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The map label for this gene is kynA [H]

Identifier: 78067379

GI number: 78067379

Start: 3030390

End: 3031322

Strand: Direct

Name: kynA [H]

Synonym: Bcep18194_A5910

Alternate gene names: 78067379

Gene position: 3030390-3031322 (Clockwise)

Preceding gene: 78067378

Following gene: 78067384

Centisome position: 82.03

GC content: 67.1

Gene sequence:

>933_bases
ATGCAGCCACCCGGCGAAGACGCGCCGGCGGGCTGCCCGTTCTCGGGCGCACGCGCCGCGCATTCGGCACCCGCGGCCCC
GGCCGCGCACGAAGCGTCGCACGTGCCCGGCGATGCCGGCTGGCACAACGCGCAGCTCGATTTCTCGAAGTCGATGAGCT
ACGGCGACTACCTGTCGCTGAATTCGATCCTCGACGCGCAGCATCCGCTGTCGCCCGATCACAACGAGATGCTGTTCATC
ATCCAGCATCAGACGAGCGAGCTGTGGATGAAGCTCGCGCTGTTCGAGCTGCGCGGCGCCCTCGATGCGGTGCGCACCGA
CGCGTTGCCGCCCGCATTCAAGATGCTCGCGCGCGTGTCGCGGATTCTCGAGCAGCTCGTGCAGGCGTGGAGCGTGCTGT
CGACGATGACGCCGTCCGAATATTCGGCGATGCGCCCGTATCTCGGGCAGTCGTCGGGCTTCCAGTCGTACCAGTACCGG
CAACTCGAATTCCTGCTCGGCAACAAGAACGTGCAGATGCTGCAGCCGCACGCGCACCGGCCCGACATCCTCGAACAGGT
GCGTGCGACGCTCGAAGCGCCGTCGTTCTACGACGAAGTCGTGCGCCTGCTCGCGCGGCGCGGCTTCCCGATCGCAGCGG
AGCGGCTCGAGCGCGACTGGACGCAGCCGACCCGGCATGACGAGACGGTCGAAGCCGCGTGGCTCGAGGTGTACCGTCAC
CCGCAGCAGCACTGGGAGCTCTACGAAATGGCCGAGGAACTCGTCGATCTCGAGGATGCGTTCCGCCAGTGGCGCTTCCG
TCACGTGACGACCGTCGAGCGCATCATCGGCTTCAAGCAGGGCACGGGCGGCACCAGCGGCGCGCCGTACCTGCGCAAGA
TGCTCGACGTCGTGCTGTTCCCCGAGCTCTGGCACGTGCGCACCACGCTGTAA

Upstream 100 bases:

>100_bases
CGAACGCGGCGCGGTGACCTGACCCGCTTCGCGCGGCGCACGCATGATGCGCGCCGCGCCCCGTCATTCAAATCTGGAGA
GAGTCGTGAATTCTGGTCAT

Downstream 100 bases:

>100_bases
CGCGCGACGCGCCCCCTGGCCTGCCCGCCGTCACGACGACGTGCGGGCCAGTTCCTCCCCTTCGCGCGGCTGCACCGCCG
CGCGCGACAGTCGCGGAATG

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MQPPGEDAPAGCPFSGARAAHSAPAAPAAHEASHVPGDAGWHNAQLDFSKSMSYGDYLSLNSILDAQHPLSPDHNEMLFI
IQHQTSELWMKLALFELRGALDAVRTDALPPAFKMLARVSRILEQLVQAWSVLSTMTPSEYSAMRPYLGQSSGFQSYQYR
QLEFLLGNKNVQMLQPHAHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAAERLERDWTQPTRHDETVEAAWLEVYRH
PQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Sequences:

>Translated_310_residues
MQPPGEDAPAGCPFSGARAAHSAPAAPAAHEASHVPGDAGWHNAQLDFSKSMSYGDYLSLNSILDAQHPLSPDHNEMLFI
IQHQTSELWMKLALFELRGALDAVRTDALPPAFKMLARVSRILEQLVQAWSVLSTMTPSEYSAMRPYLGQSSGFQSYQYR
QLEFLLGNKNVQMLQPHAHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAAERLERDWTQPTRHDETVEAAWLEVYRH
PQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL
>Mature_310_residues
MQPPGEDAPAGCPFSGARAAHSAPAAPAAHEASHVPGDAGWHNAQLDFSKSMSYGDYLSLNSILDAQHPLSPDHNEMLFI
IQHQTSELWMKLALFELRGALDAVRTDALPPAFKMLARVSRILEQLVQAWSVLSTMTPSEYSAMRPYLGQSSGFQSYQYR
QLEFLLGNKNVQMLQPHAHRPDILEQVRATLEAPSFYDEVVRLLARRGFPIAAERLERDWTQPTRHDETVEAAWLEVYRH
PQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLFPELWHVRTTL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring [H]

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI5032165, Length=169, Percent_Identity=35.5029585798817, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17552370, Length=376, Percent_Identity=26.3297872340426, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI32564651, Length=181, Percent_Identity=30.939226519337, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17530891, Length=374, Percent_Identity=29.4117647058824, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017485
- InterPro:   IPR004981 [H]

Pfam domain/function: PF03301 Trp_dioxygenase [H]

EC number: =1.13.11.11 [H]

Molecular weight: Translated: 35300; Mature: 35300

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPPGEDAPAGCPFSGARAAHSAPAAPAAHEASHVPGDAGWHNAQLDFSKSMSYGDYLSL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHCCCCCCHHHH
NSILDAQHPLSPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRTDALPPAFKMLARVS
HHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RILEQLVQAWSVLSTMTPSEYSAMRPYLGQSSGFQSYQYRQLEFLLGNKNVQMLQPHAHR
HHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCC
PDILEQVRATLEAPSFYDEVVRLLARRGFPIAAERLERDWTQPTRHDETVEAAWLEVYRH
CHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
PQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
PELWHVRTTL
HHHHHHHHCC
>Mature Secondary Structure
MQPPGEDAPAGCPFSGARAAHSAPAAPAAHEASHVPGDAGWHNAQLDFSKSMSYGDYLSL
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHCCCCCCHHHH
NSILDAQHPLSPDHNEMLFIIQHQTSELWMKLALFELRGALDAVRTDALPPAFKMLARVS
HHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
RILEQLVQAWSVLSTMTPSEYSAMRPYLGQSSGFQSYQYRQLEFLLGNKNVQMLQPHAHR
HHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCCCC
PDILEQVRATLEAPSFYDEVVRLLARRGFPIAAERLERDWTQPTRHDETVEAAWLEVYRH
CHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHC
PQQHWELYEMAEELVDLEDAFRQWRFRHVTTVERIIGFKQGTGGTSGAPYLRKMLDVVLF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHH
PELWHVRTTL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA