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The map label for this gene is bioC [H]

Identifier: 78222064

GI number: 78222064

Start: 929504

End: 930313

Strand: Direct

Name: bioC [H]

Synonym: Gmet_0844

Alternate gene names: 78222064

Gene position: 929504-930313 (Clockwise)

Preceding gene: 78222063

Following gene: 78222070

Centisome position: 23.25

GC content: 69.26

Gene sequence:

>810_bases
GTGATTGACCGCCGCAGGGTGAGACATTCCTTCCACCGGCAGGCCCTGGAGTACGACGCCCATGCAGCTGTCCAGAAACG
GGTCGTGGAACGGTTTCTCCAGATCTTGGACGACGAGGTGGGCTCTCCCCTCCGGATCCTCGACGTGGGGGCGGGCACCG
GACTCCTGGCCCGTCAGCTTGCCGACTGTCACCCCGCGGCGCTTCTCTCCTGCGTCGACCTGGCCCCCGGCATGGCCGCA
ACGGCGCGACAACGCCTCGGCTCCCGGGCACTGGTGGCCGTGGCAGATGCGGAACACCTCCCCTTTGCCGGCGCCTCGTT
CGACTGCGTCGTCTCCACCTCCACCTTCCAGTGGCTCACCACCCTCGACGCCGCTTTTGGCGAGGTGTGGCGGGTGCTGG
CCCCCGGCGGGCTCTTCGCCTTCGCCCTCTTCGGCCACGGCACCTTCCACGAGCTGAAAGACTCCTACCGGTCTGCTCTG
ACCGCCGTGGGGCGCGAGGATGAGGACCGGACCCAGCGCTTTTTCACCGAAGCCGAGGCCGGAGCGGCCCTGGAGCGGAC
CGGCTTCGGGGTGAGGCGCCTCTGCGTCGAGGATGAGGTGGAGTGGCACCCGGACGTGCCGGCTTTCCTCCGCTCCGTGA
AGCGGGTCGGTGCCGGCAACGCCTCGCCGCTCCGGGGCCGGGGCCTCGCGGAGCGGCGGGTCATGGTGGAGATGATGCGG
GTCTACGGGGAACGGTACGGCGGGGAGCGGGGGATTCCGGCCACCTACACGGTGATTTACGGGGTGGGAGTGAAGAGTGG
GCGCAAGTAG

Upstream 100 bases:

>100_bases
CGCTTCCTCTCCCTGGAGGGGACAGGGCATGCCCCGTTCCTCTCGCAGCCAGAGCGGTTCAACCAGGAGCTGAGCCGCTT
CCTTACGGAGGTGATCGACC

Downstream 100 bases:

>100_bases
CGAGGTAGCGAGATGGTTTTGCTGCTTGCTATCTCGCTATCTCACCATCTCGCTTCGTTACACGCACTGCAGCACGAAAC
ACTTGAGGTACTCGGTCTCC

Product: UbiE/COQ5 methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MIDRRRVRHSFHRQALEYDAHAAVQKRVVERFLQILDDEVGSPLRILDVGAGTGLLARQLADCHPAALLSCVDLAPGMAA
TARQRLGSRALVAVADAEHLPFAGASFDCVVSTSTFQWLTTLDAAFGEVWRVLAPGGLFAFALFGHGTFHELKDSYRSAL
TAVGREDEDRTQRFFTEAEAGAALERTGFGVRRLCVEDEVEWHPDVPAFLRSVKRVGAGNASPLRGRGLAERRVMVEMMR
VYGERYGGERGIPATYTVIYGVGVKSGRK

Sequences:

>Translated_269_residues
MIDRRRVRHSFHRQALEYDAHAAVQKRVVERFLQILDDEVGSPLRILDVGAGTGLLARQLADCHPAALLSCVDLAPGMAA
TARQRLGSRALVAVADAEHLPFAGASFDCVVSTSTFQWLTTLDAAFGEVWRVLAPGGLFAFALFGHGTFHELKDSYRSAL
TAVGREDEDRTQRFFTEAEAGAALERTGFGVRRLCVEDEVEWHPDVPAFLRSVKRVGAGNASPLRGRGLAERRVMVEMMR
VYGERYGGERGIPATYTVIYGVGVKSGRK
>Mature_269_residues
MIDRRRVRHSFHRQALEYDAHAAVQKRVVERFLQILDDEVGSPLRILDVGAGTGLLARQLADCHPAALLSCVDLAPGMAA
TARQRLGSRALVAVADAEHLPFAGASFDCVVSTSTFQWLTTLDAAFGEVWRVLAPGGLFAFALFGHGTFHELKDSYRSAL
TAVGREDEDRTQRFFTEAEAGAALERTGFGVRRLCVEDEVEWHPDVPAFLRSVKRVGAGNASPLRGRGLAERRVMVEMMR
VYGERYGGERGIPATYTVIYGVGVKSGRK

Specific function: BioC is involved in an early, but chemically unexplored, step in the conversion of pimelic acid to biotin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily [H]

Homologues:

Organism=Homo sapiens, GI40018642, Length=220, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786994, Length=247, Percent_Identity=26.7206477732794, Blast_Score=86, Evalue=3e-18,
Organism=Drosophila melanogaster, GI19922210, Length=222, Percent_Identity=28.3783783783784, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011814
- InterPro:   IPR013216 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: NA

Molecular weight: Translated: 29517; Mature: 29517

Theoretical pI: Translated: 8.34; Mature: 8.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDRRRVRHSFHRQALEYDAHAAVQKRVVERFLQILDDEVGSPLRILDVGAGTGLLARQL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHH
ADCHPAALLSCVDLAPGMAATARQRLGSRALVAVADAEHLPFAGASFDCVVSTSTFQWLT
HCCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCHHHHHH
TLDAAFGEVWRVLAPGGLFAFALFGHGTFHELKDSYRSALTAVGREDEDRTQRFFTEAEA
HHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GAALERTGFGVRRLCVEDEVEWHPDVPAFLRSVKRVGAGNASPLRGRGLAERRVMVEMMR
CCHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
VYGERYGGERGIPATYTVIYGVGVKSGRK
HHHHHCCCCCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MIDRRRVRHSFHRQALEYDAHAAVQKRVVERFLQILDDEVGSPLRILDVGAGTGLLARQL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHH
ADCHPAALLSCVDLAPGMAATARQRLGSRALVAVADAEHLPFAGASFDCVVSTSTFQWLT
HCCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCHHHHHH
TLDAAFGEVWRVLAPGGLFAFALFGHGTFHELKDSYRSALTAVGREDEDRTQRFFTEAEA
HHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
GAALERTGFGVRRLCVEDEVEWHPDVPAFLRSVKRVGAGNASPLRGRGLAERRVMVEMMR
CCHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
VYGERYGGERGIPATYTVIYGVGVKSGRK
HHHHHCCCCCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]