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The map label for this gene is norM [H]

Identifier: 77461738

GI number: 77461738

Start: 6184189

End: 6185583

Strand: Direct

Name: norM [H]

Synonym: Pfl01_5517

Alternate gene names: 77461738

Gene position: 6184189-6185583 (Clockwise)

Preceding gene: 77461735

Following gene: 77461740

Centisome position: 96.05

GC content: 65.09

Gene sequence:

>1395_bases
ATGCAGCGCCCTGTGCGTACCGAACTCTGGGCCATCCTGCGGCTGGCGGGGCCGTTGATCGCCTCGCAGTTGGCGCACAT
GCTGATGGTGCTGACCGACACCCTGATGATGGCGCGCCTCAGTCCCGAAGCGCTGGCCGGCGGCGGTCTGGGCGCGGCGA
GTTATTCGTTCGTGTCGATTTTCTGCATCGGCGTGATTGCGGCGGTTGGCACCCTCGTGGCGATTCGTCAGGGCGCCGGC
GACATCATCGGCGCCGCCCGCCTGACCCAGGCCGGGCTGTGGCTGGCGTGGCTGATGGCGCTCGGTGCCGGGCTGTTGTT
GTGGAACCTGAAACCGGTGCTGTTGCTGTTCGGCCAGACCGAGACTAACGTCAACGCCGCCGGGCAATTTCTGATCGCCC
TGCCGTTCGCCCTGCCCGGCTACCTGAGCTTCATGGCTCTGCGCGGTTTCACCAGCGCCATCGGCCGGGCGACACCGGTG
ATGGTCATCAGCCTCGCCGGCACGGTGGCCAACTTCCTGCTCAATTACGCGCTGATCACCGGCATGTTCGGCCTGCCGAA
ACTCGGGCTGACCGGTATCGGCCTGGTCACGGCGATTGTCGCCAACTGCATGGCGCTGGCGCTGGCCTGGCATATCCGTC
GGCATCCGGCCTACGACGCCTACCCGTTGCGCGAGGGTCTGTCGCGGCCAAACCGGCAGTACCTGAAAGAACTCTGGCGC
CTGGGCCTGCCGATCGGCGGGACCTACGCGGTGGAAGTCGGGCTGTTCGCCTTCGCGGCGCTGTGCATGGGCACCATGGG
CAGCACGCAACTGGCGGCGCACCAGATCGCCCTGCAAATCGTCTCGGTGGCGTTCATGGTGCCGGCGGGGATGTCGTATG
CGATCACCATGCGTGTCGGCCAGCATTACGGCGCCGGGCAATTGAGTGATGCGCGGATGTCCGGGCGGGTCGGCATCGTC
TTCGGTGCAGTGGTGATGCTGGGGTTTGCGATGGTGTTCTGGTTGCTGCCGAATCAGTTGGTCGGTTTGTTCCTCGACCA
TAACGACCCGGCGTTTGCCGAAGTGATTCGTCTGGCCGTGAGCCTGCTGGCCGTGGCGGCCTGGTTCGAGCTGTTCGACG
GCACGCAGACGATTGCCATGGGCTGCATCCGCGGGCTCAAGGATGCCAAGACCACATTCCTGGTCGGGCTTGTTTGCTAC
TGGCTGATCGGCGCGCCGGCGGCGTGGCTGATGGCGTTTCATCTGCACTGGGGGCCGACCGGCGTCTGGTGGGGTCTGGC
GCTGGGGCTGGCCTGTGCGGCGGTGAGCTTGACGCTGGCGTTCGAATGGAAGATGAAGCGAATGATTCGGCTTGAGCCGC
AATCTCAAGGTTTCAAGATCGCTCAGCCGGAATGA

Upstream 100 bases:

>100_bases
TTAATCATGCCACCCATCCTTTTTATCCCTTTGTGCAACCTGCGCCAAACCCTGAGAATCGACGGTCTCTTGCTCCCTCT
TTTATAAGGATGTGAACGCC

Downstream 100 bases:

>100_bases
GTTTCCCTGTGGGAGCAAGCTCGCTCCCACAGGGATTTGAGGCTAAACCACGATACCCAGCGGCGGCTGGCTGGCGTCAA
CCACCAGATATTCAACCAGT

Product: multidrug efflux protein NorA

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MQRPVRTELWAILRLAGPLIASQLAHMLMVLTDTLMMARLSPEALAGGGLGAASYSFVSIFCIGVIAAVGTLVAIRQGAG
DIIGAARLTQAGLWLAWLMALGAGLLLWNLKPVLLLFGQTETNVNAAGQFLIALPFALPGYLSFMALRGFTSAIGRATPV
MVISLAGTVANFLLNYALITGMFGLPKLGLTGIGLVTAIVANCMALALAWHIRRHPAYDAYPLREGLSRPNRQYLKELWR
LGLPIGGTYAVEVGLFAFAALCMGTMGSTQLAAHQIALQIVSVAFMVPAGMSYAITMRVGQHYGAGQLSDARMSGRVGIV
FGAVVMLGFAMVFWLLPNQLVGLFLDHNDPAFAEVIRLAVSLLAVAAWFELFDGTQTIAMGCIRGLKDAKTTFLVGLVCY
WLIGAPAAWLMAFHLHWGPTGVWWGLALGLACAAVSLTLAFEWKMKRMIRLEPQSQGFKIAQPE

Sequences:

>Translated_464_residues
MQRPVRTELWAILRLAGPLIASQLAHMLMVLTDTLMMARLSPEALAGGGLGAASYSFVSIFCIGVIAAVGTLVAIRQGAG
DIIGAARLTQAGLWLAWLMALGAGLLLWNLKPVLLLFGQTETNVNAAGQFLIALPFALPGYLSFMALRGFTSAIGRATPV
MVISLAGTVANFLLNYALITGMFGLPKLGLTGIGLVTAIVANCMALALAWHIRRHPAYDAYPLREGLSRPNRQYLKELWR
LGLPIGGTYAVEVGLFAFAALCMGTMGSTQLAAHQIALQIVSVAFMVPAGMSYAITMRVGQHYGAGQLSDARMSGRVGIV
FGAVVMLGFAMVFWLLPNQLVGLFLDHNDPAFAEVIRLAVSLLAVAAWFELFDGTQTIAMGCIRGLKDAKTTFLVGLVCY
WLIGAPAAWLMAFHLHWGPTGVWWGLALGLACAAVSLTLAFEWKMKRMIRLEPQSQGFKIAQPE
>Mature_464_residues
MQRPVRTELWAILRLAGPLIASQLAHMLMVLTDTLMMARLSPEALAGGGLGAASYSFVSIFCIGVIAAVGTLVAIRQGAG
DIIGAARLTQAGLWLAWLMALGAGLLLWNLKPVLLLFGQTETNVNAAGQFLIALPFALPGYLSFMALRGFTSAIGRATPV
MVISLAGTVANFLLNYALITGMFGLPKLGLTGIGLVTAIVANCMALALAWHIRRHPAYDAYPLREGLSRPNRQYLKELWR
LGLPIGGTYAVEVGLFAFAALCMGTMGSTQLAAHQIALQIVSVAFMVPAGMSYAITMRVGQHYGAGQLSDARMSGRVGIV
FGAVVMLGFAMVFWLLPNQLVGLFLDHNDPAFAEVIRLAVSLLAVAAWFELFDGTQTIAMGCIRGLKDAKTTFLVGLVCY
WLIGAPAAWLMAFHLHWGPTGVWWGLALGLACAAVSLTLAFEWKMKRMIRLEPQSQGFKIAQPE

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=443, Percent_Identity=23.9277652370203, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI153792564, Length=450, Percent_Identity=24, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI38261960, Length=490, Percent_Identity=24.0816326530612, Blast_Score=82, Evalue=9e-16,
Organism=Escherichia coli, GI48994890, Length=456, Percent_Identity=31.359649122807, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI226510954, Length=475, Percent_Identity=24.4210526315789, Blast_Score=66, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6321821, Length=396, Percent_Identity=23.7373737373737, Blast_Score=70, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320545, Length=424, Percent_Identity=20.7547169811321, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49695; Mature: 49695

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRPVRTELWAILRLAGPLIASQLAHMLMVLTDTLMMARLSPEALAGGGLGAASYSFVSI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHH
FCIGVIAAVGTLVAIRQGAGDIIGAARLTQAGLWLAWLMALGAGLLLWNLKPVLLLFGQT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHEEECCC
ETNVNAAGQFLIALPFALPGYLSFMALRGFTSAIGRATPVMVISLAGTVANFLLNYALIT
CCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
GMFGLPKLGLTGIGLVTAIVANCMALALAWHIRRHPAYDAYPLREGLSRPNRQYLKELWR
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHH
LGLPIGGTYAVEVGLFAFAALCMGTMGSTQLAAHQIALQIVSVAFMVPAGMSYAITMRVG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
QHYGAGQLSDARMSGRVGIVFGAVVMLGFAMVFWLLPNQLVGLFLDHNDPAFAEVIRLAV
CCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHH
SLLAVAAWFELFDGTQTIAMGCIRGLKDAKTTFLVGLVCYWLIGAPAAWLMAFHLHWGPT
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCH
GVWWGLALGLACAAVSLTLAFEWKMKRMIRLEPQSQGFKIAQPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCC
>Mature Secondary Structure
MQRPVRTELWAILRLAGPLIASQLAHMLMVLTDTLMMARLSPEALAGGGLGAASYSFVSI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHH
FCIGVIAAVGTLVAIRQGAGDIIGAARLTQAGLWLAWLMALGAGLLLWNLKPVLLLFGQT
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCHHEEECCC
ETNVNAAGQFLIALPFALPGYLSFMALRGFTSAIGRATPVMVISLAGTVANFLLNYALIT
CCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
GMFGLPKLGLTGIGLVTAIVANCMALALAWHIRRHPAYDAYPLREGLSRPNRQYLKELWR
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHHHH
LGLPIGGTYAVEVGLFAFAALCMGTMGSTQLAAHQIALQIVSVAFMVPAGMSYAITMRVG
CCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEC
QHYGAGQLSDARMSGRVGIVFGAVVMLGFAMVFWLLPNQLVGLFLDHNDPAFAEVIRLAV
CCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHH
SLLAVAAWFELFDGTQTIAMGCIRGLKDAKTTFLVGLVCYWLIGAPAAWLMAFHLHWGPT
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCH
GVWWGLALGLACAAVSLTLAFEWKMKRMIRLEPQSQGFKIAQPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]