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The map label for this gene is ribBA [H]

Identifier: 78222835

GI number: 78222835

Start: 1823280

End: 1824482

Strand: Direct

Name: ribBA [H]

Synonym: Gmet_1626

Alternate gene names: 78222835

Gene position: 1823280-1824482 (Clockwise)

Preceding gene: 78222834

Following gene: 78222836

Centisome position: 45.61

GC content: 58.69

Gene sequence:

>1203_bases
ATGACGGTTGCTAGAATAGAAGAAGCCATAGAGGACATCAAGCAGGGGAAAATGATCATTCTCGTGGATGATGAGGACCG
CGAGAACGAGGGTGATCTTACCATGGCCGCCGAGATGATCACCCCTGAAGCGATCAACTACATGGCAAAGTATGGCCGTG
GTCTGATCTGTCTCACCATGACCTCGGAGCGGTGCGATTACCTCAGGTTGCCGCTCATGGTGTCCGACAATACCTCGTCC
TTCGGTACCGCCTTTACCGTCTCCATTGAGGCAAAACGGGGAGTGACCACCGGCATCTCCGCCGCTGACCGTGCCCATAC
AGTTCTCACAGCCGTGGCCGATGCCACGAAACCGGAGGACCTTGCCCGGCCCGGCCACATATTCCCGCTGCGGGCCCGTA
ACGGTGGTGTCCTCGTCCGGGCGGGGCAGACCGAAGGGTCAGTGGATCTGGCCCGTCTTGCAGGCCTCAAGCCGGCTGGC
GTCATCTGTGAGATCATGAACGATGACGGCACCATGGCCCGGATGCCGCAACTGAAGAAATTCGCCAAGGAGCACGGGAT
CAAGATCTGCACTATTGCTGACCTAGTCGCCTACCGGCTCAAGCACGAGTCCTTGGTCCGCCGGGCTGCCGATGTGGAAC
TCCCCACCGAAGCTGGTGAGTTCCGGGCCATCGCCTTCGAAAACGATGTGGACAAGCTGGAGCACCTGGCACTCGTGAAG
GGAGAGATCAGTGGGGATGAGCCAATACTCGTCCGGGTTCATTCCGAGTGCATGACCGGCGATGTTTTCGGGAGTCTCCG
GTGCGATTGCGGCGGCCAGCTTCACCGGGCCATGGAGATGATTGAGGCCGAGGGGAAAGGGGCTATCCTCTATATGCGCC
AGGAAGGACGGGGAATCGGCTTGTTCAACAAGCTCAAGGCCTATGCCCTTCAGGACCAGGGGAAGGATACCGTTGAGGCT
AACCTGGAGCTCGGCTTCAAGCCCGACATGCGCGACTACGGCATCGGCGCCCAGATCCTCGTGGACCTCGGAATCAAGAA
CATCCGCCTCATGACCAACAACCCCCGGAAGCTGATTGGCCTCCAGGGATACGGAATCAATATAGTGGAACGGGTACCCA
TCGAGATTCCCGCCACGGGGAGCAATGCCGGCTACCTGAAGACAAAACGCGAGAAGCTGGGACACCTGCTGGAAAATATC
TGA

Upstream 100 bases:

>100_bases
ACGGGTCAGAAGGAGGGTGGTCTCAGTCTTGAACTGCTTGCAAAGAGCGGCTTTCTGTGAGATATAACGTTGTTATTACT
TCTCATGAACGGAGTCGACA

Downstream 100 bases:

>100_bases
GATACGGCGAGGAGGGATTTATCATGCCGCGATTTATTGAAGGAAAACTGGATGCCACGGGGCTCAAGTTCGGCATCATC
GTGGGCCGTTTCAACAGCTT

Product: GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTVARIEEAIEDIKQGKMIILVDDEDRENEGDLTMAAEMITPEAINYMAKYGRGLICLTMTSERCDYLRLPLMVSDNTSS
FGTAFTVSIEAKRGVTTGISAADRAHTVLTAVADATKPEDLARPGHIFPLRARNGGVLVRAGQTEGSVDLARLAGLKPAG
VICEIMNDDGTMARMPQLKKFAKEHGIKICTIADLVAYRLKHESLVRRAADVELPTEAGEFRAIAFENDVDKLEHLALVK
GEISGDEPILVRVHSECMTGDVFGSLRCDCGGQLHRAMEMIEAEGKGAILYMRQEGRGIGLFNKLKAYALQDQGKDTVEA
NLELGFKPDMRDYGIGAQILVDLGIKNIRLMTNNPRKLIGLQGYGINIVERVPIEIPATGSNAGYLKTKREKLGHLLENI

Sequences:

