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The map label for this gene is pphA [C]

Identifier: 78222061

GI number: 78222061

Start: 926669

End: 927349

Strand: Reverse

Name: pphA [C]

Synonym: Gmet_0841

Alternate gene names: 78222061

Gene position: 927349-926669 (Counterclockwise)

Preceding gene: 78222065

Following gene: 78222060

Centisome position: 23.2

GC content: 61.67

Gene sequence:

>681_bases
TTGAAAAGAACCCAACTCTCCCGCCGCTTTGTCATCCCCGATATCCACGGCTGCGCCCTGACTCTGGACCGCCTTCTCCG
GGAAGTCATCCACCTGAGACGCAGCGACGAGCTCTATCTCCTGGGGGACTACATCGACCGGGGCCCCCGCAGCAGGGAAG
TCCTCGACATCCTCATGGGGCTCACCCTGAAAGGATATCGGGTCTTCCCCGTGCGGGGAAACCACGAGGAGATGCTCCTG
GAGAGCTGCGGCGACCGCAACATGTTCCGGATGTGGTTCGAAAACGGCGGTCGCGCCACCCTCGACAGTTTCGGCGTGGA
GGATGCTTGCGAGATCCCTCTCCCTTACCGCCGCTTCATGGCCGAGATGCCCTACTATCGCATTCTACCCGACTTCGTGC
TGCTCCACGCGAGTCTCAACTTTGCCATCCCCTCCCCCTTTGCCGACACCGAGGCAATGCTCTGGAGCCGATCCCTGGAG
GTCCGCAAGGAGGTGATCGGTGGCCGGCGCGTCATCGGCGGCCACACCCCCATGAGCCGCTCAGAAATTCTCAGGGGACT
TTCCACCGACCGTATCGTCCTCGACAACGGCTGCGTCTACCGGGAGCGGGCCGGCATGGGGTGCCTGGCCGCCCTGGAGC
TGGACTCAATGACCCTCTCTTTTCAGGAAAATATTGATTAA

Upstream 100 bases:

>100_bases
ACACAAAGGTTGACAATCAGTGACCGTTTACTTGACAGGGGTCCGCATGGTATAAGGGGTCATTACTTCGAATGAATTTT
GCTTCCCGAATGGTATCGCA

Downstream 100 bases:

>100_bases
GCCTTCTAAAGTTTTCTCATTTTTCTCCGATATGTTTGCTTAGGACCCATCAACCAGGAGCCTTTGCAGCATGCATGCTC
TTTCAATGAAAAACCTGACC

Product: metallophosphoesterase

Products: A Protein; Orthophosphate. [C]

Alternate protein names: Serine/Threonine Protein Phosphatase; Bis(5Nucleosyl)-Tetraphosphatase ApaH; Ser/Thr Protein Phosphatase Family Protein; Serine/Threonine Protein Phosphatase I; Diadenosine Tetraphosphatase-Like Protein; Bis(5-Nucleosyl)-Tetraphosphatase; Diadenosine Tetraphosphatase; Serinethreonine Protein Phosphatase; Serine/Threonine Specific Protein Phosphatase; Protein Phosphatase; Calcineurin-Like Phosphoesterase

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKRTQLSRRFVIPDIHGCALTLDRLLREVIHLRRSDELYLLGDYIDRGPRSREVLDILMGLTLKGYRVFPVRGNHEEMLL
ESCGDRNMFRMWFENGGRATLDSFGVEDACEIPLPYRRFMAEMPYYRILPDFVLLHASLNFAIPSPFADTEAMLWSRSLE
VRKEVIGGRRVIGGHTPMSRSEILRGLSTDRIVLDNGCVYRERAGMGCLAALELDSMTLSFQENID

Sequences:

>Translated_226_residues
MKRTQLSRRFVIPDIHGCALTLDRLLREVIHLRRSDELYLLGDYIDRGPRSREVLDILMGLTLKGYRVFPVRGNHEEMLL
ESCGDRNMFRMWFENGGRATLDSFGVEDACEIPLPYRRFMAEMPYYRILPDFVLLHASLNFAIPSPFADTEAMLWSRSLE
VRKEVIGGRRVIGGHTPMSRSEILRGLSTDRIVLDNGCVYRERAGMGCLAALELDSMTLSFQENID
>Mature_226_residues
MKRTQLSRRFVIPDIHGCALTLDRLLREVIHLRRSDELYLLGDYIDRGPRSREVLDILMGLTLKGYRVFPVRGNHEEMLL
ESCGDRNMFRMWFENGGRATLDSFGVEDACEIPLPYRRFMAEMPYYRILPDFVLLHASLNFAIPSPFADTEAMLWSRSLE
VRKEVIGGRRVIGGHTPMSRSEILRGLSTDRIVLDNGCVYRERAGMGCLAALELDSMTLSFQENID

Specific function: Plays A Key Role In Signaling Protein Misfolding Via The Cpxr/Cpxa Transducing System. It Also Modulates The Phosphorylated Status Of Many Phosphoproteins In E. coli, Some Of Which Acting As Major Chaperones. Has Been Shown, In Vitro, To Act On Ser, Thr A

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.3.16 [C]

Molecular weight: Translated: 25977; Mature: 25977

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00125 SER_THR_PHOSPHATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTQLSRRFVIPDIHGCALTLDRLLREVIHLRRSDELYLLGDYIDRGPRSREVLDILMG
CCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHCCCCCHHHHHHHHHC
LTLKGYRVFPVRGNHEEMLLESCGDRNMFRMWFENGGRATLDSFGVEDACEIPLPYRRFM
CCCCCEEEEEECCCHHHHHHHHCCCCCEEEHHHHCCCCEEHHHCCCCCCCCCCCHHHHHH
AEMPYYRILPDFVLLHASLNFAIPSPFADTEAMLWSRSLEVRKEVIGGRRVIGGHTPMSR
HHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCH
SEILRGLSTDRIVLDNGCVYRERAGMGCLAALELDSMTLSFQENID
HHHHHCCCCCEEEECCCEEEECCCCCCEEEEEECCCEEEECCCCCC
>Mature Secondary Structure
MKRTQLSRRFVIPDIHGCALTLDRLLREVIHLRRSDELYLLGDYIDRGPRSREVLDILMG
CCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECHHCCCCCHHHHHHHHHC
LTLKGYRVFPVRGNHEEMLLESCGDRNMFRMWFENGGRATLDSFGVEDACEIPLPYRRFM
CCCCCEEEEEECCCHHHHHHHHCCCCCEEEHHHHCCCCEEHHHCCCCCCCCCCCHHHHHH
AEMPYYRILPDFVLLHASLNFAIPSPFADTEAMLWSRSLEVRKEVIGGRRVIGGHTPMSR
HHCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEECCCCCCCH
SEILRGLSTDRIVLDNGCVYRERAGMGCLAALELDSMTLSFQENID
HHHHHCCCCCEEEECCCEEEECCCCCCEEEEEECCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Phosphoprotein; H2O [C]

Specific reaction: A Phosphoprotein + H2O = A Protein + Orthophosphate. [C]

General reaction: Phosphoric ester hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA