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The map label for this gene is lepB [H]

Identifier: 78222976

GI number: 78222976

Start: 1982405

End: 1983085

Strand: Direct

Name: lepB [H]

Synonym: Gmet_1767

Alternate gene names: 78222976

Gene position: 1982405-1983085 (Clockwise)

Preceding gene: 78222975

Following gene: 78222977

Centisome position: 49.59

GC content: 52.57

Gene sequence:

>681_bases
ATGGACTACAAAAATTCTCAATACGGATCGAACAACGCCATGGGCGAAAGGCCGGCAGCAGAGGAGCCGCAGGTCAAGAA
AAAGCATATCGTTCGGGAATATGCCGAGTCGATCATCATCGCTGTTATCCTTGCTCTCATCATCCGTACGTTCGTGGTGC
AGGCGTTCAAGATCCCCTCCGGATCCATGGAGGACACCCTTGCCATCGGTGATCATATTCTCGTCTGCAAGTTCATCTAC
GGCACCAAGATTCCCTTTACCGACATGAAAATTGCCCCGATCCGGGAGCCGAAGCGGGGTGATGTCATTGTATTCGAGTA
TCCAGAAGATCCGAGCAAGGACTTCATCAAGCGCGTCATCGGTGTTCCTGGTGATGAAATCAGGGTCATTATGAAGACGG
TTTATGTCAACGGAAAGCCCTACAAGATTCCCCAGGAAGTTCACAAGGAGAACGAAGTTATTGCTGCTGCCCAGAATCCG
CGGGACAACTTCGGTCCCGTCACGGTGCCGGCCGGCTCCTACTTCGTCATGGGTGACAACAGGGACCGCTCCTACGACAG
CCGCTTCTGGGGATTCGTGAAAAGCGAGCAGATTAAGGGACTTGCCTTCATCAAGTATTGGTCGTGGGACCGCGACAATA
TGCGTGTCCGTTGGAAGAGCATCGGTGACCTGATTCACTGA

Upstream 100 bases:

>100_bases
ACGTGGGAAACGTGGAGTTGCCCCAGGAGGCATTTCTCGCCATTCTCAAGGTGGAAGAGTAAGGGTTTACCCATAGAACA
TTCACCGAAAAGGAACCGCA

Downstream 100 bases:

>100_bases
AATTGACCTTGACACCCTCCGTAACGGGGTGATAAAATTCTCCAAATTTTGCTGACAAACAACAGACTTTGCCTTTTAAA
TTAGCCCCGTGAGGTTAGAA

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MDYKNSQYGSNNAMGERPAAEEPQVKKKHIVREYAESIIIAVILALIIRTFVVQAFKIPSGSMEDTLAIGDHILVCKFIY
GTKIPFTDMKIAPIREPKRGDVIVFEYPEDPSKDFIKRVIGVPGDEIRVIMKTVYVNGKPYKIPQEVHKENEVIAAAQNP
RDNFGPVTVPAGSYFVMGDNRDRSYDSRFWGFVKSEQIKGLAFIKYWSWDRDNMRVRWKSIGDLIH

Sequences:

>Translated_226_residues
MDYKNSQYGSNNAMGERPAAEEPQVKKKHIVREYAESIIIAVILALIIRTFVVQAFKIPSGSMEDTLAIGDHILVCKFIY
GTKIPFTDMKIAPIREPKRGDVIVFEYPEDPSKDFIKRVIGVPGDEIRVIMKTVYVNGKPYKIPQEVHKENEVIAAAQNP
RDNFGPVTVPAGSYFVMGDNRDRSYDSRFWGFVKSEQIKGLAFIKYWSWDRDNMRVRWKSIGDLIH
>Mature_226_residues
MDYKNSQYGSNNAMGERPAAEEPQVKKKHIVREYAESIIIAVILALIIRTFVVQAFKIPSGSMEDTLAIGDHILVCKFIY
GTKIPFTDMKIAPIREPKRGDVIVFEYPEDPSKDFIKRVIGVPGDEIRVIMKTVYVNGKPYKIPQEVHKENEVIAAAQNP
RDNFGPVTVPAGSYFVMGDNRDRSYDSRFWGFVKSEQIKGLAFIKYWSWDRDNMRVRWKSIGDLIH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=245, Percent_Identity=32.6530612244898, Blast_Score=127, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 25888; Mature: 25888

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKNSQYGSNNAMGERPAAEEPQVKKKHIVREYAESIIIAVILALIIRTFVVQAFKIPS
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSMEDTLAIGDHILVCKFIYGTKIPFTDMKIAPIREPKRGDVIVFEYPEDPSKDFIKRVI
CCCCCHHHHCCCEEEEEHHHCCCCCCCCCEECCCCCCCCCCEEEEECCCCCHHHHHHHHH
GVPGDEIRVIMKTVYVNGKPYKIPQEVHKENEVIAAAQNPRDNFGPVTVPAGSYFVMGDN
CCCCHHHHEEEEHEEECCCCCCCHHHHCCCCCEEEEECCCCCCCCCEEECCCCEEEEECC
RDRSYDSRFWGFVKSEQIKGLAFIKYWSWDRDNMRVRWKSIGDLIH
CCCCCHHHHHCCCCCCCCCCEEEEEEECCCCCCCEEEHHHHCCCCC
>Mature Secondary Structure
MDYKNSQYGSNNAMGERPAAEEPQVKKKHIVREYAESIIIAVILALIIRTFVVQAFKIPS
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GSMEDTLAIGDHILVCKFIYGTKIPFTDMKIAPIREPKRGDVIVFEYPEDPSKDFIKRVI
CCCCCHHHHCCCEEEEEHHHCCCCCCCCCEECCCCCCCCCCEEEEECCCCCHHHHHHHHH
GVPGDEIRVIMKTVYVNGKPYKIPQEVHKENEVIAAAQNPRDNFGPVTVPAGSYFVMGDN
CCCCHHHHEEEEHEEECCCCCCCHHHHCCCCCEEEEECCCCCCCCCEEECCCCEEEEECC
RDRSYDSRFWGFVKSEQIKGLAFIKYWSWDRDNMRVRWKSIGDLIH
CCCCCHHHHHCCCCCCCCCCEEEEEEECCCCCCCEEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]