Click here to switch to the map view.

The map label for this gene is glcK [H]

Identifier: 78043126

GI number: 78043126

Start: 236621

End: 237577

Strand: Direct

Name: glcK [H]

Synonym: CHY_0270

Alternate gene names: 78043126

Gene position: 236621-237577 (Clockwise)

Preceding gene: 78042702

Following gene: 78045190

Centisome position: 9.85

GC content: 48.38

Gene sequence:

>957_bases
ATGGGAAATTATGTTGTGGGGATAGACCTGGGAGGTACGAAAATTTATACTGCCCTGGCTAACTTAAATGGTGAAATAGT
GGCGGAAGAAATTGAGCCGACTACCAAAGACGAAACAAAACTTTTACACCAGCTTGGGAATATGGTTAAAGGAGTTATTG
CCAAAAGCGCAGTACCGAAGGAAAAAGTGCTGGGAATCGGGATTGGTGCGCCGGGAACGGTGGACCACCGTACCGGAACG
CTTATTACCGCTCCCAATCTTCCCTGGCAAAATTACCCGCTTAAAATAAATTTGCAAGCGTTGCTCCGTTTACCGGTGGA
AGTTGATAACGATGCCAATTTAGCAGCTTTGGGTGAGTACAGGTACGGTGCTGGCCGGGGCCATAAAGACATGGTTTATG
TCACCGTAAGTACCGGGATTGGTGCGGGTATAATAATAGATGGACAGCTCTATCGGGGAAGCTCCGGCAGTGCCGGTGAG
TTAGGCCATACCATTGTTGAACCGGGGGGTCCCCGGTGCAATTGTGGCCGACGGGGCTGTCTGGAAGTAATGGCCTCGGG
TACGGCAATAGGAGAAAGGGCACGGCAATTGGTGGCCGAAGGTTTTGGCCAGGAAATTTTAAAATTGGCTCAGGGGAATA
TTGAGGCTATTAACGCTAAAACGGTGGGGGAAGCGTTTTTAGCGGGCGACCCGGAAGCAAAAGGAATATTAAACGAAGTG
GCTTTTTATCTGGGGATAGGTCTGGCCAATGTGGTGAACCTCTTAAACCCATCTCTAATCGTCCTGGGAGGCGGGGTTAT
AAATATTGGCGAACCCTTTTTAGAGTTAATTCGAGAAGAGCTGGCAGAGAAGGCTTTACCCCAGCCCTATAAAGATTTAA
CGGTAAAAAAAGCTGTTTTAGGGAGTAAAACCGGAGTCATGGGAGCGATAGCTTTAGCCTTGGAGCGGTTTTCTTAA

Upstream 100 bases:

>100_bases
CTTGAGAAAATTAAAAAGGAACTAAGGGAAGCGATGCTTTTAACCGGAGTTGCGCGGGTGACCGAAGTCCCGGGAACAAT
TATCCGGAAGGAGCAGTAAG

Downstream 100 bases:

>100_bases
AGGATGGGATCAAATGTTTTCCGGTGATTTTCATACCCATACCCGCTATAGCGATGGCCGGGGAAGTTTACGGGAAAATG
TCTGGGCAGCTTTAAAGAAA

Product: glucokinase

Products: NA

Alternate protein names: Glucose kinase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MGNYVVGIDLGGTKIYTALANLNGEIVAEEIEPTTKDETKLLHQLGNMVKGVIAKSAVPKEKVLGIGIGAPGTVDHRTGT
LITAPNLPWQNYPLKINLQALLRLPVEVDNDANLAALGEYRYGAGRGHKDMVYVTVSTGIGAGIIIDGQLYRGSSGSAGE
LGHTIVEPGGPRCNCGRRGCLEVMASGTAIGERARQLVAEGFGQEILKLAQGNIEAINAKTVGEAFLAGDPEAKGILNEV
AFYLGIGLANVVNLLNPSLIVLGGGVINIGEPFLELIREELAEKALPQPYKDLTVKKAVLGSKTGVMGAIALALERFS

Sequences:

>Translated_318_residues
MGNYVVGIDLGGTKIYTALANLNGEIVAEEIEPTTKDETKLLHQLGNMVKGVIAKSAVPKEKVLGIGIGAPGTVDHRTGT
LITAPNLPWQNYPLKINLQALLRLPVEVDNDANLAALGEYRYGAGRGHKDMVYVTVSTGIGAGIIIDGQLYRGSSGSAGE
LGHTIVEPGGPRCNCGRRGCLEVMASGTAIGERARQLVAEGFGQEILKLAQGNIEAINAKTVGEAFLAGDPEAKGILNEV
AFYLGIGLANVVNLLNPSLIVLGGGVINIGEPFLELIREELAEKALPQPYKDLTVKKAVLGSKTGVMGAIALALERFS
>Mature_317_residues
GNYVVGIDLGGTKIYTALANLNGEIVAEEIEPTTKDETKLLHQLGNMVKGVIAKSAVPKEKVLGIGIGAPGTVDHRTGTL
ITAPNLPWQNYPLKINLQALLRLPVEVDNDANLAALGEYRYGAGRGHKDMVYVTVSTGIGAGIIIDGQLYRGSSGSAGEL
GHTIVEPGGPRCNCGRRGCLEVMASGTAIGERARQLVAEGFGQEILKLAQGNIEAINAKTVGEAFLAGDPEAKGILNEVA
FYLGIGLANVVNLLNPSLIVLGGGVINIGEPFLELIREELAEKALPQPYKDLTVKKAVLGSKTGVMGAIALALERFS

Specific function: Acts As A Repressor Of The Nagebacd Operon And Acts Both As An Activator And A Repressor For The Transcription Of The Glmsu Operon. [C]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI4885285, Length=287, Percent_Identity=33.7979094076655, Blast_Score=144, Evalue=9e-35,
Organism=Homo sapiens, GI298566315, Length=287, Percent_Identity=33.7979094076655, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI298566325, Length=287, Percent_Identity=33.7979094076655, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI190014632, Length=287, Percent_Identity=33.7979094076655, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI298566312, Length=142, Percent_Identity=33.8028169014084, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1786891, Length=310, Percent_Identity=30, Blast_Score=144, Evalue=6e-36,
Organism=Escherichia coli, GI1787878, Length=301, Percent_Identity=31.2292358803987, Blast_Score=137, Evalue=7e-34,
Organism=Escherichia coli, GI87081733, Length=322, Percent_Identity=31.6770186335404, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI87082127, Length=287, Percent_Identity=29.9651567944251, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082230, Length=283, Percent_Identity=31.095406360424, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787363, Length=319, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI1790522, Length=322, Percent_Identity=27.3291925465839, Blast_Score=91, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000600
- InterPro:   IPR004654 [H]

Pfam domain/function: PF00480 ROK [H]

EC number: =2.7.1.2 [H]

Molecular weight: Translated: 33286; Mature: 33155

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNYVVGIDLGGTKIYTALANLNGEIVAEEIEPTTKDETKLLHQLGNMVKGVIAKSAVPK
CCCEEEEEECCCCEEEHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
EKVLGIGIGAPGTVDHRTGTLITAPNLPWQNYPLKINLQALLRLPVEVDNDANLAALGEY
HHEEEEECCCCCCCCCCCCCEEECCCCCCCCCCEEEEHHHHEECCCEECCCCCEEEEECC
RYGAGRGHKDMVYVTVSTGIGAGIIIDGQLYRGSSGSAGELGHTIVEPGGPRCNCGRRGC
CCCCCCCCCCEEEEEEECCCCCEEEECCEEEECCCCCCCCCCCEEECCCCCCCCCCCHHH
LEVMASGTAIGERARQLVAEGFGQEILKLAQGNIEAINAKTVGEAFLAGDPEAKGILNEV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCHHHHHHHHH
AFYLGIGLANVVNLLNPSLIVLGGGVINIGEPFLELIREELAEKALPQPYKDLTVKKAVL
HHHHHHHHHHHHHHHCCCEEEEECCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GSKTGVMGAIALALERFS
CCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
GNYVVGIDLGGTKIYTALANLNGEIVAEEIEPTTKDETKLLHQLGNMVKGVIAKSAVPK
CCEEEEEECCCCEEEHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
EKVLGIGIGAPGTVDHRTGTLITAPNLPWQNYPLKINLQALLRLPVEVDNDANLAALGEY
HHEEEEECCCCCCCCCCCCCEEECCCCCCCCCCEEEEHHHHEECCCEECCCCCEEEEECC
RYGAGRGHKDMVYVTVSTGIGAGIIIDGQLYRGSSGSAGELGHTIVEPGGPRCNCGRRGC
CCCCCCCCCCEEEEEEECCCCCEEEECCEEEECCCCCCCCCCCEEECCCCCCCCCCCHHH
LEVMASGTAIGERARQLVAEGFGQEILKLAQGNIEAINAKTVGEAFLAGDPEAKGILNEV
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCHHHHHHHHH
AFYLGIGLANVVNLLNPSLIVLGGGVINIGEPFLELIREELAEKALPQPYKDLTVKKAVL
HHHHHHHHHHHHHHHCCCEEEEECCEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
GSKTGVMGAIALALERFS
CCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]