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The map label for this gene is ribH

Identifier: 78222836

GI number: 78222836

Start: 1824506

End: 1824973

Strand: Direct

Name: ribH

Synonym: Gmet_1627

Alternate gene names: 78222836

Gene position: 1824506-1824973 (Clockwise)

Preceding gene: 78222835

Following gene: 78222837

Centisome position: 45.64

GC content: 62.18

Gene sequence:

>468_bases
ATGCCGCGATTTATTGAAGGAAAACTGGATGCCACGGGGCTCAAGTTCGGCATCATCGTGGGCCGTTTCAACAGCTTCAT
TGGTGAGCGCCTTCTGGAGGGGGCCCTCGATGCCCTGGTTCGTAACGGAGCAGATGAGGCGACCATTGATGTGGCCCGGG
TGCCCGGCGCCTTCGAGATCCCCCTGACCGCCAAGAAAATGGCCCAGACAGGGAGCTATGACGCCATCATCTGTCTCGGC
GCGGTGATCAGGGGCTCGACCCCCCATTTTGACTACGTGGCCGCCGAGGTCTCCAAGGGGGTTGCCCACGTGTCGCTGGA
AACCGGCGTTCCGGTTTCCTTCGGCGTACTCACCACCGATACCATCGAGCAGGCCGTGGAGCGGGCAGGCACCAAGGCCG
GCAACAAGGGCTTCGACGCCGCCATGACCGCCATTGAAACCGTCCGCGTTTTCCGGGAGTTCCGCTAG

Upstream 100 bases:

>100_bases
TTCCCGCCACGGGGAGCAATGCCGGCTACCTGAAGACAAAACGCGAGAAGCTGGGACACCTGCTGGAAAATATCTGAGAT
ACGGCGAGGAGGGATTTATC

Downstream 100 bases:

>100_bases
TGGGTGCCCGACGCCTCGGAAGGGAGATCGCCCTTCAGCTTCTCTACTCCCGCGATTATACCGTGGGTGAGGCCTCCTCG
CTTCTTGAGATGGTCTTTGA

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MPRFIEGKLDATGLKFGIIVGRFNSFIGERLLEGALDALVRNGADEATIDVARVPGAFEIPLTAKKMAQTGSYDAIICLG
AVIRGSTPHFDYVAAEVSKGVAHVSLETGVPVSFGVLTTDTIEQAVERAGTKAGNKGFDAAMTAIETVRVFREFR

Sequences:

>Translated_155_residues
MPRFIEGKLDATGLKFGIIVGRFNSFIGERLLEGALDALVRNGADEATIDVARVPGAFEIPLTAKKMAQTGSYDAIICLG
AVIRGSTPHFDYVAAEVSKGVAHVSLETGVPVSFGVLTTDTIEQAVERAGTKAGNKGFDAAMTAIETVRVFREFR
>Mature_154_residues
PRFIEGKLDATGLKFGIIVGRFNSFIGERLLEGALDALVRNGADEATIDVARVPGAFEIPLTAKKMAQTGSYDAIICLGA
VIRGSTPHFDYVAAEVSKGVAHVSLETGVPVSFGVLTTDTIEQAVERAGTKAGNKGFDAAMTAIETVRVFREFR

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

Organism=Escherichia coli, GI1786617, Length=154, Percent_Identity=52.5974025974026, Blast_Score=166, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6324429, Length=151, Percent_Identity=33.112582781457, Blast_Score=86, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_GEOMG (Q39V66)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384583.1
- ProteinModelPortal:   Q39V66
- SMR:   Q39V66
- STRING:   Q39V66
- GeneID:   3739366
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1627
- NMPDR:   fig|269799.3.peg.1079
- eggNOG:   COG0054
- HOGENOM:   HBG311126
- OMA:   KAGNKGW
- PhylomeDB:   Q39V66
- ProtClustDB:   PRK00061
- BioCyc:   GMET269799:GMET_1627-MONOMER
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 16462; Mature: 16331

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFIEGKLDATGLKFGIIVGRFNSFIGERLLEGALDALVRNGADEATIDVARVPGAFEI
CCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHEECCCCEEC
PLTAKKMAQTGSYDAIICLGAVIRGSTPHFDYVAAEVSKGVAHVSLETGVPVSFGVLTTD
CCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEEECCCCCEEECCCCHH
TIEQAVERAGTKAGNKGFDAAMTAIETVRVFREFR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRFIEGKLDATGLKFGIIVGRFNSFIGERLLEGALDALVRNGADEATIDVARVPGAFEI
CCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHEECCCCEEC
PLTAKKMAQTGSYDAIICLGAVIRGSTPHFDYVAAEVSKGVAHVSLETGVPVSFGVLTTD
CCCHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCCEEEEEECCCCCEEECCCCHH
TIEQAVERAGTKAGNKGFDAAMTAIETVRVFREFR
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA