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The map label for this gene is serA [H]

Identifier: 78047446

GI number: 78047446

Start: 2137228

End: 2138550

Strand: Reverse

Name: serA [H]

Synonym: XCV1890

Alternate gene names: 78047446

Gene position: 2138550-2137228 (Counterclockwise)

Preceding gene: 78047450

Following gene: 78047444

Centisome position: 41.3

GC content: 64.47

Gene sequence:

>1323_bases
GTGCGAACAGCGCATCGCGGCCACCCAATCGCGCACCCCATCTGGCATAGTTGCCGGCCCGATTGCTGCATTGCGTTCCC
CATGTCGCCGAAGAAAACCTCGTTTCCCAAGCAGGACATCCGCGTGCTGTTGCTGGAAGGCATCAGCCCGACCGCCGTGG
ACGTGTTCCGCGCCGCCGGCTACTCGCAGATCGAACTGCACGCCAAATCGCTGCCGGAAGACGAGTTGATCGCCCGCATC
TCCGACGCGCATATCGTCGGTATCCGCTCGCGCACGCAGCTGAGCGCCGAGGTGCTGGCGCATGCCAAGCGCCTGATCGC
AGTCGGCTGCTTCTGCATCGGTACCAACCAGGTGGACCTGGACGCGGCCGAGCTGGCCGGCATCCCGGTGTTCAACGCGC
CCTACTCCAATACCCGCAGCGTGGCCGAACTGGTCATCGCCGAAGCGATCCTGTTGCTGCGTGGCATTCCGCAGAAGAAC
GCGCAATGCCATCGCGGCGGCTGGTCCAAGTCGGCCGCCGGCAGCCACGAAACGCGCGGCAAGGTGCTGGGCATCGTCGG
CTACGGGCATATCGGCACCCAGGTCGGCGTGCTGGCCGAAGCGTTGGGCATGCAGGTGATCTTCCACGATATCGAAACCA
AGTTGTCGTTGGGCAACGCACGCGCGGCCATCGACCTGGACGAGCTGCTGGCGCGCTCGGACGTGGTCACCTTGCACGTG
CCGGAAACCCCGTCGACCAAGGACATGATCGGCGCAGCCGAAATCGCCCGCATGAAGCCTGGCGCGCACCTGATCAACGC
CTCGCGCGGCACCGTCATCGACATCGACGCGCTGGATGCGGCGCTCACCTCCGGCCACATCGGCGGCGCGGCGGTGGATG
TCTTTCCGATCGAGCCCAAGGGCAATGGCGATGCGTTCGAATCGCCGCTCACCGCGCACGACAATGTGATCCTGACCCCG
CACGTGGGCGGCAGCACGCTGGAGGCGCAGGACAACATCGGGATCGAGGTCGCCGCCAAACTGGTGCGCTATAGCGACAA
TGGCAGCACCTTGTCGGCAGTGAACTTTCCGGAGGTCACCCTGCCCGAGCACGCTGAAAGCCTGCGGTTGTTGCATATCC
ATCGCAATGTGCCGGGCGTGCTGTCGCAGATCAACGAATTGTTCTCGCGCCATAACGTCAACATCGACGGCCAGTTCCTG
CGCACCGACCCCAAGGTGGGCTATGTGGTCATCGATGTCAGCGCCAGCGAGGAGCTTGCCGGCGTGCTGAAGGACGAGCT
GGGACAGATCACCGGCACCTTGCGGACGCGGGTCCTGTATTGA

Upstream 100 bases:

>100_bases
CACAGCGTGCCAGCGCCGGCCTGCCTCGTCCAGCCGGCGCACTCACGGCCGACGCAGCGTTGGATTCAGCTGAAACCGTT
GCGCCGCAAGGGCTTCGCCG

Downstream 100 bases:

>100_bases
GCGGGATTTGGGAATCGGGATTCGGCATTGGTAACAGCGGTTCGCCGCAGCCGGTGGGTTCATCGGTCCAACCACGCTGT
GGGAGCAGACATGGCCCGCT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MRTAHRGHPIAHPIWHSCRPDCCIAFPMSPKKTSFPKQDIRVLLLEGISPTAVDVFRAAGYSQIELHAKSLPEDELIARI
SDAHIVGIRSRTQLSAEVLAHAKRLIAVGCFCIGTNQVDLDAAELAGIPVFNAPYSNTRSVAELVIAEAILLLRGIPQKN
AQCHRGGWSKSAAGSHETRGKVLGIVGYGHIGTQVGVLAEALGMQVIFHDIETKLSLGNARAAIDLDELLARSDVVTLHV
PETPSTKDMIGAAEIARMKPGAHLINASRGTVIDIDALDAALTSGHIGGAAVDVFPIEPKGNGDAFESPLTAHDNVILTP
HVGGSTLEAQDNIGIEVAAKLVRYSDNGSTLSAVNFPEVTLPEHAESLRLLHIHRNVPGVLSQINELFSRHNVNIDGQFL
RTDPKVGYVVIDVSASEELAGVLKDELGQITGTLRTRVLY

Sequences:

>Translated_440_residues
MRTAHRGHPIAHPIWHSCRPDCCIAFPMSPKKTSFPKQDIRVLLLEGISPTAVDVFRAAGYSQIELHAKSLPEDELIARI
SDAHIVGIRSRTQLSAEVLAHAKRLIAVGCFCIGTNQVDLDAAELAGIPVFNAPYSNTRSVAELVIAEAILLLRGIPQKN
AQCHRGGWSKSAAGSHETRGKVLGIVGYGHIGTQVGVLAEALGMQVIFHDIETKLSLGNARAAIDLDELLARSDVVTLHV
PETPSTKDMIGAAEIARMKPGAHLINASRGTVIDIDALDAALTSGHIGGAAVDVFPIEPKGNGDAFESPLTAHDNVILTP
HVGGSTLEAQDNIGIEVAAKLVRYSDNGSTLSAVNFPEVTLPEHAESLRLLHIHRNVPGVLSQINELFSRHNVNIDGQFL
RTDPKVGYVVIDVSASEELAGVLKDELGQITGTLRTRVLY
>Mature_440_residues
MRTAHRGHPIAHPIWHSCRPDCCIAFPMSPKKTSFPKQDIRVLLLEGISPTAVDVFRAAGYSQIELHAKSLPEDELIARI
SDAHIVGIRSRTQLSAEVLAHAKRLIAVGCFCIGTNQVDLDAAELAGIPVFNAPYSNTRSVAELVIAEAILLLRGIPQKN
AQCHRGGWSKSAAGSHETRGKVLGIVGYGHIGTQVGVLAEALGMQVIFHDIETKLSLGNARAAIDLDELLARSDVVTLHV
PETPSTKDMIGAAEIARMKPGAHLINASRGTVIDIDALDAALTSGHIGGAAVDVFPIEPKGNGDAFESPLTAHDNVILTP
HVGGSTLEAQDNIGIEVAAKLVRYSDNGSTLSAVNFPEVTLPEHAESLRLLHIHRNVPGVLSQINELFSRHNVNIDGQFL
RTDPKVGYVVIDVSASEELAGVLKDELGQITGTLRTRVLY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=322, Percent_Identity=34.7826086956522, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI145580578, Length=266, Percent_Identity=33.0827067669173, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI4557499, Length=266, Percent_Identity=33.0827067669173, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI61743967, Length=282, Percent_Identity=30.8510638297872, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI4557497, Length=302, Percent_Identity=30.4635761589404, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI145580575, Length=266, Percent_Identity=33.0827067669173, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI6912396, Length=280, Percent_Identity=26.4285714285714, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1789279, Length=409, Percent_Identity=61.1246943765281, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI87082289, Length=249, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1787645, Length=248, Percent_Identity=31.4516129032258, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1788660, Length=295, Percent_Identity=29.4915254237288, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI87081824, Length=151, Percent_Identity=32.4503311258278, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=323, Percent_Identity=33.7461300309598, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI25147481, Length=276, Percent_Identity=31.5217391304348, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=421, Percent_Identity=49.4061757719715, Blast_Score=416, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322116, Length=435, Percent_Identity=48.0459770114943, Blast_Score=413, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6324055, Length=242, Percent_Identity=28.9256198347107, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324964, Length=261, Percent_Identity=27.9693486590038, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6325144, Length=152, Percent_Identity=31.5789473684211, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=156, Percent_Identity=30.1282051282051, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=308, Percent_Identity=32.1428571428571, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24646446, Length=239, Percent_Identity=33.4728033472803, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646448, Length=239, Percent_Identity=33.4728033472803, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646452, Length=239, Percent_Identity=33.4728033472803, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24646450, Length=239, Percent_Identity=33.4728033472803, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI28574286, Length=261, Percent_Identity=30.2681992337165, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI62472511, Length=239, Percent_Identity=33.4728033472803, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28571528, Length=296, Percent_Identity=27.3648648648649, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24585516, Length=297, Percent_Identity=24.2424242424242, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI45552429, Length=262, Percent_Identity=25.9541984732824, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574284, Length=292, Percent_Identity=24.6575342465753, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24585514, Length=281, Percent_Identity=25.6227758007117, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28574282, Length=281, Percent_Identity=25.6227758007117, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551003, Length=262, Percent_Identity=25.9541984732824, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 47048; Mature: 47048

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTAHRGHPIAHPIWHSCRPDCCIAFPMSPKKTSFPKQDIRVLLLEGISPTAVDVFRAAG
CCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCCCCHHHEEEEEECCCCCHHHHHHHHCC
YSQIELHAKSLPEDELIARISDAHIVGIRSRTQLSAEVLAHAKRLIAVGCFCIGTNQVDL
CCEEEEEHHCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHEEEEEEECCCCCC
DAAELAGIPVFNAPYSNTRSVAELVIAEAILLLRGIPQKNAQCHRGGWSKSAAGSHETRG
CHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
KVLGIVGYGHIGTQVGVLAEALGMQVIFHDIETKLSLGNARAAIDLDELLARSDVVTLHV
CEEEEEECCCHHHHHHHHHHHHHHHHEEHHHHHHHCCCCCEEEECHHHHHHCCCEEEEEC
PETPSTKDMIGAAEIARMKPGAHLINASRGTVIDIDALDAALTSGHIGGAAVDVFPIEPK
CCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEHHHHHHHHCCCCCCEEEEEEECCCC
GNGDAFESPLTAHDNVILTPHVGGSTLEAQDNIGIEVAAKLVRYSDNGSTLSAVNFPEVT
CCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCHHHHEEHHEECCCCCEEEEECCCCCC
LPEHAESLRLLHIHRNVPGVLSQINELFSRHNVNIDGQFLRTDPKVGYVVIDVSASEELA
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEECCCHHHH
GVLKDELGQITGTLRTRVLY
HHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
MRTAHRGHPIAHPIWHSCRPDCCIAFPMSPKKTSFPKQDIRVLLLEGISPTAVDVFRAAG
CCCCCCCCCCCCHHHHCCCCCEEEEECCCCCCCCCCHHHEEEEEECCCCCHHHHHHHHCC
YSQIELHAKSLPEDELIARISDAHIVGIRSRTQLSAEVLAHAKRLIAVGCFCIGTNQVDL
CCEEEEEHHCCCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHEEEEEEECCCCCC
DAAELAGIPVFNAPYSNTRSVAELVIAEAILLLRGIPQKNAQCHRGGWSKSAAGSHETRG
CHHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCC
KVLGIVGYGHIGTQVGVLAEALGMQVIFHDIETKLSLGNARAAIDLDELLARSDVVTLHV
CEEEEEECCCHHHHHHHHHHHHHHHHEEHHHHHHHCCCCCEEEECHHHHHHCCCEEEEEC
PETPSTKDMIGAAEIARMKPGAHLINASRGTVIDIDALDAALTSGHIGGAAVDVFPIEPK
CCCCCHHHHHHHHHHHHCCCCCEEEECCCCCEEEEHHHHHHHHCCCCCCEEEEEEECCCC
GNGDAFESPLTAHDNVILTPHVGGSTLEAQDNIGIEVAAKLVRYSDNGSTLSAVNFPEVT
CCCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCHHHHEEHHEECCCCCEEEEECCCCCC
LPEHAESLRLLHIHRNVPGVLSQINELFSRHNVNIDGQFLRTDPKVGYVVIDVSASEELA
CCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEEECCCHHHH
GVLKDELGQITGTLRTRVLY
HHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]