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The map label for this gene is gmk [H]

Identifier: 77461770

GI number: 77461770

Start: 6217332

End: 6217952

Strand: Direct

Name: gmk [H]

Synonym: Pfl01_5549

Alternate gene names: 77461770

Gene position: 6217332-6217952 (Clockwise)

Preceding gene: 77461769

Following gene: 77461771

Centisome position: 96.57

GC content: 59.42

Gene sequence:

>621_bases
ATGACCCACAGCACCGGCACCCTGTACATCATTTCCGCCCCTTCGGGTGCGGGCAAGAGCAGTCTGGTCAAGGCCCTGAC
CGACACCAATCCGGACATTCGCGTCTCGATTTCCCACACCACCCGCGCCATGCGCCCGGGTGAAGTGGACGGCGTGAACT
ATCACTTCGTGACCCGCGAAGAGTTCGTGAAAATGGGCGAGCACGGCGATTTTCTGGAACGCGCCGAAGTCTTCGGCAAC
TTCTACGGCACCTCGCAAAGCCGCCTACAGCAGACCCTGGACGAAGGCCACGACCTGATTCTGGAAATCGACTGGCAAGG
CGCCGAGCAAGTGCGCAAGCTGATGCCGCAGGCCCGTTCGATCTTCATCCTGCCGCCATCACTGCAGGCCCTGCACCAGC
GCCTGACCAACCGTGGCCAGGACAGCGACGAGATCATCGATGGCCGGATGCGTGAAGCGGTCAGCGAAATGAGCCACTAC
GTCGAGTACGACTACCTGATCATCAACGACGATTTCGCCCATGCGCTGGACGATCTGAAGGCGATTTTCCGCGCCAATCA
GTTGCAACAGAAACGTCAGCAAGTGCGTTTCGGCAAATTGCTGGCTGAATTGCTGGGCTGA

Upstream 100 bases:

>100_bases
GGCCTTCGACCCGCGCAGCACACAGGCAGCGGTCAACCTCAAGGTGTTGATCGAGCAGATGCGCGAACAAGTGCAGAATA
TTGAGTAAGGCTACCCCGAC

Downstream 100 bases:

>100_bases
AACAGCACTTCCCAAAACCGCTGCAAGGGCTTTACATTGGCACTTGCAGCGCGTTGAAGAGTCTGGTCAAAAAATCAGCG
CTTCCCTAATCGCTGGTGAT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTHSTGTLYIISAPSGAGKSSLVKALTDTNPDIRVSISHTTRAMRPGEVDGVNYHFVTREEFVKMGEHGDFLERAEVFGN
FYGTSQSRLQQTLDEGHDLILEIDWQGAEQVRKLMPQARSIFILPPSLQALHQRLTNRGQDSDEIIDGRMREAVSEMSHY
VEYDYLIINDDFAHALDDLKAIFRANQLQQKRQQVRFGKLLAELLG

Sequences:

>Translated_206_residues
MTHSTGTLYIISAPSGAGKSSLVKALTDTNPDIRVSISHTTRAMRPGEVDGVNYHFVTREEFVKMGEHGDFLERAEVFGN
FYGTSQSRLQQTLDEGHDLILEIDWQGAEQVRKLMPQARSIFILPPSLQALHQRLTNRGQDSDEIIDGRMREAVSEMSHY
VEYDYLIINDDFAHALDDLKAIFRANQLQQKRQQVRFGKLLAELLG
>Mature_205_residues
THSTGTLYIISAPSGAGKSSLVKALTDTNPDIRVSISHTTRAMRPGEVDGVNYHFVTREEFVKMGEHGDFLERAEVFGNF
YGTSQSRLQQTLDEGHDLILEIDWQGAEQVRKLMPQARSIFILPPSLQALHQRLTNRGQDSDEIIDGRMREAVSEMSHYV
EYDYLIINDDFAHALDDLKAIFRANQLQQKRQQVRFGKLLAELLG

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=39.4285714285714, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=39.4285714285714, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=39.4285714285714, Blast_Score=118, Evalue=4e-27,
Organism=Homo sapiens, GI14780902, Length=195, Percent_Identity=28.7179487179487, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI38570142, Length=176, Percent_Identity=31.8181818181818, Blast_Score=81, Evalue=6e-16,
Organism=Homo sapiens, GI21361598, Length=188, Percent_Identity=29.7872340425532, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI111154074, Length=162, Percent_Identity=29.6296296296296, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI262118259, Length=178, Percent_Identity=30.3370786516854, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4505237, Length=178, Percent_Identity=30.3370786516854, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI262118263, Length=178, Percent_Identity=30.3370786516854, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI262118255, Length=178, Percent_Identity=30.3370786516854, Blast_Score=68, Evalue=4e-12,
Organism=Escherichia coli, GI1790080, Length=205, Percent_Identity=59.5121951219512, Blast_Score=246, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI193203132, Length=180, Percent_Identity=32.7777777777778, Blast_Score=106, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=180, Percent_Identity=32.7777777777778, Blast_Score=106, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17557440, Length=160, Percent_Identity=26.25, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=177, Percent_Identity=41.8079096045198, Blast_Score=134, Evalue=1e-32,
Organism=Drosophila melanogaster, GI21356141, Length=198, Percent_Identity=33.8383838383838, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI45554481, Length=190, Percent_Identity=28.4210526315789, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI85724806, Length=190, Percent_Identity=28.4210526315789, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI116007136, Length=190, Percent_Identity=28.4210526315789, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24640542, Length=190, Percent_Identity=28.4210526315789, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45554489, Length=190, Percent_Identity=28.4210526315789, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161077626, Length=190, Percent_Identity=28.4210526315789, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221330166, Length=125, Percent_Identity=33.6, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330164, Length=125, Percent_Identity=33.6, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221330162, Length=125, Percent_Identity=33.6, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23348; Mature: 23216

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHSTGTLYIISAPSGAGKSSLVKALTDTNPDIRVSISHTTRAMRPGEVDGVNYHFVTRE
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCEEEEECHH
EFVKMGEHGDFLERAEVFGNFYGTSQSRLQQTLDEGHDLILEIDWQGAEQVRKLMPQARS
HHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCE
IFILPPSLQALHQRLTNRGQDSDEIIDGRMREAVSEMSHYVEYDYLIINDDFAHALDDLK
EEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHH
AIFRANQLQQKRQQVRFGKLLAELLG
HHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
THSTGTLYIISAPSGAGKSSLVKALTDTNPDIRVSISHTTRAMRPGEVDGVNYHFVTRE
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCHHHCCCCCCCCCCEEEEECHH
EFVKMGEHGDFLERAEVFGNFYGTSQSRLQQTLDEGHDLILEIDWQGAEQVRKLMPQARS
HHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHCE
IFILPPSLQALHQRLTNRGQDSDEIIDGRMREAVSEMSHYVEYDYLIINDDFAHALDDLK
EEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHH
AIFRANQLQQKRQQVRFGKLLAELLG
HHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA