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The map label for this gene is lepA [H]

Identifier: 78222975

GI number: 78222975

Start: 1980477

End: 1982366

Strand: Direct

Name: lepA [H]

Synonym: Gmet_1766

Alternate gene names: 78222975

Gene position: 1980477-1982366 (Clockwise)

Preceding gene: 78222972

Following gene: 78222976

Centisome position: 49.54

GC content: 56.98

Gene sequence:

>1890_bases
ATGCTGGATGTATCCGGAGAATACCCTTTACAAAATCTCCCTCTTTCGGCTATTGTTCTACGGTTACACTCATTTAACGA
CAAGGTGTCTATGAAGATCGAAAATATCCGCAATTTTTCAATAATTGCTCATATCGACCACGGCAAGTCCACCCTTGCAG
ACCGGCTCCTGGAGTATACCGGTGCCCTTTCCGAGCGAGAGAGGCAGGATCAGTTCCTCGACAAGATGGATCTGGAGCGG
GAGCGCGGGATAACCATCAAGGCCCAGACCGTCCGCCTGAATTACCGGGCCGACGACGGGAAGGATTACGTGCTGAACCT
GATCGATACGCCGGGACATGTGGACTTCACCTACGAAGTTTCCCGCTCTCTCGCTGCCTGCGAGGGGGGACTTCTGGTGG
TGGATGCCTCTCAGGGGGTTGAGGCCCAGACCCTCGCCAATGTCTATCTGGCCATCGACAACAACCTTGAGGTCTTTCCC
GTTCTGAACAAAATCGACCTCCCGGCGGCGGAACCGGAGCGGGTCAAGCACGAGATCGAGGAGATCATCGGCCTGGACGC
CCACGATGCGGTGCTTGCCAGCGCCAAAGAAGGGATCGGGACCCGGGAGATCCTGGAAGAGATCGTAAAAAAGATCCCTC
CCCCGGAGGGAGACCCGGCCGCGCCGCTCAAGGCTCTGCTCTTTGATTCGTGGTATGACCAGTACCAGGGAGTCATTATT
CTGGCGAGGCTCATCGATGGCATCCTCAAGAAGGGTGATAAGATCCAGCTCGTCTCCACCGGACGTAGCTACGAGGCCCT
TAAAGTTGGTGTTTTCGCCCCGGTGATGCGGGAGGTGCCCCAGTTGTCGGCCGGTGAGGTCGGCTTTGTCATTGCCGGCA
TCAAGGACGTTGCCGACGCCAAGATCGGCGATACCGTCACCCATACCCTCAAGCCCTGTACGACCCCCCTCGGCGGTTTC
AAGGAAGTGAAGCCCATGGTCTTCTCGGGGCTCTACCCCATCGACACTTCGCAATACGAACAGCTTCGCGATGCGTTGGC
CAAACTCAAACTCAATGATTCCTCCTTCTCCTACGAGCCGGAGACATCACTGGCGCTGGGATTCGGCTTCCGGTGCGGCT
TTCTGGGGCTTCTCCACATGGAGATCATCCAGGAGCGGCTGGAGCGGGAGTTCAATCTCGACCTCATCACCACCGCGCCA
ACGGTCGTTTACAGGGTCCACCGGATCAAAGGCGACATGATCTCCATCGAGAGTGCCAACCAACTCCCCCCGACCCAGGA
GATCGACTATGTAGAGGAGCCGTTCATCCTTGCCTCCATCCACACCCCCAATGAGTTCGTCGGCGGAATTCTTGCCCTGT
GCGAGGAGAAGCGCGGGGTGCAGCGGGAGATCAAGTACCTGACCCCGACGCGGGTCATGATCATCTACGAACTCCCCCTG
AACGAGGTGGTGCTCGATTTTTACGACCGGCTCAAGTCCATCACCAAGGGGTATGCCTCCCTTGATTACGAACATCTGGA
CTATCGCCGGAGCGAGCTCGTGCGGATGAACATTATGATCAACGGCGAAGTGGTGGACGCACTCTCACTCATCATTCACA
GGGACAAGGCATACTATCGGGGCCGTGACCTCGTCTCCAAGATGAAGGAGCTGATCCCCCGCCAGATGTTCGAGGTAGCT
ATCCAGGCTGCCATTGGCGCAAAGGTCATTGCCCGGGAAACCGTCAAGGCCCTGCGCAAGGATGTCCTCGCCAAGTGTTA
TGGCGGCGACATCACCCGCAAGCGGAAACTCCTCGAAAAGCAGAAGGAAGGGAAGAAACGGATGAAGAACGTGGGAAACG
TGGAGTTGCCCCAGGAGGCATTTCTCGCCATTCTCAAGGTGGAAGAGTAA

Upstream 100 bases:

>100_bases
CCGGTGGCAGCAAATCGCCAAATCAATAATGACGCCTAATCTTGACATTTGTATATCACAGCTCCAGGGGCTCGGCAATC
GCAGAAGTGGCGGAGAATTA

Downstream 100 bases:

>100_bases
GGGTTTACCCATAGAACATTCACCGAAAAGGAACCGCAATGGACTACAAAAATTCTCAATACGGATCGAACAACGCCATG
GGCGAAAGGCCGGCAGCAGA

Product: GTP-binding protein LepA

Products: NA

Alternate protein names: EF-4; Ribosomal back-translocase LepA [H]

Number of amino acids: Translated: 629; Mature: 629

Protein sequence:

>629_residues
MLDVSGEYPLQNLPLSAIVLRLHSFNDKVSMKIENIRNFSIIAHIDHGKSTLADRLLEYTGALSERERQDQFLDKMDLER
ERGITIKAQTVRLNYRADDGKDYVLNLIDTPGHVDFTYEVSRSLAACEGGLLVVDASQGVEAQTLANVYLAIDNNLEVFP
VLNKIDLPAAEPERVKHEIEEIIGLDAHDAVLASAKEGIGTREILEEIVKKIPPPEGDPAAPLKALLFDSWYDQYQGVII
LARLIDGILKKGDKIQLVSTGRSYEALKVGVFAPVMREVPQLSAGEVGFVIAGIKDVADAKIGDTVTHTLKPCTTPLGGF
KEVKPMVFSGLYPIDTSQYEQLRDALAKLKLNDSSFSYEPETSLALGFGFRCGFLGLLHMEIIQERLEREFNLDLITTAP
TVVYRVHRIKGDMISIESANQLPPTQEIDYVEEPFILASIHTPNEFVGGILALCEEKRGVQREIKYLTPTRVMIIYELPL
NEVVLDFYDRLKSITKGYASLDYEHLDYRRSELVRMNIMINGEVVDALSLIIHRDKAYYRGRDLVSKMKELIPRQMFEVA
IQAAIGAKVIARETVKALRKDVLAKCYGGDITRKRKLLEKQKEGKKRMKNVGNVELPQEAFLAILKVEE

Sequences:

>Translated_629_residues
MLDVSGEYPLQNLPLSAIVLRLHSFNDKVSMKIENIRNFSIIAHIDHGKSTLADRLLEYTGALSERERQDQFLDKMDLER
ERGITIKAQTVRLNYRADDGKDYVLNLIDTPGHVDFTYEVSRSLAACEGGLLVVDASQGVEAQTLANVYLAIDNNLEVFP
VLNKIDLPAAEPERVKHEIEEIIGLDAHDAVLASAKEGIGTREILEEIVKKIPPPEGDPAAPLKALLFDSWYDQYQGVII
LARLIDGILKKGDKIQLVSTGRSYEALKVGVFAPVMREVPQLSAGEVGFVIAGIKDVADAKIGDTVTHTLKPCTTPLGGF
KEVKPMVFSGLYPIDTSQYEQLRDALAKLKLNDSSFSYEPETSLALGFGFRCGFLGLLHMEIIQERLEREFNLDLITTAP
TVVYRVHRIKGDMISIESANQLPPTQEIDYVEEPFILASIHTPNEFVGGILALCEEKRGVQREIKYLTPTRVMIIYELPL
NEVVLDFYDRLKSITKGYASLDYEHLDYRRSELVRMNIMINGEVVDALSLIIHRDKAYYRGRDLVSKMKELIPRQMFEVA
IQAAIGAKVIARETVKALRKDVLAKCYGGDITRKRKLLEKQKEGKKRMKNVGNVELPQEAFLAILKVEE
>Mature_629_residues
MLDVSGEYPLQNLPLSAIVLRLHSFNDKVSMKIENIRNFSIIAHIDHGKSTLADRLLEYTGALSERERQDQFLDKMDLER
ERGITIKAQTVRLNYRADDGKDYVLNLIDTPGHVDFTYEVSRSLAACEGGLLVVDASQGVEAQTLANVYLAIDNNLEVFP
VLNKIDLPAAEPERVKHEIEEIIGLDAHDAVLASAKEGIGTREILEEIVKKIPPPEGDPAAPLKALLFDSWYDQYQGVII
LARLIDGILKKGDKIQLVSTGRSYEALKVGVFAPVMREVPQLSAGEVGFVIAGIKDVADAKIGDTVTHTLKPCTTPLGGF
KEVKPMVFSGLYPIDTSQYEQLRDALAKLKLNDSSFSYEPETSLALGFGFRCGFLGLLHMEIIQERLEREFNLDLITTAP
TVVYRVHRIKGDMISIESANQLPPTQEIDYVEEPFILASIHTPNEFVGGILALCEEKRGVQREIKYLTPTRVMIIYELPL
NEVVLDFYDRLKSITKGYASLDYEHLDYRRSELVRMNIMINGEVVDALSLIIHRDKAYYRGRDLVSKMKELIPRQMFEVA
IQAAIGAKVIARETVKALRKDVLAKCYGGDITRKRKLLEKQKEGKKRMKNVGNVELPQEAFLAILKVEE

Specific function: Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- transloc

COG id: COG0481

COG function: function code M; Membrane GTPase LepA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. LepA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=631, Percent_Identity=51.6640253565769, Blast_Score=665, Evalue=0.0,
Organism=Homo sapiens, GI94966754, Length=133, Percent_Identity=45.1127819548872, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI25306283, Length=164, Percent_Identity=43.2926829268293, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI25306287, Length=164, Percent_Identity=42.6829268292683, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI19923640, Length=164, Percent_Identity=43.2926829268293, Blast_Score=109, Evalue=9e-24,
Organism=Homo sapiens, GI4503483, Length=147, Percent_Identity=41.4965986394558, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI18390331, Length=160, Percent_Identity=37.5, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI310132016, Length=129, Percent_Identity=38.7596899224806, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI310110807, Length=129, Percent_Identity=38.7596899224806, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI310123363, Length=129, Percent_Identity=38.7596899224806, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI217272894, Length=163, Percent_Identity=36.1963190184049, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI217272892, Length=163, Percent_Identity=36.1963190184049, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI53729339, Length=277, Percent_Identity=25.6317689530686, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI53729337, Length=277, Percent_Identity=25.6317689530686, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI94966752, Length=132, Percent_Identity=31.0606060606061, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI34147630, Length=255, Percent_Identity=27.4509803921569, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1788922, Length=595, Percent_Identity=61.8487394957983, Blast_Score=733, Evalue=0.0,
Organism=Escherichia coli, GI48994988, Length=510, Percent_Identity=29.2156862745098, Blast_Score=166, Evalue=6e-42,
Organism=Escherichia coli, GI1789738, Length=211, Percent_Identity=33.6492890995261, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1790835, Length=151, Percent_Identity=31.1258278145695, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789559, Length=230, Percent_Identity=29.5652173913043, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17557151, Length=612, Percent_Identity=42.483660130719, Blast_Score=496, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17556745, Length=457, Percent_Identity=27.3522975929978, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17533571, Length=146, Percent_Identity=39.7260273972603, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17506493, Length=156, Percent_Identity=37.1794871794872, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71988811, Length=134, Percent_Identity=37.3134328358209, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71988819, Length=134, Percent_Identity=37.3134328358209, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17552882, Length=133, Percent_Identity=37.593984962406, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25141371, Length=287, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17556456, Length=258, Percent_Identity=31.0077519379845, Blast_Score=70, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=602, Percent_Identity=47.5083056478405, Blast_Score=557, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6324707, Length=160, Percent_Identity=39.375, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6320593, Length=160, Percent_Identity=39.375, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6323098, Length=184, Percent_Identity=36.4130434782609, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322359, Length=115, Percent_Identity=41.7391304347826, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324166, Length=141, Percent_Identity=39.7163120567376, Blast_Score=90, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324761, Length=281, Percent_Identity=29.1814946619217, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI78706572, Length=604, Percent_Identity=46.523178807947, Blast_Score=572, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24582462, Length=161, Percent_Identity=39.7515527950311, Blast_Score=110, Evalue=4e-24,
Organism=Drosophila melanogaster, GI28574573, Length=138, Percent_Identity=42.7536231884058, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24585711, Length=151, Percent_Identity=37.7483443708609, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585713, Length=151, Percent_Identity=37.7483443708609, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585709, Length=151, Percent_Identity=37.7483443708609, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI221458488, Length=149, Percent_Identity=41.6107382550336, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21357743, Length=160, Percent_Identity=35.625, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19921738, Length=278, Percent_Identity=25.8992805755396, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281363316, Length=301, Percent_Identity=26.2458471760797, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI17864358, Length=301, Percent_Identity=26.2458471760797, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI28572034, Length=223, Percent_Identity=30.9417040358744, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR006297
- InterPro:   IPR013842
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF06421 LepA_C [H]

EC number: NA

Molecular weight: Translated: 70612; Mature: 70612

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDVSGEYPLQNLPLSAIVLRLHSFNDKVSMKIENIRNFSIIAHIDHGKSTLADRLLEYT
CCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHH
GALSERERQDQFLDKMDLERERGITIKAQTVRLNYRADDGKDYVLNLIDTPGHVDFTYEV
CCHHHHHHHHHHHHHHCCHHHCCCEEEEEEEEEEEECCCCCCEEEEEECCCCCEEEEHHH
SRSLAACEGGLLVVDASQGVEAQTLANVYLAIDNNLEVFPVLNKIDLPAAEPERVKHEIE
HHHHHHCCCCEEEEECCCCCCHHHEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHH
EIIGLDAHDAVLASAKEGIGTREILEEIVKKIPPPEGDPAAPLKALLFDSWYDQYQGVII
HHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHH
LARLIDGILKKGDKIQLVSTGRSYEALKVGVFAPVMREVPQLSAGEVGFVIAGIKDVADA
HHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHHHCCCCCCCCCEEEEECHHHHHCC
KIGDTVTHTLKPCTTPLGGFKEVKPMVFSGLYPIDTSQYEQLRDALAKLKLNDSSFSYEP
CCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCC
ETSLALGFGFRCGFLGLLHMEIIQERLEREFNLDLITTAPTVVYRVHRIKGDMISIESAN
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCEEEECCCC
QLPPTQEIDYVEEPFILASIHTPNEFVGGILALCEEKRGVQREIKYLTPTRVMIIYELPL
CCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEECCH
NEVVLDFYDRLKSITKGYASLDYEHLDYRRSELVRMNIMINGEVVDALSLIIHRDKAYYR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCEEEEEEEECCHHHHHHHHHHHCCHHHHC
GRDLVSKMKELIPRQMFEVAIQAAIGAKVIARETVKALRKDVLAKCYGGDITRKRKLLEK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QKEGKKRMKNVGNVELPQEAFLAILKVEE
HHHHHHHHHCCCCCCCCHHHHEEEEEECC
>Mature Secondary Structure
MLDVSGEYPLQNLPLSAIVLRLHSFNDKVSMKIENIRNFSIIAHIDHGKSTLADRLLEYT
CCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCEEEEEEECCCHHHHHHHHHHHH
GALSERERQDQFLDKMDLERERGITIKAQTVRLNYRADDGKDYVLNLIDTPGHVDFTYEV
CCHHHHHHHHHHHHHHCCHHHCCCEEEEEEEEEEEECCCCCCEEEEEECCCCCEEEEHHH
SRSLAACEGGLLVVDASQGVEAQTLANVYLAIDNNLEVFPVLNKIDLPAAEPERVKHEIE
HHHHHHCCCCEEEEECCCCCCHHHEEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHH
EIIGLDAHDAVLASAKEGIGTREILEEIVKKIPPPEGDPAAPLKALLFDSWYDQYQGVII
HHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCHHH
LARLIDGILKKGDKIQLVSTGRSYEALKVGVFAPVMREVPQLSAGEVGFVIAGIKDVADA
HHHHHHHHHCCCCEEEEEECCCCCCCEEEHHHHHHHHHCCCCCCCCCEEEEECHHHHHCC
KIGDTVTHTLKPCTTPLGGFKEVKPMVFSGLYPIDTSQYEQLRDALAKLKLNDSSFSYEP
CCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHEEECCCCCCCCC
ETSLALGFGFRCGFLGLLHMEIIQERLEREFNLDLITTAPTVVYRVHRIKGDMISIESAN
CCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHHHCCCEEEECCCC
QLPPTQEIDYVEEPFILASIHTPNEFVGGILALCEEKRGVQREIKYLTPTRVMIIYELPL
CCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEECCH
NEVVLDFYDRLKSITKGYASLDYEHLDYRRSELVRMNIMINGEVVDALSLIIHRDKAYYR
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCEEEEEEEECCHHHHHHHHHHHCCHHHHC
GRDLVSKMKELIPRQMFEVAIQAAIGAKVIARETVKALRKDVLAKCYGGDITRKRKLLEK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
QKEGKKRMKNVGNVELPQEAFLAILKVEE
HHHHHHHHHCCCCCCCCHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA