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The map label for this gene is glmU

Identifier: 78221330

GI number: 78221330

Start: 128528

End: 129958

Strand: Direct

Name: glmU

Synonym: Gmet_0103

Alternate gene names: 78221330

Gene position: 128528-129958 (Clockwise)

Preceding gene: 78221326

Following gene: 78221331

Centisome position: 3.22

GC content: 66.88

Gene sequence:

>1431_bases
ATGGGCGATCTTGCGGCGATAATCCTTGCCGCCGGCAAGGGAACGAGAATGAAATCCGATCTGGTCAAGGTGATGCATCC
CCTGGCCGGCGCACCGATGGTCGCGTGGCCAGTGGAGGCGGCCCGGCAGGCGGGGACGTCCCGCATGGTGCTGGTGGTCG
GCCACCAGGCGGACACCATTCGTGAGCACTTCGCAGGAACAGAACAGGTAGCCTTTGCCCTCCAGGAGGAACAACTCGGC
ACCGGTCACGCCGTGGCCAGCGCCGCCGCGGCCCTCGACGGCTTTACGGGGAGAGTCCTCATCCTCTGCGGCGACGTCCC
CCTTATCCGGCCCGAGACGCTCCGGGGGATGATCGACGCCCACGGGGCCACCGGTGCGGCCCTCACGGTCCTCACCACGC
GTCTTGAAAACCCCTTCGGCTACGGCCGGATCATCCGCGGCTTTGACGGCCGGGTCATCCGGATCGTCGAGGAGAAGGAT
GCGACTCCCGAGGAGCGGGGCCGCAGAGAGGTAAACGCCGGCATCTACTGCGCCGAGGCGGCGTTTCTCTTCGACGCGGT
CACGCGGATCGGCAACGACAACGCCCAGGGGGAATACTACCTCACCGACATCGTCACCATGGCCAACGAGCAGGGGCTCC
GCTGCACCGCCCATCCCGTGGCCGACCCGGTTGAGGTCATGGGGGTGAACGACCGGGCCCAGCTGGCCGAAGCGGGGCGG
TTTGCCCGGCAGCGGATCAACCGGGAGCTCATGCTCGACGGCGTGACCATCGTGGATCCGGCCGCCACCTACATCGACCG
GGGGGCTGTCGTGGGGCGCGACACCACGGTCCATCCGGGAGTCCACCTCTCCGGCGAGACCCGGATCGGCGAAGGGTGCA
CCATCGAACAGGGGGCCGTCATCAAGGGGAGCACCCTCGGCAACGGCTGCGTCGTGGAACCGGGGGCCGTCATCCGGAGC
TGCCGCCTCGGGAGCCACGTCATGGTGAAGGCCGGCTCCGTCATGGAGGATGCGATCATCCACGACCACACGGCCATCGG
CCCCATGGCGCACCTCAGGCCCGGAACCGAACTCATGGCCCACGTGAAGATCGGCAACTTCGTCGAAACCAAGAAAATCA
CCATGGGCGAAGGCTCCAAGGCCTCCCACCTCACCTACCTGGGTGACGCCTCCATCGGCAACAACGTCAACGTTGGATGC
GGCACCATTACCTGCAACTACGACGGGGTGCGCAAGCACCGCACCGTCATCGAGGACGACGTCTTCGTGGGAAGCGACGT
CCAGTTCGTGGCGCCCGTCACCGTCGGGCGGAACTCCCTCATCGCCGCCGGCACCACGGTGACCCGGGATGTCCCCCCCG
ACTCCCTGGCCATTGCCCGGGCCCCCCAGGTGAACAAGGACGGGTGGAAACTCAAACAGCGGGATCAGTGA

Upstream 100 bases:

>100_bases
GCTTCCCGTTGCACCCGTCTATTCGCTTGACGTCCGCGCGGGGCATCGTATAGAGTAAATGGTTTCAAATCCAATGATTT
CTCCTCAAAGGAGGGCCGTC

Downstream 100 bases:

>100_bases
CCCCTTTTTATCCATTTACTAACGGAGATTGAGACTATGTGCGGAATCGTCGGCTATATCGGCGCCCAGGAGGCGACACC
CATCATCCTCGACGGACTCA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MGDLAAIILAAGKGTRMKSDLVKVMHPLAGAPMVAWPVEAARQAGTSRMVLVVGHQADTIREHFAGTEQVAFALQEEQLG
TGHAVASAAAALDGFTGRVLILCGDVPLIRPETLRGMIDAHGATGAALTVLTTRLENPFGYGRIIRGFDGRVIRIVEEKD
ATPEERGRREVNAGIYCAEAAFLFDAVTRIGNDNAQGEYYLTDIVTMANEQGLRCTAHPVADPVEVMGVNDRAQLAEAGR
FARQRINRELMLDGVTIVDPAATYIDRGAVVGRDTTVHPGVHLSGETRIGEGCTIEQGAVIKGSTLGNGCVVEPGAVIRS
CRLGSHVMVKAGSVMEDAIIHDHTAIGPMAHLRPGTELMAHVKIGNFVETKKITMGEGSKASHLTYLGDASIGNNVNVGC
GTITCNYDGVRKHRTVIEDDVFVGSDVQFVAPVTVGRNSLIAAGTTVTRDVPPDSLAIARAPQVNKDGWKLKQRDQ

Sequences:

>Translated_476_residues
MGDLAAIILAAGKGTRMKSDLVKVMHPLAGAPMVAWPVEAARQAGTSRMVLVVGHQADTIREHFAGTEQVAFALQEEQLG
TGHAVASAAAALDGFTGRVLILCGDVPLIRPETLRGMIDAHGATGAALTVLTTRLENPFGYGRIIRGFDGRVIRIVEEKD
ATPEERGRREVNAGIYCAEAAFLFDAVTRIGNDNAQGEYYLTDIVTMANEQGLRCTAHPVADPVEVMGVNDRAQLAEAGR
FARQRINRELMLDGVTIVDPAATYIDRGAVVGRDTTVHPGVHLSGETRIGEGCTIEQGAVIKGSTLGNGCVVEPGAVIRS
CRLGSHVMVKAGSVMEDAIIHDHTAIGPMAHLRPGTELMAHVKIGNFVETKKITMGEGSKASHLTYLGDASIGNNVNVGC
GTITCNYDGVRKHRTVIEDDVFVGSDVQFVAPVTVGRNSLIAAGTTVTRDVPPDSLAIARAPQVNKDGWKLKQRDQ
>Mature_475_residues
GDLAAIILAAGKGTRMKSDLVKVMHPLAGAPMVAWPVEAARQAGTSRMVLVVGHQADTIREHFAGTEQVAFALQEEQLGT
GHAVASAAAALDGFTGRVLILCGDVPLIRPETLRGMIDAHGATGAALTVLTTRLENPFGYGRIIRGFDGRVIRIVEEKDA
TPEERGRREVNAGIYCAEAAFLFDAVTRIGNDNAQGEYYLTDIVTMANEQGLRCTAHPVADPVEVMGVNDRAQLAEAGRF
ARQRINRELMLDGVTIVDPAATYIDRGAVVGRDTTVHPGVHLSGETRIGEGCTIEQGAVIKGSTLGNGCVVEPGAVIRSC
RLGSHVMVKAGSVMEDAIIHDHTAIGPMAHLRPGTELMAHVKIGNFVETKKITMGEGSKASHLTYLGDASIGNNVNVGCG
TITCNYDGVRKHRTVIEDDVFVGSDVQFVAPVTVGRNSLIAAGTTVTRDVPPDSLAIARAPQVNKDGWKLKQRDQ

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Homo sapiens, GI11761621, Length=387, Percent_Identity=24.5478036175711, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI11761619, Length=361, Percent_Identity=25.7617728531856, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790168, Length=468, Percent_Identity=46.3675213675214, Blast_Score=377, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI133931050, Length=392, Percent_Identity=25.2551020408163, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_GEOMG (Q39ZH2)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_383077.1
- ProteinModelPortal:   Q39ZH2
- SMR:   Q39ZH2
- STRING:   Q39ZH2
- GeneID:   3738882
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_0103
- NMPDR:   fig|269799.3.peg.166
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- PhylomeDB:   Q39ZH2
- ProtClustDB:   PRK14355
- BioCyc:   GMET269799:GMET_0103-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 50517; Mature: 50386

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 383-383 BINDING 75-75 BINDING 142-142 BINDING 157-157 BINDING 172-172 BINDING 407-407 BINDING 425-425 BINDING 443-443 BINDING 460-460

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDLAAIILAAGKGTRMKSDLVKVMHPLAGAPMVAWPVEAARQAGTSRMVLVVGHQADTI
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHCCCCEEEEEECCCHHHH
REHFAGTEQVAFALQEEQLGTGHAVASAAAALDGFTGRVLILCGDVPLIRPETLRGMIDA
HHHHCCHHHHHEEEHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHC
HGATGAALTVLTTRLENPFGYGRIIRGFDGRVIRIVEEKDATPEERGRREVNAGIYCAEA
CCCCCHHHEEHHHHHCCCCCCCCEEECCCCEEEEEEECCCCCHHHHCCHHHCCCEEEHHH
AFLFDAVTRIGNDNAQGEYYLTDIVTMANEQGLRCTAHPVADPVEVMGVNDRAQLAEAGR
HHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCCCEEEECCCCCCCEEEECCCHHHHHHHHH
FARQRINRELMLDGVTIVDPAATYIDRGAVVGRDTTVHPGVHLSGETRIGEGCTIEQGAV
HHHHHCCHHEEECCEEEECCHHHHHHCCCEECCCCEECCCEEECCCCCCCCCCEECCCCE
IKGSTLGNGCVVEPGAVIRSCRLGSHVMVKAGSVMEDAIIHDHTAIGPMAHLRPGTELMA
EECCCCCCCCEECCHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCCCHHHCCCCHHEEE
HVKIGNFVETKKITMGEGSKASHLTYLGDASIGNNVNVGCGTITCNYDGVRKHRTVIEDD
EEEECCEEEEEEEEECCCCCCCEEEEEECCCCCCCCEECEEEEEECCCCCHHHHHEECCC
VFVGSDVQFVAPVTVGRNSLIAAGTTVTRDVPPDSLAIARAPQVNKDGWKLKQRDQ
EEECCCCEEEEEEEECCCCEEEECCEEECCCCCCCEEEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GDLAAIILAAGKGTRMKSDLVKVMHPLAGAPMVAWPVEAARQAGTSRMVLVVGHQADTI
CCEEEEEEECCCCCCHHHHHHHHHHHHCCCCEEEECHHHHHHCCCCEEEEEECCCHHHH
REHFAGTEQVAFALQEEQLGTGHAVASAAAALDGFTGRVLILCGDVPLIRPETLRGMIDA
HHHHCCHHHHHEEEHHHHCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHC
HGATGAALTVLTTRLENPFGYGRIIRGFDGRVIRIVEEKDATPEERGRREVNAGIYCAEA
CCCCCHHHEEHHHHHCCCCCCCCEEECCCCEEEEEEECCCCCHHHHCCHHHCCCEEEHHH
AFLFDAVTRIGNDNAQGEYYLTDIVTMANEQGLRCTAHPVADPVEVMGVNDRAQLAEAGR
HHHHHHHHHHCCCCCCCCEEEEEEHHHCCCCCCEEEECCCCCCCEEEECCCHHHHHHHHH
FARQRINRELMLDGVTIVDPAATYIDRGAVVGRDTTVHPGVHLSGETRIGEGCTIEQGAV
HHHHHCCHHEEECCEEEECCHHHHHHCCCEECCCCEECCCEEECCCCCCCCCCEECCCCE
IKGSTLGNGCVVEPGAVIRSCRLGSHVMVKAGSVMEDAIIHDHTAIGPMAHLRPGTELMA
EECCCCCCCCEECCHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCCCHHHCCCCHHEEE
HVKIGNFVETKKITMGEGSKASHLTYLGDASIGNNVNVGCGTITCNYDGVRKHRTVIEDD
EEEECCEEEEEEEEECCCCCCCEEEEEECCCCCCCCEECEEEEEECCCCCHHHHHEECCC
VFVGSDVQFVAPVTVGRNSLIAAGTTVTRDVPPDSLAIARAPQVNKDGWKLKQRDQ
EEECCCCEEEEEEEECCCCEEEECCEEECCCCCCCEEEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA