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The map label for this gene is ddc [H]

Identifier: 78222853

GI number: 78222853

Start: 1845016

End: 1846668

Strand: Direct

Name: ddc [H]

Synonym: Gmet_1644

Alternate gene names: 78222853

Gene position: 1845016-1846668 (Clockwise)

Preceding gene: 78222852

Following gene: 78222854

Centisome position: 46.16

GC content: 59.95

Gene sequence:

>1653_bases
ATGCCGAAAAATCGTGATGCAGCCCGTGCCAGCCTGGAAAACCTCTACCGGATCTTCACCGTGCCGGAAGCACCCGACTC
GACCCTCGGCGCTATTGATCAGGCGATTGCCGGCGATGTCGCCGGCTTCCTGCAGACCCATATCGTCGCCATCGAACGCC
CTCTCGAAGAGATCGAAGCGGATTTCTCCTCCTTCTCCATACCCGAGGAACCGACCTACGTCTCCGAGTATACCGAATTC
GTCAAAGAGAACCTCGTCGCCCACTCGGTCCATACCGCCTCACCGGCCTTTGTCGGCCACATGACCTCGGCGCTCCCCTA
CTTCATGCTCCCGCTGGCACGCCTCATGACCGCCCTCAACCAGAATGTGGTCAAGGTGGAGACATCCAAGGCCTTTACGC
CCATGGAGCGCCAGGTCCTTGCCATGCTTCATCACCTGGTCTATGGCCGGAATGACGACTTCTACCCGCAATGGATTCAT
AACAGCCAGCATGCCTTGGGGGCCTTCTGCTCCGGCGGCACCCTCGCCAACGTCACGGCGCTATGGGTGGCGCGCAACCG
CCTGTTCGCTCCGGACGGAGAGTTCCGCGGCATTGCCCAGGAAGGGTTGGCCCGTGCCCTGAAACATCGCGGCGCGGACG
GGATTGCCGTTCTCGTTTCCGAGCGCGGCCACTACTCTTTGGGCAAGGCCGCCGACCTCCTCGGTATCGGCAGGGATGAC
CTGATTAAGATAAAGACGGATGCAAACAACCGTATCGACCTCAAGGCGTTGAGAGAAGAATGCCGGCGACTGCAGGATCG
GAACACCCTCCCGCTGGCTCTGGTCGGCATCGCCGGGACGACCGAAACCGGCAACGTCGACCCGCTGGAGGCAATGGCCG
ATTTAGCCCAAGAGCTCGGCTGTCATTTTCATGTGGATGCCGCCTGGGGGGGGCCAACCCTTTTTTCCGACCGGCACCGT
CACCTGCTCCGCGGAATAGAACGGGCCGACTCGGTTACCATTGACGGGCACAAACAGCTCTATGTGCCGATGGGGGCGGG
GATGGTCGTCTTCAAGGATCCCACCGCCCTCTCGGCTATCGAGCATCATGCCAACTATATCCTGCGTCATGGCTCCAAGG
ACCTGGGCAGTCATACCCTGGAAGGGTCGCGGCCAGGGAAGGCGATGCTGGTTCATGCCGGGTTTTCGATCATTGGCCGC
AAGGGGTACGAGCTTCTTATCGATATGGGGATCGAGCGGGCACGCACCTTTGCCGACATGATCCAGCGCCATCCCGATTT
CGAGCTGATCAGCGAACCGGAACTGAATATTCTCACCTACCGCTACTGTCCGCCTGCCATCCAGCAGGCCCTGACCGACG
CGACGGCCCAACAGCGCGCCGCAATCAATGGACTTCTTGATCAGGTCTGTCAGCTGTTGCAGAAATATCAGCGCGAAGCG
GGTAAAACCTTTGTCTCTCGAACACGGCTGCATGTGGCTCGCCACGACATGGAGCTCACGGTCTTACGTGTCGTTCTGGC
CAATCCGCTGACGACCGATGAGATTCTGGAGGCAGTTTTGGCGGAACAATGCGAAATCGTGCGTCTGCCGGAGATTCAGG
CCTTGCTGCGGCAGGCTGAGGAACTCTGTCCCGGTCTGGCGAAAGCTGTCTAA

Upstream 100 bases:

>100_bases
TGATCGACAACTGCATCCTGGGAGAAGAGCAGTAATCATACCGTTTCCGGTACTCCCTTTATGTTAAGTCCGACCGTCAG
CTCAAAGGATGGAGCGAACA

Downstream 100 bases:

>100_bases
CGGTAGTTTGATGGAGTTGGTGTTCTTTTGTGGTAGAGTGTAATGACTGAGTAAAGACCCGTTGCCGAGAGCCCTTTCGA
TGGAACTTTACGCCGCTTCA

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 550; Mature: 549

Protein sequence:

>550_residues
MPKNRDAARASLENLYRIFTVPEAPDSTLGAIDQAIAGDVAGFLQTHIVAIERPLEEIEADFSSFSIPEEPTYVSEYTEF
VKENLVAHSVHTASPAFVGHMTSALPYFMLPLARLMTALNQNVVKVETSKAFTPMERQVLAMLHHLVYGRNDDFYPQWIH
NSQHALGAFCSGGTLANVTALWVARNRLFAPDGEFRGIAQEGLARALKHRGADGIAVLVSERGHYSLGKAADLLGIGRDD
LIKIKTDANNRIDLKALREECRRLQDRNTLPLALVGIAGTTETGNVDPLEAMADLAQELGCHFHVDAAWGGPTLFSDRHR
HLLRGIERADSVTIDGHKQLYVPMGAGMVVFKDPTALSAIEHHANYILRHGSKDLGSHTLEGSRPGKAMLVHAGFSIIGR
KGYELLIDMGIERARTFADMIQRHPDFELISEPELNILTYRYCPPAIQQALTDATAQQRAAINGLLDQVCQLLQKYQREA
GKTFVSRTRLHVARHDMELTVLRVVLANPLTTDEILEAVLAEQCEIVRLPEIQALLRQAEELCPGLAKAV

Sequences:

>Translated_550_residues
MPKNRDAARASLENLYRIFTVPEAPDSTLGAIDQAIAGDVAGFLQTHIVAIERPLEEIEADFSSFSIPEEPTYVSEYTEF
VKENLVAHSVHTASPAFVGHMTSALPYFMLPLARLMTALNQNVVKVETSKAFTPMERQVLAMLHHLVYGRNDDFYPQWIH
NSQHALGAFCSGGTLANVTALWVARNRLFAPDGEFRGIAQEGLARALKHRGADGIAVLVSERGHYSLGKAADLLGIGRDD
LIKIKTDANNRIDLKALREECRRLQDRNTLPLALVGIAGTTETGNVDPLEAMADLAQELGCHFHVDAAWGGPTLFSDRHR
HLLRGIERADSVTIDGHKQLYVPMGAGMVVFKDPTALSAIEHHANYILRHGSKDLGSHTLEGSRPGKAMLVHAGFSIIGR
KGYELLIDMGIERARTFADMIQRHPDFELISEPELNILTYRYCPPAIQQALTDATAQQRAAINGLLDQVCQLLQKYQREA
GKTFVSRTRLHVARHDMELTVLRVVLANPLTTDEILEAVLAEQCEIVRLPEIQALLRQAEELCPGLAKAV
>Mature_549_residues
PKNRDAARASLENLYRIFTVPEAPDSTLGAIDQAIAGDVAGFLQTHIVAIERPLEEIEADFSSFSIPEEPTYVSEYTEFV
KENLVAHSVHTASPAFVGHMTSALPYFMLPLARLMTALNQNVVKVETSKAFTPMERQVLAMLHHLVYGRNDDFYPQWIHN
SQHALGAFCSGGTLANVTALWVARNRLFAPDGEFRGIAQEGLARALKHRGADGIAVLVSERGHYSLGKAADLLGIGRDDL
IKIKTDANNRIDLKALREECRRLQDRNTLPLALVGIAGTTETGNVDPLEAMADLAQELGCHFHVDAAWGGPTLFSDRHRH
LLRGIERADSVTIDGHKQLYVPMGAGMVVFKDPTALSAIEHHANYILRHGSKDLGSHTLEGSRPGKAMLVHAGFSIIGRK
GYELLIDMGIERARTFADMIQRHPDFELISEPELNILTYRYCPPAIQQALTDATAQQRAAINGLLDQVCQLLQKYQREAG
KTFVSRTRLHVARHDMELTVLRVVLANPLTTDEILEAVLAEQCEIVRLPEIQALLRQAEELCPGLAKAV

Specific function: Catalyzes The Production Of Gaba. [C]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=432, Percent_Identity=28.0092592592593, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI194294551, Length=445, Percent_Identity=27.8651685393258, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI197276620, Length=485, Percent_Identity=24.7422680412371, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI4503875, Length=485, Percent_Identity=24.7422680412371, Blast_Score=155, Evalue=8e-38,
Organism=Homo sapiens, GI58331246, Length=447, Percent_Identity=25.7270693512304, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI4503281, Length=382, Percent_Identity=23.0366492146597, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI132814448, Length=382, Percent_Identity=23.0366492146597, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI92110055, Length=384, Percent_Identity=23.4375, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17555682, Length=472, Percent_Identity=26.9067796610169, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71993062, Length=454, Percent_Identity=26.8722466960352, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71993058, Length=377, Percent_Identity=28.9124668435013, Blast_Score=142, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17543922, Length=366, Percent_Identity=24.3169398907104, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17136594, Length=392, Percent_Identity=29.0816326530612, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24657193, Length=408, Percent_Identity=24.2647058823529, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24657185, Length=408, Percent_Identity=24.2647058823529, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24657188, Length=408, Percent_Identity=24.2647058823529, Blast_Score=129, Evalue=7e-30,
Organism=Drosophila melanogaster, GI21356415, Length=384, Percent_Identity=24.7395833333333, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24652373, Length=231, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 60723; Mature: 60592

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKNRDAARASLENLYRIFTVPEAPDSTLGAIDQAIAGDVAGFLQTHIVAIERPLEEIEA
CCCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFSSFSIPEEPTYVSEYTEFVKENLVAHSVHTASPAFVGHMTSALPYFMLPLARLMTALN
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
QNVVKVETSKAFTPMERQVLAMLHHLVYGRNDDFYPQWIHNSQHALGAFCSGGTLANVTA
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHCCCCCHHHHHH
LWVARNRLFAPDGEFRGIAQEGLARALKHRGADGIAVLVSERGHYSLGKAADLLGIGRDD
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
LIKIKTDANNRIDLKALREECRRLQDRNTLPLALVGIAGTTETGNVDPLEAMADLAQELG
EEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
CHFHVDAAWGGPTLFSDRHRHLLRGIERADSVTIDGHKQLYVPMGAGMVVFKDPTALSAI
CEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCCEEEEECCHHHHHH
EHHANYILRHGSKDLGSHTLEGSRPGKAMLVHAGFSIIGRKGYELLIDMGIERARTFADM
HHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEECCHHHHCCCCHHHHHHHCHHHHHHHHHH
IQRHPDFELISEPELNILTYRYCPPAIQQALTDATAQQRAAINGLLDQVCQLLQKYQREA
HHCCCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKTFVSRTRLHVARHDMELTVLRVVLANPLTTDEILEAVLAEQCEIVRLPEIQALLRQAE
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHH
ELCPGLAKAV
HHCCHHHHCC
>Mature Secondary Structure 
PKNRDAARASLENLYRIFTVPEAPDSTLGAIDQAIAGDVAGFLQTHIVAIERPLEEIEA
CCCCHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DFSSFSIPEEPTYVSEYTEFVKENLVAHSVHTASPAFVGHMTSALPYFMLPLARLMTALN
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
QNVVKVETSKAFTPMERQVLAMLHHLVYGRNDDFYPQWIHNSQHALGAFCSGGTLANVTA
CCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCHHHHHHCCCCCHHHHHH
LWVARNRLFAPDGEFRGIAQEGLARALKHRGADGIAVLVSERGHYSLGKAADLLGIGRDD
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHCCCCCC
LIKIKTDANNRIDLKALREECRRLQDRNTLPLALVGIAGTTETGNVDPLEAMADLAQELG
EEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCC
CHFHVDAAWGGPTLFSDRHRHLLRGIERADSVTIDGHKQLYVPMGAGMVVFKDPTALSAI
CEEEEECCCCCCCHHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCCEEEEECCHHHHHH
EHHANYILRHGSKDLGSHTLEGSRPGKAMLVHAGFSIIGRKGYELLIDMGIERARTFADM
HHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEECCHHHHCCCCHHHHHHHCHHHHHHHHHH
IQRHPDFELISEPELNILTYRYCPPAIQQALTDATAQQRAAINGLLDQVCQLLQKYQREA
HHCCCCCCEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GKTFVSRTRLHVARHDMELTVLRVVLANPLTTDEILEAVLAEQCEIVRLPEIQALLRQAE
HHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCEEECHHHHHHHHHHH
ELCPGLAKAV
HHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]