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The map label for this gene is hbdA [H]

Identifier: 78223279

GI number: 78223279

Start: 2331096

End: 2331941

Strand: Reverse

Name: hbdA [H]

Synonym: Gmet_2072

Alternate gene names: 78223279

Gene position: 2331941-2331096 (Counterclockwise)

Preceding gene: 78223281

Following gene: 78223278

Centisome position: 58.34

GC content: 61.82

Gene sequence:

>846_bases
ATGGTTAGCAAAATCGGAGTACTCGGCGCAGGGCAGATGGGGAGCGGCATTGCCCATGTGCTGGCCCAGCAGGGAATAGA
GGTGGTGCTGTTCGATATCGCCGAGGCGCAGCTCGCCAAGGCCGTGACCGGCATCGAGAAGAACCTGGAGCGTCAGGCCA
AGAAGGGACAGCTGGAAAGCGCCGCTATCTCGGCCATTGTGGGGCGCATCCGCACCACCCAGGCCATGGAGGACCTGGCC
GAGTGCGATATGGCCATCGAGGCGGTGACCGAGAAGGAAGCCCTGAAGCTGGAGATCTTCAGGAAGCTGGATGGGATCGT
GAAAGCGGGAGCGATCCTCGCCTCCAACACCTCGTCGATACCCATCACCCGCATTGCGGCAGTGACCGGACGGCCCGACA
AGGTCATCGGCATGCACTTCATGAACCCGGTGCCGGTCATGCAGCTCGTGGAGGTTATTCGGGGGCTTACCACCAGCGAC
GAGACCTTTGCCGCCACCACGGCCCTCGTGGCTAAGCTCGGCAAGGAGACGGCGGTATCCGCCGACTATCCCGGCTTCAT
CGTCAACCGCATCCTCATCCCCATGATCAACGAGGCGGCCTTTGCCCTCTTCGAGGGGATCGCCACGGTGGAGGACATCG
ATAAGGGGATGAAGCTCGGCACCAATCAGCCCATGGGGCCCCTGACCCTGGCCGATTTCATTGGCCTCGACACCTGTCTC
GCCATCATGAACGTCCTCCACGAAGGATTCAAGGACAGCAAGTACCGCCCCTGTCCGCTCCTGGTCAAGATGGTGGAGGC
CGGGTATCTGGGGAGGAAGACGGGGCGGGGATTCTACACCTACTGA

Upstream 100 bases:

>100_bases
TGAGCATGGAGAAAGACAAACAACTCTATTTGATTGAAATCCTGCTTTCTCATTTGCTCAGTTGCTCAGTGTTATTCCGT
ATTTGAAGTGGAGGCAGGTA

Downstream 100 bases:

>100_bases
TTGGGGGAAATGCCATGGGAACCGAGAATCTGCTTGTTGACATAAAAGACGGCGTGGCCCTGCTGACCATCAACCGGCCC
AAGGTGCTGAACGCCCTCCA

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 281; Mature: 281

Protein sequence:

>281_residues
MVSKIGVLGAGQMGSGIAHVLAQQGIEVVLFDIAEAQLAKAVTGIEKNLERQAKKGQLESAAISAIVGRIRTTQAMEDLA
ECDMAIEAVTEKEALKLEIFRKLDGIVKAGAILASNTSSIPITRIAAVTGRPDKVIGMHFMNPVPVMQLVEVIRGLTTSD
ETFAATTALVAKLGKETAVSADYPGFIVNRILIPMINEAAFALFEGIATVEDIDKGMKLGTNQPMGPLTLADFIGLDTCL
AIMNVLHEGFKDSKYRPCPLLVKMVEAGYLGRKTGRGFYTY

Sequences:

