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The map label for this gene is lysA [H]

Identifier: 77461719

GI number: 77461719

Start: 6164471

End: 6165718

Strand: Direct

Name: lysA [H]

Synonym: Pfl01_5498

Alternate gene names: 77461719

Gene position: 6164471-6165718 (Clockwise)

Preceding gene: 77461718

Following gene: 77461720

Centisome position: 95.75

GC content: 65.14

Gene sequence:

>1248_bases
ATGGACGCTTTTAACTACCGTGGCGGGGAACTGTTCGCGGAAGGTGTGGCGCTGTCCGCCATCGCCGATCGCTTCGGCAC
TCCCACCTACGTTTACTCCCGCGCGCACATCGAGGCCCAGTACCTGGCCTACGCCGATGCGCTGGCCGGCATGCCGCACC
TGGTGTGCTTTGCGGTCAAGGCCAACTCCAACCTCGGCGTCCTGAATGTCCTGGCCCGTATCGGCGCCGGTTTCGACATC
GTTTCCCGCGGCGAGCTGGAACGCGTTCTGGCCGCCGGCGGCAGCCCGGACAAGATCGTGTTCTCCGGCGTCGGCAAGAC
CCGTGACGACATGCGCCGTGCGCTGGAAGTCGGCGTGCATTGCTTCAACGTCGAATCCACTGACGAGCTCGAGCGCCTGC
AAGTGGTCGCCGCCGAGCTGGGCGTTCGCGCGCCGATTTCGCTGCGCGTGAACCCGGACGTCGATGCCGGCACCCACCCG
TACATTTCCACCGGTCTCAAAGAGAACAAGTTCGGCATCGCCATCGCCGACGCCGAAGACGTGTACGTGCGTGCCGCGCA
CCTGCCGAACCTGGAAGTGGTCGGCGTCGACTGCCACATCGGTTCGCAACTGACCACTCTGCCTCCGTTCCTCGATGCCC
TCGACCGCCTGCTGGATCTGGTCGATCGCCTCGGCGATTGCGGCATCCACCTGCGCCACATCGATCTCGGTGGCGGCCTG
GGTGTGCGTTATCGCGATGAAGAGCCGCCATTGGCCGCCGATTACATCAAGGCTGTGCGCGAGCGTCTGGTCGGCCGTGA
TCTGGCGCTGGTGTTCGAACCGGGCCGCTTCATCGTCGCCAACGCCGGCGTGCTGCTGACCCAGGTCGAGTACCTCAAGC
ACACCGAACACAAAGACTTCGCCATCGTCGACGCGGCCATGAACGACCTGATCCGCCCGGCGCTGTACCAGGCCTGGATG
GACGTGACCCCGGTCAAGCCACGCGAGACCGCTGCGCGTACCTACGACGTCGTCGGCCCGATCTGCGAAACCGGCGACTT
CCTCGCCAAGGAACGCGAACTGGCGCTGGAAGAAGGCGATCTGCTGGCCGTGCATTCGGCCGGTGCCTACGGTTTCGTGA
TGAGCTCCAACTACAACACCCGCGGCCGCGCCGCCGAAGTGCTGGTGGATGGCGATCAGGCCTTTGAAGTGCGTCGCCGC
GAAACCGTGGCCGAGCTGTTTGCCGGCGAAAGCCTGCTGCCGGAGTGA

Upstream 100 bases:

>100_bases
CCTGCCCGATGAAGATCAGGACCCGGCCGAGCAAGCCCAGTCTTCGCAAAAGCAGCCTGTCTCCAAGGCACACAAGCACG
ACGTTTACTAAGGGATCGCC

Downstream 100 bases:

>100_bases
CCCCATGCTGCTGCGTTTTACCAAGATGCATGGCCTGGGCAACGACTTCATGGTTCTCGACCTGGTCAGTCAGCACGCGC
ATATTCAGCCCAAGCACGCG

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MDAFNYRGGELFAEGVALSAIADRFGTPTYVYSRAHIEAQYLAYADALAGMPHLVCFAVKANSNLGVLNVLARIGAGFDI
VSRGELERVLAAGGSPDKIVFSGVGKTRDDMRRALEVGVHCFNVESTDELERLQVVAAELGVRAPISLRVNPDVDAGTHP
YISTGLKENKFGIAIADAEDVYVRAAHLPNLEVVGVDCHIGSQLTTLPPFLDALDRLLDLVDRLGDCGIHLRHIDLGGGL
GVRYRDEEPPLAADYIKAVRERLVGRDLALVFEPGRFIVANAGVLLTQVEYLKHTEHKDFAIVDAAMNDLIRPALYQAWM
DVTPVKPRETAARTYDVVGPICETGDFLAKERELALEEGDLLAVHSAGAYGFVMSSNYNTRGRAAEVLVDGDQAFEVRRR
ETVAELFAGESLLPE

Sequences:

>Translated_415_residues
MDAFNYRGGELFAEGVALSAIADRFGTPTYVYSRAHIEAQYLAYADALAGMPHLVCFAVKANSNLGVLNVLARIGAGFDI
VSRGELERVLAAGGSPDKIVFSGVGKTRDDMRRALEVGVHCFNVESTDELERLQVVAAELGVRAPISLRVNPDVDAGTHP
YISTGLKENKFGIAIADAEDVYVRAAHLPNLEVVGVDCHIGSQLTTLPPFLDALDRLLDLVDRLGDCGIHLRHIDLGGGL
GVRYRDEEPPLAADYIKAVRERLVGRDLALVFEPGRFIVANAGVLLTQVEYLKHTEHKDFAIVDAAMNDLIRPALYQAWM
DVTPVKPRETAARTYDVVGPICETGDFLAKERELALEEGDLLAVHSAGAYGFVMSSNYNTRGRAAEVLVDGDQAFEVRRR
ETVAELFAGESLLPE
>Mature_415_residues
MDAFNYRGGELFAEGVALSAIADRFGTPTYVYSRAHIEAQYLAYADALAGMPHLVCFAVKANSNLGVLNVLARIGAGFDI
VSRGELERVLAAGGSPDKIVFSGVGKTRDDMRRALEVGVHCFNVESTDELERLQVVAAELGVRAPISLRVNPDVDAGTHP
YISTGLKENKFGIAIADAEDVYVRAAHLPNLEVVGVDCHIGSQLTTLPPFLDALDRLLDLVDRLGDCGIHLRHIDLGGGL
GVRYRDEEPPLAADYIKAVRERLVGRDLALVFEPGRFIVANAGVLLTQVEYLKHTEHKDFAIVDAAMNDLIRPALYQAWM
DVTPVKPRETAARTYDVVGPICETGDFLAKERELALEEGDLLAVHSAGAYGFVMSSNYNTRGRAAEVLVDGDQAFEVRRR
ETVAELFAGESLLPE

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=396, Percent_Identity=25.2525252525253, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI22538418, Length=426, Percent_Identity=23.2394366197183, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI21361583, Length=426, Percent_Identity=23.2394366197183, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1789203, Length=407, Percent_Identity=35.8722358722359, Blast_Score=181, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17562780, Length=365, Percent_Identity=24.3835616438356, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322664, Length=362, Percent_Identity=24.585635359116, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24586474, Length=342, Percent_Identity=25.7309941520468, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24586472, Length=339, Percent_Identity=24.4837758112094, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45117; Mature: 45117

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAFNYRGGELFAEGVALSAIADRFGTPTYVYSRAHIEAQYLAYADALAGMPHLVCFAVK
CCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCEEEEEEEE
ANSNLGVLNVLARIGAGFDIVSRGELERVLAAGGSPDKIVFSGVGKTRDDMRRALEVGVH
CCCCCHHHHHHHHHCCCCCEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCE
CFNVESTDELERLQVVAAELGVRAPISLRVNPDVDAGTHPYISTGLKENKFGIAIADAED
EECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHCCCCCCCCEEEEECCCC
VYVRAAHLPNLEVVGVDCHIGSQLTTLPPFLDALDRLLDLVDRLGDCGIHLRHIDLGGGL
EEEEEECCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
GVRYRDEEPPLAADYIKAVRERLVGRDLALVFEPGRFIVANAGVLLTQVEYLKHTEHKDF
CEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCHHHHHHHHHHCCCCCCE
AIVDAAMNDLIRPALYQAWMDVTPVKPRETAARTYDVVGPICETGDFLAKERELALEEGD
EEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHCCCHHHHHHHHHHCCCCC
LLAVHSAGAYGFVMSSNYNTRGRAAEVLVDGDQAFEVRRRETVAELFAGESLLPE
EEEEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDAFNYRGGELFAEGVALSAIADRFGTPTYVYSRAHIEAQYLAYADALAGMPHLVCFAVK
CCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHCCCCEEEEEEEE
ANSNLGVLNVLARIGAGFDIVSRGELERVLAAGGSPDKIVFSGVGKTRDDMRRALEVGVH
CCCCCHHHHHHHHHCCCCCEECCCHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHCCE
CFNVESTDELERLQVVAAELGVRAPISLRVNPDVDAGTHPYISTGLKENKFGIAIADAED
EECCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHCCCCCCCCEEEEECCCC
VYVRAAHLPNLEVVGVDCHIGSQLTTLPPFLDALDRLLDLVDRLGDCGIHLRHIDLGGGL
EEEEEECCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCC
GVRYRDEEPPLAADYIKAVRERLVGRDLALVFEPGRFIVANAGVLLTQVEYLKHTEHKDF
CEEECCCCCCHHHHHHHHHHHHHCCCCEEEEEECCEEEEEECCHHHHHHHHHHCCCCCCE
AIVDAAMNDLIRPALYQAWMDVTPVKPRETAARTYDVVGPICETGDFLAKERELALEEGD
EEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHCCCHHHHHHHHHHCCCCC
LLAVHSAGAYGFVMSSNYNTRGRAAEVLVDGDQAFEVRRRETVAELFAGESLLPE
EEEEECCCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9618537 [H]