Click here to switch to the map view.

The map label for this gene is yfnA [H]

Identifier: 78047444

GI number: 78047444

Start: 2134873

End: 2136345

Strand: Reverse

Name: yfnA [H]

Synonym: XCV1888

Alternate gene names: 78047444

Gene position: 2136345-2134873 (Counterclockwise)

Preceding gene: 78047446

Following gene: 78047443

Centisome position: 41.25

GC content: 64.9

Gene sequence:

>1473_bases
ATGCTGAAGTCTCTGTTGAGGGTCAAATCGATCGAGCCCGCTGGCCACGTCGATGCAGGCGAACCGGTCGAAGGCAGCCT
GCAAGGCGAAGCGACGCTGCAACGGACCCTCACAGCCAAGCACCTGATCATGCTCGGTATCGGCGCGGTGATCGGCGCCG
GCATCTTCGTGCTGACCGGCCAGGCCGCGGCCAATCACGCCGGCCCGGCGGTGATGCTGTCGTTCGTGTTCGCCGGTATC
GCCTGCGCCTTCGCCGGCCTGTGCTACGCCGAATTCGCCGCGATGATGCCGGTCTCCGGCAGCGCCTATTCGTATTCATA
CGCCACGCTCGGCGAAGGCATCGCCTGGTTCATCGGCTGGTGTCTGGTGCTGGAATACCTGTTCGCCGGGTCCAGCGTTG
CCGTCGGCTGGTCTGCCTACCTGATCAGCTTCATCACCGGCACCCTGGGGTTGCCGTTCCCCGCAGAGTTGGCGGGTGCG
CCGCTGGCCTGGGACGGCCACGGCTTTGTCAGCTCCGGGAATCTGGTCAACCTGCCGGCCGTGCTGATCGTCGCGGCGGT
GAGCATCCTGTGCTACGTCGGCGTCACCCAGTCGGCGTTCGCCAACGCGATCGTGGTGGCGATCAAGGTCGTGGTGATCT
GCCTGTTCGTGGGCTTTGGCATTTCCTATATCGACCCGGCGAACTGGCACCCCTTCATCCCGGAAAACACCGGCCCTGGC
CAGTTCGGCTGGGACGGGGTGTTTCGCGCCGCGTCCATCGTGTTCTTCTCCTACATCGGCTTCGACGCGGTTTCCACCTC
GGCCGGCGAAACCAAGGATCCGCAGAAGAACATGCCGATCGGCATCCTGGTGTCGTTGGCCATCTGCACCGTCATCTACA
TCATCGTCTGCGCGGTGCTGACCGGCCTGCTGCCCTATACCCAGCTCGGCACCGCCAAGCCGGTGGCCACCGCGCTGGAA
GCCCACCCGCAACTGACCTGGCTCAAGACCGCGGTGGAAATCGGTGCCATTGCCGGCTTGTCGTCGGTGGTGCTGGTGAT
GCTGATGGCGCAGCCGCGCATCTTCTACACCATGGCCAAGGATGGGCTGATGCCCAAGCTGTTCGGCAAGGTGCACCCGA
AATTCCGCACGCCTTACGTCGGCACGCTGTTCGTGGGCGTGGTCGCCGCGCTGCTGGCCGGGGTGATCCCGTTGAACGTG
CTGGGCGAACTCGTCTCGATGGGTACCCTGCTCGCCTTCGCCACGGTCTGCGCCGGCGTGCTGGTGCTGCGCTTCACCAA
GCCCGACCTGCCGCGCCCGTTCCGGGTGCCGCTGGCGATGGTGATCTGCCCCCTGGGCGCGTTGGCCTGTCTGTTCCTGT
TCTTCCAGGCCTTCCAGGAACACTGGAAGGTGTTCGTGGGCTGGACCGTGATTGGCCTGGCGATCTACTTCGGCTACGGC
ATCCACCACAGTCGCCTCGCGAAACGGGCCTAA

Upstream 100 bases:

>100_bases
CTTTGGCAAGGTAGGCCGCTTGCCTGTCCCACCGGGATGCGGCGCACCAATTCGTCCGGGCGCCCGCGCCTTCAAGCTTT
GCCACTTAGGGATGTACCGA

Downstream 100 bases:

>100_bases
GCTTCTCTCAAGACCGGCGCGCGACGCCGGTCTTCTTGTTCAATGACCGCGCGTAGCGCCAAGCCGGAACCGCTTCATGT
TCAAACAACTTTGGGCCACC

Product: amino acid-polyamine-organocation superfamily protein

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MLKSLLRVKSIEPAGHVDAGEPVEGSLQGEATLQRTLTAKHLIMLGIGAVIGAGIFVLTGQAAANHAGPAVMLSFVFAGI
ACAFAGLCYAEFAAMMPVSGSAYSYSYATLGEGIAWFIGWCLVLEYLFAGSSVAVGWSAYLISFITGTLGLPFPAELAGA
PLAWDGHGFVSSGNLVNLPAVLIVAAVSILCYVGVTQSAFANAIVVAIKVVVICLFVGFGISYIDPANWHPFIPENTGPG
QFGWDGVFRAASIVFFSYIGFDAVSTSAGETKDPQKNMPIGILVSLAICTVIYIIVCAVLTGLLPYTQLGTAKPVATALE
AHPQLTWLKTAVEIGAIAGLSSVVLVMLMAQPRIFYTMAKDGLMPKLFGKVHPKFRTPYVGTLFVGVVAALLAGVIPLNV
LGELVSMGTLLAFATVCAGVLVLRFTKPDLPRPFRVPLAMVICPLGALACLFLFFQAFQEHWKVFVGWTVIGLAIYFGYG
IHHSRLAKRA

Sequences:

>Translated_490_residues
MLKSLLRVKSIEPAGHVDAGEPVEGSLQGEATLQRTLTAKHLIMLGIGAVIGAGIFVLTGQAAANHAGPAVMLSFVFAGI
ACAFAGLCYAEFAAMMPVSGSAYSYSYATLGEGIAWFIGWCLVLEYLFAGSSVAVGWSAYLISFITGTLGLPFPAELAGA
PLAWDGHGFVSSGNLVNLPAVLIVAAVSILCYVGVTQSAFANAIVVAIKVVVICLFVGFGISYIDPANWHPFIPENTGPG
QFGWDGVFRAASIVFFSYIGFDAVSTSAGETKDPQKNMPIGILVSLAICTVIYIIVCAVLTGLLPYTQLGTAKPVATALE
AHPQLTWLKTAVEIGAIAGLSSVVLVMLMAQPRIFYTMAKDGLMPKLFGKVHPKFRTPYVGTLFVGVVAALLAGVIPLNV
LGELVSMGTLLAFATVCAGVLVLRFTKPDLPRPFRVPLAMVICPLGALACLFLFFQAFQEHWKVFVGWTVIGLAIYFGYG
IHHSRLAKRA
>Mature_490_residues
MLKSLLRVKSIEPAGHVDAGEPVEGSLQGEATLQRTLTAKHLIMLGIGAVIGAGIFVLTGQAAANHAGPAVMLSFVFAGI
ACAFAGLCYAEFAAMMPVSGSAYSYSYATLGEGIAWFIGWCLVLEYLFAGSSVAVGWSAYLISFITGTLGLPFPAELAGA
PLAWDGHGFVSSGNLVNLPAVLIVAAVSILCYVGVTQSAFANAIVVAIKVVVICLFVGFGISYIDPANWHPFIPENTGPG
QFGWDGVFRAASIVFFSYIGFDAVSTSAGETKDPQKNMPIGILVSLAICTVIYIIVCAVLTGLLPYTQLGTAKPVATALE
AHPQLTWLKTAVEIGAIAGLSSVVLVMLMAQPRIFYTMAKDGLMPKLFGKVHPKFRTPYVGTLFVGVVAALLAGVIPLNV
LGELVSMGTLLAFATVCAGVLVLRFTKPDLPRPFRVPLAMVICPLGALACLFLFFQAFQEHWKVFVGWTVIGLAIYFGYG
IHHSRLAKRA

Specific function: Permease That Is Involved In The Transport Across The Cytoplasmic Membrane Of Lysine. [C]

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI4507047, Length=425, Percent_Identity=36.4705882352941, Blast_Score=240, Evalue=2e-63,
Organism=Homo sapiens, GI114326544, Length=429, Percent_Identity=33.1002331002331, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI114326550, Length=429, Percent_Identity=33.1002331002331, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI258614005, Length=419, Percent_Identity=33.6515513126492, Blast_Score=226, Evalue=5e-59,
Organism=Homo sapiens, GI258614003, Length=419, Percent_Identity=33.6515513126492, Blast_Score=225, Evalue=6e-59,
Organism=Homo sapiens, GI258645169, Length=419, Percent_Identity=33.1742243436754, Blast_Score=218, Evalue=8e-57,
Organism=Homo sapiens, GI181337167, Length=420, Percent_Identity=36.1904761904762, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI110347453, Length=409, Percent_Identity=35.9413202933985, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI33286428, Length=460, Percent_Identity=25.6521739130435, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI71979932, Length=470, Percent_Identity=27.6595744680851, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI186910308, Length=430, Percent_Identity=24.4186046511628, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI186910306, Length=430, Percent_Identity=24.4186046511628, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI186910304, Length=430, Percent_Identity=24.4186046511628, Blast_Score=91, Evalue=4e-18,
Organism=Homo sapiens, GI187423910, Length=459, Percent_Identity=23.3115468409586, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI7657591, Length=459, Percent_Identity=23.3115468409586, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI115648063, Length=446, Percent_Identity=23.542600896861, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI115648022, Length=446, Percent_Identity=23.542600896861, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI71999149, Length=420, Percent_Identity=25.7142857142857, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI33286430, Length=202, Percent_Identity=27.2277227722772, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI7657683, Length=380, Percent_Identity=21.8421052631579, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1788480, Length=358, Percent_Identity=27.3743016759777, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI87082023, Length=458, Percent_Identity=26.6375545851528, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87081869, Length=471, Percent_Identity=27.1762208067941, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082250, Length=367, Percent_Identity=27.5204359673025, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786694, Length=388, Percent_Identity=26.5463917525773, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1786602, Length=405, Percent_Identity=24.1975308641975, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790653, Length=432, Percent_Identity=22.6851851851852, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789017, Length=364, Percent_Identity=25.5494505494505, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87081708, Length=450, Percent_Identity=21.5555555555556, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786789, Length=433, Percent_Identity=22.8637413394919, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI87081915, Length=405, Percent_Identity=24.4444444444444, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786302, Length=443, Percent_Identity=24.3792325056433, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994972, Length=362, Percent_Identity=23.7569060773481, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=431, Percent_Identity=32.7146171693735, Blast_Score=227, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17533459, Length=410, Percent_Identity=34.390243902439, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI17531343, Length=428, Percent_Identity=32.9439252336449, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI17540018, Length=446, Percent_Identity=24.6636771300448, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17568033, Length=449, Percent_Identity=22.71714922049, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71993915, Length=433, Percent_Identity=23.3256351039261, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI32566699, Length=384, Percent_Identity=22.65625, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17537453, Length=368, Percent_Identity=22.2826086956522, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324553, Length=384, Percent_Identity=24.7395833333333, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI221512776, Length=428, Percent_Identity=35.7476635514019, Blast_Score=249, Evalue=3e-66,
Organism=Drosophila melanogaster, GI24666159, Length=428, Percent_Identity=35.7476635514019, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI24668806, Length=419, Percent_Identity=37.4701670644391, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI21356285, Length=419, Percent_Identity=37.4701670644391, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24668802, Length=419, Percent_Identity=37.4701670644391, Blast_Score=247, Evalue=2e-65,
Organism=Drosophila melanogaster, GI24667468, Length=422, Percent_Identity=36.4928909952607, Blast_Score=242, Evalue=5e-64,
Organism=Drosophila melanogaster, GI281366235, Length=434, Percent_Identity=35.9447004608295, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI116007820, Length=434, Percent_Identity=35.9447004608295, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI116007818, Length=439, Percent_Identity=34.8519362186788, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI85725152, Length=439, Percent_Identity=34.8519362186788, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI161077963, Length=451, Percent_Identity=31.4855875831486, Blast_Score=193, Evalue=3e-49,
Organism=Drosophila melanogaster, GI45550968, Length=484, Percent_Identity=22.9338842975207, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19921172, Length=484, Percent_Identity=22.9338842975207, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24651635, Length=422, Percent_Identity=24.6445497630332, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24651633, Length=422, Percent_Identity=24.6445497630332, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221331183, Length=478, Percent_Identity=24.2677824267782, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI17647653, Length=478, Percent_Identity=24.2677824267782, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24664379, Length=478, Percent_Identity=24.2677824267782, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21357367, Length=467, Percent_Identity=23.7687366167024, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR015606 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51689; Mature: 51689

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKSLLRVKSIEPAGHVDAGEPVEGSLQGEATLQRTLTAKHLIMLGIGAVIGAGIFVLTG
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEC
QAAANHAGPAVMLSFVFAGIACAFAGLCYAEFAAMMPVSGSAYSYSYATLGEGIAWFIGW
CHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHH
CLVLEYLFAGSSVAVGWSAYLISFITGTLGLPFPAELAGAPLAWDGHGFVSSGNLVNLPA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEECCCCEECCCCEECHHH
VLIVAAVSILCYVGVTQSAFANAIVVAIKVVVICLFVGFGISYIDPANWHPFIPENTGPG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
QFGWDGVFRAASIVFFSYIGFDAVSTSAGETKDPQKNMPIGILVSLAICTVIYIIVCAVL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TGLLPYTQLGTAKPVATALEAHPQLTWLKTAVEIGAIAGLSSVVLVMLMAQPRIFYTMAK
HHHCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
DGLMPKLFGKVHPKFRTPYVGTLFVGVVAALLAGVIPLNVLGELVSMGTLLAFATVCAGV
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLRFTKPDLPRPFRVPLAMVICPLGALACLFLFFQAFQEHWKVFVGWTVIGLAIYFGYG
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IHHSRLAKRA
CHHHHHHHCC
>Mature Secondary Structure
MLKSLLRVKSIEPAGHVDAGEPVEGSLQGEATLQRTLTAKHLIMLGIGAVIGAGIFVLTG
CCHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEC
QAAANHAGPAVMLSFVFAGIACAFAGLCYAEFAAMMPVSGSAYSYSYATLGEGIAWFIGW
CHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHH
CLVLEYLFAGSSVAVGWSAYLISFITGTLGLPFPAELAGAPLAWDGHGFVSSGNLVNLPA
HHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCCEEECCCCEECCCCEECHHH
VLIVAAVSILCYVGVTQSAFANAIVVAIKVVVICLFVGFGISYIDPANWHPFIPENTGPG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
QFGWDGVFRAASIVFFSYIGFDAVSTSAGETKDPQKNMPIGILVSLAICTVIYIIVCAVL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TGLLPYTQLGTAKPVATALEAHPQLTWLKTAVEIGAIAGLSSVVLVMLMAQPRIFYTMAK
HHHCCHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
DGLMPKLFGKVHPKFRTPYVGTLFVGVVAALLAGVIPLNVLGELVSMGTLLAFATVCAGV
CCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLRFTKPDLPRPFRVPLAMVICPLGALACLFLFFQAFQEHWKVFVGWTVIGLAIYFGYG
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IHHSRLAKRA
CHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]