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The map label for this gene is sdhA [H]

Identifier: 78221531

GI number: 78221531

Start: 347521

End: 349224

Strand: Direct

Name: sdhA [H]

Synonym: Gmet_0308

Alternate gene names: 78221531

Gene position: 347521-349224 (Clockwise)

Preceding gene: 78221530

Following gene: 78221532

Centisome position: 8.69

GC content: 66.61

Gene sequence:

>1704_bases
ATGGAGCACAAATTCGACATAGTCATCGTCGGGGCAGGGGGAGGAGGGCTGTTCGCCGCCCTGGAGGCGGTGCGCACCAA
CCCGCGGGTTTCCGTGGCCGTCATCTCCAAGGTCTACCCGACCCGCTCCCATACCTCCGCGGCCCAGGGGGGGGTCAACG
CGGCCCTGGGGAACAAGGACCGGGACGACACCGTGGATCTCCATGTCTTCGACACCGTCAAGGGGAGCGACTACCTGGCG
GACCAGGATGCCGTCGACTACCTCTGCAGCCAGGCCCCGTCGGTGGTGCGGGAGCTGGAGAACCTGGGGGCGCCGTTTTC
GCGATTCGCTGATGGCACCATCGCCCAGCGCCCCTTCGGCGGGACCGTGAAGGACCGCTGCTGCTACTGCGCCGACAAGA
CCGGCCATACCCTCCTCCACACCCTGTTCGAGCAGTGCCTCCGCCGGGGGGTGACGTTCTTCAACGAATATTTCCTCCTC
TCCCTGGAGCATGCCGACGGCGACTGCCAGGGGGTCATCACCCTGAACATGGCCACGAGCGCCATCGAGACCTTTGTGGC
CCCGGTGGTCATCCTGGCCACCGGCGGCCACGCCAAGATGTACTGGAACCGCTCCAGCAACGCGGCCGGCAACACCGGTG
ACGGCCAGGCCGCGGCCCTGCGGGCCGGCATTCCCCTGAAGGACATGGAGTTCATCCAGTTCCACCCGACGGGCCTGCGC
AAGAGCGGGCTCCTGGTGACGGAAGGGGCGAGGGGCGAGGGGGGGTATCTCCTCAACCGCCACGGGGAGCGCTTCATGGT
CCGCTATGCCCCCCAGAAGATGGAGCTGGGTCCCCGGGACCTGGTGGCCCGCTCCATGGAGACGGAGATCATCGAGGGGA
ACGGCTTCGAGAGCGATGCCGGGAGCTACATCGAACTGGATCTCCGCCACCTGGGTGCCGAGGCCATCAAGAAGAAGCTC
CCCCAGATCAGGGAACTCTCCATGCACTTCGAGGGGGTGGACCCCATCGCGGAGCCGATCCCGGTCCGTCCCACGGCCCA
CTACTCCATGGGGGGGATCGACGCCCACATGGCGAAGACCGCGGTCCGCGGCGTCTTTGCCGTGGGGGAGTGCGCCTGCG
TCTCCGTGCACGGGGCCAACCGGCTGGGGGGAAACTCGCTCCTGGACATCCTGGTGTTCGGGAAACGAGCGGGACAGGAG
GCGGCCGAGGAGGCCCCCCGGCGCAGGGCGCTGGGGATACCCCCGGGCGCGGTTGCGGGGATGGCCGACGAAATCAGGTC
GTACGCCAATCCTGAGCGCTACGAGCGTTACGGCATCATCAGGGAGGAGATGGGAAAGGCCATGGGGGACAACGTGGGGA
TCTATCGGGTCGAAGAGAGGCTCCGCACGGGGGTGGAAGAGATCCTGGCCCTGCGGGAGCGCTTCCGGCGCATCCGGCTC
TTCGACACGGGGACCGTCTACAACACCAACCTGATTCAGATCCTGGAGCTCAAGAACATGCTCGACCTGGCCTCCTGCGT
CGCCATCACCGCCCTGGCCCGGCAGGAGAGCAGGGGGTCCCATTACCGCGAGGACTTCCCCCGGCGTGACGACGGAGCGT
GGCACATCCATTCCCTCTGCACCATGGAGCGGGATGGCGAGGTCCGTCTCGGCCACAAGCCGGTCACCATGGGGAAATAC
TCCCTCGAGACAAGGAGTTACTAA

Upstream 100 bases:

>100_bases
GGGGATCATCAGCGAGATCGAGATCTTCCGGGCAGTCGAGGATTTGCCGGCAGTGGCCCAGGTGGCCCTGTAGCCGCAAC
ACCCACGCAGGGAGGCAGTC

Downstream 100 bases:

>100_bases
TGGAACGGCGAGAGGTTTCATTCCGCATCTACCGCTACAACCCCCAGGTTGACCGCACTCCTTTTTACGACAACTTCAGG
ATTGCCGTCGAGAAGGGGAT

Product: succinate dehydrogenase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MEHKFDIVIVGAGGGGLFAALEAVRTNPRVSVAVISKVYPTRSHTSAAQGGVNAALGNKDRDDTVDLHVFDTVKGSDYLA
DQDAVDYLCSQAPSVVRELENLGAPFSRFADGTIAQRPFGGTVKDRCCYCADKTGHTLLHTLFEQCLRRGVTFFNEYFLL
SLEHADGDCQGVITLNMATSAIETFVAPVVILATGGHAKMYWNRSSNAAGNTGDGQAAALRAGIPLKDMEFIQFHPTGLR
KSGLLVTEGARGEGGYLLNRHGERFMVRYAPQKMELGPRDLVARSMETEIIEGNGFESDAGSYIELDLRHLGAEAIKKKL
PQIRELSMHFEGVDPIAEPIPVRPTAHYSMGGIDAHMAKTAVRGVFAVGECACVSVHGANRLGGNSLLDILVFGKRAGQE
AAEEAPRRRALGIPPGAVAGMADEIRSYANPERYERYGIIREEMGKAMGDNVGIYRVEERLRTGVEEILALRERFRRIRL
FDTGTVYNTNLIQILELKNMLDLASCVAITALARQESRGSHYREDFPRRDDGAWHIHSLCTMERDGEVRLGHKPVTMGKY
SLETRSY

Sequences:

>Translated_567_residues
MEHKFDIVIVGAGGGGLFAALEAVRTNPRVSVAVISKVYPTRSHTSAAQGGVNAALGNKDRDDTVDLHVFDTVKGSDYLA
DQDAVDYLCSQAPSVVRELENLGAPFSRFADGTIAQRPFGGTVKDRCCYCADKTGHTLLHTLFEQCLRRGVTFFNEYFLL
SLEHADGDCQGVITLNMATSAIETFVAPVVILATGGHAKMYWNRSSNAAGNTGDGQAAALRAGIPLKDMEFIQFHPTGLR
KSGLLVTEGARGEGGYLLNRHGERFMVRYAPQKMELGPRDLVARSMETEIIEGNGFESDAGSYIELDLRHLGAEAIKKKL
PQIRELSMHFEGVDPIAEPIPVRPTAHYSMGGIDAHMAKTAVRGVFAVGECACVSVHGANRLGGNSLLDILVFGKRAGQE
AAEEAPRRRALGIPPGAVAGMADEIRSYANPERYERYGIIREEMGKAMGDNVGIYRVEERLRTGVEEILALRERFRRIRL
FDTGTVYNTNLIQILELKNMLDLASCVAITALARQESRGSHYREDFPRRDDGAWHIHSLCTMERDGEVRLGHKPVTMGKY
SLETRSY
>Mature_567_residues
MEHKFDIVIVGAGGGGLFAALEAVRTNPRVSVAVISKVYPTRSHTSAAQGGVNAALGNKDRDDTVDLHVFDTVKGSDYLA
DQDAVDYLCSQAPSVVRELENLGAPFSRFADGTIAQRPFGGTVKDRCCYCADKTGHTLLHTLFEQCLRRGVTFFNEYFLL
SLEHADGDCQGVITLNMATSAIETFVAPVVILATGGHAKMYWNRSSNAAGNTGDGQAAALRAGIPLKDMEFIQFHPTGLR
KSGLLVTEGARGEGGYLLNRHGERFMVRYAPQKMELGPRDLVARSMETEIIEGNGFESDAGSYIELDLRHLGAEAIKKKL
PQIRELSMHFEGVDPIAEPIPVRPTAHYSMGGIDAHMAKTAVRGVFAVGECACVSVHGANRLGGNSLLDILVFGKRAGQE
AAEEAPRRRALGIPPGAVAGMADEIRSYANPERYERYGIIREEMGKAMGDNVGIYRVEERLRTGVEEILALRERFRRIRL
FDTGTVYNTNLIQILELKNMLDLASCVAITALARQESRGSHYREDFPRRDDGAWHIHSLCTMERDGEVRLGHKPVTMGKY
SLETRSY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=563, Percent_Identity=43.5168738898757, Blast_Score=429, Evalue=1e-120,
Organism=Escherichia coli, GI1786942, Length=586, Percent_Identity=45.3924914675768, Blast_Score=458, Evalue=1e-130,
Organism=Escherichia coli, GI1790597, Length=555, Percent_Identity=42.3423423423423, Blast_Score=430, Evalue=1e-121,
Organism=Escherichia coli, GI1788928, Length=544, Percent_Identity=32.7205882352941, Blast_Score=229, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17550100, Length=570, Percent_Identity=43.1578947368421, Blast_Score=420, Evalue=1e-117,
Organism=Caenorhabditis elegans, GI17505833, Length=565, Percent_Identity=41.5929203539823, Blast_Score=410, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6322701, Length=566, Percent_Identity=44.8763250883392, Blast_Score=442, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6322416, Length=564, Percent_Identity=44.6808510638298, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI17137288, Length=556, Percent_Identity=44.7841726618705, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24655642, Length=556, Percent_Identity=44.7841726618705, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24655647, Length=556, Percent_Identity=44.7841726618705, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24663005, Length=555, Percent_Identity=42.1621621621622, Blast_Score=416, Evalue=1e-116,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 62165; Mature: 62165

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHKFDIVIVGAGGGGLFAALEAVRTNPRVSVAVISKVYPTRSHTSAAQGGVNAALGNKD
CCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCHHCCCCEECCCCCC
RDDTVDLHVFDTVKGSDYLADQDAVDYLCSQAPSVVRELENLGAPFSRFADGTIAQRPFG
CCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCCCCCCC
GTVKDRCCYCADKTGHTLLHTLFEQCLRRGVTFFNEYFLLSLEHADGDCQGVITLNMATS
CCHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEEHHHH
AIETFVAPVVILATGGHAKMYWNRSSNAAGNTGDGQAAALRAGIPLKDMEFIQFHPTGLR
HHHHHHHCEEEEEECCCEEEEEECCCCCCCCCCCCCHHEEECCCCCCCCCEEEECCCCCC
KSGLLVTEGARGEGGYLLNRHGERFMVRYAPQKMELGPRDLVARSMETEIIEGNGFESDA
CCCEEEECCCCCCCCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCCCCC
GSYIELDLRHLGAEAIKKKLPQIRELSMHFEGVDPIAEPIPVRPTAHYSMGGIDAHMAKT
CCEEEEHHHHCCHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AVRGVFAVGECACVSVHGANRLGGNSLLDILVFGKRAGQEAAEEAPRRRALGIPPGAVAG
HHHHHHEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHCHHHCCCCCCCHHHHH
MADEIRSYANPERYERYGIIREEMGKAMGDNVGIYRVEERLRTGVEEILALRERFRRIRL
HHHHHHHCCCHHHHHHHCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHEEEE
FDTGTVYNTNLIQILELKNMLDLASCVAITALARQESRGSHYREDFPRRDDGAWHIHSLC
EECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEHHH
TMERDGEVRLGHKPVTMGKYSLETRSY
EECCCCCEEECCCCEECCCCCCCCCCC
>Mature Secondary Structure
MEHKFDIVIVGAGGGGLFAALEAVRTNPRVSVAVISKVYPTRSHTSAAQGGVNAALGNKD
CCCEEEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHHHCCCCCCCCHHCCCCEECCCCCC
RDDTVDLHVFDTVKGSDYLADQDAVDYLCSQAPSVVRELENLGAPFSRFADGTIAQRPFG
CCCEEEEEEEEECCCCCCCCCHHHHHHHHHCCHHHHHHHHHCCCCHHHHCCCCCCCCCCC
GTVKDRCCYCADKTGHTLLHTLFEQCLRRGVTFFNEYFLLSLEHADGDCQGVITLNMATS
CCHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEEHHHH
AIETFVAPVVILATGGHAKMYWNRSSNAAGNTGDGQAAALRAGIPLKDMEFIQFHPTGLR
HHHHHHHCEEEEEECCCEEEEEECCCCCCCCCCCCCHHEEECCCCCCCCCEEEECCCCCC
KSGLLVTEGARGEGGYLLNRHGERFMVRYAPQKMELGPRDLVARSMETEIIEGNGFESDA
CCCEEEECCCCCCCCEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHEEECCCCCCCCC
GSYIELDLRHLGAEAIKKKLPQIRELSMHFEGVDPIAEPIPVRPTAHYSMGGIDAHMAKT
CCEEEEHHHHCCHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHH
AVRGVFAVGECACVSVHGANRLGGNSLLDILVFGKRAGQEAAEEAPRRRALGIPPGAVAG
HHHHHHEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCHHHHHHCHHHCCCCCCCHHHHH
MADEIRSYANPERYERYGIIREEMGKAMGDNVGIYRVEERLRTGVEEILALRERFRRIRL
HHHHHHHCCCHHHHHHHCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHEEEE
FDTGTVYNTNLIQILELKNMLDLASCVAITALARQESRGSHYREDFPRRDDGAWHIHSLC
EECCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCEEEEHHH
TMERDGEVRLGHKPVTMGKYSLETRSY
EECCCCCEEECCCCEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA