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The map label for this gene is frdB [H]

Identifier: 78221532

GI number: 78221532

Start: 349224

End: 350258

Strand: Direct

Name: frdB [H]

Synonym: Gmet_0309

Alternate gene names: 78221532

Gene position: 349224-350258 (Clockwise)

Preceding gene: 78221531

Following gene: 78221533

Centisome position: 8.74

GC content: 62.32

Gene sequence:

>1035_bases
ATGGAACGGCGAGAGGTTTCATTCCGCATCTACCGCTACAACCCCCAGGTTGACCGCACTCCTTTTTACGACAACTTCAG
GATTGCCGTCGAGAAGGGGATTACCATCCTGCGCGCCCTGAACCACATCAAGGAGCACCTGGAGCCGCGCCTTACCTTCC
GGGCCTTCTGCCAGGCGGGAATCTGCGGTTCCTGCGCGGTCCGCATCAACGGGGTCTCGAAGCTTGCCTGCACGACCCAG
GTCTGGGACGAGCTGGGGGGGGACGGAGAACACACGATCCTCATCGAGCCCCTGAACAATCTGGAAGTGATCCGGGACCT
GGTGGTGGACATCGACCCGATCATGGACAAGCTGAAAGAGAATTACAGCTGGGTTAAGCCGGCGATCCCCCAGGAGGAAA
TGGGTCGGAAAGAGCATCTCGTGAGCGACGGGGAGTTCGAGGCCATCAACGCGGCATCGGACTGTATCCTCTGCGGGTCG
TGCTACTCGGAGTGCAGCATGATGGAGGTGAACCGGAGCTACATCTCGCCGCCGGTCCTCGTGAAGGCGTTCCGCATGAA
TAACGACTCCCGCGACACCCTCGCCTGTGAGCGGCTGGAGCGGGTCTCCTCCGACCACGGCCTGTGGGACTGTGCCCACT
GCCACAAGTGCATGGAGCACTGCACCAAGAACATACCGATCATGGACGGCATCCACCGCCTGCGGGAGGAAGCCTTTGAG
CGGGGGATGACCGACTCCGAGGGGGCCCGTCACGCCCAGGCATTCTTCGACGACATCCGCGACCTCGGCAGGCTGAGGGA
GGTCACCTTGCCGCTCCGCACCAAGGGGATGATCGGGAGCCTCAGGATGGTACCCCTGGCGGTCAAGATGGGGCTCAAGG
GTCGGACTCCACCCCTGTGGGTGCGGCCGATTCCCGACATCGACCGGGTCAGCGACATTTACAGCCGCCTGGAGGCAAAT
CCGGGCGGGGAGGCTGTAGGGGCAATTCATGAATTGCCCCTACGGTCGGCGCCACGAAGCGGAGAGTGCCTATGA

Upstream 100 bases:

>100_bases
ACATCCATTCCCTCTGCACCATGGAGCGGGATGGCGAGGTCCGTCTCGGCCACAAGCCGGTCACCATGGGGAAATACTCC
CTCGAGACAAGGAGTTACTA

Downstream 100 bases:

>100_bases
GATACGCTTATTTCCTGAGTTGCATCAACGAGTCCATGACCAGGGAAGTGGACCAGTCCCTCCACCTGTGGAAAAAGGAC
CTGGACCTCGAACTGGTGAC

Product: succinate dehydrogenase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MERREVSFRIYRYNPQVDRTPFYDNFRIAVEKGITILRALNHIKEHLEPRLTFRAFCQAGICGSCAVRINGVSKLACTTQ
VWDELGGDGEHTILIEPLNNLEVIRDLVVDIDPIMDKLKENYSWVKPAIPQEEMGRKEHLVSDGEFEAINAASDCILCGS
CYSECSMMEVNRSYISPPVLVKAFRMNNDSRDTLACERLERVSSDHGLWDCAHCHKCMEHCTKNIPIMDGIHRLREEAFE
RGMTDSEGARHAQAFFDDIRDLGRLREVTLPLRTKGMIGSLRMVPLAVKMGLKGRTPPLWVRPIPDIDRVSDIYSRLEAN
PGGEAVGAIHELPLRSAPRSGECL

Sequences:

>Translated_344_residues
MERREVSFRIYRYNPQVDRTPFYDNFRIAVEKGITILRALNHIKEHLEPRLTFRAFCQAGICGSCAVRINGVSKLACTTQ
VWDELGGDGEHTILIEPLNNLEVIRDLVVDIDPIMDKLKENYSWVKPAIPQEEMGRKEHLVSDGEFEAINAASDCILCGS
CYSECSMMEVNRSYISPPVLVKAFRMNNDSRDTLACERLERVSSDHGLWDCAHCHKCMEHCTKNIPIMDGIHRLREEAFE
RGMTDSEGARHAQAFFDDIRDLGRLREVTLPLRTKGMIGSLRMVPLAVKMGLKGRTPPLWVRPIPDIDRVSDIYSRLEAN
PGGEAVGAIHELPLRSAPRSGECL
>Mature_344_residues
MERREVSFRIYRYNPQVDRTPFYDNFRIAVEKGITILRALNHIKEHLEPRLTFRAFCQAGICGSCAVRINGVSKLACTTQ
VWDELGGDGEHTILIEPLNNLEVIRDLVVDIDPIMDKLKENYSWVKPAIPQEEMGRKEHLVSDGEFEAINAASDCILCGS
CYSECSMMEVNRSYISPPVLVKAFRMNNDSRDTLACERLERVSSDHGLWDCAHCHKCMEHCTKNIPIMDGIHRLREEAFE
RGMTDSEGARHAQAFFDDIRDLGRLREVTLPLRTKGMIGSLRMVPLAVKMGLKGRTPPLWVRPIPDIDRVSDIYSRLEAN
PGGEAVGAIHELPLRSAPRSGECL

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=232, Percent_Identity=32.7586206896552, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1790596, Length=239, Percent_Identity=31.3807531380753, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1786943, Length=241, Percent_Identity=33.195020746888, Blast_Score=121, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17533915, Length=236, Percent_Identity=32.2033898305085, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6322987, Length=227, Percent_Identity=28.6343612334802, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24643156, Length=235, Percent_Identity=31.9148936170213, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI17137106, Length=226, Percent_Identity=31.858407079646, Blast_Score=121, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 38950; Mature: 38950

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERREVSFRIYRYNPQVDRTPFYDNFRIAVEKGITILRALNHIKEHLEPRLTFRAFCQAG
CCCCCEEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
ICGSCAVRINGVSKLACTTQVWDELGGDGEHTILIEPLNNLEVIRDLVVDIDPIMDKLKE
CCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
NYSWVKPAIPQEEMGRKEHLVSDGEFEAINAASDCILCGSCYSECSMMEVNRSYISPPVL
CCCCCCCCCCHHHCCCHHHCCCCCCCCEECCCCCEEEECCHHHHHHHHHHHHHHCCCHHH
VKAFRMNNDSRDTLACERLERVSSDHGLWDCAHCHKCMEHCTKNIPIMDGIHRLREEAFE
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RGMTDSEGARHAQAFFDDIRDLGRLREVTLPLRTKGMIGSLRMVPLAVKMGLKGRTPPLW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEE
VRPIPDIDRVSDIYSRLEANPGGEAVGAIHELPLRSAPRSGECL
ECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MERREVSFRIYRYNPQVDRTPFYDNFRIAVEKGITILRALNHIKEHLEPRLTFRAFCQAG
CCCCCEEEEEEEECCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCC
ICGSCAVRINGVSKLACTTQVWDELGGDGEHTILIEPLNNLEVIRDLVVDIDPIMDKLKE
CCCCEEEEECCCHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
NYSWVKPAIPQEEMGRKEHLVSDGEFEAINAASDCILCGSCYSECSMMEVNRSYISPPVL
CCCCCCCCCCHHHCCCHHHCCCCCCCCEECCCCCEEEECCHHHHHHHHHHHHHHCCCHHH
VKAFRMNNDSRDTLACERLERVSSDHGLWDCAHCHKCMEHCTKNIPIMDGIHRLREEAFE
HHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RGMTDSEGARHAQAFFDDIRDLGRLREVTLPLRTKGMIGSLRMVPLAVKMGLKGRTPPLW
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEE
VRPIPDIDRVSDIYSRLEANPGGEAVGAIHELPLRSAPRSGECL
ECCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]