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The map label for this gene is ggt1 [H]

Identifier: 78045870

GI number: 78045870

Start: 358273

End: 359853

Strand: Reverse

Name: ggt1 [H]

Synonym: XCV0314

Alternate gene names: 78045870

Gene position: 359853-358273 (Counterclockwise)

Preceding gene: 78045871

Following gene: 78045869

Centisome position: 6.95

GC content: 69.7

Gene sequence:

>1581_bases
ATGGTGCATACCCTGCGCGCGCGCCGCGGCATGGTGGTCGCACCGCACCACTTGGCCGCACAGGCCGGGCGCGATGTCTT
GCGCGACGGCGGCAATGCCGTCGAAGCGGTCGTGGCCACCGCCGCCTGCCTGGCGGTGGTCTACCCGCACATGACCGGCA
TCGGCGGCGATGGCTTCTGGCTCATCCACGAACCCGATGGCCGCGTGCATGCCATCGATGCCTGCGGCCGCGCGGCGCAG
GCGGCAACACTGGATTTCTATCGCGGCCACGCCCACGTTCCGTGGCGCGGGCCAGGCGCGGCCAATACCGTGGCCGGCAC
CGTCTCCGGCTGGGCGCTGGCCCTGCAGCAGGCAAACGGCAGCGTGTCGCTGCAACGCCTGTTGAGCGATGCGATCCATC
ACGCCAGCGCCGGCGTGCCGGTCACGCTGGGCGGGGCGCAGATCGCCGCCAGCAAGGGCGCAGAACTGCGTCTGCAACCC
GGCGCCTATGCCGAGATCTTCGAGCCGCACGGCGTCCCGCTGGGCGAAGGCGCGCTGCTGCACCAGGCGCAGCTCGCGCG
CACCCTGCAGCGGCTCGCCGATGAAGGGCTGGAGAGTTTCTATCGTGGCGCGATCGCACACGATATCGCCGCAGACCTGC
AGGCATTGGACAGCCCGCTCAGCGCACACGACCTGGCGATCCATCGCGCCGACGTCAGCGTGCCGTTATCGGTTGTCATC
CAGGGCGCGCGCCTCTACAACCACGCGCCACCCACGCAGGGGCTTGCCTCGCTGTTGATCCTGGCGCTCTTCGATCGCCT
GAAGGTGGAAGACGCAGACAGCTACGCACACCTGCACGGGCTGATCGAAGCCAGCAAGCAGGCGTTCCTGATCCGCGACG
CACACCTGGGCGACCCCGCCTGGATGACGCTCGACGCGCAAGCCCTGCTCGACGACAGCACCGCACTCGATGCGCTCGCC
GCACGCATCGACATGAGCGCCGCACTGCCGTGGCCACAGCCCTCGCAAGCAGGCGACACCGTCTGGTTCGGCGCCATCGA
CGCGCACGGCCGCGCGGTCAGTTGCATCCAGTCCACCTACTTCGAATTCGGCTCCGGCCTGGTGCTGCCGCGCACCGGCA
TCACCTGGCAGAACCGAGGCTGCAGCTTTCGCCTCGCCCCCGATGGCTGGAACGCCCTTGCCCCAGGCCGCAAACCCTTC
CACACCCTCAACCCGGCACTGGCCACCTTCGACGATGGCCGCGTGATGGCCTACGGCACCATGGGCGGCGAAGGCCAACC
GCAAACCCAGGCCGCCGTGTTCTCCCGCTACGCCCGCTTCGGCATGCCGCTGCAGCAGGCGGTCAGCGCACCGCGCTGGC
TGCTCGGCCGCACCTGGGGCGAAGACAGCACGGCGTTGAAGCTGGAAGACCGCTTCGACCCGGCCGTGGTGCAGGCCCTG
CGCAACGCCGGGCATGCGGTGGAACTGCTGCCGGCGTACAGCGCGGTGATGGGGCATGCCGGTGCCTTGGTGCGTGAGGT
CGATGGCGTGATCAGCGGCGCCAGTGATCCGCGCTCCGATGGGGTGGTGGCGGGGTGGTGA

Upstream 100 bases:

>100_bases
TGATCGCCGCGCCCGGCCGTGAAGACCGCCTGTTTGCGCTGGCCGCGCAACTCGAACGCGACGGCCTGCTCGCCTTCAGC
CCGCCGCCGGAGTCACGCTG

Downstream 100 bases:

>100_bases
CTAGGGCGGTCGTTCCGCTGCGGTCGCTCGCCCCATGCGCGCCATGGGCATGCACCGGGTGAAAGTGTCCATGTGTCGCA
AGACCATCGTGCCGGAGCCT

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MVHTLRARRGMVVAPHHLAAQAGRDVLRDGGNAVEAVVATAACLAVVYPHMTGIGGDGFWLIHEPDGRVHAIDACGRAAQ
AATLDFYRGHAHVPWRGPGAANTVAGTVSGWALALQQANGSVSLQRLLSDAIHHASAGVPVTLGGAQIAASKGAELRLQP
GAYAEIFEPHGVPLGEGALLHQAQLARTLQRLADEGLESFYRGAIAHDIAADLQALDSPLSAHDLAIHRADVSVPLSVVI
QGARLYNHAPPTQGLASLLILALFDRLKVEDADSYAHLHGLIEASKQAFLIRDAHLGDPAWMTLDAQALLDDSTALDALA
ARIDMSAALPWPQPSQAGDTVWFGAIDAHGRAVSCIQSTYFEFGSGLVLPRTGITWQNRGCSFRLAPDGWNALAPGRKPF
HTLNPALATFDDGRVMAYGTMGGEGQPQTQAAVFSRYARFGMPLQQAVSAPRWLLGRTWGEDSTALKLEDRFDPAVVQAL
RNAGHAVELLPAYSAVMGHAGALVREVDGVISGASDPRSDGVVAGW

Sequences:

>Translated_526_residues
MVHTLRARRGMVVAPHHLAAQAGRDVLRDGGNAVEAVVATAACLAVVYPHMTGIGGDGFWLIHEPDGRVHAIDACGRAAQ
AATLDFYRGHAHVPWRGPGAANTVAGTVSGWALALQQANGSVSLQRLLSDAIHHASAGVPVTLGGAQIAASKGAELRLQP
GAYAEIFEPHGVPLGEGALLHQAQLARTLQRLADEGLESFYRGAIAHDIAADLQALDSPLSAHDLAIHRADVSVPLSVVI
QGARLYNHAPPTQGLASLLILALFDRLKVEDADSYAHLHGLIEASKQAFLIRDAHLGDPAWMTLDAQALLDDSTALDALA
ARIDMSAALPWPQPSQAGDTVWFGAIDAHGRAVSCIQSTYFEFGSGLVLPRTGITWQNRGCSFRLAPDGWNALAPGRKPF
HTLNPALATFDDGRVMAYGTMGGEGQPQTQAAVFSRYARFGMPLQQAVSAPRWLLGRTWGEDSTALKLEDRFDPAVVQAL
RNAGHAVELLPAYSAVMGHAGALVREVDGVISGASDPRSDGVVAGW
>Mature_526_residues
MVHTLRARRGMVVAPHHLAAQAGRDVLRDGGNAVEAVVATAACLAVVYPHMTGIGGDGFWLIHEPDGRVHAIDACGRAAQ
AATLDFYRGHAHVPWRGPGAANTVAGTVSGWALALQQANGSVSLQRLLSDAIHHASAGVPVTLGGAQIAASKGAELRLQP
GAYAEIFEPHGVPLGEGALLHQAQLARTLQRLADEGLESFYRGAIAHDIAADLQALDSPLSAHDLAIHRADVSVPLSVVI
QGARLYNHAPPTQGLASLLILALFDRLKVEDADSYAHLHGLIEASKQAFLIRDAHLGDPAWMTLDAQALLDDSTALDALA
ARIDMSAALPWPQPSQAGDTVWFGAIDAHGRAVSCIQSTYFEFGSGLVLPRTGITWQNRGCSFRLAPDGWNALAPGRKPF
HTLNPALATFDDGRVMAYGTMGGEGQPQTQAAVFSRYARFGMPLQQAVSAPRWLLGRTWGEDSTALKLEDRFDPAVVQAL
RNAGHAVELLPAYSAVMGHAGALVREVDGVISGASDPRSDGVVAGW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=549, Percent_Identity=28.9617486338798, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI73915090, Length=549, Percent_Identity=28.9617486338798, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI73915096, Length=549, Percent_Identity=28.9617486338798, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI73915094, Length=549, Percent_Identity=28.9617486338798, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI113429324, Length=535, Percent_Identity=28.9719626168224, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI113429326, Length=543, Percent_Identity=28.9134438305709, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI109148539, Length=540, Percent_Identity=27.037037037037, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1789856, Length=553, Percent_Identity=29.8372513562387, Blast_Score=221, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI193208245, Length=555, Percent_Identity=27.3873873873874, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI193208247, Length=555, Percent_Identity=27.3873873873874, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI212646519, Length=502, Percent_Identity=25.0996015936255, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI72000294, Length=502, Percent_Identity=25.0996015936255, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17506189, Length=558, Percent_Identity=24.910394265233, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6323330, Length=514, Percent_Identity=22.9571984435798, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI161077878, Length=558, Percent_Identity=26.7025089605735, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24642670, Length=558, Percent_Identity=26.7025089605735, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24642666, Length=558, Percent_Identity=26.7025089605735, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI161077880, Length=558, Percent_Identity=26.7025089605735, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI45551474, Length=558, Percent_Identity=26.7025089605735, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI18859893, Length=517, Percent_Identity=25.7253384912959, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI161077496, Length=466, Percent_Identity=24.6781115879828, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI18859741, Length=436, Percent_Identity=24.5412844036697, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 55499; Mature: 55499

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVHTLRARRGMVVAPHHLAAQAGRDVLRDGGNAVEAVVATAACLAVVYPHMTGIGGDGFW
CCCCCCCCCCCEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LIHEPDGRVHAIDACGRAAQAATLDFYRGHAHVPWRGPGAANTVAGTVSGWALALQQANG
EEECCCCCEEEEHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCC
SVSLQRLLSDAIHHASAGVPVTLGGAQIAASKGAELRLQPGAYAEIFEPHGVPLGEGALL
CHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCEEEECCCCCHHHCCCCCCCCCCCHHH
HQAQLARTLQRLADEGLESFYRGAIAHDIAADLQALDSPLSAHDLAIHRADVSVPLSVVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCCHHHHE
QGARLYNHAPPTQGLASLLILALFDRLKVEDADSYAHLHGLIEASKQAFLIRDAHLGDPA
EHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCC
WMTLDAQALLDDSTALDALAARIDMSAALPWPQPSQAGDTVWFGAIDAHGRAVSCIQSTY
EEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
FEFGSGLVLPRTGITWQNRGCSFRLAPDGWNALAPGRKPFHTLNPALATFDDGRVMAYGT
HHHCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHCCCCCEEECCCEEEEEEC
MGGEGQPQTQAAVFSRYARFGMPLQQAVSAPRWLLGRTWGEDSTALKLEDRFDPAVVQAL
CCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHCCCCCCCCCEEEECCCCCHHHHHHH
RNAGHAVELLPAYSAVMGHAGALVREVDGVISGASDPRSDGVVAGW
HCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVHTLRARRGMVVAPHHLAAQAGRDVLRDGGNAVEAVVATAACLAVVYPHMTGIGGDGFW
CCCCCCCCCCCEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEE
LIHEPDGRVHAIDACGRAAQAATLDFYRGHAHVPWRGPGAANTVAGTVSGWALALQQANG
EEECCCCCEEEEHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHEEEEECCCC
SVSLQRLLSDAIHHASAGVPVTLGGAQIAASKGAELRLQPGAYAEIFEPHGVPLGEGALL
CHHHHHHHHHHHHHHCCCCEEEECCCEEECCCCCEEEECCCCCHHHCCCCCCCCCCCHHH
HQAQLARTLQRLADEGLESFYRGAIAHDIAADLQALDSPLSAHDLAIHRADVSVPLSVVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCCCCHHHHE
QGARLYNHAPPTQGLASLLILALFDRLKVEDADSYAHLHGLIEASKQAFLIRDAHLGDPA
EHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCC
WMTLDAQALLDDSTALDALAARIDMSAALPWPQPSQAGDTVWFGAIDAHGRAVSCIQSTY
EEEEEHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHH
FEFGSGLVLPRTGITWQNRGCSFRLAPDGWNALAPGRKPFHTLNPALATFDDGRVMAYGT
HHHCCCEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCHHCCCCCEEECCCEEEEEEC
MGGEGQPQTQAAVFSRYARFGMPLQQAVSAPRWLLGRTWGEDSTALKLEDRFDPAVVQAL
CCCCCCCHHHHHHHHHHHHHCCCHHHHHCCCHHHHCCCCCCCCCEEEECCCCCHHHHHHH
RNAGHAVELLPAYSAVMGHAGALVREVDGVISGASDPRSDGVVAGW
HCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]