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The map label for this gene is norM [H]

Identifier: 78221579

GI number: 78221579

Start: 402798

End: 404156

Strand: Reverse

Name: norM [H]

Synonym: Gmet_0358

Alternate gene names: 78221579

Gene position: 404156-402798 (Counterclockwise)

Preceding gene: 78221583

Following gene: 78221574

Centisome position: 10.11

GC content: 66.96

Gene sequence:

>1359_bases
ATGACGGGAAGAGGATTTACGACACGACACTTCAGGGAGCGGAAAAAGCGGATCTCCATCCGCCGCAATGTCATGAACCT
GTCGCTTCCGGTCCTCCTCTCGTCCCTCTTCCAGCGTCTCGTGGCCATCGTCGACATCTTCCTCGTGGGGGGGCTCGGCG
CAGCGGCCATCGCGGCCACGGGGCTCGGCCAGCTCCTCGTCTTCGTGACCATGACGGTCTTCTGGGGGCTTGCCACTGGC
ACCACGGTGGTGATCGCTCACCTCTGGGGAGCGGGACAGCGCCGGGAAGCCCGCCGGGCCGCCTTTGCCGCCTGCCTCGC
CTGTGCCGCCATGACGGCGGCGGCCTCGACCTTGGGGTGGTTCTTCAGCGGCGATCTGGCCGCCTTTCTCGGCGCGAAGG
ATGACGTCCTCCACCTGGCCGCCGGCTATACCCGGCTGGTCTTTCTCTATCTGGCCTTCACCACGGGGCTCAACATCCTC
TCGGCCATCATGCACGGCACCGGCAACACCCGGACCCCCATGACCGCCATTCTCCTTGTGAATGTCCTCCACGTGCTCAT
GGCCTGGCCCCTCATCTACGGCAAGCTGGGTCTCCCCGCCATGGGGGTGACCGGCGCGGCCATCGCCATCAACGCCTCCG
AGGCCATCGGCTTTTTCTACCTCCTGATCCAGGCCATGAGACTCCGCTATATCCGGGTGGGGCGCCCCGACACGGGGCTC
TTCCAGCGCATCTGGCGGGTGGGGTGGCCCGTGGCCCTGGAGCGGGTCGCCCAGCAGGGAGGGCAGCTCTTCTACTCGAA
ATTCATCATCAGCTACGGCACCGCCGCCTACGCGGCGCACCAGATCGGGCTCTCCATCGAGTCCCTCTCCTTCATGCCCG
GGGCCGGCATGGGGATCGCCGCGGCCACCCTCATGGGGCAGGCCCTCGGAGCAAAAAAATACCGCCGGGCGCGGATCAGC
CACCGTGAGGCGCTGCGTCTGGCGGTCATGGTGATGGGGACCATGGCGGCCGTCTTCCTGACGCTGCCCGGGCCCCTCAT
CGGACTCTTCACCCATGACCCGGCGGTCATCGAGAAGGGAATCGTCTTCCTGCGGCTGGTGGCCTTCGCCCAGGTCCCCC
TGGCCCTCTCCTTCGTCTACGCCGGGAGCCTGCGGGGGACCGGCGACACCTTCTACGTCTTCCTGGTGACCCTCGGCACC
ATGTGGGGGGTGCGGGTCTTCCTCTCATGGGTGGCGGCCGACTGGCTCCACCTCTCCCTCTACGCCGTCTGGGGGGTCTT
CGTCATCGACTGGTACGCGAGGGCCGTCGCCTTCTGGTGGCGGTACCGGCAGCGGGACCTCCACGCGGTAGTCATCTGA

Upstream 100 bases:

>100_bases
CCAGGCGAAAGCATGACGTTCACGGAAAGGGACAATGATCTGATGACATGGGCCGGAAGACGGGAACGCCGTGACCGACA
GGGGGGTTAGGGGATACGGG

Downstream 100 bases:

>100_bases
CACAGAAAAGGCGGGGATATCGTCCCCGCCCCTCCTCGTCCGACGCATGTCGATCTCTTCCTATTTCTGGACCCATCTCC
CGTTAGCCAGCTGTGTCCAC

Product: multi anti extrusion protein MatE

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTGRGFTTRHFRERKKRISIRRNVMNLSLPVLLSSLFQRLVAIVDIFLVGGLGAAAIAATGLGQLLVFVTMTVFWGLATG
TTVVIAHLWGAGQRREARRAAFAACLACAAMTAAASTLGWFFSGDLAAFLGAKDDVLHLAAGYTRLVFLYLAFTTGLNIL
SAIMHGTGNTRTPMTAILLVNVLHVLMAWPLIYGKLGLPAMGVTGAAIAINASEAIGFFYLLIQAMRLRYIRVGRPDTGL
FQRIWRVGWPVALERVAQQGGQLFYSKFIISYGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLMGQALGAKKYRRARIS
HREALRLAVMVMGTMAAVFLTLPGPLIGLFTHDPAVIEKGIVFLRLVAFAQVPLALSFVYAGSLRGTGDTFYVFLVTLGT
MWGVRVFLSWVAADWLHLSLYAVWGVFVIDWYARAVAFWWRYRQRDLHAVVI

Sequences:

>Translated_452_residues
MTGRGFTTRHFRERKKRISIRRNVMNLSLPVLLSSLFQRLVAIVDIFLVGGLGAAAIAATGLGQLLVFVTMTVFWGLATG
TTVVIAHLWGAGQRREARRAAFAACLACAAMTAAASTLGWFFSGDLAAFLGAKDDVLHLAAGYTRLVFLYLAFTTGLNIL
SAIMHGTGNTRTPMTAILLVNVLHVLMAWPLIYGKLGLPAMGVTGAAIAINASEAIGFFYLLIQAMRLRYIRVGRPDTGL
FQRIWRVGWPVALERVAQQGGQLFYSKFIISYGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLMGQALGAKKYRRARIS
HREALRLAVMVMGTMAAVFLTLPGPLIGLFTHDPAVIEKGIVFLRLVAFAQVPLALSFVYAGSLRGTGDTFYVFLVTLGT
MWGVRVFLSWVAADWLHLSLYAVWGVFVIDWYARAVAFWWRYRQRDLHAVVI
>Mature_451_residues
TGRGFTTRHFRERKKRISIRRNVMNLSLPVLLSSLFQRLVAIVDIFLVGGLGAAAIAATGLGQLLVFVTMTVFWGLATGT
TVVIAHLWGAGQRREARRAAFAACLACAAMTAAASTLGWFFSGDLAAFLGAKDDVLHLAAGYTRLVFLYLAFTTGLNILS
AIMHGTGNTRTPMTAILLVNVLHVLMAWPLIYGKLGLPAMGVTGAAIAINASEAIGFFYLLIQAMRLRYIRVGRPDTGLF
QRIWRVGWPVALERVAQQGGQLFYSKFIISYGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLMGQALGAKKYRRARISH
REALRLAVMVMGTMAAVFLTLPGPLIGLFTHDPAVIEKGIVFLRLVAFAQVPLALSFVYAGSLRGTGDTFYVFLVTLGTM
WGVRVFLSWVAADWLHLSLYAVWGVFVIDWYARAVAFWWRYRQRDLHAVVI

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=449, Percent_Identity=28.7305122494432, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI48994890, Length=408, Percent_Identity=25.4901960784314, Blast_Score=90, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320545, Length=418, Percent_Identity=22.7272727272727, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49331; Mature: 49200

Theoretical pI: Translated: 11.28; Mature: 11.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGRGFTTRHFRERKKRISIRRNVMNLSLPVLLSSLFQRLVAIVDIFLVGGLGAAAIAAT
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GLGQLLVFVTMTVFWGLATGTTVVIAHLWGAGQRREARRAAFAACLACAAMTAAASTLGW
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFSGDLAAFLGAKDDVLHLAAGYTRLVFLYLAFTTGLNILSAIMHGTGNTRTPMTAILLV
HHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
NVLHVLMAWPLIYGKLGLPAMGVTGAAIAINASEAIGFFYLLIQAMRLRYIRVGRPDTGL
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCHHH
FQRIWRVGWPVALERVAQQGGQLFYSKFIISYGTAAYAAHQIGLSIESLSFMPGAGMGIA
HHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHCCCHHHCCCCCCCCCHHH
AATLMGQALGAKKYRRARISHREALRLAVMVMGTMAAVFLTLPGPLIGLFTHDPAVIEKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
IVFLRLVAFAQVPLALSFVYAGSLRGTGDTFYVFLVTLGTMWGVRVFLSWVAADWLHLSL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAVWGVFVIDWYARAVAFWWRYRQRDLHAVVI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
>Mature Secondary Structure 
TGRGFTTRHFRERKKRISIRRNVMNLSLPVLLSSLFQRLVAIVDIFLVGGLGAAAIAAT
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
GLGQLLVFVTMTVFWGLATGTTVVIAHLWGAGQRREARRAAFAACLACAAMTAAASTLGW
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FFSGDLAAFLGAKDDVLHLAAGYTRLVFLYLAFTTGLNILSAIMHGTGNTRTPMTAILLV
HHCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
NVLHVLMAWPLIYGKLGLPAMGVTGAAIAINASEAIGFFYLLIQAMRLRYIRVGRPDTGL
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCHHH
FQRIWRVGWPVALERVAQQGGQLFYSKFIISYGTAAYAAHQIGLSIESLSFMPGAGMGIA
HHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHCCCHHHCCCCCCCCCHHH
AATLMGQALGAKKYRRARISHREALRLAVMVMGTMAAVFLTLPGPLIGLFTHDPAVIEKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHH
IVFLRLVAFAQVPLALSFVYAGSLRGTGDTFYVFLVTLGTMWGVRVFLSWVAADWLHLSL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YAVWGVFVIDWYARAVAFWWRYRQRDLHAVVI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]