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The map label for this gene is dacC [H]

Identifier: 78067705

GI number: 78067705

Start: 3393293

End: 3394606

Strand: Reverse

Name: dacC [H]

Synonym: Bcep18194_A6236

Alternate gene names: 78067705

Gene position: 3394606-3393293 (Counterclockwise)

Preceding gene: 78067706

Following gene: 78067704

Centisome position: 91.89

GC content: 66.44

Gene sequence:

>1314_bases
ATGCGTCTGTCTCCCCAAGGCCTCAAGTCCCTCGCTTCCTCCATCGCCTTCGGCACCGCCGCGCGCAACGTCGCGCTCGG
CGTGATGCTGCCCGTCGCGCTCGCGTCGACGATCGTCGTCGCCGAGGCGAAGCCGGCCGCCAAGGCCAAGGCCGCGCATG
CGGCGCCGGCCGCCACCGAGCAGTTCACCGGCGCGCCCGCGACCTACATGCCGGGCGCCGTACCGCCGCCGGGCGTGAAT
GCGCGCTCGTGGGTGCTCGTCGATGCGACCAGCAACACGGTGCTCGCGTCGGGCAATGCCGATGAACGCGTCGAGCCCGC
GTCGCTGACGAAGCTGATGACCGCGTACCTCGTGTTCGAGGCGCTCGACAAGAAGAAGATCTCGATGGAGCAGATCGTCA
CGCCGAGCGAGGCCGTGCGCCGCGTCGGCCGCGACGAGTCGCGCATGTTCATCGAGGCGAACAAGCCGGTGTCCGTGCAC
GACCTCGTGTACGGGATGATCATCCAGTCGGGCAACGACGCCGCGATCGCGCTGGCCGAACTCGTGGGCGGCAGCGAAGG
GCAGTTCGTCACGTTGATGAACGACGAGGCTGCGCGCCTCGGCATGAAGGGCACGCACTTCGCCGACGTGAACGGCATGC
CCGACCCGAACCACTACACGACGGCCGGCGACCTCGCGAAGCTGTCCGCGCACCTGATCCGCGATTTTCCGCAGTACTAC
AGCATCTTCTCGGAGAAGGAATTCAAGTACAACAACATCCGCCAGGGCAACCGCAACCGCCTGCTGTGGCTCGACCCGAC
GGTCGACGGCCTGAAGACGGGCCATACGCAAGCGGCCGGCTACTGCCTGATCGCGTCGGCGAAGCGCGCGATCCCGGGTG
TGGACGGCCAGCGCCGCCTGGTGTCGGTGATGATGGGCGAGCAGAAGGAAGGCGAGCGCACGCAGGACAGCATGAAGATG
CTGAACTACGGCTACAGCGCGTTCGATTCGGTGCGCCTGTTCAAGGGCGGCCAGGCGATGTCGACGCCGCGCATCTACAA
GGGCAAGGAAAACACCGTGCAGGTCGGCGTGAAGGGCGACCAGTGGGCGACCGTGCCGCGCGGCCTCGGCGACAAGATCA
AGACGGAAGTCGACGTCAATGCGCCGCTGATCGCGCCGCTCGCGGAAGGCCAGCAGGTCGGCACCGTGAAGATCGTCGCC
GACGGCAAGACGCTGTCCGAATTCCCGGTTGTGGCACTGCAGGCCGTGCCGGAAGCGGGTATCTTCGGGCGTATCTGGGA
CTCGATCCTGCTGATGTTCAGCAAGAAGAAGTAA

Upstream 100 bases:

>100_bases
TCGCCCGACGATTTCGGGCGAGTGCCCGAAACGCCCGCCGCCTTGCCGTTCAACCCTGCGCGTTTCGCACCGCACTTTCT
GCCATCAGCCTGAATCGATC

Downstream 100 bases:

>100_bases
GCACGACGGGCCTTTGTTTTTACGACTTCATCCCCATCTGTCATAGCTATGAGCCAAGCCGAATTTGAACCGATCGTCTA
CCTCAGCGTGTCGTCGCAGG

Product: penicillin-binding protein 6

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MRLSPQGLKSLASSIAFGTAARNVALGVMLPVALASTIVVAEAKPAAKAKAAHAAPAATEQFTGAPATYMPGAVPPPGVN
ARSWVLVDATSNTVLASGNADERVEPASLTKLMTAYLVFEALDKKKISMEQIVTPSEAVRRVGRDESRMFIEANKPVSVH
DLVYGMIIQSGNDAAIALAELVGGSEGQFVTLMNDEAARLGMKGTHFADVNGMPDPNHYTTAGDLAKLSAHLIRDFPQYY
SIFSEKEFKYNNIRQGNRNRLLWLDPTVDGLKTGHTQAAGYCLIASAKRAIPGVDGQRRLVSVMMGEQKEGERTQDSMKM
LNYGYSAFDSVRLFKGGQAMSTPRIYKGKENTVQVGVKGDQWATVPRGLGDKIKTEVDVNAPLIAPLAEGQQVGTVKIVA
DGKTLSEFPVVALQAVPEAGIFGRIWDSILLMFSKKK

Sequences:

>Translated_437_residues
MRLSPQGLKSLASSIAFGTAARNVALGVMLPVALASTIVVAEAKPAAKAKAAHAAPAATEQFTGAPATYMPGAVPPPGVN
ARSWVLVDATSNTVLASGNADERVEPASLTKLMTAYLVFEALDKKKISMEQIVTPSEAVRRVGRDESRMFIEANKPVSVH
DLVYGMIIQSGNDAAIALAELVGGSEGQFVTLMNDEAARLGMKGTHFADVNGMPDPNHYTTAGDLAKLSAHLIRDFPQYY
SIFSEKEFKYNNIRQGNRNRLLWLDPTVDGLKTGHTQAAGYCLIASAKRAIPGVDGQRRLVSVMMGEQKEGERTQDSMKM
LNYGYSAFDSVRLFKGGQAMSTPRIYKGKENTVQVGVKGDQWATVPRGLGDKIKTEVDVNAPLIAPLAEGQQVGTVKIVA
DGKTLSEFPVVALQAVPEAGIFGRIWDSILLMFSKKK
>Mature_437_residues
MRLSPQGLKSLASSIAFGTAARNVALGVMLPVALASTIVVAEAKPAAKAKAAHAAPAATEQFTGAPATYMPGAVPPPGVN
ARSWVLVDATSNTVLASGNADERVEPASLTKLMTAYLVFEALDKKKISMEQIVTPSEAVRRVGRDESRMFIEANKPVSVH
DLVYGMIIQSGNDAAIALAELVGGSEGQFVTLMNDEAARLGMKGTHFADVNGMPDPNHYTTAGDLAKLSAHLIRDFPQYY
SIFSEKEFKYNNIRQGNRNRLLWLDPTVDGLKTGHTQAAGYCLIASAKRAIPGVDGQRRLVSVMMGEQKEGERTQDSMKM
LNYGYSAFDSVRLFKGGQAMSTPRIYKGKENTVQVGVKGDQWATVPRGLGDKIKTEVDVNAPLIAPLAEGQQVGTVKIVA
DGKTLSEFPVVALQAVPEAGIFGRIWDSILLMFSKKK

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=368, Percent_Identity=42.6630434782609, Blast_Score=290, Evalue=9e-80,
Organism=Escherichia coli, GI1786851, Length=372, Percent_Identity=41.1290322580645, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI87082022, Length=379, Percent_Identity=39.3139841688654, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87082054, Length=221, Percent_Identity=31.2217194570136, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 46853; Mature: 46853

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLSPQGLKSLASSIAFGTAARNVALGVMLPVALASTIVVAEAKPAAKAKAAHAAPAATE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHCCCCCCHH
QFTGAPATYMPGAVPPPGVNARSWVLVDATSNTVLASGNADERVEPASLTKLMTAYLVFE
HCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
ALDKKKISMEQIVTPSEAVRRVGRDESRMFIEANKPVSVHDLVYGMIIQSGNDAAIALAE
HHCCHHCCHHHHCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHEEHEEECCCCHHHHHHH
LVGGSEGQFVTLMNDEAARLGMKGTHFADVNGMPDPNHYTTAGDLAKLSAHLIRDFPQYY
HHCCCCCCEEEEECCCHHHCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
SIFSEKEFKYNNIRQGNRNRLLWLDPTVDGLKTGHTQAAGYCLIASAKRAIPGVDGQRRL
HHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHCCCCCCCCEEEEECCHHCCCCCCHHHHH
VSVMMGEQKEGERTQDSMKMLNYGYSAFDSVRLFKGGQAMSTPRIYKGKENTVQVGVKGD
HHHHHCCCCCCCHHHHHHHHHHCCCHHHCCEEEECCCCCCCCCCEECCCCCEEEEEECCC
QWATVPRGLGDKIKTEVDVNAPLIAPLAEGQQVGTVKIVADGKTLSEFPVVALQAVPEAG
CCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCC
IFGRIWDSILLMFSKKK
HHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRLSPQGLKSLASSIAFGTAARNVALGVMLPVALASTIVVAEAKPAAKAKAAHAAPAATE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHCCCCCCHH
QFTGAPATYMPGAVPPPGVNARSWVLVDATSNTVLASGNADERVEPASLTKLMTAYLVFE
HCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEECCCCCCCCCHHHHHHHHHHHHHHH
ALDKKKISMEQIVTPSEAVRRVGRDESRMFIEANKPVSVHDLVYGMIIQSGNDAAIALAE
HHCCHHCCHHHHCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHEEHEEECCCCHHHHHHH
LVGGSEGQFVTLMNDEAARLGMKGTHFADVNGMPDPNHYTTAGDLAKLSAHLIRDFPQYY
HHCCCCCCEEEEECCCHHHCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
SIFSEKEFKYNNIRQGNRNRLLWLDPTVDGLKTGHTQAAGYCLIASAKRAIPGVDGQRRL
HHHCCCCCCCCCCCCCCCCEEEEECCCCCCHHCCCCCCCCEEEEECCHHCCCCCCHHHHH
VSVMMGEQKEGERTQDSMKMLNYGYSAFDSVRLFKGGQAMSTPRIYKGKENTVQVGVKGD
HHHHHCCCCCCCHHHHHHHHHHCCCHHHCCEEEECCCCCCCCCCEECCCCCEEEEEECCC
QWATVPRGLGDKIKTEVDVNAPLIAPLAEGQQVGTVKIVADGKTLSEFPVVALQAVPEAG
CCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCEEEEEECCCCCCCCCEEEEECCCCCC
IFGRIWDSILLMFSKKK
HHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]