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The map label for this gene is lon1 [H]

Identifier: 78223078

GI number: 78223078

Start: 2084434

End: 2086851

Strand: Reverse

Name: lon1 [H]

Synonym: Gmet_1871

Alternate gene names: 78223078

Gene position: 2086851-2084434 (Counterclockwise)

Preceding gene: 78223079

Following gene: 78223077

Centisome position: 52.2

GC content: 51.74

Gene sequence:

>2418_bases
ATGCACGATAATCAAGGTAGTCAACCGCTCAAGAGAGGGGATCTGGAAAGATTCCCTCTTTTACCATTAAGAGATATTGT
TGTGTTCCCGCACATGGTTGTTCCGCTTTTTGTCGGAAGGGAGAAGTCCATTTCTGCCCTGGAAGCAGCCATGAACGATA
ACCGTCTGATCTTTCTCGCTACCCAGAAAAACGCCAAGACCGAAGAACCGAATGAAGAGGATATCTATTCGATTGGTACG
GTTTCTCAGGTGATCCAACTCCTCAAGCTCCCCGACGGAACCGTGAAAGTTCTCGTTGAGGGGAAAAGGCGAGGTGTTAT
TGCGTCATATCACCCTGAAGCGAATCATTTTATTGTCGAGGTGCAGCCTCTTCCTGGCGAGTCAGAAACAACCTCTGAGA
TGGAAGCCCTTGTACGCAGCGCCCGTTCTACCTTTGAGAGTTACGTGAAGCTGACTAAGGGAATACCGCAGGAAACCGTC
AGTGCGACCCTTAATATTACCGACCCCGGCAGGCTTGCCGATACCCTGGCGCCTCATCTCAACCTCAAGCTGAGTGATCG
GCAGGAACTTCTTGCTCTTGCCGAGTCGGGTCATCGGTTAGAAAGGCTCCTTGCCTTCATGGAGTCCGAGGTCGAAATCC
TGCAACTTGAAAGTAAGATTCGCACCCGCGTCAAGAAGCAGATGGAGAAGAACCAGAAGGAATACTACCTCAATGAACAG
ATGAGAGCGATCCAGAAGGAGCTTGGGGGAAAGGACGACTACAAGCAGGAGATCGCAGAACTCGAGGAAAAGGTTTCACA
GGGCAAGCTCTCCAAGGAAGCAAAACAAAAGGCATTGGCCGAACTGAAAAAGCTCAAGCTCATGTCCCCTGCTTCTGCCG
AGGCGGCTGTTGTCAGAAACTATGTTGACTGGCTTGCTACACTCCCGTGGGGAAAGCTCTCCAGGGAAAAGCACGACATT
GTTGCCGCAGAGAGAATACTCGACGAGGATCATTATGGGCTTGTCAAGGTCAAGGAACGCATCCTTGAGTTCCTGTCCGT
ACAGACGCTCGTCAAGAAAATCAGGGGGCCGATTCTGTGTCTTGTTGGCCCTCCCGGGGTTGGGAAGACATCCCTCGCGC
GCTCTATTGCCACAGCGACTGGCCGAAAATTCGTCAAGATGTCGCTGGGGGGCATGCGTGACGAGGCTGAAATTCGCGGG
CATCGTCGCACGTACGTGGGGGCCATGCCCGGCAAGATTATCCAGAACCTGAAGAAGGCGGGGAGCAATAACCCCGTATT
TCTGCTGGATGAGCTCGATAAAATGAGTTCAGACTTCCGCGGTGACCCGGCATCTGCAATGCTTGAAGTTCTTGACCCCG
AGCAGAACGCCCATTTCAGCGATCATTTTCTCGATGTTGAGTATGATCTTTCACGGGTAATGTTTATTGCTACCGCCAAC
TCAATCCATGGGATACCACGCCCGCTGCTCGACAGGCTTGAGGTTATCCGACTCGACGGGTACACCGAGCATGAAAAGCT
AGCAATTGCTGAACGTTACCTCGTGAAAAAACAGATGGAGGCCAATGGTCTTGCCCTGGAGAGGGTGAGTATTTCCTCGA
AAGCAATTTTGGATATGATCAGATTTTACTCACGCGAGGCGGGGGTGCGGAACCTCGAGCGCGAGATAGCTTCGGTATGC
CGCAAGGTTGCCCACCGCATCGTGAGAGGCGAGAAGAAAAAATTTACACTCCAGCCCAAGCACCTCAAGGATTTTCTGGG
CCCTCCCCGATTCAGGATTGGAACAGCCGAGGAAAAGGATTCAGCGGGTGCCGTTACCGGCCTTGCGTGGACTGAAGTCG
GCGGAGATCTCCTCACCATCGAGGTGGCAATTGTTCCTGGAAAGGGGAAGCTTACTATAACCGGAAAGCTGGGTGAGGTA
ATGCAGGAATCGGCCCAGGCGGCCATGACTTATGTAAGATCACGTGCCCATATTCTTGGGCTTGAGCGGGATTTTTATCA
GGCAATCGATATCCATATCCATGTTCCTGAAGGTGCGATTCCAAAAGATGGGCCGTCTGCGGGAATCACCATCGCAACGG
CAATTACTTCGGCCTTGACCGGTAGAGGTGTTCGCCGGGACATCGCCATGACCGGAGAGGTGACCCTGAGAGGCAATGTG
CTTCCCATAGGCGGACTCAAGGAAAAACTTCTTGCCGCACGTCGCGGGGGGATTAAAGAAGTAATAATCCCCGGAGATAA
TCAGAAAGACCTTCATGAAATTCCCCAGGAAGTATATGAGGGAATGACTATTACATCCGTTTCCCATATGGATGAAGTCC
TGTCAAGGGCTCTTCTTGAAGGCACATTATCCGTGGTTGCTCCCTCTGGCGTAACAGTCTCTGAAGGTCAAGCAACAAAT
ATTGTTACTGCCCATTGA

Upstream 100 bases:

>100_bases
GTAAAGGAAGTAGTCATAAGCGAAGATGTAATCTATAACCGGGAAAAACCGATCATAGTCTACGAAAGTGTGGCGGAATC
CGCCTGATCTGAGGAACTAG

Downstream 100 bases:

>100_bases
GAAATAAAATTATGGTTGACAGGATGTATGGTGGTTTGGTATAAACAAAATCCGTTTTGTAAGGGCTTTGTTGTCGGAAC
TGACGTTATTTTAAGTGGTT

Product: Lon-A peptidase

Products: NA

Alternate protein names: ATP-dependent protease La 1 [H]

Number of amino acids: Translated: 805; Mature: 805

Protein sequence:

>805_residues
MHDNQGSQPLKRGDLERFPLLPLRDIVVFPHMVVPLFVGREKSISALEAAMNDNRLIFLATQKNAKTEEPNEEDIYSIGT
VSQVIQLLKLPDGTVKVLVEGKRRGVIASYHPEANHFIVEVQPLPGESETTSEMEALVRSARSTFESYVKLTKGIPQETV
SATLNITDPGRLADTLAPHLNLKLSDRQELLALAESGHRLERLLAFMESEVEILQLESKIRTRVKKQMEKNQKEYYLNEQ
MRAIQKELGGKDDYKQEIAELEEKVSQGKLSKEAKQKALAELKKLKLMSPASAEAAVVRNYVDWLATLPWGKLSREKHDI
VAAERILDEDHYGLVKVKERILEFLSVQTLVKKIRGPILCLVGPPGVGKTSLARSIATATGRKFVKMSLGGMRDEAEIRG
HRRTYVGAMPGKIIQNLKKAGSNNPVFLLDELDKMSSDFRGDPASAMLEVLDPEQNAHFSDHFLDVEYDLSRVMFIATAN
SIHGIPRPLLDRLEVIRLDGYTEHEKLAIAERYLVKKQMEANGLALERVSISSKAILDMIRFYSREAGVRNLEREIASVC
RKVAHRIVRGEKKKFTLQPKHLKDFLGPPRFRIGTAEEKDSAGAVTGLAWTEVGGDLLTIEVAIVPGKGKLTITGKLGEV
MQESAQAAMTYVRSRAHILGLERDFYQAIDIHIHVPEGAIPKDGPSAGITIATAITSALTGRGVRRDIAMTGEVTLRGNV
LPIGGLKEKLLAARRGGIKEVIIPGDNQKDLHEIPQEVYEGMTITSVSHMDEVLSRALLEGTLSVVAPSGVTVSEGQATN
IVTAH

Sequences:

>Translated_805_residues
MHDNQGSQPLKRGDLERFPLLPLRDIVVFPHMVVPLFVGREKSISALEAAMNDNRLIFLATQKNAKTEEPNEEDIYSIGT
VSQVIQLLKLPDGTVKVLVEGKRRGVIASYHPEANHFIVEVQPLPGESETTSEMEALVRSARSTFESYVKLTKGIPQETV
SATLNITDPGRLADTLAPHLNLKLSDRQELLALAESGHRLERLLAFMESEVEILQLESKIRTRVKKQMEKNQKEYYLNEQ
MRAIQKELGGKDDYKQEIAELEEKVSQGKLSKEAKQKALAELKKLKLMSPASAEAAVVRNYVDWLATLPWGKLSREKHDI
VAAERILDEDHYGLVKVKERILEFLSVQTLVKKIRGPILCLVGPPGVGKTSLARSIATATGRKFVKMSLGGMRDEAEIRG
HRRTYVGAMPGKIIQNLKKAGSNNPVFLLDELDKMSSDFRGDPASAMLEVLDPEQNAHFSDHFLDVEYDLSRVMFIATAN
SIHGIPRPLLDRLEVIRLDGYTEHEKLAIAERYLVKKQMEANGLALERVSISSKAILDMIRFYSREAGVRNLEREIASVC
RKVAHRIVRGEKKKFTLQPKHLKDFLGPPRFRIGTAEEKDSAGAVTGLAWTEVGGDLLTIEVAIVPGKGKLTITGKLGEV
MQESAQAAMTYVRSRAHILGLERDFYQAIDIHIHVPEGAIPKDGPSAGITIATAITSALTGRGVRRDIAMTGEVTLRGNV
LPIGGLKEKLLAARRGGIKEVIIPGDNQKDLHEIPQEVYEGMTITSVSHMDEVLSRALLEGTLSVVAPSGVTVSEGQATN
IVTAH
>Mature_805_residues
MHDNQGSQPLKRGDLERFPLLPLRDIVVFPHMVVPLFVGREKSISALEAAMNDNRLIFLATQKNAKTEEPNEEDIYSIGT
VSQVIQLLKLPDGTVKVLVEGKRRGVIASYHPEANHFIVEVQPLPGESETTSEMEALVRSARSTFESYVKLTKGIPQETV
SATLNITDPGRLADTLAPHLNLKLSDRQELLALAESGHRLERLLAFMESEVEILQLESKIRTRVKKQMEKNQKEYYLNEQ
MRAIQKELGGKDDYKQEIAELEEKVSQGKLSKEAKQKALAELKKLKLMSPASAEAAVVRNYVDWLATLPWGKLSREKHDI
VAAERILDEDHYGLVKVKERILEFLSVQTLVKKIRGPILCLVGPPGVGKTSLARSIATATGRKFVKMSLGGMRDEAEIRG
HRRTYVGAMPGKIIQNLKKAGSNNPVFLLDELDKMSSDFRGDPASAMLEVLDPEQNAHFSDHFLDVEYDLSRVMFIATAN
SIHGIPRPLLDRLEVIRLDGYTEHEKLAIAERYLVKKQMEANGLALERVSISSKAILDMIRFYSREAGVRNLEREIASVC
RKVAHRIVRGEKKKFTLQPKHLKDFLGPPRFRIGTAEEKDSAGAVTGLAWTEVGGDLLTIEVAIVPGKGKLTITGKLGEV
MQESAQAAMTYVRSRAHILGLERDFYQAIDIHIHVPEGAIPKDGPSAGITIATAITSALTGRGVRRDIAMTGEVTLRGNV
LPIGGLKEKLLAARRGGIKEVIIPGDNQKDLHEIPQEVYEGMTITSVSHMDEVLSRALLEGTLSVVAPSGVTVSEGQATN
IVTAH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI21396489, Length=831, Percent_Identity=38.748495788207, Blast_Score=553, Evalue=1e-157,
Organism=Homo sapiens, GI31377667, Length=583, Percent_Identity=45.1114922813036, Blast_Score=534, Evalue=1e-151,
Organism=Escherichia coli, GI1786643, Length=777, Percent_Identity=59.97425997426, Blast_Score=934, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=708, Percent_Identity=40.1129943502825, Blast_Score=509, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17556486, Length=543, Percent_Identity=39.963167587477, Blast_Score=425, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319449, Length=706, Percent_Identity=39.5184135977337, Blast_Score=521, Evalue=1e-148,
Organism=Drosophila melanogaster, GI221513036, Length=687, Percent_Identity=43.8136826783115, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24666867, Length=687, Percent_Identity=43.8136826783115, Blast_Score=534, Evalue=1e-152,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89045; Mature: 89045

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDNQGSQPLKRGDLERFPLLPLRDIVVFPHMVVPLFVGREKSISALEAAMNDNRLIFLA
CCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEE
TQKNAKTEEPNEEDIYSIGTVSQVIQLLKLPDGTVKVLVEGKRRGVIASYHPEANHFIVE
ECCCCCCCCCCHHHHEEHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEEEE
VQPLPGESETTSEMEALVRSARSTFESYVKLTKGIPQETVSATLNITDPGRLADTLAPHL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEECCCHHHHHHHCCCC
NLKLSDRQELLALAESGHRLERLLAFMESEVEILQLESKIRTRVKKQMEKNQKEYYLNEQ
CEEECCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRAIQKELGGKDDYKQEIAELEEKVSQGKLSKEAKQKALAELKKLKLMSPASAEAAVVRN
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
YVDWLATLPWGKLSREKHDIVAAERILDEDHYGLVKVKERILEFLSVQTLVKKIRGPILC
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
LVGPPGVGKTSLARSIATATGRKFVKMSLGGMRDEAEIRGHRRTYVGAMPGKIIQNLKKA
EECCCCCCHHHHHHHHHHHHCCCEEEHHCCCCCCHHHHCCCCCEEECCCCHHHHHHHHHC
GSNNPVFLLDELDKMSSDFRGDPASAMLEVLDPEQNAHFSDHFLDVEYDLSRVMFIATAN
CCCCCEEEEECHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECC
SIHGIPRPLLDRLEVIRLDGYTEHEKLAIAERYLVKKQMEANGLALERVSISSKAILDMI
CCCCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
RFYSREAGVRNLEREIASVCRKVAHRIVRGEKKKFTLQPKHLKDFLGPPRFRIGTAEEKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCCCEEECCCCCCC
SAGAVTGLAWTEVGGDLLTIEVAIVPGKGKLTITGKLGEVMQESAQAAMTYVRSRAHILG
CCCCEEEEEHHHCCCCEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
LERDFYQAIDIHIHVPEGAIPKDGPSAGITIATAITSALTGRGVRRDIAMTGEVTLRGNV
CCHHHEEEEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEECEEEEECCE
LPIGGLKEKLLAARRGGIKEVIIPGDNQKDLHEIPQEVYEGMTITSVSHMDEVLSRALLE
EECCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHH
GTLSVVAPSGVTVSEGQATNIVTAH
HHHHEECCCCCEECCCCCCCCEECC
>Mature Secondary Structure
MHDNQGSQPLKRGDLERFPLLPLRDIVVFPHMVVPLFVGREKSISALEAAMNDNRLIFLA
CCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEE
TQKNAKTEEPNEEDIYSIGTVSQVIQLLKLPDGTVKVLVEGKRRGVIASYHPEANHFIVE
ECCCCCCCCCCHHHHEEHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCEEEEE
VQPLPGESETTSEMEALVRSARSTFESYVKLTKGIPQETVSATLNITDPGRLADTLAPHL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEEECCCHHHHHHHCCCC
NLKLSDRQELLALAESGHRLERLLAFMESEVEILQLESKIRTRVKKQMEKNQKEYYLNEQ
CEEECCHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MRAIQKELGGKDDYKQEIAELEEKVSQGKLSKEAKQKALAELKKLKLMSPASAEAAVVRN
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
YVDWLATLPWGKLSREKHDIVAAERILDEDHYGLVKVKERILEFLSVQTLVKKIRGPILC
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEE
LVGPPGVGKTSLARSIATATGRKFVKMSLGGMRDEAEIRGHRRTYVGAMPGKIIQNLKKA
EECCCCCCHHHHHHHHHHHHCCCEEEHHCCCCCCHHHHCCCCCEEECCCCHHHHHHHHHC
GSNNPVFLLDELDKMSSDFRGDPASAMLEVLDPEQNAHFSDHFLDVEYDLSRVMFIATAN
CCCCCEEEEECHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCEEEEEECCCCEEEEEECC
SIHGIPRPLLDRLEVIRLDGYTEHEKLAIAERYLVKKQMEANGLALERVSISSKAILDMI
CCCCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHH
RFYSREAGVRNLEREIASVCRKVAHRIVRGEKKKFTLQPKHLKDFLGPPRFRIGTAEEKD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCCCEEECCCCCCC
SAGAVTGLAWTEVGGDLLTIEVAIVPGKGKLTITGKLGEVMQESAQAAMTYVRSRAHILG
CCCCEEEEEHHHCCCCEEEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHCC
LERDFYQAIDIHIHVPEGAIPKDGPSAGITIATAITSALTGRGVRRDIAMTGEVTLRGNV
CCHHHEEEEEEEEECCCCCCCCCCCCCCEEHHHHHHHHHHCCCCCEEEEEECEEEEECCE
LPIGGLKEKLLAARRGGIKEVIIPGDNQKDLHEIPQEVYEGMTITSVSHMDEVLSRALLE
EECCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHH
GTLSVVAPSGVTVSEGQATNIVTAH
HHHHEECCCCCEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8468287 [H]