>Translated_281_residues
MVSKIGVLGAGQMGSGIAHVLAQQGIEVVLFDIAEAQLAKAVTGIEKNLERQAKKGQLESAAISAIVGRIRTTQAMEDLA
ECDMAIEAVTEKEALKLEIFRKLDGIVKAGAILASNTSSIPITRIAAVTGRPDKVIGMHFMNPVPVMQLVEVIRGLTTSD
ETFAATTALVAKLGKETAVSADYPGFIVNRILIPMINEAAFALFEGIATVEDIDKGMKLGTNQPMGPLTLADFIGLDTCL
AIMNVLHEGFKDSKYRPCPLLVKMVEAGYLGRKTGRGFYTY
>Mature_281_residues
MVSKIGVLGAGQMGSGIAHVLAQQGIEVVLFDIAEAQLAKAVTGIEKNLERQAKKGQLESAAISAIVGRIRTTQAMEDLA
ECDMAIEAVTEKEALKLEIFRKLDGIVKAGAILASNTSSIPITRIAAVTGRPDKVIGMHFMNPVPVMQLVEVIRGLTTSD
ETFAATTALVAKLGKETAVSADYPGFIVNRILIPMINEAAFALFEGIATVEDIDKGMKLGTNQPMGPLTLADFIGLDTCL
AIMNVLHEGFKDSKYRPCPLLVKMVEAGYLGRKTGRGFYTY

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=288, Percent_Identity=43.0555555555556, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI296179427, Length=306, Percent_Identity=41.1764705882353, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI20127408, Length=283, Percent_Identity=37.8091872791519, Blast_Score=167, Evalue=7e-42,
Organism=Homo sapiens, GI261878539, Length=291, Percent_Identity=36.0824742268041, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI68989263, Length=291, Percent_Identity=36.0824742268041, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI115430219, Length=217, Percent_Identity=30.4147465437788, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1787661, Length=281, Percent_Identity=37.3665480427046, Blast_Score=191, Evalue=4e-50,
Organism=Escherichia coli, GI1790281, Length=264, Percent_Identity=35.9848484848485, Blast_Score=160, Evalue=7e-41,
Organism=Escherichia coli, GI1788682, Length=258, Percent_Identity=38.3720930232558, Blast_Score=148, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17549919, Length=287, Percent_Identity=39.0243902439024, Blast_Score=211, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17553560, Length=286, Percent_Identity=40.5594405594406, Blast_Score=206, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17563036, Length=294, Percent_Identity=41.4965986394558, Blast_Score=201, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17558304, Length=289, Percent_Identity=38.7543252595156, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI25144276, Length=282, Percent_Identity=39.0070921985816, Blast_Score=168, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17508953, Length=282, Percent_Identity=39.0070921985816, Blast_Score=168, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17508951, Length=282, Percent_Identity=39.0070921985816, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71985923, Length=282, Percent_Identity=30.1418439716312, Blast_Score=137, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI71985930, Length=282, Percent_Identity=29.7872340425532, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI193203623, Length=202, Percent_Identity=25.7425742574257, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533614, Length=202, Percent_Identity=25.7425742574257, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24583077, Length=282, Percent_Identity=38.2978723404255, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24583079, Length=282, Percent_Identity=38.2978723404255, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI19921000, Length=282, Percent_Identity=38.2978723404255, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI45549573, Length=227, Percent_Identity=30.3964757709251, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI20129993, Length=223, Percent_Identity=29.1479820627803, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 30028; Mature: 30028

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSKIGVLGAGQMGSGIAHVLAQQGIEVVLFDIAEAQLAKAVTGIEKNLERQAKKGQLES
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AAISAIVGRIRTTQAMEDLAECDMAIEAVTEKEALKLEIFRKLDGIVKAGAILASNTSSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEECCCCCC
PITRIAAVTGRPDKVIGMHFMNPVPVMQLVEVIRGLTTSDETFAATTALVAKLGKETAVS
CHHHEEEECCCCCCEEHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
ADYPGFIVNRILIPMINEAAFALFEGIATVEDIDKGMKLGTNQPMGPLTLADFIGLDTCL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AIMNVLHEGFKDSKYRPCPLLVKMVEAGYLGRKTGRGFYTY
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MVSKIGVLGAGQMGSGIAHVLAQQGIEVVLFDIAEAQLAKAVTGIEKNLERQAKKGQLES
CCCCCCCCCCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
AAISAIVGRIRTTQAMEDLAECDMAIEAVTEKEALKLEIFRKLDGIVKAGAILASNTSSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEECCCCCC
PITRIAAVTGRPDKVIGMHFMNPVPVMQLVEVIRGLTTSDETFAATTALVAKLGKETAVS
CHHHEEEECCCCCCEEHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
ADYPGFIVNRILIPMINEAAFALFEGIATVEDIDKGMKLGTNQPMGPLTLADFIGLDTCL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
AIMNVLHEGFKDSKYRPCPLLVKMVEAGYLGRKTGRGFYTY
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]