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The map label for this gene is menB [H]

Identifier: 78189675

GI number: 78189675

Start: 2233214

End: 2234035

Strand: Reverse

Name: menB [H]

Synonym: Cag_1719

Alternate gene names: 78189675

Gene position: 2234035-2233214 (Counterclockwise)

Preceding gene: 78189676

Following gene: 78189674

Centisome position: 86.86

GC content: 50.49

Gene sequence:

>822_bases
ATGAGCGCTATTGCATGGGTCGCCGCTGGCGAGTTTACTGATATTTTATACCACAAAGCTGAAGGCATTGCGAAAATCAC
CATTAACCGCCCCGAAGTGCGCAACGCTTTTCGTCCGCAAACGGTGGATGAAATGATTGAGGCGCTGCAAGATGCCCGTA
ATGATGCTGAAATTGGCGTTGTTATTCTAACGGGTCAAGGCGATTTAGCCTTTTGTTCGGGTGGCGATCAAAAAATTCGT
GGTTATGCAGGTTACGCCGATGGTAAGGGCGTTAACCGCTTGAACGTGCTCGACTTTCAGCGCGATATTCGTACCTGCCC
TAAGCCTGTGATTGCAATGGTGGCGGGTTACGCCATTGGTGGCGGGCATGTGCTGCACATGTTGTGCGATCTTACCATTG
CGGCTGAAAATGCTGTGTTTGGGCAAACAGGTCCGCGCGTTGGTTCCTTTGACGGAGGATGGGGCGCAAGCTACATGGCG
CGTCTTGTTGGGCAGAAAAAAGCTCGCGAAATATGGTTCCTCTGCCGCCAATACAATGCCGCTGAAGCGTTGCAGATGGG
ATTAGTAAATACCGTTGTGCCGCTTGAACGCCTTGAAGAGGAGACGGTGCAGTGGTGCCGCGAAATTCTTGCTAACTCTC
CACTTGCTATTCGCTGCTTAAAATCAGCCCTGAATGCTGATTGCGATGGTCAAGCTGGTTTGCAAGAGCTTGCGGGTAAC
GCCACCATGCTTTATTACATGACTGAAGAGGGGCAGGAAGGCAAAAATGCTTTTGTTGAAAAACGTAAACCCAACTTCAA
CAAATTCCCTCGCCGCCCATAA

Upstream 100 bases:

>100_bases
TCCATTGTGCCCAACTGTGGGCATACGCTTCACATTGAAAACAAGGAGAGTTTTGTGGAACAACTCCACACTTTTTTTAA
CCAATAACATTTGTAACCCT

Downstream 100 bases:

>100_bases
TGGAGCTGGAACTTTCTCTTTACCGCTATGCCATCCCTTTTACTGAGCCAATTACTGTGAAGCAGCAACGGCTTGTAATG
CGGGATGGCTTGGTGCTTGC

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSAIAWVAAGEFTDILYHKAEGIAKITINRPEVRNAFRPQTVDEMIEALQDARNDAEIGVVILTGQGDLAFCSGGDQKIR
GYAGYADGKGVNRLNVLDFQRDIRTCPKPVIAMVAGYAIGGGHVLHMLCDLTIAAENAVFGQTGPRVGSFDGGWGASYMA
RLVGQKKAREIWFLCRQYNAAEALQMGLVNTVVPLERLEEETVQWCREILANSPLAIRCLKSALNADCDGQAGLQELAGN
ATMLYYMTEEGQEGKNAFVEKRKPNFNKFPRRP

Sequences:

>Translated_273_residues
MSAIAWVAAGEFTDILYHKAEGIAKITINRPEVRNAFRPQTVDEMIEALQDARNDAEIGVVILTGQGDLAFCSGGDQKIR
GYAGYADGKGVNRLNVLDFQRDIRTCPKPVIAMVAGYAIGGGHVLHMLCDLTIAAENAVFGQTGPRVGSFDGGWGASYMA
RLVGQKKAREIWFLCRQYNAAEALQMGLVNTVVPLERLEEETVQWCREILANSPLAIRCLKSALNADCDGQAGLQELAGN
ATMLYYMTEEGQEGKNAFVEKRKPNFNKFPRRP
>Mature_272_residues
SAIAWVAAGEFTDILYHKAEGIAKITINRPEVRNAFRPQTVDEMIEALQDARNDAEIGVVILTGQGDLAFCSGGDQKIRG
YAGYADGKGVNRLNVLDFQRDIRTCPKPVIAMVAGYAIGGGHVLHMLCDLTIAAENAVFGQTGPRVGSFDGGWGASYMAR
LVGQKKAREIWFLCRQYNAAEALQMGLVNTVVPLERLEEETVQWCREILANSPLAIRCLKSALNADCDGQAGLQELAGNA
TMLYYMTEEGQEGKNAFVEKRKPNFNKFPRRP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=252, Percent_Identity=35.3174603174603, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI31542718, Length=264, Percent_Identity=31.0606060606061, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI4502327, Length=262, Percent_Identity=29.3893129770992, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI45643119, Length=221, Percent_Identity=28.5067873303167, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI260275230, Length=221, Percent_Identity=28.5067873303167, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI260274832, Length=221, Percent_Identity=28.5067873303167, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI70995211, Length=242, Percent_Identity=30.5785123966942, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4757966, Length=216, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI51538581, Length=216, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI25453481, Length=216, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI51538573, Length=216, Percent_Identity=25.9259259259259, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI37594469, Length=154, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI37594471, Length=154, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI4757968, Length=216, Percent_Identity=25.9259259259259, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI49355787, Length=216, Percent_Identity=25.9259259259259, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1788597, Length=275, Percent_Identity=76.7272727272727, Blast_Score=443, Evalue=1e-126,
Organism=Escherichia coli, GI1787659, Length=257, Percent_Identity=31.1284046692607, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI87082183, Length=254, Percent_Identity=32.2834645669291, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI221142681, Length=254, Percent_Identity=30.3149606299213, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787660, Length=264, Percent_Identity=29.1666666666667, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788682, Length=205, Percent_Identity=27.8048780487805, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25145438, Length=250, Percent_Identity=34.8, Blast_Score=123, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17554946, Length=249, Percent_Identity=32.5301204819277, Blast_Score=119, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17540714, Length=215, Percent_Identity=33.0232558139535, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17534483, Length=214, Percent_Identity=28.5046728971963, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17536985, Length=222, Percent_Identity=25.6756756756757, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17560910, Length=195, Percent_Identity=30.2564102564103, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17535521, Length=210, Percent_Identity=24.7619047619048, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17549921, Length=210, Percent_Identity=24.2857142857143, Blast_Score=70, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI25144157, Length=221, Percent_Identity=27.6018099547511, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25144160, Length=221, Percent_Identity=27.6018099547511, Blast_Score=68, Evalue=6e-12,
Organism=Drosophila melanogaster, GI20129971, Length=244, Percent_Identity=35.2459016393443, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24653477, Length=244, Percent_Identity=35.2459016393443, Blast_Score=118, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24653139, Length=277, Percent_Identity=29.6028880866426, Blast_Score=114, Evalue=5e-26,
Organism=Drosophila melanogaster, GI19922422, Length=269, Percent_Identity=25.2788104089219, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24654903, Length=200, Percent_Identity=29, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650670, Length=184, Percent_Identity=30.4347826086957, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 29919; Mature: 29787

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIAWVAAGEFTDILYHKAEGIAKITINRPEVRNAFRPQTVDEMIEALQDARNDAEIGV
CCCEEEEECCHHHHHHHHHCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHHCCCCCCEEE
VILTGQGDLAFCSGGDQKIRGYAGYADGKGVNRLNVLDFQRDIRTCPKPVIAMVAGYAIG
EEEECCCCEEEECCCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHCCC
GGHVLHMLCDLTIAAENAVFGQTGPRVGSFDGGWGASYMARLVGQKKAREIWFLCRQYNA
CHHHHHHHHHHHHEECCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
AEALQMGLVNTVVPLERLEEETVQWCREILANSPLAIRCLKSALNADCDGQAGLQELAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHCCC
ATMLYYMTEEGQEGKNAFVEKRKPNFNKFPRRP
CEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SAIAWVAAGEFTDILYHKAEGIAKITINRPEVRNAFRPQTVDEMIEALQDARNDAEIGV
CCEEEEECCHHHHHHHHHCCCEEEEEECCHHHHHCCCCCCHHHHHHHHHHCCCCCCEEE
VILTGQGDLAFCSGGDQKIRGYAGYADGKGVNRLNVLDFQRDIRTCPKPVIAMVAGYAIG
EEEECCCCEEEECCCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHCCHHHHHHHHHHCCC
GGHVLHMLCDLTIAAENAVFGQTGPRVGSFDGGWGASYMARLVGQKKAREIWFLCRQYNA
CHHHHHHHHHHHHEECCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
AEALQMGLVNTVVPLERLEEETVQWCREILANSPLAIRCLKSALNADCDGQAGLQELAGN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHCCC
ATMLYYMTEEGQEGKNAFVEKRKPNFNKFPRRP
CEEEEEECCCCCCCHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]