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The map label for this gene is ypdF [H]

Identifier: 78067845

GI number: 78067845

Start: 3541815

End: 3543779

Strand: Reverse

Name: ypdF [H]

Synonym: Bcep18194_A6376

Alternate gene names: 78067845

Gene position: 3543779-3541815 (Counterclockwise)

Preceding gene: 78067847

Following gene: 78067840

Centisome position: 95.93

GC content: 68.85

Gene sequence:

>1965_bases
ATGCGGGGTCGAGCGCCGACCGTGCAGCGGCGCCGTGCCGTGTCAGGCCTGCCTCGGGCTTGCTCCCCGCCGCGTCACCG
CCGGCCGCCGACAACAATGCATAACGGGCTTCCGATGATCGATCGACTGAAATACAGCTTCTCCGGCCTTCCCCCGTACG
ACGCGTCCGTCGCCGACACGCAGGCTGGTTTGTCGCGCCTGCTCGATACCGCGCGGCTCGACGCGGTGCTGGTCACGTCG
CAGGACGAATACGTGACCGAGTACCTGCCGCTCGCCAACAATCCGCGCTACGCGGTGTCGGGTTTCGACGGCTCGGCCGG
CTGCGGGATCTTCCTGAGCGCGGCGACCGCGCAGGCGCTCGATCTGCCCCCGTTCGTCCTGTTCGTCGATGGCCGCTATC
ACCTGCAGGCCGAGCAGCAGTGCGATCCGGCGCGCGTGCGCATCGAGAAGCTCGGGATGAACGTGACGATCTGGCAGGCG
ATGGCCGACTGGCTGGTCGCGCACGGCAGCCGGCTCGCACGGGTCGGCTACGATGCGCTGCGGATCAGCGTCGGGCAGCG
CGATCGCCTGTTCGAACAGACGCAGGCCGCATCGCTCGACTGGACGAGCCTCGCCGACCGGGAAATCGATCGCGCGATCG
CGTTGCCGGGCTGGGTCGTCGAGCGGCCGATCTTCGAAGTGCCGGAATCGGCGACCGGCCTGAGCGTCGCGCAGAACCTC
GACACGCTGAACCGCCAGCTCGCCGCGCATACCGGCGCGCCGGACGGCAAGACGGCGTTTTTCTCCTGCGCGTCGGACGA
CCTCGCGTATCTGCTGAACAGCCGCGGCTATCACATCCCGAATGCGTCGTCGCACCTCGGCTTCCTGTTCACGGTCGGCC
AGCAGGTGGCGTTGTTCCTGCCGGAAGGCTGCGACCGCTGCGAAGTCACGCTCGCGTCGTATCCGGCGCTGCACGTGATC
CGGCGCGATGTCGCGGCGCTCGAGCGCTTTCTCGCCCAGTTCGACGTCGAGCACGTGTGCTACGGCTACGAATCGGTGAA
CTGCGCGCTCGTCGACGCGGTGAAGCGGGTGTGGCCTCAGGCGCAGCATGCCGACTTCAACCCGGTCGAGGCGATGCGGG
CCGGCAAGACGCCGGCGGTGCTCGACCGGTTTCGCGACGCGTTCGCGCGCAGCTCCGCGGCGATCGCCGAGACGATGCGC
TGGGCGAAGGCCGGCGAGCCGGGCACGCGCCACACCGAATACGACCTGGCGCGCACGATCAACGACGCATACGGCGCACG
CTCGGCGGTGGCGCTGACGTTTCCGTCGATCGCGGCGAACGGCGCGAACAGCGCGTTCGCGCACTACACGGCGGCGAGCG
CCGACGTCGAGCTGACGGAAGGCGAACTCGTGCTGCTCGACAGCGGCGCCTATTACGAAGCCGGCTTCGCGACGGATTGC
ACGCGCGTGGTGCTGCGCCGGACCGACCCGGATACGGTCGCGCAGCCGTGGCAGCGCGAGATCTACACGGTCGCGCTGAA
GGCCTGCATCAAGGGGCTCGTCACGCGCTTCCCGAGCACCGCCAAGGGCGGCGACGTCGATGCGCTCGTGCGGCAGGTGT
GCCGCGACCACGGCCACGATTTCGGCCACGGCACCGGGCACGGCGTCGGGATTCACGTACACGAGGGCGGCGTCCGGTTC
GCGCCGGGCGCGAAGTACGGGCTCGTGCCGAATGCGGTGATTTCGGTCGAGCCGGGCATCTACGTGCCGGGCAAGGGCGG
CGTGCGGATCGAGAACATCGTGATCATCCACCGGGACGACGCGCAGCCGGATACCGTCACGTTCGAGAACATCGTGACGG
TCGGCTACGACTGGGACCTGATCGATCTCGACCTGCTCGACGACGACGAGCGCGCGTACCTGCGCGACTACGAGCGGCTG
TGCGTCGAACGCGGCACGCAGGTCACCGCGTGTCCGCTGCTGTAA

Upstream 100 bases:

>100_bases
TTCGGCGTGCTCTAGATTCTGCTGCGCGCATCAAACAAAGTTAAGTGGGACGAAAATTTTTCAAGGGCCTGCCGCCGGAA
CGGAACGGCGGCCCGGCGCC

Downstream 100 bases:

>100_bases
GCACCGCCGCCCGCGCCGGTCAGTTCAGCAGGCGCGCACGCACGAACGGCGCGATCCGCTCGGCGAGCCACGCGTGCGTG
CGCGTGGTCGGGTGCAGCGT

Product: peptidase M24

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MRGRAPTVQRRRAVSGLPRACSPPRHRRPPTTMHNGLPMIDRLKYSFSGLPPYDASVADTQAGLSRLLDTARLDAVLVTS
QDEYVTEYLPLANNPRYAVSGFDGSAGCGIFLSAATAQALDLPPFVLFVDGRYHLQAEQQCDPARVRIEKLGMNVTIWQA
MADWLVAHGSRLARVGYDALRISVGQRDRLFEQTQAASLDWTSLADREIDRAIALPGWVVERPIFEVPESATGLSVAQNL
DTLNRQLAAHTGAPDGKTAFFSCASDDLAYLLNSRGYHIPNASSHLGFLFTVGQQVALFLPEGCDRCEVTLASYPALHVI
RRDVAALERFLAQFDVEHVCYGYESVNCALVDAVKRVWPQAQHADFNPVEAMRAGKTPAVLDRFRDAFARSSAAIAETMR
WAKAGEPGTRHTEYDLARTINDAYGARSAVALTFPSIAANGANSAFAHYTAASADVELTEGELVLLDSGAYYEAGFATDC
TRVVLRRTDPDTVAQPWQREIYTVALKACIKGLVTRFPSTAKGGDVDALVRQVCRDHGHDFGHGTGHGVGIHVHEGGVRF
APGAKYGLVPNAVISVEPGIYVPGKGGVRIENIVIIHRDDAQPDTVTFENIVTVGYDWDLIDLDLLDDDERAYLRDYERL
CVERGTQVTACPLL

Sequences:

>Translated_654_residues
MRGRAPTVQRRRAVSGLPRACSPPRHRRPPTTMHNGLPMIDRLKYSFSGLPPYDASVADTQAGLSRLLDTARLDAVLVTS
QDEYVTEYLPLANNPRYAVSGFDGSAGCGIFLSAATAQALDLPPFVLFVDGRYHLQAEQQCDPARVRIEKLGMNVTIWQA
MADWLVAHGSRLARVGYDALRISVGQRDRLFEQTQAASLDWTSLADREIDRAIALPGWVVERPIFEVPESATGLSVAQNL
DTLNRQLAAHTGAPDGKTAFFSCASDDLAYLLNSRGYHIPNASSHLGFLFTVGQQVALFLPEGCDRCEVTLASYPALHVI
RRDVAALERFLAQFDVEHVCYGYESVNCALVDAVKRVWPQAQHADFNPVEAMRAGKTPAVLDRFRDAFARSSAAIAETMR
WAKAGEPGTRHTEYDLARTINDAYGARSAVALTFPSIAANGANSAFAHYTAASADVELTEGELVLLDSGAYYEAGFATDC
TRVVLRRTDPDTVAQPWQREIYTVALKACIKGLVTRFPSTAKGGDVDALVRQVCRDHGHDFGHGTGHGVGIHVHEGGVRF
APGAKYGLVPNAVISVEPGIYVPGKGGVRIENIVIIHRDDAQPDTVTFENIVTVGYDWDLIDLDLLDDDERAYLRDYERL
CVERGTQVTACPLL
>Mature_654_residues
MRGRAPTVQRRRAVSGLPRACSPPRHRRPPTTMHNGLPMIDRLKYSFSGLPPYDASVADTQAGLSRLLDTARLDAVLVTS
QDEYVTEYLPLANNPRYAVSGFDGSAGCGIFLSAATAQALDLPPFVLFVDGRYHLQAEQQCDPARVRIEKLGMNVTIWQA
MADWLVAHGSRLARVGYDALRISVGQRDRLFEQTQAASLDWTSLADREIDRAIALPGWVVERPIFEVPESATGLSVAQNL
DTLNRQLAAHTGAPDGKTAFFSCASDDLAYLLNSRGYHIPNASSHLGFLFTVGQQVALFLPEGCDRCEVTLASYPALHVI
RRDVAALERFLAQFDVEHVCYGYESVNCALVDAVKRVWPQAQHADFNPVEAMRAGKTPAVLDRFRDAFARSSAAIAETMR
WAKAGEPGTRHTEYDLARTINDAYGARSAVALTFPSIAANGANSAFAHYTAASADVELTEGELVLLDSGAYYEAGFATDC
TRVVLRRTDPDTVAQPWQREIYTVALKACIKGLVTRFPSTAKGGDVDALVRQVCRDHGHDFGHGTGHGVGIHVHEGGVRF
APGAKYGLVPNAVISVEPGIYVPGKGGVRIENIVIIHRDDAQPDTVTFENIVTVGYDWDLIDLDLLDDDERAYLRDYERL
CVERGTQVTACPLL

Specific function: Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro > Ala > Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is al

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24 family [H]

Homologues:

Organism=Homo sapiens, GI264681563, Length=598, Percent_Identity=26.7558528428094, Blast_Score=169, Evalue=9e-42,
Organism=Homo sapiens, GI93141226, Length=617, Percent_Identity=25.2836304700162, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI264681565, Length=597, Percent_Identity=25.2931323283082, Blast_Score=150, Evalue=4e-36,
Organism=Escherichia coli, GI1788728, Length=229, Percent_Identity=31.4410480349345, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1789275, Length=268, Percent_Identity=28.7313432835821, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17509539, Length=602, Percent_Identity=27.7408637873754, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25149105, Length=602, Percent_Identity=21.2624584717608, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6322999, Length=633, Percent_Identity=23.696682464455, Blast_Score=137, Evalue=7e-33,
Organism=Drosophila melanogaster, GI17137632, Length=605, Percent_Identity=26.7768595041322, Blast_Score=141, Evalue=2e-33,
Organism=Drosophila melanogaster, GI161078230, Length=600, Percent_Identity=24.3333333333333, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357287, Length=600, Percent_Identity=24.3333333333333, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 71468; Mature: 71468

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGRAPTVQRRRAVSGLPRACSPPRHRRPPTTMHNGLPMIDRLKYSFSGLPPYDASVADT
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCHHHH
QAGLSRLLDTARLDAVLVTSQDEYVTEYLPLANNPRYAVSGFDGSAGCGIFLSAATAQAL
HHHHHHHHHHHHCCEEEEECCCHHHHHHCCCCCCCCEEEECCCCCCCCCEEEECHHHHHC
DLPPFVLFVDGRYHLQAEQQCDPARVRIEKLGMNVTIWQAMADWLVAHGSRLARVGYDAL
CCCCEEEEECCEEEECHHCCCCHHHHHHHHHCCCEEHHHHHHHHHHHCCCHHHHCCCCCE
RISVGQRDRLFEQTQAASLDWTSLADREIDRAIALPGWVVERPIFEVPESATGLSVAQNL
EEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHCCCHHHCCCCCCCHHHHHHH
DTLNRQLAAHTGAPDGKTAFFSCASDDLAYLLNSRGYHIPNASSHLGFLFTVGQQVALFL
HHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEEEC
PEGCDRCEVTLASYPALHVIRRDVAALERFLAQFDVEHVCYGYESVNCALVDAVKRVWPQ
CCCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHCCC
AQHADFNPVEAMRAGKTPAVLDRFRDAFARSSAAIAETMRWAKAGEPGTRHTEYDLARTI
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
NDAYGARSAVALTFPSIAANGANSAFAHYTAASADVELTEGELVLLDSGAYYEAGFATDC
HHHHCCCCEEEEECCHHHCCCCCCCCEEEEECCCCEEEECCCEEEEECCCEEECCCCHHH
TRVVLRRTDPDTVAQPWQREIYTVALKACIKGLVTRFPSTAKGGDVDALVRQVCRDHGHD
HHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
FGHGTGHGVGIHVHEGGVRFAPGAKYGLVPNAVISVEPGIYVPGKGGVRIENIVIIHRDD
CCCCCCCCEEEEEECCCEEECCCCCCCCCCCEEEEECCCEEECCCCCEEEEEEEEEECCC
AQPDTVTFENIVTVGYDWDLIDLDLLDDDERAYLRDYERLCVERGTQVTACPLL
CCCCEEECCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCC
>Mature Secondary Structure
MRGRAPTVQRRRAVSGLPRACSPPRHRRPPTTMHNGLPMIDRLKYSFSGLPPYDASVADT
CCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCHHHH
QAGLSRLLDTARLDAVLVTSQDEYVTEYLPLANNPRYAVSGFDGSAGCGIFLSAATAQAL
HHHHHHHHHHHHCCEEEEECCCHHHHHHCCCCCCCCEEEECCCCCCCCCEEEECHHHHHC
DLPPFVLFVDGRYHLQAEQQCDPARVRIEKLGMNVTIWQAMADWLVAHGSRLARVGYDAL
CCCCEEEEECCEEEECHHCCCCHHHHHHHHHCCCEEHHHHHHHHHHHCCCHHHHCCCCCE
RISVGQRDRLFEQTQAASLDWTSLADREIDRAIALPGWVVERPIFEVPESATGLSVAQNL
EEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHCCCHHHCCCCCCCHHHHHHH
DTLNRQLAAHTGAPDGKTAFFSCASDDLAYLLNSRGYHIPNASSHLGFLFTVGQQVALFL
HHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEEEC
PEGCDRCEVTLASYPALHVIRRDVAALERFLAQFDVEHVCYGYESVNCALVDAVKRVWPQ
CCCCCCEEEEHHCCCHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCHHHHHHHHHHCCC
AQHADFNPVEAMRAGKTPAVLDRFRDAFARSSAAIAETMRWAKAGEPGTRHTEYDLARTI
CCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
NDAYGARSAVALTFPSIAANGANSAFAHYTAASADVELTEGELVLLDSGAYYEAGFATDC
HHHHCCCCEEEEECCHHHCCCCCCCCEEEEECCCCEEEECCCEEEEECCCEEECCCCHHH
TRVVLRRTDPDTVAQPWQREIYTVALKACIKGLVTRFPSTAKGGDVDALVRQVCRDHGHD
HHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCC
FGHGTGHGVGIHVHEGGVRFAPGAKYGLVPNAVISVEPGIYVPGKGGVRIENIVIIHRDD
CCCCCCCCEEEEEECCCEEECCCCCCCCCCCEEEEECCCEEECCCCCEEEEEEEEEECCC
AQPDTVTFENIVTVGYDWDLIDLDLLDDDERAYLRDYERLCVERGTQVTACPLL
CCCCEEECCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]