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The map label for this gene is mraY

Identifier: 78221630

GI number: 78221630

Start: 452062

End: 453138

Strand: Direct

Name: mraY

Synonym: Gmet_0409

Alternate gene names: 78221630

Gene position: 452062-453138 (Clockwise)

Preceding gene: 78221629

Following gene: 78221631

Centisome position: 11.31

GC content: 58.68

Gene sequence:

>1077_bases
ATGCTCTACCATCTCCTTTATCCGCTGGCGAGCGACTTCAGGATCTTCAACGTCTTTAAGTACCTGACGTTCAGGACCAT
TTACGCCGTCATCACCGCCCTGCTGGTGTCGTTCATTCTCGGCCCTTGGGTCATCCGGAAGCTGGAGGCGCTCCAAGCCC
GGCAGGTTATCCGCACTGACGGTCCCGAATCCCACCTGAAGAAGTCGGGTACCCCCACCATGGGCGGGATTCTCATCCTT
GCATCCATCGTGATTCCGACGCTTCTGTGGGCCGACCTGACAAACCGCTACGTCTGGACAACTCTCTTTGTGATCGTGGG
GTACGGACTTATCGGTTTCACCGACGACTACAAGAAAGTGGTGGAGAAAAACCCCAAGGGGCTCTCCCCCCGCCAGAAGA
TGGCCGGCCAGTTGCTGATCGCCGGCATGGCGGTCTGCTTCCTCGTTTTTGTGGTGAATATGTCGACTGAGCTCGCCTTC
CCCTTTTTCAAGCGACTCCACCCCGACCTTTCCTGGTTTTACATCCCCTTTGCCATGCTGGTCATCGTGGGGGCGAGCAA
TGCCGTGAACCTGACCGACGGCCTCGACGGTCTGGCCATCGGTCCCGTGGCCATCAACGCAGCAACCTATCTGCTGTTTA
CTTACATAGCCGGCAATGCTAAGCTGTCCAGCTATTTACAGACCCCCTATGTCCCCGGCGCCGGCGAGTTGGCTGTCCTT
TGCGGAGCCATGGTGGGCGCGGGAATAGGCTTTCTCTGGTACAACGCCTACCCAGCCGAGGTTTTCATGGGTGACGTGGG
ATCCCTCTCCCTCGGCGGCGGGCTCGGGACCCTGGCGGTCATCACCAAGCAGGAGATCCTCCTCGTCATCGTTGGCGGGG
TGTTCGTCGTTGAGGCCCTGTCGGTCATCTTCCAGGTGGGGTCCTATAAGTACCGGGGGAAGCGGATCTTCCGCATGGCC
CCCATCCACCACCACTTCGAGCTTAAGGGTGTGGCGGAGCCGAAGATCATCGTGCGGTTCTGGATCATCACCATTATCCT
GGCCCTGGTGGCGATCTCGACCTTGAAGCTGAGATAG

Upstream 100 bases:

>100_bases
TCATTCTTGTGAAAGGATCCCGGGGATTGGCCATGGATCGGGTCGCGGAAAAGATGCGTGAAGTCTTTGTCGCGTCCCTC
GGGAAGGGGGCCTCGGCCTA

Downstream 100 bases:

>100_bases
CATGGAAATTTCGGGAAAGAACATACTGGTCGTAGGCCTTGCCCGCACGGGCGTGGCGGTGGCCCGCTTTCTGGCGCGAA
ACGGGGCGCGGGTGACCGTG

Product: phospho-N-acetylmuramoyl-pentapeptide- transferase

Products: NA

Alternate protein names: UDP-MurNAc-pentapeptide phosphotransferase

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MLYHLLYPLASDFRIFNVFKYLTFRTIYAVITALLVSFILGPWVIRKLEALQARQVIRTDGPESHLKKSGTPTMGGILIL
ASIVIPTLLWADLTNRYVWTTLFVIVGYGLIGFTDDYKKVVEKNPKGLSPRQKMAGQLLIAGMAVCFLVFVVNMSTELAF
PFFKRLHPDLSWFYIPFAMLVIVGASNAVNLTDGLDGLAIGPVAINAATYLLFTYIAGNAKLSSYLQTPYVPGAGELAVL
CGAMVGAGIGFLWYNAYPAEVFMGDVGSLSLGGGLGTLAVITKQEILLVIVGGVFVVEALSVIFQVGSYKYRGKRIFRMA
PIHHHFELKGVAEPKIIVRFWIITIILALVAISTLKLR

Sequences:

>Translated_358_residues
MLYHLLYPLASDFRIFNVFKYLTFRTIYAVITALLVSFILGPWVIRKLEALQARQVIRTDGPESHLKKSGTPTMGGILIL
ASIVIPTLLWADLTNRYVWTTLFVIVGYGLIGFTDDYKKVVEKNPKGLSPRQKMAGQLLIAGMAVCFLVFVVNMSTELAF
PFFKRLHPDLSWFYIPFAMLVIVGASNAVNLTDGLDGLAIGPVAINAATYLLFTYIAGNAKLSSYLQTPYVPGAGELAVL
CGAMVGAGIGFLWYNAYPAEVFMGDVGSLSLGGGLGTLAVITKQEILLVIVGGVFVVEALSVIFQVGSYKYRGKRIFRMA
PIHHHFELKGVAEPKIIVRFWIITIILALVAISTLKLR
>Mature_358_residues
MLYHLLYPLASDFRIFNVFKYLTFRTIYAVITALLVSFILGPWVIRKLEALQARQVIRTDGPESHLKKSGTPTMGGILIL
ASIVIPTLLWADLTNRYVWTTLFVIVGYGLIGFTDDYKKVVEKNPKGLSPRQKMAGQLLIAGMAVCFLVFVVNMSTELAF
PFFKRLHPDLSWFYIPFAMLVIVGASNAVNLTDGLDGLAIGPVAINAATYLLFTYIAGNAKLSSYLQTPYVPGAGELAVL
CGAMVGAGIGFLWYNAYPAEVFMGDVGSLSLGGGLGTLAVITKQEILLVIVGGVFVVEALSVIFQVGSYKYRGKRIFRMA
PIHHHFELKGVAEPKIIVRFWIITIILALVAISTLKLR

Specific function: First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan

COG id: COG0472

COG function: function code M; UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N-acetylglucosamine-1-phosphate transferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 4 family. MraY subfamily

Homologues:

Organism=Escherichia coli, GI1786275, Length=361, Percent_Identity=57.3407202216066, Blast_Score=386, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MRAY_GEOMG (Q39YM2)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383377.1
- STRING:   Q39YM2
- GeneID:   3738164
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0409
- NMPDR:   fig|269799.3.peg.437
- eggNOG:   COG0472
- HOGENOM:   HBG708263
- OMA:   LRQGKGQ
- PhylomeDB:   Q39YM2
- ProtClustDB:   PRK00108
- BioCyc:   GMET269799:GMET_0409-MONOMER
- HAMAP:   MF_00038
- InterPro:   IPR000715
- InterPro:   IPR003524
- InterPro:   IPR018480
- PANTHER:   PTHR22926
- PANTHER:   PTHR22926:SF3
- TIGRFAMs:   TIGR00445

Pfam domain/function: PF00953 Glycos_transf_4; PF10555 MraY_sig1

EC number: =2.7.8.13

Molecular weight: Translated: 39303; Mature: 39303

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: PS01347 MRAY_1; PS01348 MRAY_2; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x102dd970)-; HASH(0x10153cf4)-; HASH(0x1095ffbc)-; HASH(0x1009ae84)-; HASH(0x103e5c9c)-; HASH(0x1009addc)-; HASH(0x109629a4)-; HASH(0xfc41ccc)-; HASH(0x1009aecc)-; HASH(0x10936d80)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYHLLYPLASDFRIFNVFKYLTFRTIYAVITALLVSFILGPWVIRKLEALQARQVIRTD
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPESHLKKSGTPTMGGILILASIVIPTLLWADLTNRYVWTTLFVIVGYGLIGFTDDYKKV
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHH
VEKNPKGLSPRQKMAGQLLIAGMAVCFLVFVVNMSTELAFPFFKRLHPDLSWFYIPFAML
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHH
VIVGASNAVNLTDGLDGLAIGPVAINAATYLLFTYIAGNAKLSSYLQTPYVPGAGELAVL
HHHCCCCCEECCCCCCCCEECHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHH
CGAMVGAGIGFLWYNAYPAEVFMGDVGSLSLGGGLGTLAVITKQEILLVIVGGVFVVEAL
HHHHHHCCHHHHHCCCCCHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVIFQVGSYKYRGKRIFRMAPIHHHFELKGVAEPKIIVRFWIITIILALVAISTLKLR
HHHHHHCCCEECCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCH
>Mature Secondary Structure
MLYHLLYPLASDFRIFNVFKYLTFRTIYAVITALLVSFILGPWVIRKLEALQARQVIRTD
CCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GPESHLKKSGTPTMGGILILASIVIPTLLWADLTNRYVWTTLFVIVGYGLIGFTDDYKKV
CCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCHHHHHH
VEKNPKGLSPRQKMAGQLLIAGMAVCFLVFVVNMSTELAFPFFKRLHPDLSWFYIPFAML
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHH
VIVGASNAVNLTDGLDGLAIGPVAINAATYLLFTYIAGNAKLSSYLQTPYVPGAGELAVL
HHHCCCCCEECCCCCCCCEECHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCHHHHH
CGAMVGAGIGFLWYNAYPAEVFMGDVGSLSLGGGLGTLAVITKQEILLVIVGGVFVVEAL
HHHHHHCCHHHHHCCCCCHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SVIFQVGSYKYRGKRIFRMAPIHHHFELKGVAEPKIIVRFWIITIILALVAISTLKLR
HHHHHHCCCEECCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA