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The map label for this gene is argD [H]

Identifier: 78221428

GI number: 78221428

Start: 237249

End: 238448

Strand: Direct

Name: argD [H]

Synonym: Gmet_0204

Alternate gene names: 78221428

Gene position: 237249-238448 (Clockwise)

Preceding gene: 78221427

Following gene: 78221429

Centisome position: 5.94

GC content: 61.08

Gene sequence:

>1200_bases
ATGAAATCTGCTGATTGGATAGCAAAGGGCGACAAATACATCATGAAGACCTATGGCCGGTACCCCCTGGTGCCGGTGCG
TGGCGAAGGGTGCCGGGTCTGGGACGCGGACGGGAAGGAGTATCTGGACTTTCTCGCCGGTGTGGCGGTGAACAACCTGG
GACACTGCCACCCTAAGGTGGTGGCGGCGCTTCAGAAACAGGCCGCCGAGATGATCCATTGCTCCAACTACTACAATATT
CCCACCCAGATCGAGCTGGCGGAGCTGCTCTGCAGCAACTCCTTTGCCGACAAGGCCTTCTTCTGCAACAGCGGCGCCGA
GGCCAACGAGGCCGCCATCAAGCTCGCCCGCAAGTATGCCCGGGAAAAGACCGGCGATGTCGAGCGTTATGAGATTATAA
CGGCTATTGCTTCTTTCCACGGTCGGACCATGGCCACCATCTCCGCCACGGGACAGGAGAAGGTGCAGAAGTTCTTCGAT
CCGCTCCTACACGGATTCACCTATGTCCCCTTTGACGATGCCGACGCCCTGGAGGCGGCGGTTACGCCGAAAACCTGCGC
GGTGATGCTGGAGCCGATCCAGGGAGAGGGTGGCGTGGTTATCCCTTCCGCCGACTACTTCCGGAAGGTGCGGGAAATCT
GCGATCGTCACGGGCTCCTTCTCATATTCGACGAGGTGCAGGTGGGGATCGGCCGGACCGGTAAGCTCTTCGCCCATGAG
CACTTTGATGTGACCCCCGACATCATGACCCTGGCCAAGGCCCTGGCCGGCGGCGCTCCCATCGGTTCCATGCTGGCGAA
AGATGAAGTGGCCGCCTCCTTTTCGCCCGGCACCCACGGTTCCACCTTCGGGGGAAACCCCCTGGTCACCGCCGCCGGTG
TGGCCGCCGTCCGGGCGGTGCTGGAGGAGGGGCTCCTGAACCGGGCCGAAGAAATGGGGGAATACCTCGTGGGCGAGTTG
GAGCGGCTCAAGGAGAAGTATGCGTTCATCACCGACGTTCGGGGGATCGGTCTCATGATAGGGATGGAGCTCTCCGCTCC
GGCCGGCGAGATCGTGCTCAAGGGGCTTGAGCGTGGCGTCCTCCTTAACGTGGCCCAGGACAAGGTGCTCCGGTTCGTGC
CGCCGCTCATCGTGACCAAGCAGGAAGTGAATGAAATGATCGCCGTGCTTGACGGCATTCTGGAGGAGATTAAGCAATGA

Upstream 100 bases:

>100_bases
TCCTCGAAATTTTCACTGACGTTGGCGTCGGGACCGAGATCCGACGATAGGCATGGGGTGGAAAACAGTGCCACGGGACG
AAAATTTGGAGGAAATGCGA

Downstream 100 bases:

>100_bases
CCCGGCATTTTCTTGCCCTCAACCAGTATACCAAAGAAGCCCTCGACGCCCTCTTCGCCCTGACACGGGAGCTGAAGGAA
GAGCAGAAAAAGGGGATTCC

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKSADWIAKGDKYIMKTYGRYPLVPVRGEGCRVWDADGKEYLDFLAGVAVNNLGHCHPKVVAALQKQAAEMIHCSNYYNI
PTQIELAELLCSNSFADKAFFCNSGAEANEAAIKLARKYAREKTGDVERYEIITAIASFHGRTMATISATGQEKVQKFFD
PLLHGFTYVPFDDADALEAAVTPKTCAVMLEPIQGEGGVVIPSADYFRKVREICDRHGLLLIFDEVQVGIGRTGKLFAHE
HFDVTPDIMTLAKALAGGAPIGSMLAKDEVAASFSPGTHGSTFGGNPLVTAAGVAAVRAVLEEGLLNRAEEMGEYLVGEL
ERLKEKYAFITDVRGIGLMIGMELSAPAGEIVLKGLERGVLLNVAQDKVLRFVPPLIVTKQEVNEMIAVLDGILEEIKQ

Sequences:

>Translated_399_residues
MKSADWIAKGDKYIMKTYGRYPLVPVRGEGCRVWDADGKEYLDFLAGVAVNNLGHCHPKVVAALQKQAAEMIHCSNYYNI
PTQIELAELLCSNSFADKAFFCNSGAEANEAAIKLARKYAREKTGDVERYEIITAIASFHGRTMATISATGQEKVQKFFD
PLLHGFTYVPFDDADALEAAVTPKTCAVMLEPIQGEGGVVIPSADYFRKVREICDRHGLLLIFDEVQVGIGRTGKLFAHE
HFDVTPDIMTLAKALAGGAPIGSMLAKDEVAASFSPGTHGSTFGGNPLVTAAGVAAVRAVLEEGLLNRAEEMGEYLVGEL
ERLKEKYAFITDVRGIGLMIGMELSAPAGEIVLKGLERGVLLNVAQDKVLRFVPPLIVTKQEVNEMIAVLDGILEEIKQ
>Mature_399_residues
MKSADWIAKGDKYIMKTYGRYPLVPVRGEGCRVWDADGKEYLDFLAGVAVNNLGHCHPKVVAALQKQAAEMIHCSNYYNI
PTQIELAELLCSNSFADKAFFCNSGAEANEAAIKLARKYAREKTGDVERYEIITAIASFHGRTMATISATGQEKVQKFFD
PLLHGFTYVPFDDADALEAAVTPKTCAVMLEPIQGEGGVVIPSADYFRKVREICDRHGLLLIFDEVQVGIGRTGKLFAHE
HFDVTPDIMTLAKALAGGAPIGSMLAKDEVAASFSPGTHGSTFGGNPLVTAAGVAAVRAVLEEGLLNRAEEMGEYLVGEL
ERLKEKYAFITDVRGIGLMIGMELSAPAGEIVLKGLERGVLLNVAQDKVLRFVPPLIVTKQEVNEMIAVLDGILEEIKQ

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=397, Percent_Identity=36.5239294710327, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI284507298, Length=297, Percent_Identity=38.3838383838384, Blast_Score=208, Evalue=7e-54,
Organism=Homo sapiens, GI37574042, Length=415, Percent_Identity=32.289156626506, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI13994255, Length=442, Percent_Identity=28.7330316742081, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI226442709, Length=384, Percent_Identity=32.2916666666667, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI226442705, Length=415, Percent_Identity=31.3253012048193, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI24119277, Length=419, Percent_Identity=28.8782816229117, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI188536080, Length=419, Percent_Identity=27.2076372315036, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI38679950, Length=419, Percent_Identity=27.2076372315036, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI38679946, Length=419, Percent_Identity=27.2076372315036, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1788044, Length=377, Percent_Identity=44.2970822281167, Blast_Score=341, Evalue=6e-95,
Organism=Escherichia coli, GI1789759, Length=379, Percent_Identity=43.0079155672823, Blast_Score=324, Evalue=7e-90,
Organism=Escherichia coli, GI145693181, Length=371, Percent_Identity=39.0835579514825, Blast_Score=240, Evalue=1e-64,
Organism=Escherichia coli, GI1789016, Length=411, Percent_Identity=34.7931873479319, Blast_Score=234, Evalue=7e-63,
Organism=Escherichia coli, GI1787560, Length=400, Percent_Identity=35.25, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1786991, Length=434, Percent_Identity=30.184331797235, Blast_Score=148, Evalue=5e-37,
Organism=Escherichia coli, GI1786349, Length=343, Percent_Identity=28.2798833819242, Blast_Score=110, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25144271, Length=380, Percent_Identity=38.6842105263158, Blast_Score=267, Evalue=8e-72,
Organism=Caenorhabditis elegans, GI32564660, Length=441, Percent_Identity=32.4263038548753, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI25144274, Length=258, Percent_Identity=39.1472868217054, Blast_Score=191, Evalue=6e-49,
Organism=Caenorhabditis elegans, GI71992977, Length=422, Percent_Identity=30.5687203791469, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17541228, Length=446, Percent_Identity=26.0089686098655, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71981843, Length=164, Percent_Identity=36.5853658536585, Blast_Score=104, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6323470, Length=406, Percent_Identity=34.9753694581281, Blast_Score=255, Evalue=8e-69,
Organism=Saccharomyces cerevisiae, GI6324432, Length=401, Percent_Identity=33.9152119700748, Blast_Score=235, Evalue=1e-62,
Organism=Saccharomyces cerevisiae, GI6321456, Length=373, Percent_Identity=26.8096514745308, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324386, Length=447, Percent_Identity=24.1610738255034, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357415, Length=388, Percent_Identity=39.1752577319588, Blast_Score=275, Evalue=4e-74,
Organism=Drosophila melanogaster, GI28574759, Length=427, Percent_Identity=31.615925058548, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI161085790, Length=428, Percent_Identity=31.3084112149533, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI21356575, Length=415, Percent_Identity=32.5301204819277, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI281366494, Length=434, Percent_Identity=23.7327188940092, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667139, Length=434, Percent_Identity=23.7327188940092, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24667143, Length=434, Percent_Identity=23.7327188940092, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 43325; Mature: 43325

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS00599 AA_TRANSFER_CLASS_2 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSADWIAKGDKYIMKTYGRYPLVPVRGEGCRVWDADGKEYLDFLAGVAVNNLGHCHPKV
CCCCCCCCCCCHHHHHHCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHCCCCCCHHH
VAALQKQAAEMIHCSNYYNIPTQIELAELLCSNSFADKAFFCNSGAEANEAAIKLARKYA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHH
REKTGDVERYEIITAIASFHGRTMATISATGQEKVQKFFDPLLHGFTYVPFDDADALEAA
HHCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCEECCCCCCHHHHHH
VTPKTCAVMLEPIQGEGGVVIPSADYFRKVREICDRHGLLLIFDEVQVGIGRTGKLFAHE
CCCHHHHHEEECCCCCCCEEECCHHHHHHHHHHHHCCCEEEEEECCHHCCCCCCCEEEEC
HFDVTPDIMTLAKALAGGAPIGSMLAKDEVAASFSPGTHGSTFGGNPLVTAAGVAAVRAV
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LEEGLLNRAEEMGEYLVGELERLKEKYAFITDVRGIGLMIGMELSAPAGEIVLKGLERGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCC
LLNVAQDKVLRFVPPLIVTKQEVNEMIAVLDGILEEIKQ
EEEHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSADWIAKGDKYIMKTYGRYPLVPVRGEGCRVWDADGKEYLDFLAGVAVNNLGHCHPKV
CCCCCCCCCCCHHHHHHCCCCCEEEECCCCCEEECCCCHHHHHHHHHHHHHCCCCCCHHH
VAALQKQAAEMIHCSNYYNIPTQIELAELLCSNSFADKAFFCNSGAEANEAAIKLARKYA
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHH
REKTGDVERYEIITAIASFHGRTMATISATGQEKVQKFFDPLLHGFTYVPFDDADALEAA
HHCCCCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHCCEECCCCCCHHHHHH
VTPKTCAVMLEPIQGEGGVVIPSADYFRKVREICDRHGLLLIFDEVQVGIGRTGKLFAHE
CCCHHHHHEEECCCCCCCEEECCHHHHHHHHHHHHCCCEEEEEECCHHCCCCCCCEEEEC
HFDVTPDIMTLAKALAGGAPIGSMLAKDEVAASFSPGTHGSTFGGNPLVTAAGVAAVRAV
CCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LEEGLLNRAEEMGEYLVGELERLKEKYAFITDVRGIGLMIGMELSAPAGEIVLKGLERGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCC
LLNVAQDKVLRFVPPLIVTKQEVNEMIAVLDGILEEIKQ
EEEHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]