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The map label for this gene is panC

Identifier: 78222852

GI number: 78222852

Start: 1844099

End: 1844950

Strand: Direct

Name: panC

Synonym: Gmet_1643

Alternate gene names: 78222852

Gene position: 1844099-1844950 (Clockwise)

Preceding gene: 78222851

Following gene: 78222853

Centisome position: 46.13

GC content: 60.33

Gene sequence:

>852_bases
ATGAGAATCATTGAAACCGTAGCCGAGATGCAGGCCTTTTCGCGGGAGGCACGAAGGGAGGGGAAAAGCATTTCCCTGGT
CCCGACCATGGGGTTCCTCCACGAGGGACACGCCTCGCTTATGATCGAGGGGAAGAAGCGGGCCGATATCCTCGTAACGA
GCATCTTTGTTAACCCAACCCAGTTCGGTCCCACCGAGGACTTCGATGCCTATCCGCGCGACCTGGCGCGGGACCGTAAC
GTGGCCGAGACGGCGGGAGTAGATGTTATCTTCGCTCCCAAGGCGTCCGACATGTATCCCCGGGGATTTCAGACCTATGT
GAACGTGGAGGAACTGACGCGTCCCCTCTGTGGCGCGAGCCGCCCCGGCCACTTCCAGGGTGTCACCACCGTGGTTGCCA
AACTGTTGAACATCGTTCTGCCCCACGTGGCCCTCTTTGGCAAGAAGGACTTCCAGCAGTTGGCAGTCATCCGCCGCATG
GCCGCCGACCTGAACATGGACGTGGAAATCGTCGGCATGCCCATTGTGCGTGAAGCGGACGGCCTTGCCATGAGCTCCCG
CAATGCCTACCTGGGGCCCGAAGAGCGGAAAAACGCTCTTTGTCTCAGCCGCGCCCTTGCCACGGCCCGGGACCTCTTCC
TGGATGGGGAGCGCAGCGTTGGAACGCTGCGGGATAAGGTGCTCCGGGTCATCGGCGAGGTTCCCGGCGCCGTCATCGAC
TATGCGGATTTTCGCGATGGCGACACCCTTGAGACAGTCGAAACGGCCAACGGGCGAACTCTTATCGCCTTGGCCGTGAA
GATAGGAAAGACAAGGCTGATCGACAACTGCATCCTGGGAGAAGAGCAGTAA

Upstream 100 bases:

>100_bases
TACGGGGACGCCAATGCGCTGATAACCAGCGCGGTTTCCTCATACATCGCCGAAGTGAAGAAAGGAGAATTCCCCGACGA
GGGGCATTCATTCAGCTGAG

Downstream 100 bases:

>100_bases
TCATACCGTTTCCGGTACTCCCTTTATGTTAAGTCCGACCGTCAGCTCAAAGGATGGAGCGAACAATGCCGAAAAATCGT
GATGCAGCCCGTGCCAGCCT

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MRIIETVAEMQAFSREARREGKSISLVPTMGFLHEGHASLMIEGKKRADILVTSIFVNPTQFGPTEDFDAYPRDLARDRN
VAETAGVDVIFAPKASDMYPRGFQTYVNVEELTRPLCGASRPGHFQGVTTVVAKLLNIVLPHVALFGKKDFQQLAVIRRM
AADLNMDVEIVGMPIVREADGLAMSSRNAYLGPEERKNALCLSRALATARDLFLDGERSVGTLRDKVLRVIGEVPGAVID
YADFRDGDTLETVETANGRTLIALAVKIGKTRLIDNCILGEEQ

Sequences:

>Translated_283_residues
MRIIETVAEMQAFSREARREGKSISLVPTMGFLHEGHASLMIEGKKRADILVTSIFVNPTQFGPTEDFDAYPRDLARDRN
VAETAGVDVIFAPKASDMYPRGFQTYVNVEELTRPLCGASRPGHFQGVTTVVAKLLNIVLPHVALFGKKDFQQLAVIRRM
AADLNMDVEIVGMPIVREADGLAMSSRNAYLGPEERKNALCLSRALATARDLFLDGERSVGTLRDKVLRVIGEVPGAVID
YADFRDGDTLETVETANGRTLIALAVKIGKTRLIDNCILGEEQ
>Mature_283_residues
MRIIETVAEMQAFSREARREGKSISLVPTMGFLHEGHASLMIEGKKRADILVTSIFVNPTQFGPTEDFDAYPRDLARDRN
VAETAGVDVIFAPKASDMYPRGFQTYVNVEELTRPLCGASRPGHFQGVTTVVAKLLNIVLPHVALFGKKDFQQLAVIRRM
AADLNMDVEIVGMPIVREADGLAMSSRNAYLGPEERKNALCLSRALATARDLFLDGERSVGTLRDKVLRVIGEVPGAVID
YADFRDGDTLETVETANGRTLIALAVKIGKTRLIDNCILGEEQ

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=281, Percent_Identity=48.0427046263345, Blast_Score=248, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6322046, Length=309, Percent_Identity=40.453074433657, Blast_Score=196, Evalue=4e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_GEOMG (Q39V50)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384599.1
- HSSP:   P0A5R0
- ProteinModelPortal:   Q39V50
- SMR:   Q39V50
- STRING:   Q39V50
- GeneID:   3740412
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1643
- NMPDR:   fig|269799.3.peg.1960
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   Q39V50
- ProtClustDB:   PRK00380
- BioCyc:   GMET269799:GMET_1643-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31106; Mature: 31106

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIETVAEMQAFSREARREGKSISLVPTMGFLHEGHASLMIEGKKRADILVTSIFVNPT
CHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCEEEEEECCCCCEEEEEEEEECCC
QFGPTEDFDAYPRDLARDRNVAETAGVDVIFAPKASDMYPRGFQTYVNVEELTRPLCGAS
CCCCCCCCCCCCHHHHHCCCCHHHCCCEEEECCCCCCCCCCCHHHEECHHHHHHHHHCCC
RPGHFQGVTTVVAKLLNIVLPHVALFGKKDFQQLAVIRRMAADLNMDVEIVGMPIVREAD
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCEEECCC
GLAMSSRNAYLGPEERKNALCLSRALATARDLFLDGERSVGTLRDKVLRVIGEVPGAVID
CCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEE
YADFRDGDTLETVETANGRTLIALAVKIGKTRLIDNCILGEEQ
CCCCCCCCCCHHEECCCCCEEEEEEEHHCCHHHHHHHHCCCCC
>Mature Secondary Structure
MRIIETVAEMQAFSREARREGKSISLVPTMGFLHEGHASLMIEGKKRADILVTSIFVNPT
CHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHHHCCCEEEEEECCCCCEEEEEEEEECCC
QFGPTEDFDAYPRDLARDRNVAETAGVDVIFAPKASDMYPRGFQTYVNVEELTRPLCGAS
CCCCCCCCCCCCHHHHHCCCCHHHCCCEEEECCCCCCCCCCCHHHEECHHHHHHHHHCCC
RPGHFQGVTTVVAKLLNIVLPHVALFGKKDFQQLAVIRRMAADLNMDVEIVGMPIVREAD
CCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEECCCEEECCC
GLAMSSRNAYLGPEERKNALCLSRALATARDLFLDGERSVGTLRDKVLRVIGEVPGAVID
CCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEE
YADFRDGDTLETVETANGRTLIALAVKIGKTRLIDNCILGEEQ
CCCCCCCCCCHHEECCCCCEEEEEEEHHCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA