRTPLGSFGGELSDVEAPRLAATVIRELLQRSGLPAEGVDEVIVGQVLAGGTGQAPARQAMRYAELPDSIPA
MTINKVCGSGLKALMLGADAIRLGDVGVVIAGGMENMSLAPYVLSKGRNGYRLGNGELIDLLVNDGLLDPYSGNHMGVIA
EATTEKHGISRADQDAFAFRSYQKAQTAVKEGIFRDEIVPVVKKGRKGDVTVSDDEEPFKVDFTKLMGLKSAFKKEGTIT
AGNASTINDGAALTLLASGEAVKKYGLKPRARLVAYASNSLHPDQFTEAPVGAIEKACAKAGLKLEDIDLFEINEAFAAV
TMLAIKQLGLDPEKVNVNGGAVAIGHPLGASGGRLAATLVRELHRRQARFGLATLCIGGGEAVAAIFERV

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI4557237, Length=393, Percent_Identity=45.5470737913486, Blast_Score=341, Evalue=6e-94,
Organism=Homo sapiens, GI148539872, Length=390, Percent_Identity=45.8974358974359, Blast_Score=327, Evalue=8e-90,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=40.0510204081633, Blast_Score=274, Evalue=1e-73,
Organism=Homo sapiens, GI4501853, Length=400, Percent_Identity=40.25, Blast_Score=235, Evalue=4e-62,
Organism=Homo sapiens, GI4504327, Length=422, Percent_Identity=31.7535545023697, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI194353979, Length=391, Percent_Identity=31.7135549872123, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI19923233, Length=378, Percent_Identity=26.1904761904762, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI302344760, Length=324, Percent_Identity=26.8518518518519, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI302344767, Length=324, Percent_Identity=26.8518518518519, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI87082165, Length=392, Percent_Identity=48.469387755102, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1788554, Length=393, Percent_Identity=47.8371501272265, Blast_Score=341, Evalue=5e-95,
Organism=Escherichia coli, GI1787663, Length=402, Percent_Identity=44.2786069651741, Blast_Score=304, Evalue=8e-84,
Organism=Escherichia coli, GI48994986, Length=402, Percent_Identity=39.0547263681592, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1788683, Length=411, Percent_Identity=29.9270072992701, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=44.4444444444444, Blast_Score=323, Evalue=8e-89,
Organism=Caenorhabditis elegans, GI133906874, Length=389, Percent_Identity=40.1028277634961, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17535921, Length=395, Percent_Identity=40.5063291139241, Blast_Score=271, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=34.1645885286783, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=424, Percent_Identity=31.8396226415094, Blast_Score=187, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=44.5843828715365, Blast_Score=318, Evalue=7e-88,
Organism=Saccharomyces cerevisiae, GI6322031, Length=396, Percent_Identity=35.8585858585859, Blast_Score=213, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=48.6005089058524, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=45.5470737913486, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=40.920716112532, Blast_Score=275, Evalue=5e-74,
Organism=Drosophila melanogaster, GI17137578, Length=423, Percent_Identity=31.6784869976359, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 41058; Mature: 40926

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVYVIESLRTPLGSFGGELSDVEAPRLAATVIRELLQRSGLPAEGVDEVIVGQVLAGG
CCCEEEHHHHHCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
TGQAPARQAMRYAELPDSIPAMTINKVCGSGLKALMLGADAIRLGDVGVVIAGGMENMSL
CCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHCCCCEEECCCCEEEECCCCCCCC
APYVLSKGRNGYRLGNGELIDLLVNDGLLDPYSGNHMGVIAEATTEKHGISRADQDAFAF
CHHHHHCCCCCEEECCCCEEEEEECCCCCCCCCCCCEEEEEECCCHHHCCCCCCHHHHHH
RSYQKAQTAVKEGIFRDEIVPVVKKGRKGDVTVSDDEEPFKVDFTKLMGLKSAFKKEGTI
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEECCCCCCCEEHHHHHHHHHHHHHCCCCE
TAGNASTINDGAALTLLASGEAVKKYGLKPRARLVAYASNSLHPDQFTEAPVGAIEKACA
ECCCCCCCCCCCEEEEEECCHHHHHHCCCCHHEEEEEECCCCCCHHHCCCCHHHHHHHHH
KAGLKLEDIDLFEINEAFAAVTMLAIKQLGLDPEKVNVNGGAVAIGHPLGASGGRLAATL
HCCCEEECCCEEHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCCCHHHHHH
VRELHRRQARFGLATLCIGGGEAVAAIFERV
HHHHHHHHHHHCEEEEEECCCHHHHHHHHCC
>Mature Secondary Structure 
SDVYVIESLRTPLGSFGGELSDVEAPRLAATVIRELLQRSGLPAEGVDEVIVGQVLAGG
CCEEEHHHHHCHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCC
TGQAPARQAMRYAELPDSIPAMTINKVCGSGLKALMLGADAIRLGDVGVVIAGGMENMSL
CCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCHHHHHHCCCCEEECCCCEEEECCCCCCCC
APYVLSKGRNGYRLGNGELIDLLVNDGLLDPYSGNHMGVIAEATTEKHGISRADQDAFAF
CHHHHHCCCCCEEECCCCEEEEEECCCCCCCCCCCCEEEEEECCCHHHCCCCCCHHHHHH
RSYQKAQTAVKEGIFRDEIVPVVKKGRKGDVTVSDDEEPFKVDFTKLMGLKSAFKKEGTI
HHHHHHHHHHHHCCHHHHHHHHHHCCCCCCEEECCCCCCCEEHHHHHHHHHHHHHCCCCE
TAGNASTINDGAALTLLASGEAVKKYGLKPRARLVAYASNSLHPDQFTEAPVGAIEKACA
ECCCCCCCCCCCEEEEEECCHHHHHHCCCCHHEEEEEECCCCCCHHHCCCCHHHHHHHHH
KAGLKLEDIDLFEINEAFAAVTMLAIKQLGLDPEKVNVNGGAVAIGHPLGASGGRLAATL
HCCCEEECCCEEHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCCCCCCCCHHHHHH
VRELHRRQARFGLATLCIGGGEAVAAIFERV
HHHHHHHHHHHCEEEEEECCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]