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The map label for this gene is fmt [H]

Identifier: 78049481

GI number: 78049481

Start: 4505553

End: 4506476

Strand: Reverse

Name: fmt [H]

Synonym: XCV3925

Alternate gene names: 78049481

Gene position: 4506476-4505553 (Counterclockwise)

Preceding gene: 78049482

Following gene: 78049480

Centisome position: 87.02

GC content: 71.0

Gene sequence:

>924_bases
ATGAGAATCATCTTCGCCGGTACGCCGGATTTTGCCGTTCCGTCGCTACGTGCCGCTGCGCAGCGGCATGAGGTGGTGGC
GGTGTACACGCAGCCGGATCGCCCCGCCGGGCGTGGCCGCGGGTTGACGCCCTCGCCGGTCAAGCTGGAGGCAGTCGCGC
GCGGCATTCCCGTGTTCCAGCCGCAGACGCTGCGTTCGCCCGAAGCATTGGCGACGGTGCGCAAGCTGGATGCGGACCTG
ATGGTGGTGGTGGCTTACGGGTTGATCCTGCCCAAGGCAGTGCTGGCCGCGCCGACGCACGGCTGCTGGAATGTGCATGC
CTCGTTGCTGCCGCGCTGGCGTGGCGCCGCGCCGATCCAGCGTGCGATCGAGGCCGGCGACACCGAGACCGGGGTGTGCC
TGATGCAGATGGAAGCCGGGTTGGACACCGGCCCGGTGCTGCTGTCGCAGCGCATCGAAATTGGCGAGCAGGAAACCGGC
GGGCAGCTGCACGACCGGCTGGCCGCGCTGGGCGCGCAGGTGCTGTCCGATGGCCTGGGCCTGTTGCGCGCCGGCATCCG
TCCGGTGGCGCAACCGCAGCCGGACGACGGGGTGACCTATGCGCACAAGCTGGACAAGGCGCAGGCGCGGCTGGATTGGG
CGCAGCCGGCGCAGGAACTGGCGCGGCGCGTGCGGGCGTTCAACCCATGGCCGGTGGCCGAGGCAATCCTGGCGGGCGAG
CGCGTGCGCCTGCATGGCGCGGTGGCGCTTGAACTGGCCCATCAACACCCCCCGGGCACCCTGCTGGCGGCCAGCAAGCA
GGGCATCGATATCGCCTGCGGTGAGGGTGCGCTGCGGGTGCGCGTGCTCCAGCGCGAGGGCGGCAAGGCGATCACCGCCG
CCGATTACCTCAACGCGCGACGCGACCTGCCGGCGCTGCGCTGA

Upstream 100 bases:

>100_bases
CCACAAATCTGCTCCTACCTCTCAGCTCCACGCCATTCGCGCCCCGGCCAGCACACCTGCCGTTGCCCATCCCGAATCCC
AAATCCCGAATCCCAGCCTT

Downstream 100 bases:

>100_bases
TGTCGGCCGATACCGCAACCGCCGGCGTTGCCTCGCGCCTGGCCGCCGCACGCGTGCTGACGGCGGTGTTCGATCAGGGC
CGGTCGTTGAAGGCCGAACT

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MRIIFAGTPDFAVPSLRAAAQRHEVVAVYTQPDRPAGRGRGLTPSPVKLEAVARGIPVFQPQTLRSPEALATVRKLDADL
MVVVAYGLILPKAVLAAPTHGCWNVHASLLPRWRGAAPIQRAIEAGDTETGVCLMQMEAGLDTGPVLLSQRIEIGEQETG
GQLHDRLAALGAQVLSDGLGLLRAGIRPVAQPQPDDGVTYAHKLDKAQARLDWAQPAQELARRVRAFNPWPVAEAILAGE
RVRLHGAVALELAHQHPPGTLLAASKQGIDIACGEGALRVRVLQREGGKAITAADYLNARRDLPALR

Sequences:

>Translated_307_residues
MRIIFAGTPDFAVPSLRAAAQRHEVVAVYTQPDRPAGRGRGLTPSPVKLEAVARGIPVFQPQTLRSPEALATVRKLDADL
MVVVAYGLILPKAVLAAPTHGCWNVHASLLPRWRGAAPIQRAIEAGDTETGVCLMQMEAGLDTGPVLLSQRIEIGEQETG
GQLHDRLAALGAQVLSDGLGLLRAGIRPVAQPQPDDGVTYAHKLDKAQARLDWAQPAQELARRVRAFNPWPVAEAILAGE
RVRLHGAVALELAHQHPPGTLLAASKQGIDIACGEGALRVRVLQREGGKAITAADYLNARRDLPALR
>Mature_307_residues
MRIIFAGTPDFAVPSLRAAAQRHEVVAVYTQPDRPAGRGRGLTPSPVKLEAVARGIPVFQPQTLRSPEALATVRKLDADL
MVVVAYGLILPKAVLAAPTHGCWNVHASLLPRWRGAAPIQRAIEAGDTETGVCLMQMEAGLDTGPVLLSQRIEIGEQETG
GQLHDRLAALGAQVLSDGLGLLRAGIRPVAQPQPDDGVTYAHKLDKAQARLDWAQPAQELARRVRAFNPWPVAEAILAGE
RVRLHGAVALELAHQHPPGTLLAASKQGIDIACGEGALRVRVLQREGGKAITAADYLNARRDLPALR

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI238814322, Length=292, Percent_Identity=30.8219178082192, Blast_Score=118, Evalue=6e-27,
Organism=Homo sapiens, GI21614513, Length=297, Percent_Identity=28.6195286195286, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI164663775, Length=314, Percent_Identity=28.6624203821656, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1789683, Length=305, Percent_Identity=53.7704918032787, Blast_Score=302, Evalue=2e-83,
Organism=Escherichia coli, GI1788589, Length=272, Percent_Identity=29.0441176470588, Blast_Score=111, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI133930964, Length=321, Percent_Identity=26.791277258567, Blast_Score=107, Evalue=7e-24,
Organism=Drosophila melanogaster, GI45550868, Length=307, Percent_Identity=31.5960912052117, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28571984, Length=228, Percent_Identity=33.7719298245614, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24585660, Length=261, Percent_Identity=28.3524904214559, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 32793; Mature: 32793

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIIFAGTPDFAVPSLRAAAQRHEVVAVYTQPDRPAGRGRGLTPSPVKLEAVARGIPVFQ
CEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHCCCCCCC
PQTLRSPEALATVRKLDADLMVVVAYGLILPKAVLAAPTHGCWNVHASLLPRWRGAAPIQ
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHH
RAIEAGDTETGVCLMQMEAGLDTGPVLLSQRIEIGEQETGGQLHDRLAALGAQVLSDGLG
HHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLRAGIRPVAQPQPDDGVTYAHKLDKAQARLDWAQPAQELARRVRAFNPWPVAEAILAGE
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHCCC
RVRLHGAVALELAHQHPPGTLLAASKQGIDIACGEGALRVRVLQREGGKAITAADYLNAR
EEEEEHHEEEEEHHCCCCCCEEEECCCCCEEEECCCCEEEEEEECCCCCEEEHHHHHHHH
RDLPALR
CCCCCCC
>Mature Secondary Structure
MRIIFAGTPDFAVPSLRAAAQRHEVVAVYTQPDRPAGRGRGLTPSPVKLEAVARGIPVFQ
CEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEHHHHHCCCCCCC
PQTLRSPEALATVRKLDADLMVVVAYGLILPKAVLAAPTHGCWNVHASLLPRWRGAAPIQ
CCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCHHH
RAIEAGDTETGVCLMQMEAGLDTGPVLLSQRIEIGEQETGGQLHDRLAALGAQVLSDGLG
HHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LLRAGIRPVAQPQPDDGVTYAHKLDKAQARLDWAQPAQELARRVRAFNPWPVAEAILAGE
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHCCC
RVRLHGAVALELAHQHPPGTLLAASKQGIDIACGEGALRVRVLQREGGKAITAADYLNAR
EEEEEHHEEEEEHHCCCCCCEEEECCCCCEEEECCCCEEEEEEECCCCCEEEHHHHHHHH
RDLPALR
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]