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The map label for this gene is argB

Identifier: 78221427

GI number: 78221427

Start: 236320

End: 237198

Strand: Direct

Name: argB

Synonym: Gmet_0203

Alternate gene names: 78221427

Gene position: 236320-237198 (Clockwise)

Preceding gene: 78221426

Following gene: 78221428

Centisome position: 5.91

GC content: 61.89

Gene sequence:

>879_bases
GTGCAGCATCTCATCGAAAAGGCCAACACCCTCATGGAGGCGCTCCCCTACATCCGGCGCTTCTCCGGCAAGACCATCGT
CATCAAGTACGGCGGCCACGCCATGTCCGACGAGGCCCTGAAAAAGTCCTTCGCCCTCGACGTCATCCTTCTCAAATCCC
TCGGCATCAACACCGTCGTGGTTCACGGCGGAGGCCCCCAGATCAACGAGACCCTCAAACGCTACGGTATCGTCTCCGAA
TTCGTGCGGGGGATGCGTGTCACCGACGCCGCCACCATGCAGGTGGTGGAGATGGTTCTCACCGGTCAGGTCAACAAGGA
AGTGGTGGGGTACCTGAACCAGCATGGCGGCCGGGCCGTGGGTCTCTCCGGCAAGGACGGCAGTCTCCTTCTCTGTCGGA
AGCTTCTCCAGGAGGTGAAGCAGGGCGACGGTTCCCTGGAGAAGGTGGACATCGGCTTCGTAGGGGACGTGGTCAAGGTG
AACCAGGAACTGATCCAGACCCTGGAGCACGGCAAGTTCATTCCGGTCATCGCCCCGGTGGGCGTAGGGGAGGATGGCGA
AAGCTACAACGTGAACGCGGATCTCGTGGCGGGCCGGGTGGCTGGGGCACTCAAGGCCGAGAAACTGATCCTTCTCACCG
ACGTGGAGGGGGTCAAGGACAAGGCGGGAGAGCTGATCCCCGGCATCGTCCTGGATGACGTTCCGCGACTCATCGACGGT
GGCGTCATCACCGGCGGGATGATCCCCAAGGTCACCTGCTGTGTCGACGCCATCGAGGAGGGGGTCAAGAAGGCCTCCAT
CATCGACGGCCGGGTTCTCCACGCGGTTCTCCTCGAAATTTTCACTGACGTTGGCGTCGGGACCGAGATCCGACGATAG

Upstream 100 bases:

>100_bases
ACCCGCCTTTCGTATTGATTATTTCCCCCTATCTGCTATAGTTGCACCTTTCTTGAGCCCCTTCCGGCACCACTTTCCGA
CGAACGGGAGGTTCAACCGC

Downstream 100 bases:

>100_bases
GCATGGGGTGGAAAACAGTGCCACGGGACGAAAATTTGGAGGAAATGCGAATGAAATCTGCTGATTGGATAGCAAAGGGC
GACAAATACATCATGAAGAC

Product: acetylglutamate kinase

Products: NA

Alternate protein names: N-acetyl-L-glutamate 5-phosphotransferase; NAG kinase; AGK

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MQHLIEKANTLMEALPYIRRFSGKTIVIKYGGHAMSDEALKKSFALDVILLKSLGINTVVVHGGGPQINETLKRYGIVSE
FVRGMRVTDAATMQVVEMVLTGQVNKEVVGYLNQHGGRAVGLSGKDGSLLLCRKLLQEVKQGDGSLEKVDIGFVGDVVKV
NQELIQTLEHGKFIPVIAPVGVGEDGESYNVNADLVAGRVAGALKAEKLILLTDVEGVKDKAGELIPGIVLDDVPRLIDG
GVITGGMIPKVTCCVDAIEEGVKKASIIDGRVLHAVLLEIFTDVGVGTEIRR

Sequences:

>Translated_292_residues
MQHLIEKANTLMEALPYIRRFSGKTIVIKYGGHAMSDEALKKSFALDVILLKSLGINTVVVHGGGPQINETLKRYGIVSE
FVRGMRVTDAATMQVVEMVLTGQVNKEVVGYLNQHGGRAVGLSGKDGSLLLCRKLLQEVKQGDGSLEKVDIGFVGDVVKV
NQELIQTLEHGKFIPVIAPVGVGEDGESYNVNADLVAGRVAGALKAEKLILLTDVEGVKDKAGELIPGIVLDDVPRLIDG
GVITGGMIPKVTCCVDAIEEGVKKASIIDGRVLHAVLLEIFTDVGVGTEIRR
>Mature_292_residues
MQHLIEKANTLMEALPYIRRFSGKTIVIKYGGHAMSDEALKKSFALDVILLKSLGINTVVVHGGGPQINETLKRYGIVSE
FVRGMRVTDAATMQVVEMVLTGQVNKEVVGYLNQHGGRAVGLSGKDGSLLLCRKLLQEVKQGDGSLEKVDIGFVGDVVKV
NQELIQTLEHGKFIPVIAPVGVGEDGESYNVNADLVAGRVAGALKAEKLILLTDVEGVKDKAGELIPGIVLDDVPRLIDG
GVITGGMIPKVTCCVDAIEEGVKKASIIDGRVLHAVLLEIFTDVGVGTEIRR

Specific function: Arginine biosynthesis; first step. [C]

COG id: COG0548

COG function: function code E; Acetylglutamate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetylglutamate kinase family

Homologues:

Organism=Escherichia coli, GI1789181, Length=287, Percent_Identity=28.9198606271777, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI145693208, Length=267, Percent_Identity=32.9588014981273, Blast_Score=101, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6320913, Length=298, Percent_Identity=29.1946308724832, Blast_Score=89, Evalue=8e-19,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ARGB_GEOMG (Q39Z75)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383174.1
- HSSP:   Q9HTN2
- ProteinModelPortal:   Q39Z75
- SMR:   Q39Z75
- STRING:   Q39Z75
- GeneID:   3739665
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0203
- NMPDR:   fig|269799.3.peg.234
- eggNOG:   COG0548
- HOGENOM:   HBG497643
- OMA:   MDIVEMV
- PhylomeDB:   Q39Z75
- ProtClustDB:   PRK00942
- BioCyc:   GMET269799:GMET_0203-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00082_B
- InterPro:   IPR004662
- InterPro:   IPR001048
- InterPro:   IPR001057
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF000728
- PRINTS:   PR00474
- TIGRFAMs:   TIGR00761

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.2.8

Molecular weight: Translated: 31171; Mature: 31171

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: BINDING 86-86 BINDING 190-190

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHLIEKANTLMEALPYIRRFSGKTIVIKYGGHAMSDEALKKSFALDVILLKSLGINTVV
CHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VHGGGPQINETLKRYGIVSEFVRGMRVTDAATMQVVEMVLTGQVNKEVVGYLNQHGGRAV
EECCCCCHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEE
GLSGKDGSLLLCRKLLQEVKQGDGSLEKVDIGFVGDVVKVNQELIQTLEHGKFIPVIAPV
ECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEEC
GVGEDGESYNVNADLVAGRVAGALKAEKLILLTDVEGVKDKAGELIPGIVLDDVPRLIDG
CCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHCC
GVITGGMIPKVTCCVDAIEEGVKKASIIDGRVLHAVLLEIFTDVGVGTEIRR
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MQHLIEKANTLMEALPYIRRFSGKTIVIKYGGHAMSDEALKKSFALDVILLKSLGINTVV
CHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEE
VHGGGPQINETLKRYGIVSEFVRGMRVTDAATMQVVEMVLTGQVNKEVVGYLNQHGGRAV
EECCCCCHHHHHHHHCHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEE
GLSGKDGSLLLCRKLLQEVKQGDGSLEKVDIGFVGDVVKVNQELIQTLEHGKFIPVIAPV
ECCCCCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEEEC
GVGEDGESYNVNADLVAGRVAGALKAEKLILLTDVEGVKDKAGELIPGIVLDDVPRLIDG
CCCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCCCHHHHHCCCCCCHHHHHHHHHHCC
GVITGGMIPKVTCCVDAIEEGVKKASIIDGRVLHAVLLEIFTDVGVGTEIRR
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA