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The map label for this gene is catF [H]

Identifier: 78065105

GI number: 78065105

Start: 502893

End: 504095

Strand: Reverse

Name: catF [H]

Synonym: Bcep18194_A3629

Alternate gene names: 78065105

Gene position: 504095-502893 (Counterclockwise)

Preceding gene: 78065106

Following gene: 78065104

Centisome position: 13.65

GC content: 67.83

Gene sequence:

>1203_bases
ATGACAGACGCCTATATCTGCGACGCGATTCGCACCCCAATCGGCCGCTACGGCGGCGCCCTGAAAGATGTCCGCGCCGA
CGACCTCGGTGCGGTGCCGCTCAAGGCGCTCATCGAGCGCAACCGTGACGTCGACTGGACGGCGATCGACGACGTGATCT
ACGGCTGCGCGAACCAGGCCGGCGAGGACAACCGCAACGTCGCGCGTATGTCGGCGCTGCTCGGGGGCCTGCCGACCGAC
GTGCCCGGCACGACGCTGAACCGGCTGTGCGGCTCCGGGATGGACGCGGTCGGCACAGCTGCGCGCGCGATCAAGGCGGG
CGAGGCGCGCTTGATGATCGCAGGCGGCGTCGAGAGCATGACGCGTGCGCCGTTCGTGATGGGCAAGGCCACGAGCGCGT
TCGCACGCCAAGCTGACATTTTCGACACGACGATCGGTTGGCGCTTCATCAATCCGCTGATGAAACAGCTGTATGGCGTC
GATTCGATGCCCGAGACGGCCGAAAACGTCGCGGTCGACTACAACATCAGCCGCGCCGACCAGGATCTGTTCGCGCTGCG
CAGCCAGCAGAAGGCCGCGCGTGCGCAGCAGGACGGCACGCTCGCCGAGGAAATCGTCGCCGTCACGATTCCGCAGAAGA
AAGGCGATCCGGTGGTCGTATCGCGCGACGAGCACCCTCGCGAGACGTCGCTCGAAGCGCTCGCGAAACTGAAAGGCGTC
GTGCGTGCGGACGGCTCGGTGACGGCCGGCAACGCATCGGGCGTCAACGACGGTGCGTGCGCGCTGCTGCTCGCCAATGC
GCAGGCAGCCGACCAGTACGGCCTGCGCCGCCGCGCACGTGTCATCGGTATGGCGACAGCCGGCGTCGCGCCGCGCGTGA
TGGGCATCGGGCCCGCACCCGCCACGCAGAAACTGCTGCGCCAGCTCGGCATGACCATCGATCAGTTCGACGTGATCGAG
CTGAACGAGGCGTTCGCGTCCCAAGGGCTCGCGGTACTGCGCATGCTCGGCGTCGCCGACGACGATCCGCGCGTGAACCC
GAACGGTGGCGCAATCGCACTGGGGCATCCGCTCGGCGCATCGGGCGCCCGGCTCGTGACCACGGCGCTCCACCAACTCG
AGCGTACGGGCGGCCGCTTTGCGCTCTGTACGATGTGCATCGGCGTCGGCCAGGGCATCGCACTCGCGATCGAACGCGTG
TAA

Upstream 100 bases:

>100_bases
CCAGCCGGCATAACCCGAATGGCCGACGTGCAAACGCCGCCACGTTCTCTACCATGAACGAATCCGCCACCTGGCGGGTT
CGTTGCTCATCGATACGCCC

Downstream 100 bases:

>100_bases
CCCACGCACCGCGCGCCTATAACGAAGTCATGAAGGAGATACTGCATGTCCTATCAGGCGATTCAGCTGGATATCGATCA
CGCGTCGAACGTGGCCACGA

Product: beta-ketoadipyl CoA thiolase

Products: NA

Alternate protein names: 3-oxoadipyl-CoA thiolase [H]

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MTDAYICDAIRTPIGRYGGALKDVRADDLGAVPLKALIERNRDVDWTAIDDVIYGCANQAGEDNRNVARMSALLGGLPTD
VPGTTLNRLCGSGMDAVGTAARAIKAGEARLMIAGGVESMTRAPFVMGKATSAFARQADIFDTTIGWRFINPLMKQLYGV
DSMPETAENVAVDYNISRADQDLFALRSQQKAARAQQDGTLAEEIVAVTIPQKKGDPVVVSRDEHPRETSLEALAKLKGV
VRADGSVTAGNASGVNDGACALLLANAQAADQYGLRRRARVIGMATAGVAPRVMGIGPAPATQKLLRQLGMTIDQFDVIE
LNEAFASQGLAVLRMLGVADDDPRVNPNGGAIALGHPLGASGARLVTTALHQLERTGGRFALCTMCIGVGQGIALAIERV

Sequences:

>Translated_400_residues
MTDAYICDAIRTPIGRYGGALKDVRADDLGAVPLKALIERNRDVDWTAIDDVIYGCANQAGEDNRNVARMSALLGGLPTD
VPGTTLNRLCGSGMDAVGTAARAIKAGEARLMIAGGVESMTRAPFVMGKATSAFARQADIFDTTIGWRFINPLMKQLYGV
DSMPETAENVAVDYNISRADQDLFALRSQQKAARAQQDGTLAEEIVAVTIPQKKGDPVVVSRDEHPRETSLEALAKLKGV
VRADGSVTAGNASGVNDGACALLLANAQAADQYGLRRRARVIGMATAGVAPRVMGIGPAPATQKLLRQLGMTIDQFDVIE
LNEAFASQGLAVLRMLGVADDDPRVNPNGGAIALGHPLGASGARLVTTALHQLERTGGRFALCTMCIGVGQGIALAIERV
>Mature_399_residues
TDAYICDAIRTPIGRYGGALKDVRADDLGAVPLKALIERNRDVDWTAIDDVIYGCANQAGEDNRNVARMSALLGGLPTDV
PGTTLNRLCGSGMDAVGTAARAIKAGEARLMIAGGVESMTRAPFVMGKATSAFARQADIFDTTIGWRFINPLMKQLYGVD
SMPETAENVAVDYNISRADQDLFALRSQQKAARAQQDGTLAEEIVAVTIPQKKGDPVVVSRDEHPRETSLEALAKLKGVV
RADGSVTAGNASGVNDGACALLLANAQAADQYGLRRRARVIGMATAGVAPRVMGIGPAPATQKLLRQLGMTIDQFDVIEL
NEAFASQGLAVLRMLGVADDDPRVNPNGGAIALGHPLGASGARLVTTALHQLERTGGRFALCTMCIGVGQGIALAIERV

Specific function: Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=395, Percent_Identity=40.7594936708861, Blast_Score=278, Evalue=9e-75,
Organism=Homo sapiens, GI148539872, Length=397, Percent_Identity=38.2871536523929, Blast_Score=254, Evalue=8e-68,
Organism=Homo sapiens, GI4501853, Length=407, Percent_Identity=39.8034398034398, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4557237, Length=407, Percent_Identity=33.6609336609337, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI4504327, Length=427, Percent_Identity=30.9133489461358, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI194353979, Length=254, Percent_Identity=32.2834645669291, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=67.8304239401496, Blast_Score=546, Evalue=1e-157,
Organism=Escherichia coli, GI87082165, Length=401, Percent_Identity=45.1371571072319, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=46.039603960396, Blast_Score=281, Evalue=5e-77,
Organism=Escherichia coli, GI48994986, Length=405, Percent_Identity=42.2222222222222, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=31.7073170731707, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI133906874, Length=402, Percent_Identity=43.0348258706468, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI25147385, Length=404, Percent_Identity=33.4158415841584, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17535921, Length=410, Percent_Identity=33.6585365853659, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17551802, Length=430, Percent_Identity=31.6279069767442, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17535917, Length=412, Percent_Identity=29.6116504854369, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325229, Length=406, Percent_Identity=35.7142857142857, Blast_Score=221, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6322031, Length=414, Percent_Identity=36.4734299516908, Blast_Score=215, Evalue=9e-57,
Organism=Drosophila melanogaster, GI24655093, Length=401, Percent_Identity=43.142144638404, Blast_Score=309, Evalue=2e-84,
Organism=Drosophila melanogaster, GI17648125, Length=406, Percent_Identity=38.9162561576355, Blast_Score=252, Evalue=3e-67,
Organism=Drosophila melanogaster, GI24640423, Length=405, Percent_Identity=34.5679012345679, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=30.3529411764706, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012793
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.174 [H]

Molecular weight: Translated: 42022; Mature: 41890

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAYICDAIRTPIGRYGGALKDVRADDLGAVPLKALIERNRDVDWTAIDDVIYGCANQA
CCCHHHHHHHHCCHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
GEDNRNVARMSALLGGLPTDVPGTTLNRLCGSGMDAVGTAARAIKAGEARLMIAGGVESM
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHHH
TRAPFVMGKATSAFARQADIFDTTIGWRFINPLMKQLYGVDSMPETAENVAVDYNISRAD
HHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCHHH
QDLFALRSQQKAARAQQDGTLAEEIVAVTIPQKKGDPVVVSRDEHPRETSLEALAKLKGV
HHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
VRADGSVTAGNASGVNDGACALLLANAQAADQYGLRRRARVIGMATAGVAPRVMGIGPAP
HCCCCCEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHEEECCCCCCCEEECCCCH
ATQKLLRQLGMTIDQFDVIELNEAFASQGLAVLRMLGVADDDPRVNPNGGAIALGHPLGA
HHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
SGARLVTTALHQLERTGGRFALCTMCIGVGQGIALAIERV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECC
>Mature Secondary Structure 
TDAYICDAIRTPIGRYGGALKDVRADDLGAVPLKALIERNRDVDWTAIDDVIYGCANQA
CCHHHHHHHHCCHHHHCCCHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCC
GEDNRNVARMSALLGGLPTDVPGTTLNRLCGSGMDAVGTAARAIKAGEARLMIAGGVESM
CCCCCHHHHHHHHHCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCHHHH
TRAPFVMGKATSAFARQADIFDTTIGWRFINPLMKQLYGVDSMPETAENVAVDYNISRAD
HHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHEEEEEECCHHH
QDLFALRSQQKAARAQQDGTLAEEIVAVTIPQKKGDPVVVSRDEHPRETSLEALAKLKGV
HHHHHHHHHHHHHHHHHCCCHHHHEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHH
VRADGSVTAGNASGVNDGACALLLANAQAADQYGLRRRARVIGMATAGVAPRVMGIGPAP
HCCCCCEECCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHEEECCCCCCCEEECCCCH
ATQKLLRQLGMTIDQFDVIELNEAFASQGLAVLRMLGVADDDPRVNPNGGAIALGHPLGA
HHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCC
SGARLVTTALHQLERTGGRFALCTMCIGVGQGIALAIERV
CCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8125318 [H]