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The map label for this gene is trxC [H]

Identifier: 78046883

GI number: 78046883

Start: 1491397

End: 1491843

Strand: Reverse

Name: trxC [H]

Synonym: XCV1327

Alternate gene names: 78046883

Gene position: 1491843-1491397 (Counterclockwise)

Preceding gene: 78046884

Following gene: 78046881

Centisome position: 28.81

GC content: 65.55

Gene sequence:

>447_bases
ATGACCGATGCACCACTACTGATCGCCTGCCCGAGTTGCGCTGCGATGAACCGTATTGCGCCCACGCGCCTGCGCGATGC
GCCCAACTGCGGCAGCTGCCATCGGCCGCTGTTCCTGGGGACGCCGGTGGCCTTGTCGGCTGCAGATTTCGACAAGCATG
CGGTGCGCAGTGCACTGCCGCTGGTGGTGGATTTCTGGGCACCTTGGTGCGGGCCATGCCTGAGCATGGCGCCGAAATTT
GCCGCAGCCGCTGCAGCATTGGAACCGCAGGTGCGCCTGGCCAAGGTGGATACCGACCTGCATCCGGCGCTGGGCACGCG
CTTTGGCATCCGCAGCATTCCCACCTTGCTGGTCATCCAGGGCGGGCAGGAACTGGGCCGTCATTCCGGCGCGGTGAGCA
GCGCGCAAATCGTCAACTGGGTGCGCTCTGTCCTGAGCAAGCGGTGA

Upstream 100 bases:

>100_bases
ACGGAATCGCTGGTGGTGATCGCTACACTGGCCGCATGCAGCATGCGCCGCCAGCGATGGCCGGAGACAGCGCAGGCAGC
GCCGCCGACTGGAGACCAAC

Downstream 100 bases:

>100_bases
AACGACACGACGACCAGCTGCGCATACACGCAGTCGGCCTATCCACCTGCAGGAAACATCACTGCGGCGCAGTTGCCGCA
GTGACTGCATCAGCCGATCA

Product: putative thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MTDAPLLIACPSCAAMNRIAPTRLRDAPNCGSCHRPLFLGTPVALSAADFDKHAVRSALPLVVDFWAPWCGPCLSMAPKF
AAAAAALEPQVRLAKVDTDLHPALGTRFGIRSIPTLLVIQGGQELGRHSGAVSSAQIVNWVRSVLSKR

Sequences:

>Translated_148_residues
MTDAPLLIACPSCAAMNRIAPTRLRDAPNCGSCHRPLFLGTPVALSAADFDKHAVRSALPLVVDFWAPWCGPCLSMAPKF
AAAAAALEPQVRLAKVDTDLHPALGTRFGIRSIPTLLVIQGGQELGRHSGAVSSAQIVNWVRSVLSKR
>Mature_147_residues
TDAPLLIACPSCAAMNRIAPTRLRDAPNCGSCHRPLFLGTPVALSAADFDKHAVRSALPLVVDFWAPWCGPCLSMAPKFA
AAAAALEPQVRLAKVDTDLHPALGTRFGIRSIPTLLVIQGGQELGRHSGAVSSAQIVNWVRSVLSKR

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI5031973, Length=101, Percent_Identity=35.6435643564356, Blast_Score=75, Evalue=1e-14,
Organism=Homo sapiens, GI21361403, Length=97, Percent_Identity=31.9587628865979, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI20070125, Length=87, Percent_Identity=35.632183908046, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI21361657, Length=86, Percent_Identity=37.2093023255814, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1788936, Length=136, Percent_Identity=41.9117647058824, Blast_Score=120, Evalue=3e-29,
Organism=Escherichia coli, GI87082331, Length=104, Percent_Identity=32.6923076923077, Blast_Score=77, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI212646193, Length=101, Percent_Identity=30.6930693069307, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554386, Length=85, Percent_Identity=40, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17549970, Length=101, Percent_Identity=34.6534653465347, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144092, Length=102, Percent_Identity=34.3137254901961, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI32566189, Length=104, Percent_Identity=29.8076923076923, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI193209454, Length=104, Percent_Identity=29.8076923076923, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=105, Percent_Identity=29.5238095238095, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17569137, Length=103, Percent_Identity=30.0970873786408, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI28573567, Length=96, Percent_Identity=36.4583333333333, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=37.5, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17647799, Length=84, Percent_Identity=38.0952380952381, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921434, Length=102, Percent_Identity=30.3921568627451, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 15691; Mature: 15560

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDAPLLIACPSCAAMNRIAPTRLRDAPNCGSCHRPLFLGTPVALSAADFDKHAVRSALP
CCCCCEEEECCCHHHHHCCCCHHHCCCCCCCCCCCCEEECCCCEECCCCHHHHHHHHHHH
LVVDFWAPWCGPCLSMAPKFAAAAAALEPQVRLAKVDTDLHPALGTRFGIRSIPTLLVIQ
HHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCHHHCCEEEEEE
GGQELGRHSGAVSSAQIVNWVRSVLSKR
CCHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDAPLLIACPSCAAMNRIAPTRLRDAPNCGSCHRPLFLGTPVALSAADFDKHAVRSALP
CCCCEEEECCCHHHHHCCCCHHHCCCCCCCCCCCCEEECCCCEECCCCHHHHHHHHHHH
LVVDFWAPWCGPCLSMAPKFAAAAAALEPQVRLAKVDTDLHPALGTRFGIRSIPTLLVIQ
HHHHHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCHHHCCEEEEEE
GGQELGRHSGAVSSAQIVNWVRSVLSKR
CCHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]