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The map label for this gene is ilvD [H]

Identifier: 77461579

GI number: 77461579

Start: 6017583

End: 6019424

Strand: Direct

Name: ilvD [H]

Synonym: Pfl01_5358

Alternate gene names: 77461579

Gene position: 6017583-6019424 (Clockwise)

Preceding gene: 77461578

Following gene: 77461581

Centisome position: 93.46

GC content: 62.81

Gene sequence:

>1842_bases
ATGCCAGATTACCGCTCGAAAACATCCACCCACGGCCGCAACATGGCCGGCGCCCGCGCACTGTGGCGCGCCACCGGGAT
GAAAGATGACGACTTCAAGAAGCCGATCATCGCCATTGCCAACTCCTTCACCCAGTTCGTCCCGGGCCACGTCCACCTGA
AGGACCTCGGCCAGCTGGTTGCCCGTGAGATCGAACGCGCTGGCGGCGTTGCAAAAGAATTCAACACCATCGCCGTGGAT
GACGGCATCGCCATGGGCCACGACGGCATGCTCTATTCGCTGCCGAGCCGCGAGATCATCGCCGACTCCGTCGAGTACAT
GGTCAACGCCCACTGCGCCGACGCCATCGTCTGCATCTCGAACTGCGACAAGATCACCCCCGGCATGCTGATGGCCGCGC
TGCGCCTGAACATCCCGGTGATCTTCGTCTCCGGCGGTCCGATGGAAGCCGGCAAGACCAAACTGGCCAGCCACGGTCTC
GACCTCGTCGACGCCATGGTCATCGCCGCCGACTCCAGCGCTTCTGACGAGAAGGTTGCCGAGTACGAGCGCAGCGCCTG
CCCGACCTGCGGTTCGTGCTCCGGCATGTTCACCGCCAACTCGATGAACTGCCTGACCGAGGCCCTGGGCCTTGCATTGC
CGGGCAACGGTTCGACCCTGGCCACCCACAGCGACCGCGAACAGCTGTTCCTGCAGGCCGGCCGTACCATCGTCGAGCTG
TGCAAACGCTACTACGGCGAGAACGACGAGTCGGTACTGCCGCGCAACATCGCCAACTTCAAGGCGTTCGAGAACGCGAT
GATGCTCGACATCGCCATGGGCGGTTCGACCAACACCATCCTGCACTTGCTGGCCGCAGCCCAGGAAGCAGAGATCGACT
TCGACCTGCGTGACATTGATCGTCTGTCGCGCAAGGTGCCGCAACTGTGCAAGGTCGCGCCGAACATCCAGAAGTACCAC
ATGGAAGACGTGCACCGCGCCGGCGGCATCTTCAGCATTCTCGGTTCGCTGGCCCGTGGCGGCCTGCTGCACACCGACCT
GCCGACCGTGCACAGTCGCAGCATGGAAGAAGCCATCGCCAAATGGGACATCACCCAGACCGACGATGAAGCCGTGCATC
ATTTCTTCAAGGCCGGCCCGGCCGGCATTCCGACGCAGACCGCGTTCAGCCAGTCGACCCGCTGGGAAACCCTGGACGAC
GACCGTGAAAACGGCTGCATCCGCAGCTTTGAACACGCTTATTCGAAAGAAGGCGGCCTGGCCGTGCTGTACGGCAACAT
CGCCCTGGACGGCTGCGTGGTGAAAACCGCCGGTGTCGACGAGTCGATCCACGTGTTCGAAGGCAACGCGAAGATCTTCG
AAAGCCAGGACAGCGCCGTACGCGGCATCCTCGCCGACGAAGTAAAGGAAGGCGACATCGTCATCATTCGCTACGAAGGC
CCGAAAGGCGGCCCGGGCATGCAGGAAATGCTCTATCCGACCTCGTACCTGAAATCCAAAGGCCTGGGCAAAGCCTGCGC
CCTGCTGACCGACGGTCGTTTCTCCGGCGGTACGTCCGGCTTGTCCATCGGCCACGCTTCACCAGAGGCTGCGGCCGGCG
GCGCGATCGGCCTGGTACAGGACGGCGACAAGGTGCTGATCGACATTCCGAACCGTTCGATCAACCTGCTGATCAGCGAC
GAAGAACTGGCGGCACGCCGGGTCGAGCAGGACAAGAAAGGCTGGAAACCGGTCGAACAGCGTCCACGCAAAGTGACCAC
CGCCCTCAAGGCCTACGCCCTGCTGGCGACCAGCGCCGACAAGGGTGCTGTGCGTAACAAGGCGATGCTCGACGGGCTGT
AA

Upstream 100 bases:

>100_bases
GTCATCGGCAACATCAGGACACACGGCCATTTCTGAGTGTTCCAGACGTCAATAGAAGCTCACTCCCCTTTGATACCTGA
TTAGCCGCCCGGAGTGCTCC

Downstream 100 bases:

>100_bases
GCGTCAAATCGCAGAAACAAAAATGCCCCGCCAAGTGCGGGGCATTTTTTTGCCTTCAGGTTTACTGAATTTCTTCCGGT
TTGACGATCACCCAGTTCTT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 613; Mature: 612

Protein sequence:

>613_residues
MPDYRSKTSTHGRNMAGARALWRATGMKDDDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLASHGL
DLVDAMVIAADSSASDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHSDREQLFLQAGRTIVEL
CKRYYGENDESVLPRNIANFKAFENAMMLDIAMGGSTNTILHLLAAAQEAEIDFDLRDIDRLSRKVPQLCKVAPNIQKYH
MEDVHRAGGIFSILGSLARGGLLHTDLPTVHSRSMEEAIAKWDITQTDDEAVHHFFKAGPAGIPTQTAFSQSTRWETLDD
DRENGCIRSFEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGNAKIFESQDSAVRGILADEVKEGDIVIIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLISD
EELAARRVEQDKKGWKPVEQRPRKVTTALKAYALLATSADKGAVRNKAMLDGL

Sequences:

>Translated_613_residues
MPDYRSKTSTHGRNMAGARALWRATGMKDDDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLASHGL
DLVDAMVIAADSSASDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHSDREQLFLQAGRTIVEL
CKRYYGENDESVLPRNIANFKAFENAMMLDIAMGGSTNTILHLLAAAQEAEIDFDLRDIDRLSRKVPQLCKVAPNIQKYH
MEDVHRAGGIFSILGSLARGGLLHTDLPTVHSRSMEEAIAKWDITQTDDEAVHHFFKAGPAGIPTQTAFSQSTRWETLDD
DRENGCIRSFEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGNAKIFESQDSAVRGILADEVKEGDIVIIRYEG
PKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLISD
EELAARRVEQDKKGWKPVEQRPRKVTTALKAYALLATSADKGAVRNKAMLDGL
>Mature_612_residues
PDYRSKTSTHGRNMAGARALWRATGMKDDDFKKPIIAIANSFTQFVPGHVHLKDLGQLVAREIERAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCISNCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLASHGLD
LVDAMVIAADSSASDEKVAEYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHSDREQLFLQAGRTIVELC
KRYYGENDESVLPRNIANFKAFENAMMLDIAMGGSTNTILHLLAAAQEAEIDFDLRDIDRLSRKVPQLCKVAPNIQKYHM
EDVHRAGGIFSILGSLARGGLLHTDLPTVHSRSMEEAIAKWDITQTDDEAVHHFFKAGPAGIPTQTAFSQSTRWETLDDD
RENGCIRSFEHAYSKEGGLAVLYGNIALDGCVVKTAGVDESIHVFEGNAKIFESQDSAVRGILADEVKEGDIVIIRYEGP
KGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQDGDKVLIDIPNRSINLLISDE
ELAARRVEQDKKGWKPVEQRPRKVTTALKAYALLATSADKGAVRNKAMLDGL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=617, Percent_Identity=74.5542949756888, Blast_Score=952, Evalue=0.0,
Organism=Escherichia coli, GI1786464, Length=555, Percent_Identity=30.8108108108108, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI1788157, Length=537, Percent_Identity=29.0502793296089, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI2367371, Length=510, Percent_Identity=30.9803921568627, Blast_Score=192, Evalue=6e-50,
Organism=Saccharomyces cerevisiae, GI6322476, Length=605, Percent_Identity=37.3553719008264, Blast_Score=357, Evalue=4e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 65875; Mature: 65743

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYRSKTSTHGRNMAGARALWRATGMKDDDFKKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIERAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEEC
NCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLASHGLDLVDAMVIAADSSASDEKVA
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHEECCCCCCHHHHH
EYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHSDREQLFLQAGRTIVEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCEEECCCCCEEEECCHHHHHHHHHCHHHHHH
CKRYYGENDESVLPRNIANFKAFENAMMLDIAMGGSTNTILHLLAAAQEAEIDFDLRDID
HHHHCCCCCCCCCCCHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHH
RLSRKVPQLCKVAPNIQKYHMEDVHRAGGIFSILGSLARGGLLHTDLPTVHSRSMEEAIA
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHH
KWDITQTDDEAVHHFFKAGPAGIPTQTAFSQSTRWETLDDDRENGCIRSFEHAYSKEGGL
HCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCE
AVLYGNIALDGCVVKTAGVDESIHVFEGNAKIFESQDSAVRGILADEVKEGDIVIIRYEG
EEEECCEEECCEEEEECCCCCCEEEEECCCEEEECCCHHHHHHHHHHCCCCCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQ
CCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
DGDKVLIDIPNRSINLLISDEELAARRVEQDKKGWKPVEQRPRKVTTALKAYALLATSAD
CCCEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC
KGAVRNKAMLDGL
CCHHHCCHHHCCC
>Mature Secondary Structure 
PDYRSKTSTHGRNMAGARALWRATGMKDDDFKKPIIAIANSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIERAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAIVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHEEEEC
NCDKITPGMLMAALRLNIPVIFVSGGPMEAGKTKLASHGLDLVDAMVIAADSSASDEKVA
CCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHEECCCCCCHHHHH
EYERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSTLATHSDREQLFLQAGRTIVEL
HHHHHCCCCCCCCCCCEECCHHHHHHHHHCEEECCCCCEEEECCHHHHHHHHHCHHHHHH
CKRYYGENDESVLPRNIANFKAFENAMMLDIAMGGSTNTILHLLAAAQEAEIDFDLRDID
HHHHCCCCCCCCCCCHHHHHHHHCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCHHHHH
RLSRKVPQLCKVAPNIQKYHMEDVHRAGGIFSILGSLARGGLLHTDLPTVHSRSMEEAIA
HHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHCCEEECCCCCHHHHHHHHHHH
KWDITQTDDEAVHHFFKAGPAGIPTQTAFSQSTRWETLDDDRENGCIRSFEHAYSKEGGL
HCCCCCCCHHHHHHHHHCCCCCCCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCE
AVLYGNIALDGCVVKTAGVDESIHVFEGNAKIFESQDSAVRGILADEVKEGDIVIIRYEG
EEEECCEEECCEEEEECCCCCCEEEEECCCEEEECCCHHHHHHHHHHCCCCCEEEEEECC
PKGGPGMQEMLYPTSYLKSKGLGKACALLTDGRFSGGTSGLSIGHASPEAAAGGAIGLVQ
CCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
DGDKVLIDIPNRSINLLISDEELAARRVEQDKKGWKPVEQRPRKVTTALKAYALLATSAD
CCCEEEEECCCCCEEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCC
KGAVRNKAMLDGL
CCHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA