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The map label for this gene is glmS [H]

Identifier: 78221331

GI number: 78221331

Start: 129995

End: 131824

Strand: Direct

Name: glmS [H]

Synonym: Gmet_0104

Alternate gene names: 78221331

Gene position: 129995-131824 (Clockwise)

Preceding gene: 78221330

Following gene: 78221340

Centisome position: 3.25

GC content: 65.3

Gene sequence:

>1830_bases
ATGTGCGGAATCGTCGGCTATATCGGCGCCCAGGAGGCGACACCCATCATCCTCGACGGACTCAAGCGCCTTGAGTACCG
GGGGTACGACTCCGCCGGGGTCTGCACCCTCGATGCCGGCCGGGCCAAGGTACGGCGGAGCGAAGGGAAGCTCTTCAACC
TGGAGCGTCTCGTGGCGGCCCAGCCCCTGCTGGGGCGGATCGGCATCGGCCACACCCGCTGGGCCACCCACGGCAGACCC
TCCGAGATCAACGCCCATCCCCACCAGGCGGGCTCCGTCATCGTGGTCCACAACGGCATCATCGAGAACTATCTGGAGTT
GCGGGAACGGCTGAGGGGAACCGGCCGGGAGTTCCTGAGCGAAACCGACACGGAGGTGATTTCCCACCTCATCGACGAGA
AGTATGGGGCCTGCGGCGACTTCGAGCGCGCCACCCGGCAGGCCCTGGCGGAGCTGCGGGGGGCCTACGCCGTCTGCGTC
CTCTGCGAAAAGGAACCGGGGGTCCTCATCGCCGCCAAGCAGGGCTCCCCCATGGTGGTGGGGCTCGGCACCGGCGAGTT
CTTCGTGGCCTCGGACATCCCCGCCATCCTCTCCCACACCCGGGAGATGGTCTTTCTCGATGACGGGGAGATGGTCGTCT
TCCGCGACGGCACCCCCTCCTTCAGCCGGGTGAGCGGCGAGCCGCTGGAAAAGGCCTCCCGCCACATCGACTGGTCTCCC
CTCATGGCCGAGAAGGGGGGATACAAGCACTTCATGCTCAAGGAAATCTTCGAGCAGCCCCGGGCAGTCCGCGACACCAT
CGCCGGCCGGCTCCGGGAGGAGCAGGGAGATGTCTACCTCGAAGACCTGAAACTCACCGATGAGGAGCTCAGGGGCATTG
ACCGGATCTGCATCATCGCCTGCGGCACCTCGTGGCACGCGGCCCTGGTGGGAAAGTTCCTCCTGGAAGAACACTGCCGC
CTCCCGGTGGAGGTGGACATCGCCTCCGAATTCCGCTACCGCAACCCGGTGGTGAACGACCGGACCCTCATGGTTCTCAT
CTCCCAGTCGGGAGAGACCGCCGACACCCTGGCCGCCATGCGCGAGGGAAAAGCGCGGGGGGCCAGGAACATCGCCATCT
GCAATGTGGTTGACTCCTCCATCGCCCGTGAGGCCGCGGGGGTCGTCTACACCCACGCGGGACCCGAAATTGGCGTCGCC
TCCACCAAGGCATTCGTTACCCAGTTGGTGGCCCTCTACCTCTTCACCATCCGGCTCGGCCGGGCACTGGGCACCCTGGA
CCAGGCCAAGGGGCGCGCCATGATCGGCGAGCTCGTGAAGATCCCCGCCCTCCTCGAAAAGACCCTGGAGATGAACGACA
CGGTGGAGAAGGTGGCCCGCCGCTACATGAACGCCCGGGATTTCCTCTACCTGGGGCGCGGCGTCTGCTACCCCATCGCC
CTGGAAGGCGCCCTGAAGCTCAAGGAGATTTCCTACATCCACGCCGAGGGATACCCCGCCGGCGAGATGAAGCACGGCCC
CATCGCCCTCATCGACGAAAACATGCCGGTGGTGGTCCTCGTGCCGAAGAACTCCACCTACGAGAAGGTTCTCTCCAACA
TGGAGGAAGTCATTGCCCGGGGGGGAAGGGTCATCGCCATTTGTTCCTCCGGCGACGACGGCGTTAGCCAGAAGGCTGAG
GAGACCCTCGAAGTCCCCTCAGACGGCGAGGAACTGGCGACGATCCTCTTGTCGGTCCCGCTCCAACTCCTGGCGTACCA
CGTGGCCGTTCTCAAGGGAACCGACGTGGATCAGCCCCGGAACCTGGCCAAGAGCGTGACCGTGGAATAG

Upstream 100 bases:

>100_bases
GGCCATTGCCCGGGCCCCCCAGGTGAACAAGGACGGGTGGAAACTCAAACAGCGGGATCAGTGACCCCTTTTTATCCATT
TACTAACGGAGATTGAGACT

Downstream 100 bases:

>100_bases
CGGTTGACTACTAGAAACAGCCAAGCTGGCACTGCCGGATCTTATACCTCTTGCTATTGGCCGCGTTCGCGACGGACATC
GGCTTTACGTTCAGTTCGTT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 609; Mature: 609

Protein sequence:

>609_residues
MCGIVGYIGAQEATPIILDGLKRLEYRGYDSAGVCTLDAGRAKVRRSEGKLFNLERLVAAQPLLGRIGIGHTRWATHGRP
SEINAHPHQAGSVIVVHNGIIENYLELRERLRGTGREFLSETDTEVISHLIDEKYGACGDFERATRQALAELRGAYAVCV
LCEKEPGVLIAAKQGSPMVVGLGTGEFFVASDIPAILSHTREMVFLDDGEMVVFRDGTPSFSRVSGEPLEKASRHIDWSP
LMAEKGGYKHFMLKEIFEQPRAVRDTIAGRLREEQGDVYLEDLKLTDEELRGIDRICIIACGTSWHAALVGKFLLEEHCR
LPVEVDIASEFRYRNPVVNDRTLMVLISQSGETADTLAAMREGKARGARNIAICNVVDSSIAREAAGVVYTHAGPEIGVA
STKAFVTQLVALYLFTIRLGRALGTLDQAKGRAMIGELVKIPALLEKTLEMNDTVEKVARRYMNARDFLYLGRGVCYPIA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDENMPVVVLVPKNSTYEKVLSNMEEVIARGGRVIAICSSGDDGVSQKAE
ETLEVPSDGEELATILLSVPLQLLAYHVAVLKGTDVDQPRNLAKSVTVE

Sequences:

>Translated_609_residues
MCGIVGYIGAQEATPIILDGLKRLEYRGYDSAGVCTLDAGRAKVRRSEGKLFNLERLVAAQPLLGRIGIGHTRWATHGRP
SEINAHPHQAGSVIVVHNGIIENYLELRERLRGTGREFLSETDTEVISHLIDEKYGACGDFERATRQALAELRGAYAVCV
LCEKEPGVLIAAKQGSPMVVGLGTGEFFVASDIPAILSHTREMVFLDDGEMVVFRDGTPSFSRVSGEPLEKASRHIDWSP
LMAEKGGYKHFMLKEIFEQPRAVRDTIAGRLREEQGDVYLEDLKLTDEELRGIDRICIIACGTSWHAALVGKFLLEEHCR
LPVEVDIASEFRYRNPVVNDRTLMVLISQSGETADTLAAMREGKARGARNIAICNVVDSSIAREAAGVVYTHAGPEIGVA
STKAFVTQLVALYLFTIRLGRALGTLDQAKGRAMIGELVKIPALLEKTLEMNDTVEKVARRYMNARDFLYLGRGVCYPIA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDENMPVVVLVPKNSTYEKVLSNMEEVIARGGRVIAICSSGDDGVSQKAE
ETLEVPSDGEELATILLSVPLQLLAYHVAVLKGTDVDQPRNLAKSVTVE
>Mature_609_residues
MCGIVGYIGAQEATPIILDGLKRLEYRGYDSAGVCTLDAGRAKVRRSEGKLFNLERLVAAQPLLGRIGIGHTRWATHGRP
SEINAHPHQAGSVIVVHNGIIENYLELRERLRGTGREFLSETDTEVISHLIDEKYGACGDFERATRQALAELRGAYAVCV
LCEKEPGVLIAAKQGSPMVVGLGTGEFFVASDIPAILSHTREMVFLDDGEMVVFRDGTPSFSRVSGEPLEKASRHIDWSP
LMAEKGGYKHFMLKEIFEQPRAVRDTIAGRLREEQGDVYLEDLKLTDEELRGIDRICIIACGTSWHAALVGKFLLEEHCR
LPVEVDIASEFRYRNPVVNDRTLMVLISQSGETADTLAAMREGKARGARNIAICNVVDSSIAREAAGVVYTHAGPEIGVA
STKAFVTQLVALYLFTIRLGRALGTLDQAKGRAMIGELVKIPALLEKTLEMNDTVEKVARRYMNARDFLYLGRGVCYPIA
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDENMPVVVLVPKNSTYEKVLSNMEEVIARGGRVIAICSSGDDGVSQKAE
ETLEVPSDGEELATILLSVPLQLLAYHVAVLKGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=683, Percent_Identity=38.7994143484627, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI205277386, Length=682, Percent_Identity=37.683284457478, Blast_Score=444, Evalue=1e-124,
Organism=Escherichia coli, GI1790167, Length=612, Percent_Identity=47.8758169934641, Blast_Score=552, Evalue=1e-158,
Organism=Escherichia coli, GI1788651, Length=244, Percent_Identity=29.0983606557377, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI87082251, Length=314, Percent_Identity=24.5222929936306, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17539970, Length=438, Percent_Identity=41.324200913242, Blast_Score=316, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI17532899, Length=439, Percent_Identity=40.0911161731207, Blast_Score=307, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17532897, Length=439, Percent_Identity=40.0911161731207, Blast_Score=306, Evalue=2e-83,
Organism=Saccharomyces cerevisiae, GI6322745, Length=448, Percent_Identity=41.0714285714286, Blast_Score=311, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6323731, Length=428, Percent_Identity=31.5420560747664, Blast_Score=220, Evalue=4e-58,
Organism=Saccharomyces cerevisiae, GI6323730, Length=208, Percent_Identity=34.1346153846154, Blast_Score=114, Evalue=4e-26,
Organism=Drosophila melanogaster, GI21357745, Length=685, Percent_Identity=38.6861313868613, Blast_Score=455, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 66635; Mature: 66635

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGYIGAQEATPIILDGLKRLEYRGYDSAGVCTLDAGRAKVRRSEGKLFNLERLVAA
CCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHCCCCEECHHHHHHC
QPLLGRIGIGHTRWATHGRPSEINAHPHQAGSVIVVHNGIIENYLELRERLRGTGREFLS
CCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHH
ETDTEVISHLIDEKYGACGDFERATRQALAELRGAYAVCVLCEKEPGVLIAAKQGSPMVV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEE
GLGTGEFFVASDIPAILSHTREMVFLDDGEMVVFRDGTPSFSRVSGEPLEKASRHIDWSP
EECCCCEEEECCCHHHHHCCCEEEEEECCCEEEEECCCCCHHHCCCCCHHHHHCCCCCCC
LMAEKGGYKHFMLKEIFEQPRAVRDTIAGRLREEQGDVYLEDLKLTDEELRGIDRICIIA
HHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCEEEEEE
CGTSWHAALVGKFLLEEHCRLPVEVDIASEFRYRNPVVNDRTLMVLISQSGETADTLAAM
ECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHH
REGKARGARNIAICNVVDSSIAREAAGVVYTHAGPEIGVASTKAFVTQLVALYLFTIRLG
HHCCCCCCCCEEEEEHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RALGTLDQAKGRAMIGELVKIPALLEKTLEMNDTVEKVARRYMNARDFLYLGRGVCYPIA
HHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHEEECCCCEEEEE
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDENMPVVVLVPKNSTYEKVLSNMEEVIAR
ECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHC
GGRVIAICSSGDDGVSQKAEETLEVPSDGEELATILLSVPLQLLAYHVAVLKGTDVDQPR
CCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC
>Mature Secondary Structure
MCGIVGYIGAQEATPIILDGLKRLEYRGYDSAGVCTLDAGRAKVRRSEGKLFNLERLVAA
CCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEECCHHHHHHCCCCEECHHHHHHC
QPLLGRIGIGHTRWATHGRPSEINAHPHQAGSVIVVHNGIIENYLELRERLRGTGREFLS
CCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCHHHHHH
ETDTEVISHLIDEKYGACGDFERATRQALAELRGAYAVCVLCEKEPGVLIAAKQGSPMVV
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEECCCCCEEE
GLGTGEFFVASDIPAILSHTREMVFLDDGEMVVFRDGTPSFSRVSGEPLEKASRHIDWSP
EECCCCEEEECCCHHHHHCCCEEEEEECCCEEEEECCCCCHHHCCCCCHHHHHCCCCCCC
LMAEKGGYKHFMLKEIFEQPRAVRDTIAGRLREEQGDVYLEDLKLTDEELRGIDRICIIA
HHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCEEEEEE
CGTSWHAALVGKFLLEEHCRLPVEVDIASEFRYRNPVVNDRTLMVLISQSGETADTLAAM
ECCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHCCCCCCCCEEEEEEECCCCHHHHHHHH
REGKARGARNIAICNVVDSSIAREAAGVVYTHAGPEIGVASTKAFVTQLVALYLFTIRLG
HHCCCCCCCCEEEEEHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHH
RALGTLDQAKGRAMIGELVKIPALLEKTLEMNDTVEKVARRYMNARDFLYLGRGVCYPIA
HHHCCHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHEEECCCCEEEEE
LEGALKLKEISYIHAEGYPAGEMKHGPIALIDENMPVVVLVPKNSTYEKVLSNMEEVIAR
ECCCEEEEHEEEEEECCCCCCCCCCCCEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHC
GGRVIAICSSGDDGVSQKAEETLEVPSDGEELATILLSVPLQLLAYHVAVLKGTDVDQPR
CCCEEEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
NLAKSVTVE
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA