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The map label for this gene is kynU [H]

Identifier: 78067378

GI number: 78067378

Start: 3029058

End: 3030311

Strand: Direct

Name: kynU [H]

Synonym: Bcep18194_A5909

Alternate gene names: 78067378

Gene position: 3029058-3030311 (Clockwise)

Preceding gene: 78067377

Following gene: 78067379

Centisome position: 82.0

GC content: 69.86

Gene sequence:

>1254_bases
ATGATCAAGACCCGTGAAGACGCGCTCGCGCTCGACCGCGACGATCCGCTCGCCCCGCTGCGCGACCAGTTCTCCCTGCC
TGACGGCGTGATTTACCTCGACGGCAACTCGCTCGGCGCGCAGCCGCGCGCGTCCGCCGCCCGCGCGCAGCAGGTGATCG
GCGCCGAATGGGGCGAAGGCCTGATCCGCAGCTGGAACACGGCCGGCTGGTTCGCGCTGCCGCGCCGTCTCGGCGACAAG
CTCGCGACGCTGATCGGCGGCGCACCCGGCGAAACGGTCGTGACCGATACGATCTCGATCAACCTGTTCAAGCTGCTGTC
GGCGATGGTGCGCCACCAGGCCGAGCGCGCGCCCGAGCGCCGCGTGATCGTGTCGGAACGCTCGAACTTCCCGACCGACC
TGTATATCGCGCAGGGGCTGATCGAACAGCTCGGCGGCGACTACGAACTGCGCCTGATCGACGACCCGGCCGACCTGCCC
GGCGCGCTCGGCGCGGACACGGCCGTCGCGATGATCACGCACGTGAACTACCGCACCGGCTACATGCACGACATGCCGGC
CGTCACGCAGCTCGTGCACGACGCGGGTGGCCTGATGCTGTGGGATCTCGCGCACTCGGCCGGCGCGGTGCCGGTCGACC
TGAACGGCGCGCGCGCGGACGGCGCGGTCGGCTGCACGTACAAGTACCTGAACGGCGGCCCCGGTTCGCCCGCCTTCGTG
TGGGTGCCGCAGCGCCATCACGCGCACTTCTCGCAGCCGCTGTCCGGCTGGTGGGGCCACCGCGCACCGTTCGCGATGCA
GCCGGGTTTCGCGCCCGATCCGGGCATCGCTCGCTTCCTGTGCGGCACGCAGCCGATCGTGTCGATGTCGATGGTCGAAT
GCGGGCTCGACGTGTTCCTGCAGACCGACATGCACGCGATCCGCCGCAAGTCGCTTGCGCTGACCGATACGTTCATCGCG
CTCGTCGAAGCGCGCTGCGCGGGCCTGTCGCTGAAGCTCGTCACGCCGCGCGCGCATCACCAGCGCGGCTCGCAGGCGAG
CTTCGAGCATCCGCACGGCTACGAAGTGATGCAGGCGCTGATCGCGCGCGGCGTGATCGGCGACTACCGCGAGCCGTACG
TGCTGCGCTTCGGCTTCACGCCGCTCTATACGCGCTTCGCCGACGTGTGGGATGCCGTCGAGACGCTGCGCGACATCCTC
GCCACCGATGCGTGGAAGGCACCCGAGTTCGCCGAACGCGGCGCGGTGACCTGA

Upstream 100 bases:

>100_bases
CCGCTGAAATTCGCGACGCTCGACGCAAGCCCCGTGCGTGCGGTGCTGCGCGCGCTGCCCGCGCGTGCCTCCTGATTACC
CCGACTGACGACCCCACATC

Downstream 100 bases:

>100_bases
CCCGCTTCGCGCGGCGCACGCATGATGCGCGCCGCGCCCCGTCATTCAAATCTGGAGAGAGTCGTGAATTCTGGTCATAT
GCAGCCACCCGGCGAAGACG

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MIKTREDALALDRDDPLAPLRDQFSLPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDK
LATLIGGAPGETVVTDTISINLFKLLSAMVRHQAERAPERRVIVSERSNFPTDLYIAQGLIEQLGGDYELRLIDDPADLP
GALGADTAVAMITHVNYRTGYMHDMPAVTQLVHDAGGLMLWDLAHSAGAVPVDLNGARADGAVGCTYKYLNGGPGSPAFV
WVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFLQTDMHAIRRKSLALTDTFIA
LVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFADVWDAVETLRDIL
ATDAWKAPEFAERGAVT

Sequences:

>Translated_417_residues
MIKTREDALALDRDDPLAPLRDQFSLPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDK
LATLIGGAPGETVVTDTISINLFKLLSAMVRHQAERAPERRVIVSERSNFPTDLYIAQGLIEQLGGDYELRLIDDPADLP
GALGADTAVAMITHVNYRTGYMHDMPAVTQLVHDAGGLMLWDLAHSAGAVPVDLNGARADGAVGCTYKYLNGGPGSPAFV
WVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFLQTDMHAIRRKSLALTDTFIA
LVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFADVWDAVETLRDIL
ATDAWKAPEFAERGAVT
>Mature_417_residues
MIKTREDALALDRDDPLAPLRDQFSLPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEGLIRSWNTAGWFALPRRLGDK
LATLIGGAPGETVVTDTISINLFKLLSAMVRHQAERAPERRVIVSERSNFPTDLYIAQGLIEQLGGDYELRLIDDPADLP
GALGADTAVAMITHVNYRTGYMHDMPAVTQLVHDAGGLMLWDLAHSAGAVPVDLNGARADGAVGCTYKYLNGGPGSPAFV
WVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFLQTDMHAIRRKSLALTDTFIA
LVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQALIARGVIGDYREPYVLRFGFTPLYTRFADVWDAVETLRDIL
ATDAWKAPEFAERGAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=443, Percent_Identity=27.9909706546275, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI74101437, Length=277, Percent_Identity=25.2707581227437, Blast_Score=83, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17550466, Length=431, Percent_Identity=26.9141531322506, Blast_Score=144, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6323261, Length=456, Percent_Identity=29.1666666666667, Blast_Score=147, Evalue=4e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45514; Mature: 45514

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTREDALALDRDDPLAPLRDQFSLPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEG
CCCCCCCHHEECCCCCCCCHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCH
LIRSWNTAGWFALPRRLGDKLATLIGGAPGETVVTDTISINLFKLLSAMVRHQAERAPER
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCC
RVIVSERSNFPTDLYIAQGLIEQLGGDYELRLIDDPADLPGALGADTAVAMITHVNYRTG
EEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCC
YMHDMPAVTQLVHDAGGLMLWDLAHSAGAVPVDLNGARADGAVGCTYKYLNGGPGSPAFV
CCCCHHHHHHHHHHCCCEEEEEHHHCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEEE
WVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFL
ECCCHHCCCCCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCHHHHH
QTDMHAIRRKSLALTDTFIALVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHHH
IARGVIGDYREPYVLRFGFTPLYTRFADVWDAVETLRDILATDAWKAPEFAERGAVT
HHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC
>Mature Secondary Structure
MIKTREDALALDRDDPLAPLRDQFSLPDGVIYLDGNSLGAQPRASAARAQQVIGAEWGEG
CCCCCCCHHEECCCCCCCCHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCH
LIRSWNTAGWFALPRRLGDKLATLIGGAPGETVVTDTISINLFKLLSAMVRHQAERAPER
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCC
RVIVSERSNFPTDLYIAQGLIEQLGGDYELRLIDDPADLPGALGADTAVAMITHVNYRTG
EEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCC
YMHDMPAVTQLVHDAGGLMLWDLAHSAGAVPVDLNGARADGAVGCTYKYLNGGPGSPAFV
CCCCHHHHHHHHHHCCCEEEEEHHHCCCCCEEECCCCCCCCCCEEEEEECCCCCCCCEEE
WVPQRHHAHFSQPLSGWWGHRAPFAMQPGFAPDPGIARFLCGTQPIVSMSMVECGLDVFL
ECCCHHCCCCCCCHHCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHCHHHHH
QTDMHAIRRKSLALTDTFIALVEARCAGLSLKLVTPRAHHQRGSQASFEHPHGYEVMQAL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHCCCCCCCCCCCCCHHHHHHH
IARGVIGDYREPYVLRFGFTPLYTRFADVWDAVETLRDILATDAWKAPEFAERGAVT
HHHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA