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The map label for this gene is lutP [H]

Identifier: 78044577

GI number: 78044577

Start: 372256

End: 374001

Strand: Direct

Name: lutP [H]

Synonym: CHY_0431

Alternate gene names: 78044577

Gene position: 372256-374001 (Clockwise)

Preceding gene: 78045135

Following gene: 78043260

Centisome position: 15.5

GC content: 45.76

Gene sequence:

>1746_bases
GTGACCTGGACGCAAAACTACGACCCGTTTAACAACATTGCACTGTCGGCTTTGGTGGCAGCGATTCCGATTTTTTTCCT
GTTCTGGGCGCTGGCCATCAAAAAGATGAAAGGTTATATTGCGGGCCTTTTAACGTTGCTTTTGGCCATTATTGTGGTGA
TTTTCGAGTACAAGATGCCCGTAAATCTTGCTTTAATGGCTGCGGTAAACGGCGCATTATATGGTCTTTTCCCTATTGGC
TGGATTGTTATTACTGCAGTTTACCTCTATAACCTTACCGTAAAAGCGGGACAGTTTGAAATTATTAAGGATTCCATTGC
TTCTATTACCGAAGACCGGAGGCTTCAAGCTCTGTTGATTGCTTTTGCCTTTGGAGCGTTTTTAGAGGGGGCCGCTGGCT
TTGGTACCCCGGTGGCGATTACGGCAGCAATGCTCGTTGGTCTTGGTTTTAACCCCTTGTATGCTGCAGGAATTTGCTTG
ATTGCCAACACTGCTCCCGTTGCTTTTGGAGGAATAGGTATCCCCATTATTGTGGCCGGACAGGTAACGGGAATTGATGC
TATGGCGATTAGTAAAATGGTAGGCCGTCAGTTGCCGCTTTTATCGGTAGCCATTCCTGCCTGGTTGGTCTTTATCATGT
CCGGGTGGAAGGGTCTTCTTGAGGTCTTACCAGCAGTGTTGGTTACCGGTATTTCCTTTGCCGGTGCTCAGTGGTTTTCT
GCAAACTACCTTTCGCCGATGCTCCCAGACATAATCTCTTCCCTTGTTTCAATTATCGCTTTGGTCTTATTCTTAAAGGT
TTGGAAGCCGAAAAATATCTGGCGATTTGCCAATGAACCTCCGGCAACATTACAGGTGAAGAAGCATTCCGCAGGGGCTA
TTTTAAAAGCCTGGTCGCCGTTTATTGTATTAACGATTTTGGTGGGCGACTGGGGGTTAAATCAGGTAAAAAATGTGTTA
GACCTTGTTACCCTTAAGTTTCATGTTCCCGGCCTTGATGGTTTAATTTATAAGCCCGGTGCGGACAAAGCCATGGAAGC
AGTCTTTAAATTTAACTGGTTGTCAGCAGCCGGGACGGCAATCCTTATTGCTGCAATAATTACGATTTTAATTTTACGAA
TTAGCTTTAAAGATGCGGTTTCGGTATTTGTTGATACTCTTAAAAGCTTAAAATATCCGCTAATTAACATCGCAGCGGTA
TTGGGTTTTGCTTATGTCGCTAACTTCTCGGGTATGAGCCAAACGCTGGGTTTATCGCTAACCGTTACAGGAAAAGCGTT
TGCCTTTCTTTCACCAATGCTTGGTTGGCTCGGGGTATTTATAACCGGTTCGGATACATCGGCTAATGCTCTTTTCGCTA
AATTGCAGGCTGCTTCAGCGGAAAAGCTGGGTATTGATCCGGTCTTAACTGTTGCAGCTAACTCTTCCGGTGGAGTTACC
GGTAAGATGATTTCACCGCAAAGCATTGCGGTAGCTACCGCTTCGGTGGGCTTGGTGGGCAAAGAAGCGGAGCTTTTCCG
GTTTACCGTGCTGCACAGCTTCTTATTTGCTGTGGTGGTAGGCATCATTACTTATCTCCAGGCGTACTACCTGAAAAGCT
GGATTCCGGTTTACAAAATGATTGAAAGTGCTGGAGCTGCAGCTCAAGCTCAGGTAGAAACCGGTCCAGGACTTACCATT
CTCGGGATTACCGCAGTGGTAATTTTAGCCCTTTGGGGCTTAGTTGCAGCCCTTAATAAAAAATAA

Upstream 100 bases:

>100_bases
AAAATTTAAATTTATATGGTAAACTAATAGTCAAGAGGTCAGACCATCATACGGCCGTATGATTAGGTTATTGACAAATT
TTTTTCAGGAGGGGTATTTG

Downstream 100 bases:

>100_bases
ATTAAAATAAAACTAAGCGGGGGGAGCTATTCCCCCCGGATAGTTTTGAGGAGGTTTTTTAAAGTGGAAGCACTGGCGAA
GCTACAAAAAATTCTTGGTT

Product: L-lactate/glycolate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MTWTQNYDPFNNIALSALVAAIPIFFLFWALAIKKMKGYIAGLLTLLLAIIVVIFEYKMPVNLALMAAVNGALYGLFPIG
WIVITAVYLYNLTVKAGQFEIIKDSIASITEDRRLQALLIAFAFGAFLEGAAGFGTPVAITAAMLVGLGFNPLYAAGICL
IANTAPVAFGGIGIPIIVAGQVTGIDAMAISKMVGRQLPLLSVAIPAWLVFIMSGWKGLLEVLPAVLVTGISFAGAQWFS
ANYLSPMLPDIISSLVSIIALVLFLKVWKPKNIWRFANEPPATLQVKKHSAGAILKAWSPFIVLTILVGDWGLNQVKNVL
DLVTLKFHVPGLDGLIYKPGADKAMEAVFKFNWLSAAGTAILIAAIITILILRISFKDAVSVFVDTLKSLKYPLINIAAV
LGFAYVANFSGMSQTLGLSLTVTGKAFAFLSPMLGWLGVFITGSDTSANALFAKLQAASAEKLGIDPVLTVAANSSGGVT
GKMISPQSIAVATASVGLVGKEAELFRFTVLHSFLFAVVVGIITYLQAYYLKSWIPVYKMIESAGAAAQAQVETGPGLTI
LGITAVVILALWGLVAALNKK

Sequences:

>Translated_581_residues
MTWTQNYDPFNNIALSALVAAIPIFFLFWALAIKKMKGYIAGLLTLLLAIIVVIFEYKMPVNLALMAAVNGALYGLFPIG
WIVITAVYLYNLTVKAGQFEIIKDSIASITEDRRLQALLIAFAFGAFLEGAAGFGTPVAITAAMLVGLGFNPLYAAGICL
IANTAPVAFGGIGIPIIVAGQVTGIDAMAISKMVGRQLPLLSVAIPAWLVFIMSGWKGLLEVLPAVLVTGISFAGAQWFS
ANYLSPMLPDIISSLVSIIALVLFLKVWKPKNIWRFANEPPATLQVKKHSAGAILKAWSPFIVLTILVGDWGLNQVKNVL
DLVTLKFHVPGLDGLIYKPGADKAMEAVFKFNWLSAAGTAILIAAIITILILRISFKDAVSVFVDTLKSLKYPLINIAAV
LGFAYVANFSGMSQTLGLSLTVTGKAFAFLSPMLGWLGVFITGSDTSANALFAKLQAASAEKLGIDPVLTVAANSSGGVT
GKMISPQSIAVATASVGLVGKEAELFRFTVLHSFLFAVVVGIITYLQAYYLKSWIPVYKMIESAGAAAQAQVETGPGLTI
LGITAVVILALWGLVAALNKK
>Mature_580_residues
TWTQNYDPFNNIALSALVAAIPIFFLFWALAIKKMKGYIAGLLTLLLAIIVVIFEYKMPVNLALMAAVNGALYGLFPIGW
IVITAVYLYNLTVKAGQFEIIKDSIASITEDRRLQALLIAFAFGAFLEGAAGFGTPVAITAAMLVGLGFNPLYAAGICLI
ANTAPVAFGGIGIPIIVAGQVTGIDAMAISKMVGRQLPLLSVAIPAWLVFIMSGWKGLLEVLPAVLVTGISFAGAQWFSA
NYLSPMLPDIISSLVSIIALVLFLKVWKPKNIWRFANEPPATLQVKKHSAGAILKAWSPFIVLTILVGDWGLNQVKNVLD
LVTLKFHVPGLDGLIYKPGADKAMEAVFKFNWLSAAGTAILIAAIITILILRISFKDAVSVFVDTLKSLKYPLINIAAVL
GFAYVANFSGMSQTLGLSLTVTGKAFAFLSPMLGWLGVFITGSDTSANALFAKLQAASAEKLGIDPVLTVAANSSGGVTG
KMISPQSIAVATASVGLVGKEAELFRFTVLHSFLFAVVVGIITYLQAYYLKSWIPVYKMIESAGAAAQAQVETGPGLTIL
GITAVVILALWGLVAALNKK

Specific function: Is the principal permease for the uptake of L-lactate in B.subtilis [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=551, Percent_Identity=56.442831215971, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI1790031, Length=548, Percent_Identity=55.8394160583942, Blast_Score=563, Evalue=1e-162,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 61623; Mature: 61492

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWTQNYDPFNNIALSALVAAIPIFFLFWALAIKKMKGYIAGLLTLLLAIIVVIFEYKMP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VNLALMAAVNGALYGLFPIGWIVITAVYLYNLTVKAGQFEIIKDSIASITEDRRLQALLI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHHHH
AFAFGAFLEGAAGFGTPVAITAAMLVGLGFNPLYAAGICLIANTAPVAFGGIGIPIIVAG
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCEEECCCCCEECCCCCCEEEEC
QVTGIDAMAISKMVGRQLPLLSVAIPAWLVFIMSGWKGLLEVLPAVLVTGISFAGAQWFS
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHC
ANYLSPMLPDIISSLVSIIALVLFLKVWKPKNIWRFANEPPATLQVKKHSAGAILKAWSP
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCEEEEECCCCCCHHHHCCH
FIVLTILVGDWGLNQVKNVLDLVTLKFHVPGLDGLIYKPGADKAMEAVFKFNWLSAAGTA
HHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
ILIAAIITILILRISFKDAVSVFVDTLKSLKYPLINIAAVLGFAYVANFSGMSQTLGLSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHCCEEE
TVTGKAFAFLSPMLGWLGVFITGSDTSANALFAKLQAASAEKLGIDPVLTVAANSSGGVT
EECCHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCHHHCCCCCEEEEEECCCCCCE
GKMISPQSIAVATASVGLVGKEAELFRFTVLHSFLFAVVVGIITYLQAYYLKSWIPVYKM
EEECCCCHHEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IESAGAAAQAQVETGPGLTILGITAVVILALWGLVAALNKK
HHHCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TWTQNYDPFNNIALSALVAAIPIFFLFWALAIKKMKGYIAGLLTLLLAIIVVIFEYKMP
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
VNLALMAAVNGALYGLFPIGWIVITAVYLYNLTVKAGQFEIIKDSIASITEDRRLQALLI
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHHHHHHHHH
AFAFGAFLEGAAGFGTPVAITAAMLVGLGFNPLYAAGICLIANTAPVAFGGIGIPIIVAG
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCEEECCCCCEECCCCCCEEEEC
QVTGIDAMAISKMVGRQLPLLSVAIPAWLVFIMSGWKGLLEVLPAVLVTGISFAGAQWFS
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCHHHC
ANYLSPMLPDIISSLVSIIALVLFLKVWKPKNIWRFANEPPATLQVKKHSAGAILKAWSP
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCEEEEECCCCCCHHHHCCH
FIVLTILVGDWGLNQVKNVLDLVTLKFHVPGLDGLIYKPGADKAMEAVFKFNWLSAAGTA
HHHHHHHHCCCCHHHHHHHHHHHHHEEECCCCCCEEECCCCCHHHHHHHHHHHHHHHHHH
ILIAAIITILILRISFKDAVSVFVDTLKSLKYPLINIAAVLGFAYVANFSGMSQTLGLSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHCCEEE
TVTGKAFAFLSPMLGWLGVFITGSDTSANALFAKLQAASAEKLGIDPVLTVAANSSGGVT
EECCHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHCCHHHCCCCCEEEEEECCCCCCE
GKMISPQSIAVATASVGLVGKEAELFRFTVLHSFLFAVVVGIITYLQAYYLKSWIPVYKM
EEECCCCHHEEEHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IESAGAAAQAQVETGPGLTILGITAVVILALWGLVAALNKK
HHHCCCCCEEEECCCCCEEHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8969506 [H]