Click here to switch to the map view.

The map label for this gene is caiD [C]

Identifier: 78222736

GI number: 78222736

Start: 1727154

End: 1727924

Strand: Direct

Name: caiD [C]

Synonym: Gmet_1524

Alternate gene names: 78222736

Gene position: 1727154-1727924 (Clockwise)

Preceding gene: 78222735

Following gene: 78222737

Centisome position: 43.21

GC content: 61.35

Gene sequence:

>771_bases
ATGGGAGTTGATTTCGTAACAGAGGGGAATGTCGCCTACATCACACTGAACCGTCCCGACGCCATGAACGCGCTGGACCC
CGAGGGGCTCGTGCGGCTGGCGGAGATATGGGGCGAGGTGAAAAATAACCCCGAGATTCGGATCGCGGTGCTGACCGGGG
CAGGGGAGAAGGCCTTTTGCACCGGCACGGACATGAAGAAGGCGAAGGTTCCTGATGAATGCATGGCAGCACTCTACTAC
AAGGAGGGGCAGCCGATCATCCCGCACATGAAAATGTGGAAGCCGATCATTGCCTGCATCAACGGGTACGCCGTGGGGGG
CGGACTGGAGATGGCCCTGGCGTGCGACCTGAGGATCTGCAGCACCACGGCCAAATTCGCCCTCACAGAGACGAAGGTGG
CAAGCCTTGCCGGCCTGAACGGGACCCAGTGCCTGCCCAGAGCCATACCTCAGGCGGTTGCCATGAAGATGCTCCTGACC
GGCGAGATGATCGACGCCGCCGAGGCGCACCGGGTCGGGCTGGTGAGTGATGTTGCCGAACCGGACCAACTGATGGCCCT
GGCCCGGAAATACGCGGAAAAGATCGCCTCCAACGCTCCCTTGAGCGTCATGGCGGCCAAGCAGGCTGCAGTGATGGGGA
TGGACATGCCGCTCCCCCATGCCATCGACTTTTCGTACCTGCTGTGGGGAATACTGCGGGACACGGAAGACCGGAAAGAG
GGATTCACCGCCTTTGCCGAGAAGAGAGCGCCCCAGTATCGGGGGAGATAG

Upstream 100 bases:

>100_bases
TGTTGAAGGAGAAGAAGCCGTACAATCCGTTTATCGTTGCCGCCGACGAGGAGTGACCCTACATGACGATGTACCGTCTA
AACCATACCAGGAGGATGCA

Downstream 100 bases:

>100_bases
GAGCCGGATCATGCAGATAGTCGTCTTGGCAAAGGTGGTGCCGGATTACGAAGTGCCGTCCGCGGACTTCGAACTGGTGG
GGAACAGAGCCCATCCCCGG

Product: short chain enoyl-CoA hydratase

Products: NA

Alternate protein names: 3-hydroxypropionyl-CoA dehydratase [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MGVDFVTEGNVAYITLNRPDAMNALDPEGLVRLAEIWGEVKNNPEIRIAVLTGAGEKAFCTGTDMKKAKVPDECMAALYY
KEGQPIIPHMKMWKPIIACINGYAVGGGLEMALACDLRICSTTAKFALTETKVASLAGLNGTQCLPRAIPQAVAMKMLLT
GEMIDAAEAHRVGLVSDVAEPDQLMALARKYAEKIASNAPLSVMAAKQAAVMGMDMPLPHAIDFSYLLWGILRDTEDRKE
GFTAFAEKRAPQYRGR

Sequences:

>Translated_256_residues
MGVDFVTEGNVAYITLNRPDAMNALDPEGLVRLAEIWGEVKNNPEIRIAVLTGAGEKAFCTGTDMKKAKVPDECMAALYY
KEGQPIIPHMKMWKPIIACINGYAVGGGLEMALACDLRICSTTAKFALTETKVASLAGLNGTQCLPRAIPQAVAMKMLLT
GEMIDAAEAHRVGLVSDVAEPDQLMALARKYAEKIASNAPLSVMAAKQAAVMGMDMPLPHAIDFSYLLWGILRDTEDRKE
GFTAFAEKRAPQYRGR
>Mature_255_residues
GVDFVTEGNVAYITLNRPDAMNALDPEGLVRLAEIWGEVKNNPEIRIAVLTGAGEKAFCTGTDMKKAKVPDECMAALYYK
EGQPIIPHMKMWKPIIACINGYAVGGGLEMALACDLRICSTTAKFALTETKVASLAGLNGTQCLPRAIPQAVAMKMLLTG
EMIDAAEAHRVGLVSDVAEPDQLMALARKYAEKIASNAPLSVMAAKQAAVMGMDMPLPHAIDFSYLLWGILRDTEDRKEG
FTAFAEKRAPQYRGR

Specific function: Plays a role in autotrophic carbon fixation via the 3- hydroxypropionate/4-hydroxybutyrate cycle. Catalyzes the reversible dehydration of 3-hydroxypropionyl-CoA to form acryloyl- CoA, and the reversible dehydration of (S)-3-hydroxybutyryl-CoA to form crot

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=248, Percent_Identity=37.5, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI4502327, Length=251, Percent_Identity=33.0677290836653, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI20127408, Length=186, Percent_Identity=33.8709677419355, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI150378541, Length=251, Percent_Identity=25.0996015936255, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI70995211, Length=234, Percent_Identity=27.7777777777778, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI31542718, Length=254, Percent_Identity=28.740157480315, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI157694516, Length=239, Percent_Identity=25.5230125523013, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI213417737, Length=239, Percent_Identity=25.5230125523013, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI37594469, Length=204, Percent_Identity=27.4509803921569, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI37594471, Length=204, Percent_Identity=27.4509803921569, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI68989263, Length=191, Percent_Identity=31.413612565445, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI157694520, Length=202, Percent_Identity=24.2574257425743, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI221142681, Length=257, Percent_Identity=36.9649805447471, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1787659, Length=250, Percent_Identity=36, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1787660, Length=256, Percent_Identity=31.25, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1788597, Length=261, Percent_Identity=28.3524904214559, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI87082183, Length=260, Percent_Identity=29.6153846153846, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1788682, Length=202, Percent_Identity=34.6534653465347, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1790281, Length=210, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25145438, Length=245, Percent_Identity=39.1836734693878, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17554946, Length=250, Percent_Identity=36.4, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17540714, Length=213, Percent_Identity=31.924882629108, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17560910, Length=223, Percent_Identity=29.5964125560538, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17534483, Length=230, Percent_Identity=25.6521739130435, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17549921, Length=202, Percent_Identity=28.2178217821782, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25144160, Length=197, Percent_Identity=27.9187817258883, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25144157, Length=197, Percent_Identity=27.9187817258883, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17558304, Length=199, Percent_Identity=28.643216080402, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17540306, Length=230, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508953, Length=202, Percent_Identity=30.6930693069307, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=202, Percent_Identity=30.6930693069307, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17508951, Length=202, Percent_Identity=30.6930693069307, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=202, Percent_Identity=24.2574257425743, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI20129971, Length=246, Percent_Identity=38.2113821138211, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24653477, Length=246, Percent_Identity=38.2113821138211, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24653139, Length=252, Percent_Identity=35.3174603174603, Blast_Score=145, Evalue=3e-35,
Organism=Drosophila melanogaster, GI19920382, Length=228, Percent_Identity=28.0701754385965, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24650670, Length=254, Percent_Identity=27.1653543307087, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21357171, Length=174, Percent_Identity=29.8850574712644, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI19922422, Length=262, Percent_Identity=26.3358778625954, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571729, Length=180, Percent_Identity=28.3333333333333, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI28571730, Length=180, Percent_Identity=28.3333333333333, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI19921000, Length=176, Percent_Identity=31.8181818181818, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583077, Length=176, Percent_Identity=31.8181818181818, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24583079, Length=176, Percent_Identity=31.8181818181818, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24654903, Length=195, Percent_Identity=24.1025641025641, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.116 [H]

Molecular weight: Translated: 27724; Mature: 27593

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVDFVTEGNVAYITLNRPDAMNALDPEGLVRLAEIWGEVKNNPEIRIAVLTGAGEKAFC
CCCCEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEE
TGTDMKKAKVPDECMAALYYKEGQPIIPHMKMWKPIIACINGYAVGGGLEMALACDLRIC
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEECCCCEEEEEECEEEE
STTAKFALTETKVASLAGLNGTQCLPRAIPQAVAMKMLLTGEMIDAAEAHRVGLVSDVAE
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHCCC
PDQLMALARKYAEKIASNAPLSVMAAKQAAVMGMDMPLPHAIDFSYLLWGILRDTEDRKE
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHH
GFTAFAEKRAPQYRGR
HHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GVDFVTEGNVAYITLNRPDAMNALDPEGLVRLAEIWGEVKNNPEIRIAVLTGAGEKAFC
CCCEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCEEE
TGTDMKKAKVPDECMAALYYKEGQPIIPHMKMWKPIIACINGYAVGGGLEMALACDLRIC
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCEEECCCCEEEEEECEEEE
STTAKFALTETKVASLAGLNGTQCLPRAIPQAVAMKMLLTGEMIDAAEAHRVGLVSDVAE
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHHCCC
PDQLMALARKYAEKIASNAPLSVMAAKQAAVMGMDMPLPHAIDFSYLLWGILRDTEDRKE
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHHH
GFTAFAEKRAPQYRGR
HHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA