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The map label for this gene is exo [H]

Identifier: 78046504

GI number: 78046504

Start: 1075905

End: 1076891

Strand: Reverse

Name: exo [H]

Synonym: XCV0948

Alternate gene names: 78046504

Gene position: 1076891-1075905 (Counterclockwise)

Preceding gene: 78046505

Following gene: 78046503

Centisome position: 20.8

GC content: 68.19

Gene sequence:

>987_bases
GTGACCACACCGACCGACCCGCTCGACGCTGCGCCGCTGGCCATCCGGCGCCCGACCCCGCTGTATCTGGTGGATGCCAG
CCTGTACGTGTTCCGCGCCTGGCATTCCATCCCGGACGAATTTCAGGATGTGCAGGGCTGGCCGACCAATGCGGTGCACG
GGTTTGCGCGGTTTCTGCTGGACCTGCTCGAACGCGAGGATCCACAGCACATCACCATTGCCTTTGACGAAGCCCTGGAC
AGCTGCTTCCGGCATGCGATCTACCCGGCCTACAAAGGCAACCGCACGCCTGCGCCGGATGCGTTGCGCCGCCAGTTCGC
GCATTGCAAGGCGCTGTGCGCAGCGCTCGGGCTGAGCGTGCTGGCCCACCGCGATTACGAGGCCGACGACCTGATCGGCA
GCGCGCTGCACAGCGTGCGGGCGCATGGCTTGCGCGGGGTGATCGTGTCGGCCGACAAGGACCTGTCGCAGTTATTGCTC
GAGCATGACGAGCAGTGGGACTACGCGCGCAACCAGCGCTGGGGCATCGACGGGGTGAAGGCGCGCCATGGCGTGCATGC
GCACCAGATCGCCGACTACCTGGCGTTGTGCGGCGATGCCATCGACAACATCCCCGGCGTGACCGGCATCGGCGCCAAAT
CGGCAGCGGTGCTGCTGGCGCACTTCGGCAGCCTGGATGCGCTGCTGGAGCGCATCGACGAGATTCCCTTCCTGCGCCTG
CGCGGCGCGGCGCAGATGGCGGTGCGGCTGCGCGAACAGCGCGAACATGCATTGCTGTGGCGTCAGCTCACCACCATCGC
GCTCGACGCGCCGCTGGCGCTCACCGAGGCCGGCTTCACGCGTGCCCACGCCGATGCGGACATGCTCACCGGGTTGTGCG
AGAGCCTGCGCTTCGGCCCGCTCACCCGGCGCCGTCTGTTGGCCGCCAGCACCGGCGCCGCCGCACCGTTTCCTCCCGTT
TCCCTGGCACAAGGTCCCCGCCCATGA

Upstream 100 bases:

>100_bases
ACGAACGCATCGCCGGCTTCATCCACATCGGCACGCCGCGCATGCAGGTGCCCGAACGCGAGCGCCCGGACCCGCGTGCC
TTGCTGCGCGACTGGACCCC

Downstream 100 bases:

>100_bases
ACCGACACGACACCCCGCCCACCGTGGTCTACGAAGGCAAGTACCAGCGCATGGTCGTGCGTGGCACCTGGGAGTATTCC
GAGCGTGTGCATGCCGGCGG

Product: exodeoxyribonuclease IX

Products: NA

Alternate protein names: POL I [H]

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MTTPTDPLDAAPLAIRRPTPLYLVDASLYVFRAWHSIPDEFQDVQGWPTNAVHGFARFLLDLLEREDPQHITIAFDEALD
SCFRHAIYPAYKGNRTPAPDALRRQFAHCKALCAALGLSVLAHRDYEADDLIGSALHSVRAHGLRGVIVSADKDLSQLLL
EHDEQWDYARNQRWGIDGVKARHGVHAHQIADYLALCGDAIDNIPGVTGIGAKSAAVLLAHFGSLDALLERIDEIPFLRL
RGAAQMAVRLREQREHALLWRQLTTIALDAPLALTEAGFTRAHADADMLTGLCESLRFGPLTRRRLLAASTGAAAPFPPV
SLAQGPRP

Sequences:

>Translated_328_residues
MTTPTDPLDAAPLAIRRPTPLYLVDASLYVFRAWHSIPDEFQDVQGWPTNAVHGFARFLLDLLEREDPQHITIAFDEALD
SCFRHAIYPAYKGNRTPAPDALRRQFAHCKALCAALGLSVLAHRDYEADDLIGSALHSVRAHGLRGVIVSADKDLSQLLL
EHDEQWDYARNQRWGIDGVKARHGVHAHQIADYLALCGDAIDNIPGVTGIGAKSAAVLLAHFGSLDALLERIDEIPFLRL
RGAAQMAVRLREQREHALLWRQLTTIALDAPLALTEAGFTRAHADADMLTGLCESLRFGPLTRRRLLAASTGAAAPFPPV
SLAQGPRP
>Mature_327_residues
TTPTDPLDAAPLAIRRPTPLYLVDASLYVFRAWHSIPDEFQDVQGWPTNAVHGFARFLLDLLEREDPQHITIAFDEALDS
CFRHAIYPAYKGNRTPAPDALRRQFAHCKALCAALGLSVLAHRDYEADDLIGSALHSVRAHGLRGVIVSADKDLSQLLLE
HDEQWDYARNQRWGIDGVKARHGVHAHQIADYLALCGDAIDNIPGVTGIGAKSAAVLLAHFGSLDALLERIDEIPFLRLR
GAAQMAVRLREQREHALLWRQLTTIALDAPLALTEAGFTRAHADADMLTGLCESLRFGPLTRRRLLAASTGAAAPFPPVS
LAQGPRP

Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity. It is able to utilize nicked circular duplex DNA as a template and can unwind the parental DNA strand from its template [H]

COG id: COG0258

COG function: function code L; 5'-3' exonuclease (including N-terminal domain of PolI)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 5'-3' exonuclease domain [H]

Homologues:

Organism=Escherichia coli, GI1790294, Length=280, Percent_Identity=37.5, Blast_Score=174, Evalue=8e-45,
Organism=Escherichia coli, GI226510970, Length=250, Percent_Identity=31.2, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR020046
- InterPro:   IPR020045
- InterPro:   IPR002421
- InterPro:   IPR020047
- InterPro:   IPR019760
- InterPro:   IPR001098
- InterPro:   IPR018320
- InterPro:   IPR002298
- InterPro:   IPR008918
- InterPro:   IPR003583
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 36023; Mature: 35892

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTDPLDAAPLAIRRPTPLYLVDASLYVFRAWHSIPDEFQDVQGWPTNAVHGFARFLL
CCCCCCCCCCCCEEECCCCCEEEECHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHH
DLLEREDPQHITIAFDEALDSCFRHAIYPAYKGNRTPAPDALRRQFAHCKALCAALGLSV
HHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAHRDYEADDLIGSALHSVRAHGLRGVIVSADKDLSQLLLEHDEQWDYARNQRWGIDGVK
HHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCHHHCCCCCCCCHH
ARHGVHAHQIADYLALCGDAIDNIPGVTGIGAKSAAVLLAHFGSLDALLERIDEIPFLRL
HHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCEEEH
RGAAQMAVRLREQREHALLWRQLTTIALDAPLALTEAGFTRAHADADMLTGLCESLRFGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHCCHHHHHHHHHHHCCCC
LTRRRLLAASTGAAAPFPPVSLAQGPRP
HHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TTPTDPLDAAPLAIRRPTPLYLVDASLYVFRAWHSIPDEFQDVQGWPTNAVHGFARFLL
CCCCCCCCCCCEEECCCCCEEEECHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHH
DLLEREDPQHITIAFDEALDSCFRHAIYPAYKGNRTPAPDALRRQFAHCKALCAALGLSV
HHHCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LAHRDYEADDLIGSALHSVRAHGLRGVIVSADKDLSQLLLEHDEQWDYARNQRWGIDGVK
HHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCHHHCCCCCCCCHH
ARHGVHAHQIADYLALCGDAIDNIPGVTGIGAKSAAVLLAHFGSLDALLERIDEIPFLRL
HHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCEEEH
RGAAQMAVRLREQREHALLWRQLTTIALDAPLALTEAGFTRAHADADMLTGLCESLRFGP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHCCHHHHHHHHHHHCCCC
LTRRRLLAASTGAAAPFPPVSLAQGPRP
HHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6276402; 8346018; 9278503; 6183253; 6302278; 7035456; 3883192; 1989886; 8469987; 8260491; 9514742; 9888810; 10588690; 8442659 [H]