>Translated_400_residues
MTVARIEEAIEDIKQGKMIILVDDEDRENEGDLTMAAEMITPEAINYMAKYGRGLICLTMTSERCDYLRLPLMVSDNTSS
FGTAFTVSIEAKRGVTTGISAADRAHTVLTAVADATKPEDLARPGHIFPLRARNGGVLVRAGQTEGSVDLARLAGLKPAG
VICEIMNDDGTMARMPQLKKFAKEHGIKICTIADLVAYRLKHESLVRRAADVELPTEAGEFRAIAFENDVDKLEHLALVK
GEISGDEPILVRVHSECMTGDVFGSLRCDCGGQLHRAMEMIEAEGKGAILYMRQEGRGIGLFNKLKAYALQDQGKDTVEA
NLELGFKPDMRDYGIGAQILVDLGIKNIRLMTNNPRKLIGLQGYGINIVERVPIEIPATGSNAGYLKTKREKLGHLLENI
>Mature_399_residues
TVARIEEAIEDIKQGKMIILVDDEDRENEGDLTMAAEMITPEAINYMAKYGRGLICLTMTSERCDYLRLPLMVSDNTSSF
GTAFTVSIEAKRGVTTGISAADRAHTVLTAVADATKPEDLARPGHIFPLRARNGGVLVRAGQTEGSVDLARLAGLKPAGV
ICEIMNDDGTMARMPQLKKFAKEHGIKICTIADLVAYRLKHESLVRRAADVELPTEAGEFRAIAFENDVDKLEHLALVKG
EISGDEPILVRVHSECMTGDVFGSLRCDCGGQLHRAMEMIEAEGKGAILYMRQEGRGIGLFNKLKAYALQDQGKDTVEAN
LELGFKPDMRDYGIGAQILVDLGIKNIRLMTNNPRKLIGLQGYGINIVERVPIEIPATGSNAGYLKTKREKLGHLLENI

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=199, Percent_Identity=55.2763819095477, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1787533, Length=192, Percent_Identity=54.6875, Blast_Score=214, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6320695, Length=201, Percent_Identity=43.2835820895522, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319438, Length=197, Percent_Identity=45.1776649746193, Blast_Score=149, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 43740; Mature: 43609

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVARIEEAIEDIKQGKMIILVDDEDRENEGDLTMAAEMITPEAINYMAKYGRGLICLTM
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHHHHCCCEEEEEE
TSERCDYLRLPLMVSDNTSSFGTAFTVSIEAKRGVTTGISAADRAHTVLTAVADATKPED
ECCCCCEEEEEEEEECCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHH
LARPGHIFPLRARNGGVLVRAGQTEGSVDLARLAGLKPAGVICEIMNDDGTMARMPQLKK
HCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHH
FAKEHGIKICTIADLVAYRLKHESLVRRAADVELPTEAGEFRAIAFENDVDKLEHLALVK
HHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHEEE
GEISGDEPILVRVHSECMTGDVFGSLRCDCGGQLHRAMEMIEAEGKGAILYMRQEGRGIG
CCCCCCCCEEEEEECCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCC
LFNKLKAYALQDQGKDTVEANLELGFKPDMRDYGIGAQILVDLGIKNIRLMTNNPRKLIG
HHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHCCCCCEEEEECCCCEEEEEECCCCEEEE
LQGYGINIVERVPIEIPATGSNAGYLKTKREKLGHLLENI
ECCCCCEEEEECCEEECCCCCCCCCEEEHHHHHHHHHHCC
>Mature Secondary Structure 
TVARIEEAIEDIKQGKMIILVDDEDRENEGDLTMAAEMITPEAINYMAKYGRGLICLTM
CHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHHHHCCCEEEEEE
TSERCDYLRLPLMVSDNTSSFGTAFTVSIEAKRGVTTGISAADRAHTVLTAVADATKPED
ECCCCCEEEEEEEEECCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCHH
LARPGHIFPLRARNGGVLVRAGQTEGSVDLARLAGLKPAGVICEIMNDDGTMARMPQLKK
HCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHH
FAKEHGIKICTIADLVAYRLKHESLVRRAADVELPTEAGEFRAIAFENDVDKLEHLALVK
HHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCHHHHHHHHEEE
GEISGDEPILVRVHSECMTGDVFGSLRCDCGGQLHRAMEMIEAEGKGAILYMRQEGRGIG
CCCCCCCCEEEEEECCCCCCCCCCCEECCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCC
LFNKLKAYALQDQGKDTVEANLELGFKPDMRDYGIGAQILVDLGIKNIRLMTNNPRKLIG
HHHHHHHHHCCCCCCCEEEEEEEECCCCCCHHCCCCCEEEEECCCCEEEEEECCCCEEEE
LQGYGINIVERVPIEIPATGSNAGYLKTKREKLGHLLENI
ECCCCCEEEEECCEEECCCCCCCCCEEEHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA