Click here to switch to the map view.

The map label for this gene is rppH [H]

Identifier: 77461599

GI number: 77461599

Start: 6041613

End: 6042092

Strand: Reverse

Name: rppH [H]

Synonym: Pfl01_5378

Alternate gene names: 77461599

Gene position: 6042092-6041613 (Counterclockwise)

Preceding gene: 77461601

Following gene: 77461598

Centisome position: 93.84

GC content: 58.75

Gene sequence:

>480_bases
GTGATCGACCCCGATGGTTTCCGCCCTAATGTCGGGATCATTCTGACGAATGACGCCGGCCAGGTGCTATGGGCTCGCCG
TATCAATCAGGATGCCTGGCAGTTTCCACAGGGGGGAATCAATCCCGAGGAGACGCCGGAAGACGCCTTGTACCGCGAGC
TGAACGAAGAAGTTGGCCTGGAACGCGAAGATGTTGAAATTCTCGCCTGTACCCGGGGCTGGTTGCGCTATCGTTTGCCG
CAACGTCTGGTGCGAACCCACAGCCAACCGCTGTGCATCGGCCAGAAACAGAAGTGGTTTCTCCTGCGCCTGATCTCCAA
CGAGCAGCGGGTGCGGATGGATTTGACCGGTAAACCGGAGTTCGATGGCTGGCGCTGGGTCAGTTATTGGTATCCGTTGG
GCCAGGTGGTGACATTCAAGCGCGAAGTGTATCGCCGCGCTCTCAAAGAGCTTGCCCCGCGCCTTTTAGCGCGCGACTGA

Upstream 100 bases:

>100_bases
CGGTCTTTTCACAAGAGTGCACATAAGCTCGGAACCTTCGTTGCCGCCTTCACAACCTTTGTGGAACAATGCGGCGACAT
GCGTTTGCGAGGTTGTTGCC

Downstream 100 bases:

>100_bases
CGACGGAGTTCGACCCCGAGCCATGCTCAATACGCTGCGCAAGATCGTCCAGGAAGTTAACTCCGCCAAGGATCTCAAGG
CGGCGTTGGGGATTATTGTG

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MIDPDGFRPNVGIILTNDAGQVLWARRINQDAWQFPQGGINPEETPEDALYRELNEEVGLEREDVEILACTRGWLRYRLP
QRLVRTHSQPLCIGQKQKWFLLRLISNEQRVRMDLTGKPEFDGWRWVSYWYPLGQVVTFKREVYRRALKELAPRLLARD

Sequences:

>Translated_159_residues
MIDPDGFRPNVGIILTNDAGQVLWARRINQDAWQFPQGGINPEETPEDALYRELNEEVGLEREDVEILACTRGWLRYRLP
QRLVRTHSQPLCIGQKQKWFLLRLISNEQRVRMDLTGKPEFDGWRWVSYWYPLGQVVTFKREVYRRALKELAPRLLARD
>Mature_159_residues
MIDPDGFRPNVGIILTNDAGQVLWARRINQDAWQFPQGGINPEETPEDALYRELNEEVGLEREDVEILACTRGWLRYRLP
QRLVRTHSQPLCIGQKQKWFLLRLISNEQRVRMDLTGKPEFDGWRWVSYWYPLGQVVTFKREVYRRALKELAPRLLARD

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=157, Percent_Identity=64.968152866242, Blast_Score=227, Evalue=3e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18850; Mature: 18850

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDPDGFRPNVGIILTNDAGQVLWARRINQDAWQFPQGGINPEETPEDALYRELNEEVGL
CCCCCCCCCCCCEEEECCCCHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
EREDVEILACTRGWLRYRLPQRLVRTHSQPLCIGQKQKWFLLRLISNEQRVRMDLTGKPE
CCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEEHHHCCCCEEEEECCCCCC
FDGWRWVSYWYPLGQVVTFKREVYRRALKELAPRLLARD
CCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDPDGFRPNVGIILTNDAGQVLWARRINQDAWQFPQGGINPEETPEDALYRELNEEVGL
CCCCCCCCCCCCEEEECCCCHHHHHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHCC
EREDVEILACTRGWLRYRLPQRLVRTHSQPLCIGQKQKWFLLRLISNEQRVRMDLTGKPE
CCCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEEHHHCCCCEEEEECCCCCC
FDGWRWVSYWYPLGQVVTFKREVYRRALKELAPRLLARD
CCCEEEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA