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The map label for this gene is cobQ

Identifier: 78048873

GI number: 78048873

Start: 3794345

End: 3795781

Strand: Reverse

Name: cobQ

Synonym: XCV3317

Alternate gene names: 78048873

Gene position: 3795781-3794345 (Counterclockwise)

Preceding gene: 78048874

Following gene: 78048872

Centisome position: 73.3

GC content: 67.08

Gene sequence:

>1437_bases
ATGAGCGCGCGCGTCCTGATGGTGCAGGGCTGCACCTCCGATGCGGGCAAGAGCACGCTGGTGGCCGCGCTGTGCCGGTG
GCTGCATCGGCAGGGCATTGCGGTGGCGCCATTCAAGCCGCAGAACATGGCGTTGAATTCGGCAGTGACGGTGGACGGTG
GCGAAATCGGCCGCGCGCAGGCATTGCAGGCACAGGCATGCGGGCTGGAGCCGCAGACCGATTTCAACCCGGTGTTGCTC
AAGCCCAACAGCGATACCGGTGCGCAGGTCATCGTGCACGGGCATCCGGTCGCCACCCTGGATGCGGTGGGCTATCACGC
CTACAAGGCGACCGCATTCAACGCCGTGTTGGCCTCGCACGCGCGCCTGGTCGAGCGCTTCGATGTGGTGCTGGTGGAAG
GTGCTGGCAGCCCGGCCGAGATCAATTTGCGCGACAACGACATCGCCAACATGGGCTATGCCGAAGCGGTGGACTGCGCC
GTGATCCTGGTGGCCGACATCGACCGCGGCGGTGTGTTCGCCCATCTGGTCGGCACGCTGGCGTTGCTCTCGGCCAGCGA
GCGCGCACGCGTTGCCGGTGTTGTGATCAATCGGTTTCGCGGGGATCTGGCGCTGCTGCAGCCCGGGCTGGCGTGGCTGG
AGCGCGAAACGGGCAAGCCGGTGCTCGGCGTGCTGCCGTATCTGCACGGACTGCAGCTGGATGCCGAAGATGCGGTGCCA
CGCAACGCGCCGCAGGAACCACAGTCGCAATTGCGCGTGGTGGTGCCGGTGCTGCCGCGCATCAGCAATCACACCGATGT
CGACGCGTTGCTGGCGCATCCGCAGGTGGATGTGCGCTTGATCGGTCCCGGGCAGACGCCGCCGCCGTGCGATCTGATCC
TGTTGCCGGGCAGCAAATCCACCCGGCACGATCTGCAGTGGCTGCGTACGCACGGGTGGGACGCCGCCATTGCCCGTCAC
CTGCGCTACGGCGGAAAACTGCTTGGCATCTGCGGTGGACTGCAGATGCTGGGCACCCATCTCCACGACCCGCGTGGCAT
CGAGGGGGCAGCGGGCAGCAGCCCCGGTCTTGGGTGGCTGTCGCTGCAAACCACGCTGCAGCCGCACAAGCAACTGCATC
GCGTGCACGGGCGCCTGCTGCTGGGCGACGCCAGTGTCAGCGGCTATGAAATTCACTGCGCTCTCAGCAGCGGCGCCGCG
CTGGCACGGCCATTGCTGCAGCTGGACGATGGGCGTACCGATGGCGCCATCTCCGACGATGGCCAGGTGCTCGGCACCTA
TGTGCATGGGGTGTTCGACCACCCCATGCACTGGCTGCATTGCTGGCGTGGGCCGGTCTGGCGCAGGCCGCGCCACTGGA
TCTTGCCGCGCTGCGCGAAGCCAGCCTGGAGCGTCTGGCCGATGCGGTGCACACGCATCTGGATACCGCGGCACTGA

Upstream 100 bases:

>100_bases
TGACGCGGCTGTTCGACACACCGAACAGTCTGCGCCTGGGTCTTCCACCCGACGCCGCGGGCGAGGCGCGCCTGGGCGTG
GCACTGCGCCAGGTGCTGGC

Downstream 100 bases:

>100_bases
CACGCCTCATCAGCAGGGAACCGGCATGCAGCAACTGATTCTTGGCGGCGCCCGTTCGGGCAAGAGCGCGCTGGCCGAGC
GCATCGCGGCAGGGTCCGGG

Product: cobyric acid synthase

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 478; Mature: 477

Protein sequence:

>478_residues
MSARVLMVQGCTSDAGKSTLVAALCRWLHRQGIAVAPFKPQNMALNSAVTVDGGEIGRAQALQAQACGLEPQTDFNPVLL
KPNSDTGAQVIVHGHPVATLDAVGYHAYKATAFNAVLASHARLVERFDVVLVEGAGSPAEINLRDNDIANMGYAEAVDCA
VILVADIDRGGVFAHLVGTLALLSASERARVAGVVINRFRGDLALLQPGLAWLERETGKPVLGVLPYLHGLQLDAEDAVP
RNAPQEPQSQLRVVVPVLPRISNHTDVDALLAHPQVDVRLIGPGQTPPPCDLILLPGSKSTRHDLQWLRTHGWDAAIARH
LRYGGKLLGICGGLQMLGTHLHDPRGIEGAAGSSPGLGWLSLQTTLQPHKQLHRVHGRLLLGDASVSGYEIHCALSSGAA
LARPLLQLDDGRTDGAISDDGQVLGTYVHGVFDHPMHWLHCWRGPVWRRPRHWILPRCAKPAWSVWPMRCTRIWIPRH

Sequences:

>Translated_478_residues
MSARVLMVQGCTSDAGKSTLVAALCRWLHRQGIAVAPFKPQNMALNSAVTVDGGEIGRAQALQAQACGLEPQTDFNPVLL
KPNSDTGAQVIVHGHPVATLDAVGYHAYKATAFNAVLASHARLVERFDVVLVEGAGSPAEINLRDNDIANMGYAEAVDCA
VILVADIDRGGVFAHLVGTLALLSASERARVAGVVINRFRGDLALLQPGLAWLERETGKPVLGVLPYLHGLQLDAEDAVP
RNAPQEPQSQLRVVVPVLPRISNHTDVDALLAHPQVDVRLIGPGQTPPPCDLILLPGSKSTRHDLQWLRTHGWDAAIARH
LRYGGKLLGICGGLQMLGTHLHDPRGIEGAAGSSPGLGWLSLQTTLQPHKQLHRVHGRLLLGDASVSGYEIHCALSSGAA
LARPLLQLDDGRTDGAISDDGQVLGTYVHGVFDHPMHWLHCWRGPVWRRPRHWILPRCAKPAWSVWPMRCTRIWIPRH
>Mature_477_residues
SARVLMVQGCTSDAGKSTLVAALCRWLHRQGIAVAPFKPQNMALNSAVTVDGGEIGRAQALQAQACGLEPQTDFNPVLLK
PNSDTGAQVIVHGHPVATLDAVGYHAYKATAFNAVLASHARLVERFDVVLVEGAGSPAEINLRDNDIANMGYAEAVDCAV
ILVADIDRGGVFAHLVGTLALLSASERARVAGVVINRFRGDLALLQPGLAWLERETGKPVLGVLPYLHGLQLDAEDAVPR
NAPQEPQSQLRVVVPVLPRISNHTDVDALLAHPQVDVRLIGPGQTPPPCDLILLPGSKSTRHDLQWLRTHGWDAAIARHL
RYGGKLLGICGGLQMLGTHLHDPRGIEGAAGSSPGLGWLSLQTTLQPHKQLHRVHGRLLLGDASVSGYEIHCALSSGAAL
ARPLLQLDDGRTDGAISDDGQVLGTYVHGVFDHPMHWLHCWRGPVWRRPRHWILPRCAKPAWSVWPMRCTRIWIPRH

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBQ_XANC5 (Q3BQB5)

Other databases:

- EMBL:   AM039952
- RefSeq:   YP_365048.1
- ProteinModelPortal:   Q3BQB5
- SMR:   Q3BQB5
- STRING:   Q3BQB5
- GeneID:   3733049
- GenomeReviews:   AM039952_GR
- KEGG:   xcv:XCV3317
- NMPDR:   fig|316273.3.peg.3332
- eggNOG:   COG1492
- HOGENOM:   HBG302271
- OMA:   ICLPRIS
- ProtClustDB:   PRK00784
- HAMAP:   MF_00028
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- TIGRFAMs:   TIGR00313

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3

EC number: 6.3.5.10

Molecular weight: Translated: 51616; Mature: 51485

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS51274 GATASE_COBBQ

Important sites: ACT_SITE 331-331 ACT_SITE 429-429

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARVLMVQGCTSDAGKSTLVAALCRWLHRQGIAVAPFKPQNMALNSAVTVDGGEIGRAQ
CCCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEECCEEEECCCCCCHHH
ALQAQACGLEPQTDFNPVLLKPNSDTGAQVIVHGHPVATLDAVGYHAYKATAFNAVLASH
HHHHHHCCCCCCCCCCCEEEECCCCCCCEEEEECCCCEEHHHCCHHHHHHHHHHHHHHHH
ARLVERFDVVLVEGAGSPAEINLRDNDIANMGYAEAVDCAVILVADIDRGGVFAHLVGTL
HHHHHHEEEEEEECCCCCEEEEECCCCCCCCCCHHHCCEEEEEEEECCCCCHHHHHHHHH
ALLSASERARVAGVVINRFRGDLALLQPGLAWLERETGKPVLGVLPYLHGLQLDAEDAVP
HHHCCCCCHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCCCHHHHHHHHHCCEECHHHCCC
RNAPQEPQSQLRVVVPVLPRISNHTDVDALLAHPQVDVRLIGPGQTPPPCDLILLPGSKS
CCCCCCCHHHHEEEEEHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCC
TRHDLQWLRTHGWDAAIARHLRYGGKLLGICGGLQMLGTHLHDPRGIEGAAGSSPGLGWL
CHHHHHHHHHCCCHHHHHHHHHHCCEEEHHHHCHHHHHHHCCCCCCCCCCCCCCCCCEEE
SLQTTLQPHKQLHRVHGRLLLGDASVSGYEIHCALSSGAALARPLLQLDDGRTDGAISDD
EEEHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCC
GQVLGTYVHGVFDHPMHWLHCWRGPVWRRPRHWILPRCAKPAWSVWPMRCTRIWIPRH
CCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCC
>Mature Secondary Structure 
SARVLMVQGCTSDAGKSTLVAALCRWLHRQGIAVAPFKPQNMALNSAVTVDGGEIGRAQ
CCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEECCEEEECCCCCCHHH
ALQAQACGLEPQTDFNPVLLKPNSDTGAQVIVHGHPVATLDAVGYHAYKATAFNAVLASH
HHHHHHCCCCCCCCCCCEEEECCCCCCCEEEEECCCCEEHHHCCHHHHHHHHHHHHHHHH
ARLVERFDVVLVEGAGSPAEINLRDNDIANMGYAEAVDCAVILVADIDRGGVFAHLVGTL
HHHHHHEEEEEEECCCCCEEEEECCCCCCCCCCHHHCCEEEEEEEECCCCCHHHHHHHHH
ALLSASERARVAGVVINRFRGDLALLQPGLAWLERETGKPVLGVLPYLHGLQLDAEDAVP
HHHCCCCCHHHHHHHHHHHCCCHHHHCCCHHHHHHCCCCCHHHHHHHHHCCEECHHHCCC
RNAPQEPQSQLRVVVPVLPRISNHTDVDALLAHPQVDVRLIGPGQTPPPCDLILLPGSKS
CCCCCCCHHHHEEEEEHHCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCC
TRHDLQWLRTHGWDAAIARHLRYGGKLLGICGGLQMLGTHLHDPRGIEGAAGSSPGLGWL
CHHHHHHHHHCCCHHHHHHHHHHCCEEEHHHHCHHHHHHHCCCCCCCCCCCCCCCCCEEE
SLQTTLQPHKQLHRVHGRLLLGDASVSGYEIHCALSSGAALARPLLQLDDGRTDGAISDD
EEEHHHHHHHHHHHHCCEEEEECCCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCCCCCC
GQVLGTYVHGVFDHPMHWLHCWRGPVWRRPRHWILPRCAKPAWSVWPMRCTRIWIPRH
CCCHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA